Abstract：
:The purpose of this study is to evaluate whole lysyl oxidase like 1 (LOXL1) gene by sequence analysis in Turkish patients with exfoliation glaucoma (XFG). A total of 48 (35 male, 13 female) patients with XFG were enrolled. Besides routine ophthalmological examination, peripapillary retinal nerve fibre layer (RNFL) analysis with optic coherence tomography was performed. Blood samples of 2 ml with EDTA were obtained and sent to Medical Genetics Department, Molecular Genetics Laboratory for LOXL1 polymorphism (PCR and agarose gel imaging) analysis. The role of the detected changes on disease severity was evaluated. No LOXL1 gene mutations in any of the patients were detected. Three types of single-nucleotide polymorphisms (SNPs) including R141L(rs1048661), A320A(rs41435250), and F184F were detected in 17 (35.3 %) patients. When compared, SNP-positive patients had thinner RNFL than SNP-negative patients (64.5 ± 17.6 and 66.1 ± 20.4 µ, respectively), and SNP-positive patients had higher cupping/disc ratio than SNP-negative patients (0.76 ± 0.2 and 0.70 ± 0.3, respectively). However, both values were not statistically significant (p = 0.966 and p = 0.539, respectively). When compared, R141L-positive patients had significantly thinner cornea thickness (516.11 ± 30.3 µ) than R141L-negative patients (556.69 ± 27.2 µ) (p = 0.004). There was not any statistical significant difference in the means of age, gender, BCVA, MD, PSD, IOP, number of hypotensive agents, and percent of glaucoma surgery (p > 0.05). In this study group of Turkish population, no LOXL1 mutations were found. No associations between the defined SNPs (A320A, R141L and F184F) and the severity of the disease were detected.
journal_name
Int Ophthalmoljournal_title
International ophthalmologyauthors
Yilmaz SG,Palamar M,Onay H,Ilim O,Aykut A,Ozkinay FF,Yagci Adoi
10.1007/s10792-016-0174-ysubject
Has Abstractpub_date
2016-10-01 00:00:00pages
629-35issue
5eissn
0165-5701issn
1573-2630pii
10.1007/s10792-016-0174-yjournal_volume
36pub_type
杂志文章abstract：PURPOSE:To compare stage of visual field loss (VFL) and age at diagnosis between patients with different types of glaucoma with regard to glaucoma screening and driving ability. METHODS:In a cross-sectional study of 1988 consecutive patients with different types of glaucoma VFL at diagnosis and age at diagnosis were a...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-017-0477-7
更新日期：2018-04-01 00:00:00
abstract：PURPOSE:To investigate the changes in the anterior chamber volume (ACV) with swept-source optical coherence tomography (SS-OCT) after cataract surgery and the factors that influence these ACV changes. METHODS:This was a prospective cohort study. Fifty-one patients who underwent cataract surgery were enrolled. Their AC...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-018-1012-1
更新日期：2019-08-01 00:00:00
abstract：:Strabismus is a well recognized complication of retrobulbar anesthesia for cataract surgery. This may manifest as either paresis or sometimes contracture (overaction) in the late stage. Management of the patient is tailored to the individual case. Herein, we report a patient with inferior rectus paresis and medial rec...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-010-9342-7
更新日期：2010-08-01 00:00:00
abstract：PURPOSE:To evaluate the importance of "en toto" globe submission in the assessment of high-risk pathological findings in retinoblastoma cases, aiming at identifying the additional value from full globe examination of enucleated eyes (including the calottes). METHODS:Retrospective histopathological case series of eight...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-016-0410-5
更新日期：2018-02-01 00:00:00
abstract：PURPOSE:To identify baseline optical coherence tomography (OCT) factors in ischemic central retinal vein occlusion (CRVO) that predict response to bevacizumab injections. METHODS:Patients underwent OCT at diagnosis and the central macular thickness, subretinal fluid width and height as well as the presence of intraret...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-020-01604-0
更新日期：2020-10-22 00:00:00
abstract：PURPOSE:To examine the retinal layers' changes and alterations in retinal microvasculature in patients with rhegmatogenous retinal detachment (RRD) treated with pars plana vitrectomy (PPV). METHODS:Participants in this study were 103 patients with RRD, 85 macula off and 18 macula on, who were treated with PPV and gas ...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-020-01521-2
更新日期：2020-12-01 00:00:00
abstract：:The purpose of this study was to evaluate the effect of Nd.YAG-laser treatment on retinal function. All the patients treated showed a temporary decrease of visual acuity immediately after treatment. The ERG and EOG recordings were identical before and after treatment. The Umazume-Ohta test showed temporary central or ...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF02027893
