Abstract：
:To evaluate the role of brimonidine (BMD), an alpha-2 agonist, in the management of clinically significant macular edema (CSME) in diabetic maculopathy with ischemic changes. A prospective, randomized controlled trial including 30 eyes of 30 metabolically stable diabetic patients with CSME showing fundus fluorescein angiography documented ischemic changes. Group I included 17 eyes of patients who received topical BMD (0.2 %) twice daily for 6 months while Group II included 13 eyes of age-matched patients who were kept under observation and acted as controls. The mean change in logMAR visual acuity and any change in the grade of the foveal avascular zone (FAZ) size, outline, capillary non-perfusion, or capillary dilatation was noted in the two groups and compared at the end of 6 months. The FAZ area and radius was significantly less in the study group than the control group. However, no significant difference in FAZ capillary outline, FAZ capillary loss, FAZ capillary dilatation and overall grade of ischemia between the two groups was seen. There was improvement in visual acuity from baseline to 6 months but it was comparable between the two groups (p = 0.02). BMD may have a role in the treatment of ischemic macula in CSME since the FAZ area and radius were significantly less in the study group. However, a larger sample size and a longer follow-up are needed to further authenticate the results of this pilot study.
journal_name
Int Ophthalmoljournal_title
International ophthalmologyauthors
Gupta PC,Sood S,Narang S,Ichhpujani Pdoi
10.1007/s10792-013-9871-ysubject
Has Abstractpub_date
2014-08-01 00:00:00pages
787-92issue
4eissn
0165-5701issn
1573-2630journal_volume
34pub_type
杂志文章,随机对照试验abstract：PURPOSE:To assess the comparative efficacy and the long-term cost-utility of alternative minimally invasive glaucoma surgeries (MIGSs) when combined with cataract surgery in patients with primary open-angle glaucoma (POAG). METHODS:Treatment effects, as measured by the 1-year reduction in intraocular pressure (IOP), w...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-020-01314-7
更新日期：2020-06-01 00:00:00
abstract：PURPOSE:To evaluate the accuracy of intraocular lens (IOL) power calculation in relation to optical biometry devices and refraction types. METHODS:Patients undergoing cataract phacoemulsification and insertion of the MX60 IOL were enrolled. Optical biometric measurements were performed with both IOLMaster 700 and Lens...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-020-01355-y
更新日期：2020-07-01 00:00:00
abstract：PURPOSE:To report the fluorescein fundus angiographic (FFA) findings in the different clinical stages of Vogt-Koyanagi-Harada (VKH) patients. METHODS:Retrospective, transversal and descriptive study. All patients underwent FFA at least in one occasion. Patients with incomplete clinical files or a deficient FFA were ex...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-006-9027-4
更新日期：2007-04-01 00:00:00
abstract：PURPOSE:To investigate the effects of glaucomatous damage on the mfVEP parameters of patients suffering from primary open-angle glaucoma (POAG). METHODS:Fifteen healthy subjects and 15 patients with unilateral POAG participated in this study. In addition, routine ophthalmological examinations including visual acuity, ...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-019-01138-0
更新日期：2019-12-01 00:00:00
abstract：:The authors reviewed their experience with 429 cases of orbital exenteration between 1963 and 1993. Apart from the 22 cases operated in concert with other physicians, 407 cases were operated by an ophthalmologist and spontaneous granulation technique was used. Total or eyelid-sacrificing exenteration was carried out f...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00133735
更新日期：1995-01-01 00:00:00
abstract：PURPOSE:Retinal vascular abnormalities are associated with choroidal melanoma. Although tumor ischemia, resulting in soluble angiogenic factor production, is a proposed etiology of these abnormalities, other sources of ischemia may also contribute. Mushroom-shaped choroidal melanomas have increased loss of the overlyin...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1023/a:1021170402679
更新日期：2001-01-01 00:00:00
abstract：:In order to evaluate possible etiological factors and the natural course of 'idiopathic' preretinal fibrosis in young persons, nine consecutive patients with macular pucker diagnosed under the age of 50 years were examined. There were six women and three men with the mean age of 27.2 years (range 15-50) and the mean f...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00202776
更新日期：1987-02-01 00:00:00
abstract：PURPOSE:To study the connective tissue (CT) structure of upper eyelid skin of primary open-angle glaucoma (POAG) patients. PATIENTS AND METHODS:Forty-seven patients aged 47-91 expecting blepharoplasty formed 3 groups: group 1 [16 subjects without POAG, median age 55 years (interquartile range 54-55.5)], group 2 [12 su...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-018-1035-7
