Abstract：
AIMS/BACKGROUND:We evaluated the retinal toxicity of spartanamicin B and its efficacy in a rabbit model of Candidal endophthalmitis. METHODS:Toxicity. Fourteen albino rabbit eyes were injected intravitreally with spartanamicin B (1, 2, 5, 10, 25, 50, and 100 microg); 2 eyes received the vehicle alone. Efficacy. Ten rabbit eyes were inoculated with 3000 Candida organisms which caused endophthalmitis in 24 hours. Eight eyes were treated with intravitreal spartanamicin B in doses of 1, 2, 5, or 10 microg/0.1 ml; 2 untreated eyes served as controls. RESULTS:Toxicity. The eyes injected with < or =10 microg and the control group eyes exhibited no clinical, histological, or electroretinographic evidence of retinal toxicity. Doses >10 microg caused vitritis. Efficacy. Clinical examination of the treated eyes showed a gradual improvement over 3-6 days; mild opacities remained until day 14. Results of cultures performed 15 days after infection were negative in all treated eyes. CONCLUSIONS:Intravitreally injected spartanamicin B (10 microg) is nontoxic to the retina, effective against C. albicans in the endophthalmitis model in the rabbit eye and caused no discernible histological changes in the retina.
journal_name
Int Ophthalmoljournal_title
International ophthalmologyauthors
Serracarbassa PD,Peyman GA,Liang C,Calixto N Jr,Nair MGdoi
10.1023/a:1006191629625subject
Has Abstractpub_date
1998-01-01 00:00:00pages
53-8issue
1eissn
0165-5701issn
1573-2630journal_volume
22pub_type
杂志文章abstract：PURPOSE:To evaluate the efficacy of long-tube shunt surgery (LTSS) without valve in uveitic glaucoma (UG) eyes. METHODS:We retrospectively analyzed the data of 45 UG eyes that underwent only LTSS or LTSS combined with trabeculectomy (TLE) (LTSS/TLE). The UG eyes were analyzed by categorizing them into granulomatous/no...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-020-01601-3
更新日期：2020-10-14 00:00:00
abstract：:This study evaluates the efficiency of fluid-air exchange on the reattachment of the retina and clarifies the possibility that a posterior retinotomy is a cause for intra- and postoperative complications. A consecutive series of 211 eyes with retinal detachments due to P.V.R. (47%), diabetic traction, perforating trau...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00951805
更新日期：1994-01-01 00:00:00
abstract：:I have developed two protective caps that fit on the viewing windows of the indirect ophthalmoscope. These caps contain filters that absorb the argon laser beam and protect the operator's eyes during endolaser treatment. ...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00225937
更新日期：1986-04-01 00:00:00
abstract：:Gyrate atrophy of the choroid and retina is caused by deficient activity of ornithine ketoacid aminotransferase, a pyridoxal phosphate dependent enzyme. Besides the typical eye findings, abnormalities have been found on muscle biopsy, electro-encephalography, electromyography and electrocardiography, establishing this...