更新日期：1987-10-01 00:00:00
abstract：PURPOSE:To evaluate the effect of metronidazole ophthalmic solutions on corneal neovascularization (CNV) in a rat model. METHODS:A chemical burn was created in the right central cornea of 40 rats. Animals were randomized and distributed into four study groups (n = 10 rats per group) designated Met_0.1%, Met_0.5%, sham...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-018-0922-2
更新日期：2019-05-01 00:00:00
abstract：:To describe the epidemiology, mechanism of injury, and final visual and anatomical outcomes of pediatric patients with open globe injury. The medical records of patients aged ≤ 16 years diagnosed with open globe injury between January 2006 and December 2010 were retrospectively reviewed. Forty-nine pediatric patients ...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-013-9890-8
更新日期：2014-08-01 00:00:00
abstract：:Blindness in diabetics is largely due to retinopathy and/or cataract. Hyperglycaemia and the duration of diabetes are major risk factors for the development of cataract and retinopathy. This review details some of the reactions of glucose that are relevant to the development of complications, and follows the elucidati...
journal_title：International ophthalmology
pub_type： 杂志文章,评审
doi：10.1007/BF00150976
更新日期：1991-01-01 00:00:00
abstract：PURPOSE:Coagulase-negative staphylococci have been reported to be the most frequent cause of bacterial postoperative endophthalmitis. Biofilm formation is the major virulence factor of Staphylococcus epidermidis and is often associated with methicillin resistance. This study aims at evaluating the presence of biofilm-p...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-016-0339-8
更新日期：2017-08-01 00:00:00
abstract：BACKGROUND:With the increasing prevalence of electronic readers (e-readers) for vocational and professional uses, it is important to discover if there are visual consequences in the use of these products. There are no studies in the literature quantifying the incidence or severity of eyestrain, nor are there clinical c...
journal_title：International ophthalmology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10792-016-0281-9
更新日期：2017-04-01 00:00:00
abstract：PURPOSE:To compare capillaries perfusion in macular areas at different layers and peripapillary region in radial peripapillary capillaries (RPC) between healthy subjects and subjects with obstructive sleep apnea-hypopnea (OSA) using spectral-domain optical coherence tomography angiography (OCTA). METHODS:Totally 16 ey...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-020-01518-x
更新日期：2020-12-01 00:00:00
abstract：:To assess the effect of intravitreal dexamethasone implant (Ozurdex) for the treatment of macular edema secondary to retinal vein occlusion (RVO) resistant to repeated intravitreal ranibizumab injection. Retrospective review of 11 patients (11 eyes) with ranibizumab-resistant macular edema secondary to RVO. Macular ed...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-016-0226-3
更新日期：2017-02-01 00:00:00
abstract：:The effect of therapeutic ultrasound for the treatment of refractory glaucoma was evaluated in 44 patients by comparing average IOP curves measured before and 3-4 months after treatment. The insonification regime was standardized and the glaucoma medication in each individual patient was unchanged during IOP curve mea...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00918000
更新日期：1992-09-01 00:00:00
abstract：:Acute and invasive fungal infections are usually seen in immunocompromised and debilitated patients. We report a young immunocompetent 28-year-old Indian male who presented with unilateral endogenous endophthalmitis in the left eye and was managed with pars plana vitreous surgery. The polymerase chain reaction from th...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-008-9235-1
更新日期：2009-08-01 00:00:00
abstract：PURPOSE:We evaluated the ability of optic disc parameters and nerve fiber analysis with the Glaucoma-scope to distinguish glaucoma from normal or hypertensive eyes. METHODS:Glaucoma-scope examination was performed on 68 eyes of 44 patients split into following groups based on Humphrey 24-2 visual field and clinical cr...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00212942
更新日期：1996-01-01 00:00:00
abstract：:The traditional opinion that increased intraocular pressure is the cause of glaucoma is controversial, probably mainly because of the fact that firm evidence for the value of pressure reduction is largely lacking. The present article reviews results from short term studies of visual fields before and after pressure re...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF02028651
更新日期：1989-01-01 00:00:00
