Abstract：
BACKGROUND:To evaluate the retinal nerve fiber layer (RNFL) and peripapillary vascular density (VD) changes in the pediatric group with optic disk drusen (ODD). METHODS:Sixty eyes of 30 patients with buried ODD referred by the pediatric or neurology physicians to ophthalmology clinic with a preliminary diagnosis of papillary edema were included in this retrospective study. Sixty eyes of 30 healthy children were included as the control group. Thickness of RNFL (micrometer) and VD percentages (%) of the superior, inferior, nasal, and temporal quadrants of the peripapillary region of all cases were evaluated with optical coherence tomography angiography (OCT-A) device. RESULTS:The study and control groups were homogeneous in terms of age and gender. VD values were significantly lower in the study group for all four quadrants, when compared to controls (p < 0.001, p < 0.001, p = 0.003, and p < 0.001, for inferior, superior, nasal, and temporal quadrants, respectively. For RFNL thickness measurements, a significant difference between groups was only evident for the nasal quadrant, where the study group had significantly higher nasal RFNL thickness (p = 0.001). CONCLUSION:This study detected decreases in peripapillary VD values in all quadrants and peripapillary RNFL thickening in nasal quadrant in pediatric cases with buried drusen compared to healthy controls. Further studies are necessary to reveal the effects of drusen pathogenesis on optic nerve head perfusion and to understand the underlying mechanisms of related complications.
journal_name
Int Ophthalmoljournal_title
International ophthalmologyauthors
Türker IÇ,Doğan CU,Uzun SÜ,Güven Ddoi
10.1007/s10792-021-01700-9subject
Has Abstractpub_date
2021-01-18 00:00:00eissn
0165-5701issn
1573-2630pii
10.1007/s10792-021-01700-9pub_type
杂志文章abstract：PURPOSE:Growth factors are considered as key molecules that participating in fibrosis formation. This research aimed to clarify potential effects of p53 on regulation of transforming growth factor β (TGF-β) and fibrosis formation and investigate the associated mechanisms. METHODS:Vimentin was examined to identify huma...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-020-01320-9
更新日期：2020-06-01 00:00:00
abstract：PURPOSE:To investigate the effects of 1% cyclopentolate hydrochloride and 1% tropicamide eye drops on aqueous flare measurements by using the laser flare meter. METHODS:One hundred forty eight eyes of 83 patients with inactive uveitis were enrolled. The patients were randomly assigned to receive either 1% tropicamide ...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-020-01639-3
更新日期：2020-11-16 00:00:00
abstract：PURPOSE:To explore the protective effect of probucol on human retinal Müller cells cultured in high glucose. METHODS:Primary Müller cells from human retinas were cultured in complete DMEM. Third-generation Müller cells were identified using glutamine synthetase (GS) antibody and randomly divided into three groups: nor...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-019-01130-8
更新日期：2019-12-01 00:00:00
abstract：:To report a patient with optic disc pit who showed decreased inner diameter of the optic disc pit along with resolution of recurrent macular detachment after pars plana vitrectomy. Pneumatic retinopexy and peripapillary laser photocoagulation was performed in a 28-year-old female with optic disc pit and serous macular...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-012-9656-8
更新日期：2013-04-01 00:00:00
abstract：PURPOSE:To evaluate the long-term safety and efficacy of Mycophenolate Mofetil (MMF) for the control of cystoid macular oedema (CMO) secondary to noninfectious uveitis (NU). METHODS:The medical records of 19 consecutive patients with inflammatory CMO treated with MMF were retrospectively reviewed. Patient demographics...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-008-9200-z
更新日期：2009-06-01 00:00:00
abstract：PURPOSE:To describe the epidemiology and prevalence, rates of progression, difference between adult and pediatric populations, and therapeutic approaches to pediatric keratoconus from documented literature. METHODS:A literature search was done on PubMed using key words including pediatric keratoconus, children with ke...
journal_title：International ophthalmology
pub_type： 杂志文章,评审
doi：10.1007/s10792-017-0699-8
更新日期：2018-10-01 00:00:00
abstract：:Preliminary results of a larger investigation on correlation between Retinal Nerve Fiber Layer Defects (RNFL) and Automated Perimetry (AP) are presented. A group of ocular hypertensive patients was recruited and a cross-section, randomized study was carried out. The group was composed of 54 eyes from 28 patients; 15 m...