更新日期：2019-09-01 00:00:00
abstract：PURPOSE:We report a case of atypical, extratarsal chalazion referred with a history of a chronic inflammatory mass found on the edge of the lower eyelid. METHODS:A 3-year-old female developed a small mass on the medial side of the right lower lid in 4-month duration. She was seen by her ophthalmologist and the diagnos...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-016-0409-y
更新日期：2017-12-01 00:00:00
abstract：:We studied the changes in the thickness of the retinal nerve fiber layer (RNFL) after surgery for idiopathic macular hole (MH) using spectral-domain optical coherence tomography (SD-OCT). Twenty eyes of 20 consecutive patients who underwent vitrectomy to close a MH were studied. The peripapillary RNFL thickness was me...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-013-9855-y
更新日期：2014-06-01 00:00:00
abstract：:To determine the optimal area of retinal photocoagulation required for suppressing active neovascularisation (NVI) associated with diabetic retinopathy. We studied 1 eye each of 4 patients in whom active NVI was ophthalmoscopically shown to have been suppressed by additional photocoagulation. These patients initially ...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-013-9802-y
更新日期：2014-10-01 00:00:00
abstract：INTRODUCTION:We report on a 62-year-old healthy woman who suffered from bilateral predescemetic opacities, where the underlying disorder could not be identified. She had bilateral keratopathy with corneal edema, a diffuse predescemetic avascular haze and deszemetic folds. Because of high hyperopia (right +7.50/left +7....
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1023/b:inte.0000018521.88103.17
更新日期：2004-01-01 00:00:00
abstract：:Transvitreal pars plana sclerotomy using the contact Nd:YAG laser with a sapphire probe was performed on a group of rabbit eyes and compared with a similar procedure performed with a Ziegler knife. Although the intraocular pressure (IOP) was lowered in both groups of animals, the reduction was greater and more lasting...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00130620
更新日期：1988-01-01 00:00:00
abstract：:This paper builds on results of a previous paper on the prevalence of trachomatous visual impairment as the foundation for assessing the global burden of trachomatous blindness and low vision: approximately 2.9 million cases of trachomatous blindness and 3.8 million low visioned corresponding to a global prevalence of...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00130921
更新日期：1995-01-01 00:00:00
abstract：PURPOSE:Our purpose is to describe a safe and easy technique for the removal of the BrightOcular cosmetic iris implants. Our technique involves cutting the implant into five parts rather than removal as a whole with less intraocular manipulation and no rotation of the implant. METHODS:We have used this technique in tw...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-020-01328-1
更新日期：2020-06-01 00:00:00
abstract：:To report a unusual case of an isolated traumatic stellated tarso-conjunctival laceration located in the upper left eyelid without eyelid margin involvement and with normal ocular examination. A 19 year-old male wounded by a bokken (wooden katana) while practicing a sham duel had an isolated eyelid tarso-conjunctival ...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-012-9573-x
更新日期：2012-08-01 00:00:00
abstract：:To report a case of bilateral granulomatous post-streptococcal syndrome uveitis in association with reactive arthritis as manifestation of post-streptococcal syndrome. To our knowledge, this could represent the first reported case in the literature. A 9-year-old girl, with no past ocular history, presented with a 5-da...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-012-9626-1
更新日期：2015-10-01 00:00:00
abstract：:In the original publication, first line of methods under the Abstract section was published incorrectly. ...
journal_title：International ophthalmology
pub_type： 已发布勘误
doi：10.1007/s10792-020-01327-2
更新日期：2020-04-01 00:00:00
abstract：PURPOSE:To compare capillaries perfusion in macular areas at different layers and peripapillary region in radial peripapillary capillaries (RPC) between healthy subjects and subjects with obstructive sleep apnea-hypopnea (OSA) using spectral-domain optical coherence tomography angiography (OCTA). METHODS:Totally 16 ey...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-020-01518-x
更新日期：2020-12-01 00:00:00
abstract：:Corneal ulcer is a devastating corneal disease which is potentially sight-threatening and conventionally is treated by topical antibiotics and in some cases with more invasive procedures such as keratoplasty. The aim of this study is to evaluate the efficacy of corneal collagen cross-linking in resistant corneal ulcer...
