Abstract：
BACKGROUND:Cardiac surgery and sternotomy are procedures accompanied by substantial postoperative pain which is challenging to treat. In general, intravenous (IV) opioids are used in the immediate postoperative phase, followed by oral opioids. Oral opioids are easier to use and generally less expensive. Our goal was thus to determine whether a new opioid preparation provides adequate analgesia after sternotomy. In particular, we tested the primary hypothesis that total opioid use (in morphine equivalents) is not greater with oral opioid compared with patient-controlled IV morphine. Our secondary hypothesis was that analgesic efficacy is similar with oral and IV opioids. METHODS:A total of 51 patients having elective cardiac surgery were enrolled in this study. After rapid postoperative respiratory weaning, the patients were randomised into one of two groups receiving different types of analgesia: oral Targin (a combination of oxycodone-hydrochloride and the opioid antagonist naloxone hydrochloride-dihydrate) or patient-controlled IV morphine. Pain score (visual analogue scale), sedation (Ramsey score), respiratory rate and side effects were assessed at 3, 5, 7, 9 and 11 h after surgery, and every 6 h throughout the third postoperative evening. RESULTS:The total opioid dose in morphine equivalent doses was significantly lower with oral opioid than with IV morphine (adjusted geometric means [95 % confidence interval]: 34 [29; 38] vs. 69 [61; 78] mg, respectively). Pain scores were similar in each group. CONCLUSIONS:Analgesic quality was comparable with oral and IV opioids, suggesting that postoperative pain even after very painful procedures can be sufficiently managed with oral opioids.
journal_name
J Anesthjournal_title
Journal of anesthesiaauthors
Ruetzler K,Blome CJ,Nabecker S,Makarova N,Fischer H,Rinoesl H,Goliasch G,Sessler DI,Koinig Hdoi
10.1007/s00540-013-1770-xsubject
Has Abstractpub_date
2014-08-01 00:00:00pages
580-6issue
4eissn
0913-8668issn
1438-8359journal_volume
28pub_type
杂志文章,随机对照试验abstract：BACKGROUND:Transcutaneous electrical acupoint stimulation (TEAS), a non-invasive and non-pharmacological adjunctive intervention for perioperative analgesia, may also reduce the incidence of postoperative pulmonary complications. The effect of TEAS on video-assisted thoracic surgical (VATS) patients is still unknown, h...
journal_title：Journal of anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00540-015-2057-1
更新日期：2017-02-01 00:00:00
abstract：PURPOSE:To compare clinical advantages and hemodynamic and respiratory changes during one lung-collapsed ventilation (OLCV) using a double-lumen tube (DLT) or a single-lumen tube (SLT) with intrathoracic CO(2) insufflation, in patients undergoing thoracic sympathectomy (TS) under general anesthesia. METHODS:One hundre...
journal_title：Journal of anesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s540-002-8088-z
更新日期：2002-01-01 00:00:00
abstract：:Although anaphylactoid reactions to local anesthetics are well known, a radioallergosorbent test (RAST) to detect specific drug reagin (IgE) anti-body has not been developed. We established RAST for local anesthetics by using carboxylic acid derivatives of lidocaine, procaine and methylparaben. Serum samples were take...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s0054090030074
更新日期：1989-03-01 00:00:00
abstract：PURPOSE:Epinephrine added to local anesthetic agents for spinal anesthesia is frequently used to prolong the duration of anesthesia. Epinephrine stimulates the alpha-adrenoceptor, and it is known that the alpha2-adrenoceptor agonists have a central inhibitory effect. We investigated the effect of intrathecal epinephrin...
journal_title：Journal of anesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00540-004-0233-9
更新日期：2004-01-01 00:00:00
abstract：PURPOSE:Postoperative nausea and vomiting (PONV) after adenotonsillectomy in children is, in spite of the prophylactic administration of tropisetron, still a frequent event. The aim of this study was to evaluate the benefit of the additional systemic administration of low-dose dexamethasone (0.15 mg x kg(-1)) for the p...
