Abstract:
PURPOSE:Multimodal analgesia increases the chance of successful discharge and pain control after surgery, and pregabalin is being promoted as an effective analgesic, based on placebo-controlled studies. We investigated whether adding pregabalin improved pain control and reduced opioid requests when it was added to a multimodal analgesic regimen for cosmetic surgery. METHODS:One hundred and ten women who underwent same-day cosmetic surgery were randomized to receive oral pregabalin, 75 mg q12 h for five consecutive days starting the night before surgery, or identical placebos. Participants, outcomes assessors, and the statistician were blinded. The primary outcome was postoperative numerical movement-evoked pain scores at 2, 24, 48, 72, and 96 h after surgery. The secondary outcomes included pain scores at rest; incidence of moderate to severe pain; and analgesic and antiemetic requirements; as well as the incidence of nausea, vomiting, and somnolence. RESULTS:Based on 99 patients who completed the study, we found no difference between the groups in the primary outcome; 72 h after surgery, movement-evoked median pain scores were <4/10 in both groups. We found no differences in opioid requirements (p = 0.95) or anti-inflammatory requirements (p = 0.45), and no difference in opioid-related adverse events. CONCLUSION:Perioperative pregabalin 75 mg twice a day does not increase benefit when it is added to an already multimodal analgesic regimen for patients undergoing cosmetic surgery. Several factors could explain our findings, including the possibility of publication bias in the current literature.
journal_name
J Anesthjournal_title
Journal of anesthesiaauthors
Chaparro LE,Clarke H,Valdes PA,Mira M,Duque L,Mitsakakis Ndoi
10.1007/s00540-012-1447-xsubject
Has Abstractpub_date
2012-12-01 00:00:00pages
829-35issue
6eissn
0913-8668issn
1438-8359journal_volume
26pub_type
杂志文章,随机对照试验abstract::We encountered three cases of lung disorders caused by drowning in the recent large tsunami that struck following the Great East Japan Earthquake. All three were females, and two of them were old elderly. All segments of both lungs were involved in all the three patients, necessitating ICU admission and endotracheal i...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-011-1273-6
更新日期:2012-04-01 00:00:00
abstract:PURPOSE:The purpose of this study was to determine whether intraoperative infusion of remifentanil induces acute tolerance to opioids, and compare the postoperative pain and opioid consumption by the effect site concentrations of remifentanil. METHODS:One hundred and ninety-eight patients undergoing gastrectomy were r...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-018-2569-6
更新日期:2018-12-01 00:00:00
abstract:PURPOSE:A large proportion of patients experience chronic post-surgical pain (CPSP) following inguinal hernia repair surgery. The aim of this study was to investigate the predictive risk factors and protective factors for CPSP following inguinal hernia surgery. METHODS:After institutional ethics approval was obtained,...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-020-02743-5
更新日期:2020-06-01 00:00:00
abstract::A 72-year-old woman presented pulmonary embolism. Continuous intravenous administration of heparin was controlled with values of activated clotting time targeted from 150 to 180 s. On the sixth intensive care unit (ICU) day, a central vein (CV) catheter was inserted through the right axillary vein. On the ninth ICU da...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-010-0894-5
更新日期:2010-04-01 00:00:00
abstract:PURPOSE:The properties of two new-generation CO(2) absorbents, Amsorb Plus (Armstrong Medical, Coleraine, UK) and Drägersorb Free (Drager, Lubeck, Germany), were compared with those of Amsorb (Armstrong Medical) and Sodasorb II (W.R. Grace, Lexington, MA, USA). METHODS:The concentration of compound A produced by each ...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-004-0253-5
更新日期:2004-01-01 00:00:00
abstract::Cardiac effects of sevoflurane (SE) with or without nitrous oxide were examined in the canine blood-perfused papillary muscle and sinoatrial node preparations. Although SE depressed developed tension (DT), mean arterial pressure (MAP) and heart rate of the donor dog (DHR) dose dependently, sinoatrial rate (SAR) was no...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s0054090030145
更新日期:1989-09-01 00:00:00
abstract:PURPOSE:To elucidate the mechanisms of the more profound hypotensive effects of propofol relative to thiamylal, we monitored changes in left ventricular (LV) preload, afterload, and contractility during the course of anesthetic induction with propofol and thiamylal. METHODS:Thirty-two patients (ASA I) were randomly as...
