Abstract：
PURPOSE:To compare the efficacy and safety of two intravitreal anti-vascular endothelial growth factor (anti-VEGF) agents, ranibizumab and aflibercept, for the treatment of vascularized pigment epithelium detachment (vPED) due to age-related macular degeneration (AMD) in a follow-up time of 12 months. METHODS:Participants in this study were 71 patients (71 eyes) with vPED due to AMD, who were treated with intravitreal 0.5 mg ranibizumab (n = 38) or 2.0 mg aflibercept (n = 33) and had at least 12-month follow-up. All patients underwent best-corrected visual acuity (BCVA) measurement and optical coherence tomography at baseline and at every visit. The PED height, the presence of subretinal fluid (SRF), intraretinal fluid and diffuse macular edema (DME) were recorded at each visit. RESULTS:There was a statistically significant difference in BCVA between the two groups at month 12 in favor of aflibercept. However, both agents were found to improve or stabilize BCVA in the majority of patients at the end of the follow-up. The change in PED height did not differ significantly between the two groups at the end of the follow-up with similar number of injections. At month 12, there was a significant improvement in SRF presence in both groups compared to baseline. CONCLUSIONS:Although aflibercept was found to be superior to ranibizumab regarding BCVA improvement, both agents showed anatomical effectiveness with significant reduction in PED height and SRF absorption in patients with vPED due to AMD.
journal_name
Int Ophthalmoljournal_title
International ophthalmologyauthors
Rouvas A,Chatziralli I,Androu A,Mpougatsou P,Alonistiotis D,Douvali M,Kabanarou SA,Theodossiadis Pdoi
10.1007/s10792-018-0833-2subject
Has Abstractpub_date
2019-02-01 00:00:00pages
431-440issue
2eissn
0165-5701issn
1573-2630pii
10.1007/s10792-018-0833-2journal_volume
39pub_type
杂志文章abstract：PURPOSE:To report two cases of retinal vascular occlusion and associated subconjunctival hemorrhage in needle optic nerve injury during local bulbar anesthesia. METHODS:Surgical records of these two subjects who presented with acute vision loss after cataract extraction were studied, and systemic workup and ocular ima...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-017-0539-x
更新日期：2018-06-01 00:00:00
abstract：:To evaluate the clinical efficacy of transcutaneous everting sutures for lower eyelid involutional entropion in Chinese patients. A retrospective, non-comparative, interventional case series. This retrospective study consecutively reviewed the medical records of all patients with involutional lower eyelid entropion wh...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-013-9893-5
更新日期：2014-08-01 00:00:00
abstract：:The glistening and delayed opacification of intraocular lenses (IOLs) has been reported in literature as a late and permanent change in the acrylic IOL due to temperature change. We report a case in which clouding and opacification of an IOL occurred intraoperatively within a few seconds of implantation into the capsu...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-011-9481-5
更新日期：2011-12-01 00:00:00
abstract：:The authors reviewed their experience with 429 cases of orbital exenteration between 1963 and 1993. Apart from the 22 cases operated in concert with other physicians, 407 cases were operated by an ophthalmologist and spontaneous granulation technique was used. Total or eyelid-sacrificing exenteration was carried out f...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00133735
更新日期：1995-01-01 00:00:00
abstract：PURPOSE:To report a case of subtotal iridodialysis that was repaired using suturing with the assistance of a guide needle. PATIENT AND METHODS:A 52-year-old man had subtotal iridodialysis of approximately 300° with massive hyphema and vitreous hemorrhage after blunt trauma. The patient was treated with pars plana vitr...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-017-0465-y
更新日期：2018-02-01 00:00:00
abstract：:Primary lacrimal sac melanoma is an extremely rare clinical entity with fewer than 25 cases reported in the literature. We present a well-documented case of lacrimal sac melanoma with anterior lacrimal crest infiltration and discuss the clinical, radiological and histopathological features along with surgical challeng...
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更新日期：2014-02-01 00:00:00
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journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-005-2035-y
更新日期：2004-10-01 00:00:00
abstract：:The purpose of this study was to evaluate the impact of intravitreal bevacizumab injections on the management and outcome of patients affected by retinal vein occlusions, their effectiveness on morphological and functional parameters, the modalities of long-term management and the need for additional laser treatment d...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-014-0002-1
更新日期：2014-12-01 00:00:00
abstract：PURPOSE:Proliferative vitreoretinopathy in the inferior retina remains clinically challenging. Heavier-than-water intraocular tamponades have been developed to improve inferior tamponading properties, and their chemical compositions have been substantially improved over the years, in parallel with developments in vitre...
