Abstract:
PURPOSE:Several reports indicate that a neutrophil elastase inhibitor, sivelestat, may have prophylactic efficacy against a systemic inflammatory response after cardiovascular surgery with cardiopulmonary bypass (CPB). We evaluated the clinical pulmonary and cardiac effects of sivelestat. METHODS:We performed a retrospective study of 25 pediatric patients who underwent elective cardiovascular surgery with CPB for ventricular septal defect with pulmonary hypertension. Ten patients received 0.2 mg x kg(-1) x h(-1) sivelestat; the other is patients were the control group. There were no significant differences in demographic characteristics between the two groups. The P(a)O(2)/fractional inspired oxygen (F(I)O(2); P/F) ratio, the respiratory index (RI), and the fractional area change (FAC) of the left ventricle (LV) in the postoperative course were measured. RESULTS:The P/F ratio was higher in the sivelestat group compared with the control group and there were significant differences between the two groups immediately after weaning form CPB, and at 12 h after weaning from CPB (P < 0.05). The RI was lower in the sivelestat group compared with the control group and there were significant differences between the two groups at immediately after weaning from CPB, and at 6 h and 12 h after CPB (P < 0.05). The FAC of the LV was significantly better in the sivelestat group and there was a significant difference between the two groups on postoperative day (POD) 3 (P < 0.05). CONCLUSION:We have shown that pediatric patients who underwent cardiovascular surgery with CPB who received sivelestat had a higher P/F ratio, a lower RI, and better FAC of the LV in the postoperative course.
journal_name
J Anesthjournal_title
Journal of anesthesiaauthors
Toyama S,Hatori F,Shimizu A,Takagi Tdoi
10.1007/s00540-008-0645-zsubject
Has Abstractpub_date
2008-01-01 00:00:00pages
341-6issue
4eissn
0913-8668issn
1438-8359journal_volume
22pub_type
杂志文章abstract:PURPOSE:We evaluated the hemodynamic and respiratory effects of dexmedetomidine in intubated, spontaneously breathing patients after endoscopic submucosal dissection (ESD) for cervical esophageal or pharyngeal cancer. METHODS:This retrospective study included 129 patients aged 66.5 ± 8.3 years, who underwent ESD under...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-016-2175-4
更新日期:2016-08-01 00:00:00
abstract:PURPOSE:Hypoxia promotes the progression of lung cancer cells. Unfortunately, anesthetic technique might aggravate hypoxia of lung cancer cells. Sevoflurane is a commonly used anesthetic. Its effect on hypoxia-induced aggressiveness of lung cancer cells remains unknown. The aim of the study is to investigate the effect...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-015-2035-7
更新日期:2015-12-01 00:00:00
abstract::Cardiopulmonary resuscitation (CPR) in the lateral position during noncardiac surgery has been described in only a few reports in the past. Here, we report a case of cardiac arrest in a 61-year-old man undergoing microvascular decompression surgery for trigeminal neuralgia in the left lateral decubitus position. Durin...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-010-0911-8
更新日期:2010-06-01 00:00:00
abstract::We report here a 59-year-old man with a saber-sheath tracheal narrowing who was scheduled to undergo pharyngeal tumor resection under general anesthesia. The tracheal narrowing was not clearly detected by chest radiography during the preoperative examination, but it was visible on axial computed tomography (CT) images...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-009-0841-5
更新日期:2010-02-01 00:00:00
abstract:PURPOSE:The recommended method for elucidating the effects of strong ions other than lactate on acid-base balance is to calculate the non-lactate strong ion difference (SIDnl). A relationship between HCO3 (-) and SIDnl in hyperchloremic patients has already been demonstrated; in the present study, the relationships bet...