journal_title:Journal of anesthesia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s005400070021
更新日期:2000-01-01 00:00:00
abstract:PURPOSE:To evaluate the role of the phosphatidylinositol 3 kinase (PI3K)/protein kinase B (Akt)/hypoxia-inducible factor 1α (HIF-1α) signaling pathway in the protection by dexmedetomidine against lung ischemia-reperfusion injury (IRI) in rats. METHODS:Forty-eight male Sprague-Dawley rats weighing 250-350 g were random...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-016-2214-1
更新日期:2016-10-01 00:00:00
abstract::The purpose of this multi-center study was to evaluate the efficacy and safety of prostaglandin E1 (PGE1) administration in achieving deliberate hypotension and in treating intraoperative hypertension for patients with a history of hypertension and ischemic heart disease. PGE1 (0.08 microg.kg(-1).min(-1)) decreased sy...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s0054030070173
更新日期:1993-04-01 00:00:00
abstract:PURPOSE:We assessed the accuracy of a point-of-care blood gas analyzer in providing data from saline samples obtained by gastrointestinal tonometry (Tonometrics Catheter; Tonometrics Division, Instrumentarium, Helsinki, Finland) for the calculation of intramucosal pH (pHi) and the P(CO)(2) gap (intramucosal P(CO)(2) - ...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-003-0209-1
更新日期:2004-01-01 00:00:00
abstract:PURPOSE:Propofol and ketamine have become progressively popular in electroconvulsive therapy (ECT) anesthesia, although propofol shortened seizure duration and ketamine might cause cardiotoxicity, psychotic episodes, and delayed recovery. Ketofol is a combination of ketamine and propofol, and the current study was desi...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-012-1378-6
更新日期:2012-08-01 00:00:00
abstract::Mechanical influences independent of chemoreceptor function on ventilatory control were studied in halothane-anesthetized, artificially ventilated patients using the technique reported by Altose et al. (Respir Physiol 66: 171-180, 1986). Contribution of mechanical factor was indirectly assessed by comparing the values...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s0054020060387
更新日期:1992-10-01 00:00:00
abstract:PURPOSE:We hypothesized that, after axillary block, positioning the patient in a lateral position with the injected side down and simultaneously in a 20° Trendelenburg position will increase the success rate and quality of the block. METHODS:Fifty patients with chronic renal failure (ASA 2-3) scheduled for arterioveno...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-013-1766-6
更新日期:2014-08-01 00:00:00
abstract:PURPOSE:Ultrasound (US)-guided continuous interscalene brachial plexus block (CBPB) is known to provide effective pain relief for arthroscopic rotator cuff repair. This study was conducted to compare analgesic efficacy and forearm muscle tone of the basal infusion rate and bolus dose of 0.2 % ropivacaine for US-guided ...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-013-1681-x
更新日期:2014-02-01 00:00:00
abstract::Neuropathic pain has a substantial effect on quality of life (QOL). The Japanese Society of Pain Clinicians (JSPC) has developed clinical guidelines of pharmacotherapy for neuropathic pain. These guidelines offer clarity on recommendations based on both the most recent scientific evidence and expert opinions. Understa...