journal_title：International ophthalmology
pub_type： 杂志文章,评审
doi：10.1007/BF00139577
更新日期：1981-08-01 00:00:00
abstract：:The glistening and delayed opacification of intraocular lenses (IOLs) has been reported in literature as a late and permanent change in the acrylic IOL due to temperature change. We report a case in which clouding and opacification of an IOL occurred intraoperatively within a few seconds of implantation into the capsu...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-011-9481-5
更新日期：2011-12-01 00:00:00
abstract：PURPOSE:To assess safety and efficacy of deep topical anesthesia with ropivacaine-soaked sponge compared with topical anesthesia with oxybuprocaine in patients undergoing phacoemulsification. METHODS:This was a retrospective study where records of patients operated for cataract were evaluated. Patients using a visual ...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-019-01132-6
更新日期：2019-12-01 00:00:00
abstract：PURPOSE:The study aims to evaluate changes in neopterin levels and tryptophan degradation which are induced by Th1-type immune response and nitric oxide metabolism which may be involved in allergic inflammation. METHODS:Serum nitrite, kynurenine, tryptophan and neopterin levels were evaluated in 36 patients with seaso...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-017-0669-1
更新日期：2018-10-01 00:00:00
abstract：:Evaluation of brain cluster activation using the functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) was sought in strabismic amblyopes. In this hospital-based case-control cross-sectional study, fMRI and DTI were conducted in strabismic amblyopes before initiation of any therapy and after ...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-015-0159-2
更新日期：2016-08-01 00:00:00
abstract：PURPOSE:The quality of cataract surgery delivered in sub-Saharan Africa (SSA) is a significant constraint to achieving the elimination of avoidable blindness. No published reports from routine SSA cataract services attain the WHO benchmarks for visual outcomes; poor outcomes (<6/60) often comprise 20% in published case...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-017-0599-y
更新日期：2018-08-01 00:00:00
abstract：PURPOSE:To investigate the changes in the anterior chamber volume (ACV) with swept-source optical coherence tomography (SS-OCT) after cataract surgery and the factors that influence these ACV changes. METHODS:This was a prospective cohort study. Fifty-one patients who underwent cataract surgery were enrolled. Their AC...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-018-1012-1
更新日期：2019-08-01 00:00:00
abstract：:To report a unusual case of an isolated traumatic stellated tarso-conjunctival laceration located in the upper left eyelid without eyelid margin involvement and with normal ocular examination. A 19 year-old male wounded by a bokken (wooden katana) while practicing a sham duel had an isolated eyelid tarso-conjunctival ...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-012-9573-x
更新日期：2012-08-01 00:00:00
abstract：:The purpose of this study was to evaluate the effect of Nd.YAG-laser treatment on retinal function. All the patients treated showed a temporary decrease of visual acuity immediately after treatment. The ERG and EOG recordings were identical before and after treatment. The Umazume-Ohta test showed temporary central or ...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF02027893
更新日期：1987-10-01 00:00:00
abstract：PURPOSE:To report a technique of intra-scleral fixation of the iris hooks for trans-scleral capsular bag fixation in patient with zonular dialysis. METHODS:Two scleral flaps, two scleral tunnels and two sclerotomies were formed. The anterior capsule was captured and pulled by the iris hooks resulting in the IOL adopti...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-017-0623-2
更新日期：2018-08-01 00:00:00
abstract：:Published data on growth rates of uveal melanomas and effects of treatment modalities raise important considerations. Dissemination from uveal melanomas starts after the tumour is larger than 7 mm diameter; growth from 7 to 10 mm diameter increases the risk of metastases incrementally to approximately 16%. Estimations...
journal_title：International ophthalmology
pub_type： 杂志文章,评审
doi：10.1007/BF00132688
更新日期：1995-01-01 00:00:00
abstract：:The purpose of this study was to compare the keratometry (K) values obtained by the Scheimpflug camera combined with placido-disk corneal topography (Sirius) and optical biometry (Lenstar) for intraocular lens (IOL) power calculation before the cataract surgery, and to evaluate the accuracy of postoperative refraction...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-016-0330-4
更新日期：2017-08-01 00:00:00
abstract：:The association between HLA-A29 and birdshot chorioretinopathy is the strongest of all associations between HLA and disease. Determination of HLA-A29 is even of diagnostic significance. The association between HLA-B27 and acute anterior uveitis (AAU) is much weaker, but B27 positive AAU may be considered as a distinct...