abstract：PURPOSE:This study aims to evaluate the efficacy and safety of XEN45 gel stent (Allergan plc, Dublin, Ireland) in East Asian patients with glaucoma. METHODS:A retrospective study of consecutive XEN45 gel stent implantation surgeries with or without concurrent cataract surgery from May 2017 to August 2018 was performed...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-020-01284-w
更新日期：2020-05-01 00:00:00
abstract：PURPOSE:We aimed to analyze the clinical characteristics of idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) syndrome. Furthermore, we aimed to correlate the number and location of retinal aneurysms with the size of retinal non-perfusion area and neovascularization. METHODS:Six patients with IRVAN ...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-018-0962-7
更新日期：2019-07-01 00:00:00
abstract：:This study aimed to present precancerous and cancerous epithelial eyelid lesions, their histopathological features, and possible correlations with clinical parameters. The retrospective study included 147 formalin-fixed, paraffin-embedded samples. We studied precancerous and cancerous epithelial eyelid lesions. Preneo...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-016-0258-8
更新日期：2017-02-01 00:00:00
abstract：:Fifty patients who developed preretinal or papillary neovascularization following tributary vein occlusion were treated by laser photocoagulation. Areas of non-perfused retina within the distribution of the obstructed vein were identified by fluorescein angiography and ablated using moderately intense laser photocoagu...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00130697
更新日期：1981-05-01 00:00:00
abstract：PURPOSE:To describe the intraoperative complications and the learning curve of microincision cataract surgery assisted by femtosecond laser (FLACS) with bimanual technique performed by an experienced surgeon. METHODS:It is a prospective, observational, comparative case series. A total of 120 eyes which underwent biman...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-017-0776-z
更新日期：2019-01-01 00:00:00
abstract：:Trichiasis/Entropion are the severe consequences of chronic trachoma during early life. Blindness and vision loss is preventable with timely lid surgery to correct trichiasis. In a trachoma hyperendemic region of Central Tanzania, a two year follow-up survey was conducted among 205 women with trichiasis to determine t...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00919249
更新日期：1994-01-01 00:00:00
abstract：PURPOSES:This research aimed to investigate effects and risk factors on non-contact tonometer (NCT) readings in healthy myopic subjects by employing cross-sectional study design. METHODS:Totally, sixty otherwise healthy myopic volunteers (mean 28.4 years old) with 90% female were recruited in ophthalmic clinic. The ro...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-019-01203-8
更新日期：2020-02-01 00:00:00
abstract：:This study reports the outcomes of therapeutic penetrating keratoplasties, defined as keratoplasties performed to eradicate active infectious corneal diseases or to repair a structural defect of the cornea. The records of 24 eyes of 24 patients (17 female and 7 male) treated with therapeutic penetrating keratoplasty b...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-014-9931-y
更新日期：2015-04-01 00:00:00
abstract：:The purpose of this study was to determine the causes of childhood visual impairment and blindness in students of a school for blind children, to determine how many students had some residual vision, and to evaluate any unmet low-vision care. A survey of students in the blind school was conducted in two parts in May-J...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-007-9134-x
更新日期：2008-10-01 00:00:00
abstract：:Central serous chorioretinopathy (CSCR) is characterized by neurosensory retinal detachment. Because the retina pigment epithelium and choroidal pathology is the current mechanism in CSCR, many studies in the literature focused on the outer retinal layers. There is little information about the functional or histologic...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-016-0278-4
更新日期：2017-04-01 00:00:00
abstract：:In a randomized, double-masked, single drop study the effect of topical isosorbid-mononitrate (ISMO) 0.5% eye drops, the main metabolite of isosorbid-dinitrate, widely used in the treatment of coronary heart diseases, was studied in patients suffering from open angle glaucoma or ocular hypertension. There was no stati...
journal_title：International ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00171028
更新日期：1991-07-01 00:00:00
abstract：PURPOSE:The aim of this study was to evaluate the corneal biomechanical parameters in patients with ankylosing spondylitis (AS) and to compare them with the healthy subjects. METHODS:Sixty patients with AS (study group) and 60 healthy subjects (control group) were enrolled in this prospective study. The study group wa...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-016-0368-3
更新日期：2017-08-01 00:00:00