journal_title：Journal of anesthesia
pub_type： 杂志文章,评审
doi：10.1007/s00540-007-0523-0
更新日期：2007-01-01 00:00:00
abstract：:Muscle relaxation induced by neuromuscular blocking agents (NMBAs) is necessary for tracheal intubation and immobilization during surgery. Although acetylcholinesterase inhibitors have been successfully used as antagonists for NMBAs, they have their limitations; their effects are transient and ineffective against prof...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-020-02836-1
更新日期：2020-10-01 00:00:00
abstract：BACKGROUND:The purpose of this study was to assess whether preanesthetic laboratory values can predict in-hospital mortality and morbidity in patients who have undergone burr hole craniostomy due to chronic subdural hematoma. METHODS:From January 2007 to February 2016, the records of 502 consecutive patients who under...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-016-2259-1
更新日期：2016-12-01 00:00:00
abstract：PURPOSE:Newborns are often sedated during MRI but sedation itself creates adverse events and management is more challenging in this environment. Oral glucose/sucrose administration has been studied in newborns during painful procedures; however, its effectiveness in keeping newborns sleepy and motionlessness during pai...
journal_title：Journal of anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00540-016-2296-9
更新日期：2017-04-01 00:00:00
abstract：PURPOSE:It has been suggested that the different degrees of fade induced by nondepolarizing neuromuscular blocking agents in repetitive muscular contractions may be due to the varying affinities or binding kinetics of presynaptic nicotinic receptors. We compared the degree of fade induced by mivacurium, cisatracurium, ...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s005400300024
更新日期：2003-01-01 00:00:00
abstract：:We report a case involving a 55-year-old man who had a recent resection of tracheal carcinoma and tracheal reanastomosis. He subsequently developed tracheomalacia and anastomotic dehiscence requiring airway stenting via an armored endotracheal tube (ETT). Placement of the armored ETT was technically difficult. It requ...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-006-0463-0
更新日期：2007-01-01 00:00:00
abstract：:Fifteen surgical patients received an epidural injection of 12 ml of 1.5% lidocaine through a catheter placed at C7-T1, followed by further injection as required. An intravenous bolus of 0.5 mg of atropine sulfate was administered simultaneously with the initial epidural injection. The high-(HFC: 0.15-0.4 Hz) and low-...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/BF02482031
更新日期：1995-03-01 00:00:00
abstract：:We encountered three cases of lung disorders caused by drowning in the recent large tsunami that struck following the Great East Japan Earthquake. All three were females, and two of them were old elderly. All segments of both lungs were involved in all the three patients, necessitating ICU admission and endotracheal i...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-011-1273-6
更新日期：2012-04-01 00:00:00
abstract：PURPOSE:A large proportion of patients experience chronic post-surgical pain (CPSP) following inguinal hernia repair surgery. The aim of this study was to investigate the predictive risk factors and protective factors for CPSP following inguinal hernia surgery. METHODS:After institutional ethics approval was obtained,...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-020-02743-5
更新日期：2020-06-01 00:00:00
abstract：BACKGROUND:Clinical histological studies demonstrate that the distribution of natural killer (NK) cells, other immune cells and μ-opioid receptors (MOR) within cancer tissue can predict cancer prognosis. No clinical study has evaluated whether anesthetic technique influences immune cell and MOR expression within human ...
journal_title：Journal of anesthesia
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s00540-018-2554-0
更新日期：2018-12-01 00:00:00
abstract：PURPOSE:Numerous reports suggest that intravenously administered (IV) anesthetics affect postsynaptic events in the central nervous system. However, there is little evidence about how general anesthetics influence the presynaptic processes. The level of presynaptic calcium (Ca(2+)) concentration ([Ca(2+)](pre)) regulat...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-011-1186-4
更新日期：2011-10-01 00:00:00
abstract：PURPOSE:The sedative effects of pregabalin during perioperative period have not been sufficiently characterized. The aim of this study was to verify the sedative effects of premedication with pregabalin on intravenous sedation (IVS) using propofol and also to assess the influences of this agent on circulation, respirat...
journal_title：Journal of anesthesia
pub_type： 临床试验,杂志文章
doi：10.1007/s00540-017-2366-7
更新日期：2017-08-01 00:00:00
abstract：:The pharmacokinetics and pharmacodynamics of vecuronium bromide were studied in patients under general anesthesia of enflurane and nitrous oxide in oxygen. Eighteen patients were randomly divided into two groups which received either 0.05 mg.kg(-1) (low dose group) or 0.20 mg.kg(-1) (high dose group) of vecuronium int...
journal_title：Journal of anesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s0054020060028
更新日期：1992-01-01 00:00:00
abstract：PURPOSE:The ProSeal™ laryngeal mask airway (PLMA) can be more difficult to insert than the classic laryngeal mask, especially in patients who have a thin palate with a steep oropharyngeal curve. Here, an oral gastric (OG) tube-guided technique is considered as a method that makes it easier to successfully insert a PLMA...