journal_title:Journal of anesthesia
pub_type: 杂志文章,多中心研究
doi:10.1007/s00540-016-2158-5
更新日期:2016-06-01 00:00:00
abstract:PURPOSE:Dexmedetomidine acts as a selective α2-adrenergic receptor agonist and an imidazoline receptor agonist, both of which are known to affect insulin secretion. Here, we investigated the effects of clinically relevant concentrations of dexmedetomidine on insulin secretion under in vivo conditions. Furthermore, its ...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-014-1943-2
更新日期:2015-06-01 00:00:00
abstract::Recent publications provided controversial results indicating that perioperative heparin bridging anticoagulation (HBA) increased the bleeding risk without decreasing the thromboembolic risk in patients undergoing minor surgery. To investigate if this is also the case in high-risk patients undergoing major abdominal m...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-016-2187-0
更新日期:2016-08-01 00:00:00
abstract::The optimal time of intravenous lidocaine for attenuation of pressor responses to laryngoscopy and endotracheal intubation was evaluated in fifty adult patients and the correlation between plasma lidocaine level and its clinical effects were also studied. The plasma lidocaine levels were highest 0.5 min after administ...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s0054000040150
更新日期:1990-04-01 00:00:00
abstract:PURPOSE:We hypothesized anterograde amnesia could be predicted by the bispectral index (BIS) during epidural puncture in patients premedicated with intramuscular midazolam. METHODS:We investigated 64 consecutive patients undergoing gynecological laparotomy under general anesthesia combined with epidural anesthesia. Mi...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-009-0748-1
更新日期:2009-01-01 00:00:00
abstract:PURPOSE:Facemask ventilation during the induction of general anesthesia in paediatric patients remains a challenge as it may result in hypoxic conditions and gastric insufflation with subsequent regurgitation and aspiration. So far, it is unclear if pressure-controlled or manual facemask ventilation is preferable in ch...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-018-2580-y
更新日期:2019-02-01 00:00:00
abstract::The incidence of an abnormal increase in the serum levels of glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) following anesthesia with halothane and 65% nitrous oxide in oxygen (halothane group) or with sevoflurane and 65% nitrous oxide in oxygen (sevoflurane group) was compared in wome...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/BF02479843
更新日期:1995-06-01 00:00:00
abstract:PURPOSE:Because blood concentrations of local anesthetics sometimes reach toxic levels after transversus abdominis plane (TAP) block, reduction of the dose has been necessary to reduce the risk of systemic toxicity. We therefore investigated the effects of TAP block with 0.25 % levobupivacaine (100 mg) on postoperative...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-015-1993-0
更新日期:2015-08-01 00:00:00
abstract::We report an 83-year-old man with myasthenia gravis (MG) who developed respiratory depression after spinal anesthesia for transurethral laser enucleation of the prostate. He became less responsive after complained of dyspnea, with a decrease of SpO2 to 83% approximately 13 min after intrathecal administration of 0.5% ...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-020-02874-9
更新日期:2021-02-01 00:00:00
abstract:PURPOSE:In emergency situations, rescuers occasionally must secure the airway while the patient is in a position other than the ideal supine position. We hypothesized that the laryngeal mask airway Supreme(®) (Supreme) may be useful for emergent airway management in several positions and compared the utility of the Sup...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-011-1145-0
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:We hypothesized that body shape metrics influence the anatomy of spinal canal and intraabdominal pressure in three dimensions. We explored the effects of abdominal circumference, trunk length, and their combination on the level of spinal anesthesia in the term parturient in this study. METHODS:Thirty term p...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-013-1715-4
更新日期:2014-04-01 00:00:00
abstract:PURPOSE:The incidence of postoperative pharyngolaryngeal complications after laryngeal mask airway (LMA) insertion can be as high as 50%. Over-inflation of the LMA cuff may be a causal factor. We conducted a single-centre parallel group randomised trial to determine whether maintaining LMA-ProSeal intra-cuff pressures ...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-014-1811-0
更新日期:2014-10-01 00:00:00
abstract::Bronchial thermoplasty (BT) is a recently introduced bronchoscopic treatment for patients with asthma refractory to pharmacotherapy. Intraprocedural sedation management is important for successful performance of BT. However, the results of general anesthesia in patients undergoing BT have not been well described. The ...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-018-2485-9
更新日期:2018-06-01 00:00:00
abstract:PURPOSE:We aimed to evaluate postoperative analgesia of morphine, or clonidine, or morphine plus clonidine, added to caudal bupivacaine in children undergoing infra-umbilical urological and genital procedures. METHODS:Eighty patients aged 1-10 years were prospectively enrolled. After the induction of general anesthesi...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-011-1297-y
更新日期:2012-04-01 00:00:00
abstract:PURPOSE:Patients undergoing extensive cervical spine surgery (ECSS) occasionally require emergency reintubation due to postoperative airway complications. To avoid it, an endotracheal tube is retained in patients maintained under sedation overnight. This study was conducted to determine whether dexmedetomidine would be...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-011-1300-7
更新日期:2012-04-01 00:00:00
abstract:PURPOSE:The sedative effects of pregabalin during perioperative period have not been sufficiently characterized. The aim of this study was to verify the sedative effects of premedication with pregabalin on intravenous sedation (IVS) using propofol and also to assess the influences of this agent on circulation, respirat...
