Abstract：
PURPOSE:We previously confirmed the effectiveness of dexmedetomidine (DEX) for stabilizing hemodynamics as well as sparing anesthetics during anesthetic induction in patients undergoing cardiac surgery (Kunisawa et al. in J Clin Anesth 21:194-199, 1). In this study, we investigated whether these effects of DEX continue until the start of cardiopulmonary bypass (CPB). METHODS:Twenty-two patients with mild to moderate cardiovascular disease were randomized into two groups [DF2 group: DEX dose of 0.7 μg/kg/h after initial dose and effect-site concentration (ESC) of fentanyl of 2 ng/ml; PF4 group: saline and ESC of fentanyl of 4 ng/ml]. Propofol was administered for anesthetic induction and maintenance. Hemodynamics, cardiovascular drugs, ESC of propofol, and cardiovascular responses to skin incision (SI) and sternotomy (St) were measured or calculated. RESULTS:Blood pressure (BP) at the pre-/post-SI periods was higher in the DEX group (137 ± 17/140 ± 16 mmHg) than in the placebo group (85 ± 9/109 ± 24 mmHg). Percent increases in cardiovascular response to SI or St were lower in the DEX group than in the placebo group (for example, 1.9 ± 2.2 vs. 27.4 ± 19.9% in systolic BP due to SI). ESCs of propofol at SI and St in the DEX group were lower than those in the placebo group. CONCLUSIONS:DEX combined with 2 ng/ml fentanyl before CPB can suppress the decrease in blood pressure at the pre- and post-SI periods, can blunt the cardiovascular responses to SI and St, and can spare the required ESC of propofol despite fentanyl concentration, which was half of that in the placebo group.
journal_name
J Anesthjournal_title
Journal of anesthesiaauthors
Kunisawa T,Ueno M,Kurosawa A,Nagashima M,Hayashi D,Sasakawa T,Suzuki A,Takahata O,Iwasaki Hdoi
10.1007/s00540-011-1215-3subject
Has Abstractpub_date
2011-12-01 00:00:00pages
818-22issue
6eissn
0913-8668issn
1438-8359journal_volume
25pub_type
杂志文章,随机对照试验abstract：:To evaluate the effects of subanesthetic enflurane and sevoflurane on the sympathetic nervous system (SNS) and the parasympathetic nervous system (PNS), the blood level of norepinephrine (NE) and fluctuations in the R-R intervals were measured on electrocardiogram in humans given either 0.5 MAC enflurane or sevofluran...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/BF02482745
更新日期：1994-03-01 00:00:00
abstract：PURPOSE:This prospective, randomized trial was designed to assess whether the i-gel supraglottic airway device is suitable for volume-controlled ventilation while applying positive end-expiratory pressure (PEEP) of 5 cmH(2)O under general anesthesia. It was believed that this device might improve arterial oxygenation. ...
journal_title：Journal of anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00540-013-1628-2
更新日期：2013-12-01 00:00:00
abstract：:The incidence of noncardiac surgery in patients with the Fontan circulation has increased over the years due to the elongated life expectancy of these patients. In patients with the Fontan circulation, pulmonary blood flow is passive, so it is important to keep pulmonary vascular resistance low. One-lung ventilation (...
journal_title：Journal of anesthesia
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doi：10.1007/s00540-012-1333-6
更新日期：2012-06-01 00:00:00
abstract：:To determine whether there is any systemic relationship between the distance from the skin to the epidural space and physical constitution, the distance from the skin to the epidural space was measured in 1007 epidural punctures. The distance from the skin to the epidural space in male was greater than that in female ...
journal_title：Journal of anesthesia
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doi：10.1007/s0054080020198
更新日期：1988-09-01 00:00:00
abstract：:Tracheomalacia after thyroidectomy is a life-threatening situation. However, it is difficult to predict postoperative tracheal obstruction with certainty. A case of a 74-year-old woman with a long-standing adenomatous goiter (98 g) is reported. She had undergone partial right lobe thyroidectomy 54 years earlier. After...