journal_title：Journal of anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00540-012-1361-2
更新日期：2012-08-01 00:00:00
abstract：PURPOSE:We aimed to evaluate postoperative analgesia of morphine, or clonidine, or morphine plus clonidine, added to caudal bupivacaine in children undergoing infra-umbilical urological and genital procedures. METHODS:Eighty patients aged 1-10 years were prospectively enrolled. After the induction of general anesthesi...
journal_title：Journal of anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00540-011-1297-y
更新日期：2012-04-01 00:00:00
abstract：:The effect-compartment concentration (C(e)) of a drug at a specific pharmacodynamic endpoint should be independent of the rate of drug injection. We used this assumption to derive an effect-compartment equilibrium rate constant (k(eo)) for propofol during induction of anesthesia, using a target controlled infusion dev...
journal_title：Journal of anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00540-005-0378-1
更新日期：2006-01-01 00:00:00
abstract：PURPOSE:In many countries, patients are generally allowed to have clear fluids until 2-3 h before surgery. In Japan, long preoperative fasting is still common practice. To shorten the preoperative fasting period in Japan, we tested the safety and efficacy of oral rehydration therapy until 2 h before surgery. METHODS:T...
journal_title：Journal of anesthesia
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s00540-011-1261-x
更新日期：2012-02-01 00:00:00
abstract：:In this case series study, we prospectively examined whether it might be possible to check the effect of spinal anesthesia (SA), based on the disappearance of lower extremity reflexes and spasticity, in patients with spinal cord injury (SCI), in whom the effect cannot be confirmed by the pinprick test or by using the ...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-012-1429-z
更新日期：2012-12-01 00:00:00
abstract：:Airway management in patients of faciomaxillary injury is of great concern to the anesthesiologist. Bag and mask ventilation and orotracheal intubation may be difficult with these patients. Recently, a middle aged, obese female presented in the emergency department after sustaining a blast injury, with laceration of t...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-010-1091-2
更新日期：2011-04-01 00:00:00
abstract：PURPOSE:Hypoxia promotes the progression of lung cancer cells. Unfortunately, anesthetic technique might aggravate hypoxia of lung cancer cells. Sevoflurane is a commonly used anesthetic. Its effect on hypoxia-induced aggressiveness of lung cancer cells remains unknown. The aim of the study is to investigate the effect...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-015-2035-7
更新日期：2015-12-01 00:00:00
abstract：:The excretion of trifluoroacetic acid (TFAA) in bile, saliva and gastric juice of two groups of guinea pigs with bile fistulae was measured by ion-chromatography during inhalation of halothane (0.25% and 1.0%) for two hours and after inhalation of halothane. In another two groups without bile fistulae, excretion of TF...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s0054080020133
更新日期：1988-09-01 00:00:00
abstract：:Tracheomalacia after thyroidectomy is a life-threatening situation. However, it is difficult to predict postoperative tracheal obstruction with certainty. A case of a 74-year-old woman with a long-standing adenomatous goiter (98 g) is reported. She had undergone partial right lobe thyroidectomy 54 years earlier. After...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-011-1181-9
更新日期：2011-10-01 00:00:00
abstract：PURPOSE:Our purpose was to examine the effect of dexmedetomidine, when used with phenylephrine during cardiopulmonary resuscitation (CPR), on the cerebral and systemic circulations. METHODS:In pentobarbital-anesthetized, mechanically ventilated dogs, we evaluated pial vessel diameters, cerebral oxygen extraction, and ...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-006-0402-0
更新日期：2006-01-01 00:00:00
abstract：BACKGROUND:Epidemiologic studies suggest the possibility of a modestly elevated risk of adverse neurodevelopmental outcomes in children exposed to anesthesia during early childhood. Sevoflurane is widely used in pediatric anesthetic practice because of its rapid induction and lower pungency. However, it is reported tha...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-018-2545-1
更新日期：2018-10-01 00:00:00
abstract：:The electroencephalograms (EEG) of 55 children under isoflurane anesthesia were studied to elucidate any change in pattern with age. The children ranged from 1 month to 14 years of age were divided into six age groups. The standard minimum alveolar concentration (MAC) was determined in each group. Anesthesia was induc...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/BF02514699
更新日期：1994-06-01 00:00:00
abstract：PURPOSE:Inhaled anesthetics increase the incidence of postoperative residual neuromuscular blockade, and the mechanism is still unclear. We have investigated the synergistic effect of low-concentration inhaled anesthetics and rocuronium on inhibition of the inward current of the adult-type muscle nicotinic acetylcholin...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-012-1527-y
更新日期：2013-06-01 00:00:00