journal_title:Journal of anesthesia
pub_type: 临床试验,杂志文章
doi:10.1007/s00540-017-2366-7
更新日期:2017-08-01 00:00:00
abstract::The coronavirus disease 2019 (COVID-19) pandemic is caused by a coronavirus that is transmitted primarily via aerosol, droplets or direct contact. This may place anesthetists at higher risk of infection due to their frequent involvement in aerosol-generating airway interventions. Many anesthethetic COVID-19 guidelines...
journal_title:Journal of anesthesia
pub_type: 杂志文章,评审
doi:10.1007/s00540-020-02819-2
更新日期:2020-12-01 00:00:00
abstract:PURPOSE:This study aimed to investigate the efficacy of the ClearSight™ system (Edwards Lifesciences, Irvine, CA) for reducing the incidence of hypotension compared with the traditional oscillometric blood pressure monitoring in cesarean delivery under spinal anesthesia. METHODS:Forty patients undergoing cesarean deli...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-018-2560-2
更新日期:2018-12-01 00:00:00
abstract:PURPOSE:Because the safety of intravenous fentanyl patient-controlled analgesia (iv-PCA) administered during labor remains unclear, we retrospectively examined the labor records from January 2005 to December 2007 in our institution, with a focus on both maternal and neonatal outcomes, as compared to no analgesia. METH...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-011-1292-3
更新日期:2012-04-01 00:00:00
abstract:PURPOSE:Local epinephrine infiltration often causes beta1-adrenoceptor-mediated tachycardia, hypertension, and arrhythmia. Landiolol, a short acting beta1-adrenoceptor blocker, may represent the most ideal agent to attenuate these adverse effects. In this study, we examined the effects of landiolol on the hemodynamic c...
journal_title:Journal of anesthesia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00540-004-0281-1
更新日期:2005-01-01 00:00:00
abstract:PURPOSE:Stroke volume variation (SVV) is affected by many factors. Although elevated intra-abdominal pressure and a pneumoperitoneum have been shown to increase SVV in animals, a recent human study showed that SVV did not change as a pneumoperitoneum was established. However, we considered the results of this study que...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-014-1963-y
更新日期:2015-08-01 00:00:00
abstract::Alveolar capillary dysplasia (ACD), which is a rare and lethal congenital pulmonary anomaly found in newborns, begins its onset or causes deterioration of the infant's condition some time after birth. Various congenital anomalies in combination with ACD have been reported, except for subglottic stenosis. Therefore, we...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-010-1080-5
更新日期:2011-04-01 00:00:00
abstract:PURPOSE:We previously confirmed the effectiveness of dexmedetomidine (DEX) for stabilizing hemodynamics as well as sparing anesthetics during anesthetic induction in patients undergoing cardiac surgery (Kunisawa et al. in J Clin Anesth 21:194-199, 1). In this study, we investigated whether these effects of DEX continue...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-011-1215-3
更新日期:2011-12-01 00:00:00
abstract::Cervical spinal cord injury is a rare but serious complication after general anesthesia. The risk factors include traumatic cervical injury, cervical spine instability, and difficult airway management. It has also occurred in the absence of cervical instability. Here we report a patient who had a history of intermitte...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-013-1667-8
更新日期:2014-02-01 00:00:00
abstract:PURPOSE:Inhaled anesthetics increase the incidence of postoperative residual neuromuscular blockade, and the mechanism is still unclear. We have investigated the synergistic effect of low-concentration inhaled anesthetics and rocuronium on inhibition of the inward current of the adult-type muscle nicotinic acetylcholin...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-012-1527-y
更新日期:2013-06-01 00:00:00
abstract::A modified thermodilution catheter (KATS catheter) capable of monitoring continuous cardiac output by thermodeprivation and preserving its conventional function was devised. The KATS catheter has a thermistor incorporated closer to the tip of the catheter in addition to the usual thermistor used for conventional therm...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s0054010050205
更新日期:1991-07-01 00:00:00