journal_title：International ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00917968
更新日期：1992-09-01 00:00:00
abstract：:A 37 year old woman presented with a bilateral vitritis. 4 months previously, she had developed in her left eye a necrotizing retinitis compatible with acute retinal necrosis (ARN). A trial of Acyclovir was unsuccessful as were systemic steroids. Over the following 2 months the vitritis worsened. The patient underwent...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00163568
更新日期：1990-10-01 00:00:00
abstract：PURPOSE:To investigate the changes in ocular higher-order aberrations (HOA) after trabeculectomy using mitomycin-C (MMC). METHODS:We retrospectively reviewed data for 63 eyes from 63 glaucoma patients who had undergone MMC augmented trabeculectomy. We measured intraocular pressure (IOP), refractive errors, anterior ch...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-017-0802-1
更新日期：2019-01-01 00:00:00
abstract：PURPOSE:The purpose of the study was to assess adjuvant treatment with topical nonsteroidal anti-inflammatory drugs (NSAIDs) (0.9 % bromfenac, 0.1 % nepafenac, 0.5 % indomethacin, or 0.1 % diclofenac) in addition to topical steroidal treatment with 0.1 % dexamethasone and 0.3 % netilmicin for prevention of cystoid macu...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-016-0374-5
更新日期：2017-10-01 00:00:00
abstract：INTRODUCTION:Uveitis encompasses a wide variety of sight-threatening diseases characterized by intraocular inflammation. It is often classified as infectious and non-infectious uveitis. Unlike infectious uveitis, a distinct infectious agent cannot be identified in non-infectious uveitis and disease origin is usually au...
journal_title：International ophthalmology
pub_type： 杂志文章,评审
doi：10.1007/s10792-018-0984-1
更新日期：2019-07-01 00:00:00
abstract：:The aim of this study is to compare a portable spectral domain optical coherence tomography (SD-OCT) device with a non-portable SD-OCT for the identification of anterior chamber angle parameters based on location of Schwalbe's line (SL) and to measure their reproducibility. 99 eyes from 46 normal, healthy participants...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-016-0223-6
更新日期：2017-02-01 00:00:00
abstract：:The purpose of this study is to evaluate whole lysyl oxidase like 1 (LOXL1) gene by sequence analysis in Turkish patients with exfoliation glaucoma (XFG). A total of 48 (35 male, 13 female) patients with XFG were enrolled. Besides routine ophthalmological examination, peripapillary retinal nerve fibre layer (RNFL) ana...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-016-0174-y
更新日期：2016-10-01 00:00:00
abstract：PURPOSE:To compare the systemic and ocular characteristics and laboratory findings of patients developing toxic anterior segment syndrome (TASS) after uneventful phaco surgery with unaffected subjects undergoing the same surgery in the same session. DESIGN:A retrospective case-control study. METHODS:The study group c...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-016-0418-x
更新日期：2018-02-01 00:00:00
abstract：:Trichiasis/Entropion are the severe consequences of chronic trachoma during early life. Blindness and vision loss is preventable with timely lid surgery to correct trichiasis. In a trachoma hyperendemic region of Central Tanzania, a two year follow-up survey was conducted among 205 women with trichiasis to determine t...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00919249
更新日期：1994-01-01 00:00:00
abstract：:There has been great controversy about the pathogenesis of the focal changes in the retinal pigment epithelium (RPE) causing detachment of the neurosensory retina in central serous chorioretinopathy (CSC). This study was performed to evaluate changes in choroidal perfusion in 15 patients with CSC. Fluorescein and indo...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00133176
更新日期：1995-01-01 00:00:00
abstract：:We examined nine patients who presented cilioretinal artery occlusion (CLRAO) associated with retinal vein occlusion (RVO). CLRAO was probably secondary to the raised intraluminal resistance consequent to the RVO in patients showing initially a delayed filling of the cilioretinal artery in fluorescein angiography. Int...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF01007789
更新日期：1993-10-01 00:00:00
abstract：PURPOSE:To evaluate and compare outcomes of CO2 laser-assisted sclerectomy surgery (CLASS) with mitomycin C (MMC) combined with or without phacoemulsification in adult Asian glaucoma patients. DESIGN:Retrospective, comparative study. METHODS:Adult Asian glaucoma patients who underwent CLASS alone or combined with pha...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-021-01707-2
更新日期：2021-01-22 00:00:00
abstract：PURPOSE:To describe the outcome of a series of Acanthamoeba keratitis treated with a similar regimen. METHODS:All cases diagnosed with Acanthamoeba keratitis in a referral centre from June 1994 through June 1997 were included. Diagnosis of Acanthamoeba keratitis was based in clinical presentation and laboratory result...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1023/a:1006055918101
更新日期：1997-01-01 00:00:00
abstract：PURPOSE:To identify risk factors for endogenous endophthalmitis (EE) in hospitalized adults, under 65 years of age, with a history of intravenous opioid use and non-ocular infection. METHODS:The National Inpatient Sample Database was used to identify cases of EE with a recent history of intravenous opioid use disorder...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-021-01709-0
更新日期：2021-01-27 00:00:00
abstract：:Suprachoroidal hemorrhages were created in 15 albino rabbit eyes by injecting 0.1 cc of autologous blood into the suprachoroidal space. One day later, 10 of these eyes were treated with intravenous tissue plasminogen activator (TPA). Doses of 1 mg per kg were given to each rabbit over 2 to 3 hours by intravenous infus...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00159862
更新日期：1990-07-01 00:00:00
abstract：:Corneal ulcer is a devastating corneal disease which is potentially sight-threatening and conventionally is treated by topical antibiotics and in some cases with more invasive procedures such as keratoplasty. The aim of this study is to evaluate the efficacy of corneal collagen cross-linking in resistant corneal ulcer...