journal_title:Journal of anesthesia
pub_type: 杂志文章,实务指引
doi:10.1007/s00540-018-2501-0
更新日期:2018-06-01 00:00:00
abstract:PURPOSE:Although an α-adrenoceptor has been suggested to be involved in the mechanism of asthma, the effect of α1-agonist on the airway is still unclear. In this study we evaluated the effect of phenylephrine on the airway with a direct visualization method using a superfine fiberoptic bronchoscope (SFB). METHODS:Seve...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/BF02480091
更新日期:1998-09-01 00:00:00
abstract:PURPOSE:This study demonstrated the effects of perfluorobutane (Sonazoid®) with contrast-enhanced ultrasonography (CEUS) to identify the spread of local anesthetics in ultrasound-guided nerve block. METHODS:This study consists of simulation, cadaveric, and animal studies. In a simulation study, 1% lidocaine with 10- t...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-017-2347-x
更新日期:2017-06-01 00:00:00
abstract::Within continuously controlled limits of cuff pressure, an endotracheal tube cuff made of polyurethane (PU) prevents secretion inflow better than a conventional polyvinylchloride cuff. However, the temperature difference between ventilator gas and the air inside a PU cuff produces condensation droplets that accumulate...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-014-1849-z
更新日期:2014-12-01 00:00:00
abstract::In a prospective controlled trial to compare conventional interscalene brachial plexus block (ISBPB) using anatomic landmarks and electro-stimulation with a combined technique of ultrasound guidance followed by nerve stimulation, 60 patients were randomized into 2 matched equal groups: Group A using nerve stimulation ...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-012-1366-x
更新日期:2012-08-01 00:00:00
abstract::We report an unusual complication that occurred late in the postoperative period, due to a damaged and malpositioned peripherally inserted central catheter (PICC) used for central venous pressure monitoring during esophagocoloplasty and for postoperative parenteral nutrition. On the seventh postoperative day, the deve...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-008-0724-1
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVES:When physicians become patients, they may expect special privileges, extra attention from caregivers, and non-routine treatments. Consequently, physician patients may not be treated per routine-which possibly worsens care rather than improving it. We thus tested the primary hypothesis that in-hospital mortal...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-016-2273-3
更新日期:2017-02-01 00:00:00
abstract:PURPOSE:The present case-control study was conducted to evaluate whether acute normovolemic hemodilution (ANH) can reduce the need for perioperative allogeneic blood transfusion (ABT) and affect the incidence of perioperative complications in free-flap reconstruction of the head and neck. METHODS:This single-center, r...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-019-02714-5
更新日期:2020-04-01 00:00:00
abstract:PURPOSE:The diaphragm is one of the organs directly affected by abdominal sepsis. Evidence suggests that sepsis induces diaphragmatic fatigability and that activated neutrophils play a crucial role in the development of diaphragmatic fatigability. In the present study, we investigated whether olprinone, a phosphodieste...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-007-0572-4
更新日期:2008-01-01 00:00:00
abstract::The antiarrhythmic effect of flecainide acetate (FCN), a newly developed class I antiarrhythmic drug, was evaluated on epinephrine (E)-halothane induced arrhythmias in dogs. The arrhythmogenic dose of E (ADE) under 1% of halothane was significantly increased from 0.71 +/- 0.08 to 1.08 +/- 0.11 and 1.84 +/- 0.23 micro ...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s0054000040303
更新日期:1990-10-01 00:00:00
abstract::We report a case of hypermagnesemia in a hospitalized patient after prolonged laxative use; due to preexisting impaired consciousness and digestive problems, the hypermagnesemia was difficult to detect until it almost became fatal. A 64-year-old man who was a patient at another hospital for treatment of head injury an...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-006-0492-8
更新日期:2007-01-01 00:00:00
abstract:PURPOSE:Because blood concentrations of local anesthetics sometimes reach toxic levels after transversus abdominis plane (TAP) block, reduction of the dose has been necessary to reduce the risk of systemic toxicity. We therefore investigated the effects of TAP block with 0.25 % levobupivacaine (100 mg) on postoperative...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-015-1993-0
更新日期:2015-08-01 00:00:00
abstract:PURPOSE:Our purpose was to examine the effect of dexmedetomidine, when used with phenylephrine during cardiopulmonary resuscitation (CPR), on the cerebral and systemic circulations. METHODS:In pentobarbital-anesthetized, mechanically ventilated dogs, we evaluated pial vessel diameters, cerebral oxygen extraction, and ...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-006-0402-0
更新日期:2006-01-01 00:00:00
abstract:PURPOSE:Postoperative sore throat (POST) after general anesthesia with endotracheal intubation is a common and undesirable complication. In this study, we evaluated the combined effects of paracetamol and dexamethasone on the prevention of POST in patients after general anesthesia. METHODS:A total of 226 patients sche...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-017-2411-6
更新日期:2017-12-01 00:00:00
abstract:PURPOSE:Patients undergoing laparoscopic gynecological surgery are susceptible to postoperative nausea and vomiting (PONV). We hypothesized that a combination of epidural and general anesthesia to minimize intraoperative opioid administration would reduce the incidence of PONV following laparoscopic gynecological surge...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-018-2525-5
更新日期:2018-08-01 00:00:00
abstract:PURPOSE:Compared with open thoracotomy, minimally invasive esophagectomy (MIE) methods, such as transhiatal or thoracoscopic esophagectomy, likely have lower morbidity. However, the relationship between intraoperative fluid management and postoperative complications after MIE remains unclear. Thus, we investigated the ...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-020-02766-y
更新日期:2020-06-01 00:00:00