Lipid peroxide and leukotriene B3 production in patients undergoing cardiopulmonary bypass.

Abstract:

:Cardiac surgery with cardiopulmonary bypass (CPB) is frequently associated with a complex array of post-operative clinical abnormalities, including low-output syndrome and pulmonary dysfunction. It has been reported that oxygen free radicals are one of the important factors causing reperfusion injury. To determine whether oxygen free radicals are produced during cardiac surgery, we studied nine patients anesthetized with high doses of fentanyl. Lipid peroxide (LPO) and leukotriene B4 (LTB4) levels increased significantly from 60 min after aortic ligation to 180 min after reperfusion (aortic declamping), compared with the levels before surgery, while superoxide dismutase (SOD) was not affected markedly. Creatine kinase (CK), CK muscle-brain (CK-MB), and neutrophils increased from 60 min after aortic declamping. Correlations were not observed between LPO and CK nor between LPO and CK-MB. These results suggest that free radicals are generated during cardiac surgery with cardiopulmonary bypass (CPB), but it is unclear whether free radicals cause tissue injury after cardiac surgery with CPB.

journal_name

J Anesth

journal_title

Journal of anesthesia

authors

Kawamura T,Sakurada H,Okada K,Wakusawa R,Ito H

doi

10.1007/BF02483345

subject

Has Abstract

pub_date

1996-06-01 00:00:00

pages

111-114

issue

2

eissn

0913-8668

issn

1438-8359

pii

10.1007/BF02483345

journal_volume

10

pub_type

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