journal_title：Journal of anesthesia
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doi：10.1007/s00540-011-1181-9
更新日期：2011-10-01 00:00:00
abstract：PURPOSE:Although uniportal video-assisted thoracoscopic surgery (VATS) has been widely used, the associated postoperative pain is still severe. Currently, a variety of regional anesthesia methods have been used to relieve postoperative pain. In our study, we wanted to evaluate the effectiveness of ultrasound-guided ere...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-020-02848-x
更新日期：2021-02-01 00:00:00
abstract：PURPOSE:The study was planned to compare the sensitivity of a twitch neuromuscular monitoring test, the train-of-four (TOF), with a tetanic test, double-burst stimulation (DBS), during a subclinical dose of vecuronium. METHODS:Twenty consenting. ASA I patients (16 to 65 years of age) of both sexes were studied. The ul...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/BF02480738
更新日期：1997-12-01 00:00:00
abstract：PURPOSE:Several reports indicate that a neutrophil elastase inhibitor, sivelestat, may have prophylactic efficacy against a systemic inflammatory response after cardiovascular surgery with cardiopulmonary bypass (CPB). We evaluated the clinical pulmonary and cardiac effects of sivelestat. METHODS:We performed a retros...
journal_title：Journal of anesthesia
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doi：10.1007/s00540-008-0645-z
更新日期：2008-01-01 00:00:00
abstract：PURPOSE:This study aims to identify prognostic factors related to short-term and long-term outcomes of patients with hematological malignancy (HM) admitted to the intensive care unit (ICU) in Japan during ICU stay and after discharge from ICU. METHODS:We conducted a retrospective, observational study of 169 patients w...
journal_title：Journal of anesthesia
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更新日期：2017-10-01 00:00:00
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journal_title：Journal of anesthesia
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doi：10.1007/s00540-016-2214-1
更新日期：2016-10-01 00:00:00
abstract：:We tested hypertonic saline solution (HS) to determine its effectiveness in surgical procedures for prostatic hypertrophy. We randomly selected 40 patients undergoing elective transurethral resection of the prostate for either infusion of HS (3% NaCl) at 4ml·kg(-1)·min(-1) (HS group) or lactated Ringer's solution (LR)...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/BF02471385
更新日期：1996-09-01 00:00:00
abstract：:Lead aprons are worn by medical workers to reduce the effects of the radiation doses to which they are exposed during radiography and surgery performed with radioscopic apparatus. Regarding the management of such aprons, the Radiation Protection Section of the Japanese Society of Radiological Technology issued the "Gu...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-016-2140-2
更新日期：2016-06-01 00:00:00
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journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/BF02483394
更新日期：1996-12-01 00:00:00
abstract：:Since perioperative anaphylaxis occurs suddenly, and it can be life-threatening, anesthesiologists need to have sufficient knowledge of the epidemiology of perioperative anaphylaxis and appropriate coping strategies to deal with it. Recent studies conducted in Western countries reported the characteristics of perioper...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-020-02886-5
更新日期：2021-02-01 00:00:00
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journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-010-0929-y
更新日期：2010-06-01 00:00:00
abstract：:The influence of sevoflurane on lidocaine-induced convulsions was studied in cats. The convulsive threshold (mean +/- SD) was 41.4 +/- 6.5 mg. l(-1) with lidocaine infusion (6 mg.kg(-1).min(-1)), increasing significantly to 66.6 +/- 10.9 mg. l(-1) when the end-tidal concentration of sevoflurane was 0.8%. However, the ...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s0054010050060
更新日期：1991-01-01 00:00:00
abstract：:The effect of famotidine on neonates was studied in 34 obstetric patients who underwent elective cesarean section. In the famotidine group, 20 mg of famotidine was intramuscularly injected at 60 min before induction of anesthesia, and 0.5 mg of atropine was injected at 30 min before induction. In the control group, on...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s0054010050276
更新日期：1991-07-01 00:00:00
abstract：:Anesthesia requires informed consent because it is an invasive procedure with certain risks. However, the state of informed consent for anesthesia in Japan remains unclear. The purpose of this survey was to examine the state of informed consent for anesthesia in Japan. A questionnaire was sent to all hospitals certifi...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-005-0332-2
更新日期：2005-01-01 00:00:00
abstract：BACKGROUND:The effect of the Mega Acer kit(@), a new heated and humidified breathing circuit (HHBC) containing a fluid-warming device, was investigated on intraoperative core temperature (T c). METHODS:A total of 102 patients undergoing elective craniotomies were randomly divided into three groups based on the breathi...
