Abstract：
PURPOSE:To study the connective tissue (CT) structure of upper eyelid skin of primary open-angle glaucoma (POAG) patients. PATIENTS AND METHODS:Forty-seven patients aged 47-91 expecting blepharoplasty formed 3 groups: group 1 [16 subjects without POAG, median age 55 years (interquartile range 54-55.5)], group 2 [12 subjects without POAG, median age 73 (72-76.5)], and group 3 [(19 subjects with POAG, median age 74 (70-80.5)]. Age differences between groups 1 and 2 and groups 1 and 3 are significant (p < 0.05). Thermodynamic parameters of skin samples taken during blepharoplasty: Endothermic peak ([Formula: see text], °C) and denaturation enthalpy ([Formula: see text], J/g of dry weight) were determined using differential scanning calorimetry. RESULTS:[Formula: see text] and [Formula: see text] in groups 1-3 were, respectively, 8.41 (7.42-10.25) and 66.55 (59.9-66.7); 7.10 (5.76-10.17) and 67.35 (67.0-68.03); 11.40 (9.0-14.9) and 67.70 (67.05-68.45). [Formula: see text] differences between groups 1 and 2 are significant (p < 0.05), and Spearman's correlation between the age and [Formula: see text] is direct, medium (R = 0.638) and significant. [Formula: see text] in group 3 is significantly higher than in group 2. [Formula: see text] and [Formula: see text] in patients without POAG (groups 1 and 2) and those with POAG (group 3) are, respectively, 7.79 (6.9-10.17) and 66.6 (61.2-67,3); 11.40 (9.0-14.9); 67.7 (67.05-68.45); the respective differences are significant. CONCLUSION:Patients without POAG show a significant increase in [Formula: see text] with age, while [Formula: see text] slightly decreases. In POAG, [Formula: see text] is significantly higher and [Formula: see text] tends to grow, which may indicate structural changes in eyelid CT (collagen accumulation and cross-linking level rise). Since the upper lid is unaffected by increasing IOP directly, the changes may be viewed as manifestations of systemic CT pathology.
journal_name
Int Ophthalmoljournal_title
International ophthalmologyauthors
Svetikova LA,Iomdina EN,Ignatyeva NY,Serik AN,Migal SF,Nazarova NAdoi
10.1007/s10792-018-1035-7subject
Has Abstractpub_date
2019-09-01 00:00:00pages
2005-2014issue
9eissn
0165-5701issn
1573-2630pii
10.1007/s10792-018-1035-7journal_volume
39pub_type
杂志文章abstract：:The ocular surface is exposed to many chronic inflammatory stimuli, and goblet cell hyperplasia of the conjunctiva occurs in many situations. We report two cases of epithelial goblet cell hyperplasia with nonspecific chronic inflammation which occurred on the internal canthus of elderly people. These cases shared the ...
journal_title：International ophthalmology
pub_type： 杂志文章,评审
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journal_title：International ophthalmology
pub_type： 杂志文章,评审
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pub_type： 临床试验,杂志文章
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journal_title：International ophthalmology
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pub_type： 杂志文章
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更新日期：1988-01-01 00:00:00
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,多中心研究
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更新日期：2011-10-01 00:00:00
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更新日期：2019-11-01 00:00:00
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pub_type： 杂志文章,多中心研究
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pub_type： 杂志文章
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更新日期：2018-02-01 00:00:00
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更新日期：2004-10-01 00:00:00