journal_title：International ophthalmology
pub_type： 临床试验,杂志文章
doi：10.1007/s10792-012-9633-2
更新日期：2013-02-01 00:00:00
abstract：PURPOSE:The purpose of this article was to introduce a novel surgical technique for the management of peripheral Descemet's membrane perforation during deep anterior lamellar keratoplasty (DALK). METHODS:First, a thin stromal patch was prepared either from the anterior stromal lamella cut during DALK or from the anter...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-018-01065-6
更新日期：2019-10-01 00:00:00
abstract：:We evaluated the in vitro effects of the 1.3 u wavelength of a Nd:YAG laser using a fiberoptic delivery system, with or without sapphire tips on ocular tissue. Conjunctival and retinal adhesions were achieved best with a noncontact technique compared with a contact method. ...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00155628
更新日期：1987-08-01 00:00:00
abstract：PURPOSE:To investigate the overexpression of genes in sebaceous gland carcinoma (SGC) of the eyelid compared to sebaceous adenoma of the eyelid in order to elucidate the molecular mechanism underlying pathogenesis. METHODS:We performed histopathological examination of eyelid tissues surgically removed from four patien...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-019-01185-7
更新日期：2020-02-01 00:00:00
abstract：:Retinal astrocytic hamartomas are benign tumors of the retinal nerve fiber layer (NFL) that may be found in association with tuberous sclerosis (TS). We describe the spectral-domain optical coherence tomography (SD-OCT) features of type 1 astrocytic hamartomas in a child with TS that may aid in the diagnosis and follo...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-012-9586-5
更新日期：2012-10-01 00:00:00
abstract：:Published data on growth rates of uveal melanomas and effects of treatment modalities raise important considerations. Dissemination from uveal melanomas starts after the tumour is larger than 7 mm diameter; growth from 7 to 10 mm diameter increases the risk of metastases incrementally to approximately 16%. Estimations...
journal_title：International ophthalmology
pub_type： 杂志文章,评审
doi：10.1007/BF00132688
更新日期：1995-01-01 00:00:00
abstract：PURPOSE:Growth factors are considered as key molecules that participating in fibrosis formation. This research aimed to clarify potential effects of p53 on regulation of transforming growth factor β (TGF-β) and fibrosis formation and investigate the associated mechanisms. METHODS:Vimentin was examined to identify huma...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-020-01320-9
更新日期：2020-06-01 00:00:00
abstract：PURPOSE:To evaluate the performance of full-thickness (FT) versus partial-thickness (PT) sutures in a full-thickness corneal wound in an animal model. METHODS:This is a prospective, experimental, comparative, longitudinal study. A 6-mm linear, full-thickness corneal incision was performed on the right eye of eight dom...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-020-01585-0
更新日期：2021-01-01 00:00:00
abstract：:To analyze the pattern of intermediate uveitis (IU) in a referral center in Tunisia, North Africa. A retrospective, descriptive study of 87 consecutive patients (145 eyes) examined at the Department of Ophthalmology of Monastir (Tunisia) from January 1996 to August 2008. All patients underwent an extensive ocular and ...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-010-9352-5
更新日期：2010-10-01 00:00:00
abstract：PURPOSE:To determine the cytokine levels in vitreous samples of diabetic macular edema (DME) patients in comparison with nondiabetic patients, and to evaluate the effect of subretinal fluid on the cytokine levels of vitreous samples. METHODS:In this prospective case-control study, 11 eyes of 11 patients with DME and s...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-018-0874-6
更新日期：2019-04-01 00:00:00
abstract：PURPOSE:To gain an insight into the manufacturing and fitting of artificial eyes in children and potential improvements to the process. METHOD:An online qualitative survey was distributed to 39 ocularists/prosthetists in Europe and Canada. Participants were recruited through purposive sampling, specifically maximum va...
journal_title：International ophthalmology
pub_type： 杂志文章,多中心研究
doi：10.1007/s10792-016-0383-4
更新日期：2017-10-01 00:00:00