journal_title：Journal of anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00540-015-1994-z
更新日期：2015-08-01 00:00:00
abstract：PURPOSE:Remifentanil has been available in Japan for 3 years. The use of this new opioid is considered a useful adjuvant to general anesthesia. Knowing the exact cost-effectiveness of remifentanil should lead to improved anesthetic outcomes with a reasonable cost. METHODS:This single-blinded, prospective, randomized s...
journal_title：Journal of anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00540-010-1006-2
更新日期：2010-12-01 00:00:00
abstract：:The effect of verapamil on ventricular dysrhythmias was evaluated using two canine models. In one model, ventricular dysrhythmias were induced by 1% halothane-epinephrine (1.5 approximately 30 micro g/kg/min.) in 20 dogs (Group I). In the other model, ventricular dysrhythmias were induced by digoxin (0.1 approximately...
journal_title：Journal of anesthesia
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doi：10.1007/s0054080020028
更新日期：1988-03-01 00:00:00
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journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-003-0187-3
更新日期：2003-01-01 00:00:00
abstract：:The anesthesia information management system (AIMS) will be part of the future of healthcare. An electronic medical records system or AIMS will provide clear and concise information and have the potential to integrate information across the entire hospital system, improve quality of care, reduce errors, decrease risks...
journal_title：Journal of anesthesia
pub_type： 杂志文章,评审
doi：10.1007/s00540-008-0643-1
更新日期：2008-01-01 00:00:00
abstract：:A male patient with Marfan syndrome underwent aortic root replacement and developed left ventricular (LV) failure. Four years later, he underwent aortic arch and aortic valve replacement. Thereafter, his LV failure progressed, and cardiogenic pulmonary edema (CPE) appeared, which we treated with extracorporeal LV assi...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-016-2163-8
更新日期：2016-08-01 00:00:00
abstract：PURPOSE:The general public's perceptions of anesthesia and the risks associated with it may be skewed. The outpatient preoperative appointment with an anesthesiologist allows for patient education regarding different anesthetic options and counseling regarding anxiety related to anesthesia and surgery. This study inves...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-018-02608-y
更新日期：2019-04-01 00:00:00
abstract：:Cardiopulmonary resuscitation (CPR) in the lateral position during noncardiac surgery has been described in only a few reports in the past. Here, we report a case of cardiac arrest in a 61-year-old man undergoing microvascular decompression surgery for trigeminal neuralgia in the left lateral decubitus position. Durin...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-010-0911-8
更新日期：2010-06-01 00:00:00
abstract：:We report on the anesthetic management of a 69-year-old female Jehovah's Witness undergoing cardiopulmonary bypass to replace the ascending aorta; the patient refused transfusion of stored autologous or allogeneic blood products for religious reasons. The strategy involved preoperative hematopoiesis with recombinant h...
journal_title：Journal of anesthesia
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更新日期：2009-01-01 00:00:00
abstract：PURPOSE:This observational study was designed to evaluate the clinical value of cardiac output (CO) obtained via bioreactance (NICOM™) as compared with values of CO obtained via thermodilution (using pulmonary artery catheter, Vigilance™) and the thoracic bioimpedance (BioZ.com™), in patients undergoing off-pump corona...
journal_title：Journal of anesthesia
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doi：10.1007/s00540-014-1938-z
更新日期：2015-06-01 00:00:00
abstract：:The concentrations of extracellular glutamate (Glu), aspartate (Asp) and glycine (Gly) were measured by microdialysis method in the cortex and hippocampus before, during and after 15 min of total cerebral ischemia in dogs. The correlations between the concentrations of amino acids and the changes in EEG and evoked pot...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s0054030070334
更新日期：1993-07-01 00:00:00
abstract：PURPOSE:The aim of this pilot study was to evaluate the diagnostic value of pleth variability index (PVI) to predict fluid responsiveness in newborn infants during surgery. METHODS:PVI was continuously recorded in 29 mechanically ventilated newborn infants during surgery, and episodes of clinically indicated volume ex...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-012-1511-6
更新日期：2013-04-01 00:00:00