journal_title：International ophthalmology
pub_type： 杂志文章,评审
doi：10.1007/s10792-017-0489-3
更新日期：2018-04-01 00:00:00
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journal_title：International ophthalmology
pub_type： 杂志文章,评审
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更新日期：2019-07-01 00:00:00
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journal_title：International ophthalmology
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更新日期：2020-08-01 00:00:00
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journal_title：International ophthalmology
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更新日期：2014-10-01 00:00:00
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journal_title：International ophthalmology
pub_type： 杂志文章
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更新日期：2019-06-01 00:00:00
abstract：OBJECTIVE:To assess the comprehensive effects of raloxifene hydrochloride on retinal, choroidal and retrobulbar hemodynamics and on visual function in post-menopausal women. DESIGN:Twenty-four post-menopausal women (age 55 +/- 3.8 years) were recruited for this cross-sectional study: 12 received placebo and 12 receive...
journal_title：International ophthalmology
pub_type： 临床试验,杂志文章
doi：10.1007/s10792-008-9224-4
更新日期：2009-08-01 00:00:00
abstract：PURPOSE:Recently, the vasodilator relaxin 2 has been introduced as a treatment for acute heart failure. However, its role on vessels of the eye and intraocular pressure (IOP) remains unclear though it has been hypothesized to induce a decrease IOP after intramuscular injection in humans. We aimed to test whether the ho...
journal_title：International ophthalmology
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doi：10.1007/s10792-018-0884-4
更新日期：2019-04-01 00:00:00
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journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1023/a:1006191629625
更新日期：1998-01-01 00:00:00
abstract：INTRODUCTION:Vogt-Koyanagi-Harada syndrome (VKHS) is an inflammatory systemic autoimmune disease principally affecting pigmented tissues in the ocular, auditory, integumentary and central nervous systems. Patients are generally women in the fourth decade of life. The prognosis is correlated mainly with the time between...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-017-0504-8
更新日期：2018-04-01 00:00:00
abstract：PURPOSE:A population-based study was conducted to determine the prevalence of color deficiencies in secondary-school students (ages 12-14) in Tehran. METHODS:A total of 2,058 students (1,136 males, 922 females) were examined with Ishihara pseudoisochromatic color plates. RESULTS:In the study population, 97 cases of d...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00175263
更新日期：1996-01-01 00:00:00
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更新日期：2016-04-01 00:00:00
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journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00139585
更新日期：1981-08-01 00:00:00
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journal_title：International ophthalmology
pub_type： 杂志文章
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更新日期：1989-01-01 00:00:00
abstract：:A 37 year old woman presented with a bilateral vitritis. 4 months previously, she had developed in her left eye a necrotizing retinitis compatible with acute retinal necrosis (ARN). A trial of Acyclovir was unsuccessful as were systemic steroids. Over the following 2 months the vitritis worsened. The patient underwent...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00163568
更新日期：1990-10-01 00:00:00
abstract：:To evaluate the effect of intracameral carbachol on foveal thickness in patients who underwent uneventful cataract surgery. This retrospective study included two groups: the study group patients (group 1, n = 47 eyes) had uneventful cataract surgery and received only carbachol 0.01 % for miosis; the control group pati...
journal_title：International ophthalmology
pub_type： 杂志文章
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更新日期：2012-10-01 00:00:00
abstract：:Gyrate atrophy of the choroid and retina is caused by deficient activity of ornithine ketoacid aminotransferase, a pyridoxal phosphate dependent enzyme. Besides the typical eye findings, abnormalities have been found on muscle biopsy, electro-encephalography, electromyography and electrocardiography, establishing this...
journal_title：International ophthalmology
pub_type： 杂志文章,评审
doi：10.1007/BF00139577
更新日期：1981-08-01 00:00:00
abstract：PURPOSE:To identify baseline optical coherence tomography (OCT) factors in ischemic central retinal vein occlusion (CRVO) that predict response to bevacizumab injections. METHODS:Patients underwent OCT at diagnosis and the central macular thickness, subretinal fluid width and height as well as the presence of intraret...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-020-01604-0
更新日期：2020-10-22 00:00:00
abstract：PURPOSE:To assess the level of awareness among UK ophthalmic surgeons of the potential risks from starch powdered surgical gloves during ophthalmic surgery and to show by electron microscopy that starch granule contamination can occur during ophthalmic surgery. SETTING:A sample (N = 46) of UK ophthalmologists from the...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1023/a:1006392915801
更新日期：1998-01-01 00:00:00
abstract：PURPOSE:To investigate the antibacterial effect of topical anesthetic proparacaine on conjunctival flora. METHODS:One hundred and forty-four eyes of 72 patients awaiting cataract surgery were included in the study. A commercially available solution of proparacaine, preserved with benzalkonium chloride 0.01%, was insti...
journal_title：International ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1023/a:1026567912389
更新日期：1999-01-01 00:00:00
