Abstract:
PURPOSE:We aimed to evaluate postoperative analgesia of morphine, or clonidine, or morphine plus clonidine, added to caudal bupivacaine in children undergoing infra-umbilical urological and genital procedures. METHODS:Eighty patients aged 1-10 years were prospectively enrolled. After the induction of general anesthesia, the patients were randomized to four caudal anesthesia groups: Group B (1.0 mL/kg of bupivacaine 0.166% with epinephrine 1:600,000); Group BM (1.0 mL/kg of bupivacaine 0.166% with epinephrine 1:600,000 plus morphine 20 μg/kg); Group BC (bupivacaine 0.166% with epinephrine 1:600,000 plus clonidine 1.0 μg/kg), and Group BMC (bupivacaine 0.166% with epinephrine 1:600,000 plus morphine 20 μg/kg and clonidine 1.0 μg/kg). Duration of surgery, emergence time, postoperative pain score measured by the face, legs, activity, cry, consolability (FLACC) scale, postoperative analgesia time, and overall use of rescue analgesics were recorded. RESULTS:The FLACC pain score (6, 12, and 24 h after the surgery) and the number of patients requiring analgesics during the first 24 h of the postoperative period were higher in Groups B and BC than in Groups BM and BMC (p < 0.05). The incidence of pruritus and urinary retention was comparable between the groups (p > 0.05). However, the incidence of postoperative nausea and vomiting (PONV) was higher in Groups BM (35%) and BMC (25%) than in Groups B (5%) and BC (5%) (p < 0.05). CONCLUSION:To conclude, we showed that 20 μg/kg of morphine added to caudal bupivacaine 0.166% plus epinephrine 1:600,000 decreased the use of analgesics in the postoperative period, although it was associated with an increased incidence of PONV. However, the addition of clonidine (1.0 μg/kg) to caudal bupivacaine provided no additional clinical benefit over bupivacaine alone.
journal_name
J Anesthjournal_title
Journal of anesthesiaauthors
Fernandes ML,Pires KC,Tibúrcio MA,Gomez RSdoi
10.1007/s00540-011-1297-ysubject
Has Abstractpub_date
2012-04-01 00:00:00pages
213-8issue
2eissn
0913-8668issn
1438-8359journal_volume
26pub_type
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abstract::Intractable perineal pain often appears in the anal region following abdominoperineal resection for the treatment of rectal cancer. In such cases, a subarachnoid block or transsacral block is generally used to control pain. However, these procedures sometimes cause complications such as dysuria or sensory paralysis of...
journal_title:Journal of anesthesia
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pub_type: 杂志文章
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journal_title:Journal of anesthesia
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abstract::Familial dysautonomia is an inherited disorder characterized by autonomic and sensory nervous system neuropathy resulting in extremely labile blood pressure (severe hypertension followed by hypotension). As more patients with familial dysautonomia reach adulthood due to improved medical treatment, perioperative encoun...
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更新日期:2009-01-01 00:00:00
abstract:PURPOSE:We investigated the mechanism by which inhibition of carbonic anhydrase (CA) increases organ blood flow. METHODS:Regional blood flow (rBF) in white rabbits anesthetized with ketamine/urethane was measured in the kidney, liver, stomach wall, and abdominal muscle by means of laser blood flow probes. Data obtaine...
journal_title:Journal of anesthesia
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journal_title:Journal of anesthesia
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更新日期:2014-04-01 00:00:00
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journal_title:Journal of anesthesia
pub_type: 杂志文章
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更新日期:2003-01-01 00:00:00
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journal_title:Journal of anesthesia
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journal_title:Journal of anesthesia
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Journal of anesthesia
pub_type: 已发布勘误
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更新日期:2020-08-01 00:00:00
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更新日期:2011-06-01 00:00:00
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更新日期:1994-06-01 00:00:00