journal_title：International ophthalmology
pub_type： 杂志文章,评审
doi：10.1007/BF00163552
更新日期：1990-10-01 00:00:00
abstract：:We made two trips to Cuba, as part of an invited international delegation, to investigate an epidemic of optic neuropathy-induced blindness. We worked closely with Cuban scientists and clinicians in their efforts to understand and then deal with 50,000 cases of blindness and an entire population at risk. This gave an ...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00930318
更新日期：1994-01-01 00:00:00
abstract：:We report a case of choroidal melanoma with features suggestive of orbital cellulitis. A 24-year-old Asian Indian male presented with a 20-day history of sudden loss of vision in the right eye. Edematous eyelids with complete mechanical ptosis, complete ophthalmoplegia, gross proptosis accompanied by massive chemosis,...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-013-9836-1
更新日期：2014-06-01 00:00:00
abstract：PURPOSE:To estimate objective visual acuity in subjects suffering from cataract and age-related macular degeneration via the optokinetic response evoked by a non-conventional induction method (oktotype); in addition, to compare such objective outcome with the subjective acuity based on the ETDRS charts. METHODS:Patien...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-018-1001-4
更新日期：2019-08-01 00:00:00
abstract：:To investigate the correlation between the perifoveal capillary blood flow velocity (BFV) and the vitreous level of pigment epithelium-derived factor (PEDF) in patients with branch retinal vein occlusion (BRVO) and macular edema. In a retrospective interventional study of patients with BRVO and macular edema, undilute...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-012-9584-7
更新日期：2012-10-01 00:00:00
abstract：:The melanocytoma of the optic disc is a deeply-pigmented tumor located on the optic nerve head. In contrast to malignant melanoma, it appears to occur in equal frequency in whites and non-whites. Histologically, it consists of deeply-pigmented plump nervus cells with benign characteristics. No treatment is usually nec...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00133275
更新日期：1978-09-01 00:00:00
abstract：PURPOSE:To determine the visual outcome and incidence of complications after posterior capsule rupture during phacoemulsification surgery. METHODS:Forty-four eyes of 43 patients which sustained posterior capsule rupture or zonulysis during phacoemulsification surgery between April 1993 and May 1996 were retrospectivel...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1023/a:1006462928542
更新日期：1999-01-01 00:00:00
abstract：:We evaluated the in vitro effects of the 1.3 u wavelength of a Nd:YAG laser using a fiberoptic delivery system, with or without sapphire tips on ocular tissue. Conjunctival and retinal adhesions were achieved best with a noncontact technique compared with a contact method. ...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00155628
更新日期：1987-08-01 00:00:00
abstract：:We report the first case of ischaemic optic neuropathy (ION) linked to chronic myelomonocytic leukaemia (CMML) and its associated vasculitis. We discuss the link between CMML and vasculitis and the evidence suggesting it can cause anterior ischaemic optic neuropathy through a vasculitic process. We highlight the diffi...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-012-9675-5
更新日期：2013-08-01 00:00:00
abstract：:The beneficial effect of photocoagulation in diabetic retinopathy is now established (2-6, 10). Whereas the capability of providing photocoagulation is widespread, the indications and actual techniques are poorly defined. In this paper, we propose to discuss the principles of photocoagulation. In a following paper the...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00133274
更新日期：1978-09-01 00:00:00
abstract：:Out of 49 patients diagnosed as having Stargardt's disease that have been clinically reviewed, 22 of these cases have been followed for a period up to 13 years. The cases have been studied in three subgroups, according to their fundus appearance. Patients from group I were those whose lesions were confined to the macu...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00137651
更新日期：1985-11-01 00:00:00
abstract：PURPOSE:To report a unique case of congenital simple hamartoma of retinal pigment epithelium (CSHRPE) associated with full-thickness macular hole (FTMH). METHODS:A 14-year-old female with a previous diagnosis of simple hamartoma of retinal pigment epithelium in the left eye presented with a 3-week onset of reduced vis...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-017-0676-2
更新日期：2018-10-01 00:00:00
abstract：:Postural behaviour of intraocular pressure (IOP) was studied in 29 glaucomatous eyes before and after argon laser trabeculoplasty (ALT) and compared with that of 60 normal eyes. Although argon laser trabeculoplasty was successful in lowering the IOP below 21 mm Hg, it produced little effect on the postural behaviour o...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00916436
更新日期：1992-05-01 00:00:00
abstract：:To report a patient with optic disc pit who showed decreased inner diameter of the optic disc pit along with resolution of recurrent macular detachment after pars plana vitrectomy. Pneumatic retinopexy and peripapillary laser photocoagulation was performed in a 28-year-old female with optic disc pit and serous macular...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-012-9656-8
更新日期：2013-04-01 00:00:00
abstract：PURPOSE:To report a case of toxic optic neuropathy caused by an ocular bee sting. METHODS:Case report and literature review. RESULTS:A 44-year-old female presented with no light perception vision 2 days after a corneal bee sting in her right eye. She was found to have diffuse cornea edema with overlying epithelial de...
journal_title：International ophthalmology
pub_type： 杂志文章,评审
doi：10.1007/s10792-018-0978-z
更新日期：2019-07-01 00:00:00