journal_title：International ophthalmology
pub_type： 临床试验,杂志文章
doi：10.1007/s10792-012-9633-2
更新日期：2013-02-01 00:00:00
abstract：:Glaucoma after penetrating keratoplasty is a frequently observed post-operative complication and is a risk factor for graft failure. Penetrating keratoplasty performed for aphakic and pseudophakic bullous keratopathy and inflammatory conditions are more likely to cause postoperative glaucoma compared with keratoconus ...
journal_title：International ophthalmology
pub_type： 杂志文章,评审
doi：10.1007/s10792-008-9223-5
更新日期：2008-06-01 00:00:00
abstract：:The beneficial effect of photocoagulation in diabetic retinopathy is now established (2-6, 10). Whereas the capability of providing photocoagulation is widespread, the indications and actual techniques are poorly defined. In this paper, we propose to discuss the principles of photocoagulation. In a following paper the...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00133274
更新日期：1978-09-01 00:00:00
abstract：:Spontaneous hyphema has been linked to many conditions. We describe a patient with recurrent spontaneous hyphema caused by an abnormal angle vessel without associated rubeosis iridis, glaucoma, or other vascular abnormalities as documented by iris fluorescein angiography. After treatment with several sessions of argon...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00136495
更新日期：1985-09-01 00:00:00
abstract：:Early-onset sarcoidosis (EOS) and Blau syndrome are rare auto-inflammatory diseases characterized by a triad of skin rash, granulomatous uveitis, and symmetrical polyarthritis occurring in early childhood. In this paper, we describe a case report very interesting for the multidisciplinary management (pediatric rheumat...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-015-0135-x
更新日期：2016-02-01 00:00:00
abstract：OBJECTIVES:To evaluate the safety indexes and efficacy of Artisan phakic intraocular lens (IOL) for the correction of high myopia. METHODS:Retrospective interventional case series reports. Thirty-one eyes (22 patients) with myopia from -5.25 to -19.00 diopters underwent implantation of an Artisan phakic IOL. Follow-up...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-005-5016-2
更新日期：2004-07-01 00:00:00
abstract：:To describe a congenital retinal macrovessel with macular thickening. This case was investigated using fundus photography, fluorescein angiography, Spectralis optical coherence tomography and a 10-2 visual field test. A 23-year-old man was referred to our clinic with decreased vision in the right eye. Fundus examinati...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-010-9402-z
更新日期：2011-02-01 00:00:00
abstract：BACKGROUND:A study of the characteristics and the results obtained in 99 consecutive eyes operated on for rhegmatogenous retinal detachment associated with aphakia or pseudophakia in order to find the predictive factors of poor anatomical and functional results. METHODS:The authors retrospectively reviewed the files o...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00176882
更新日期：1996-01-01 00:00:00
abstract：AIMS/BACKGROUND:We evaluated the retinal toxicity of spartanamicin B and its efficacy in a rabbit model of Candidal endophthalmitis. METHODS:Toxicity. Fourteen albino rabbit eyes were injected intravitreally with spartanamicin B (1, 2, 5, 10, 25, 50, and 100 microg); 2 eyes received the vehicle alone. Efficacy. Ten ra...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1023/a:1006191629625
更新日期：1998-01-01 00:00:00
