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The effect of verapamil on halothane-epinephrine or digitalis-induced ventricular dysrhythmias in dogs.

Abstract：

:The effect of verapamil on ventricular dysrhythmias was evaluated using two canine models. In one model, ventricular dysrhythmias were induced by 1% halothane-epinephrine (1.5 approximately 30 micro g/kg/min.) in 20 dogs (Group I). In the other model, ventricular dysrhythmias were induced by digoxin (0.1 approximately 0.2 mg/kg) in 27 dogs (Group II). Verapamil (0.2 approximately 0.5 mg/kg) was given to treat these ventricular dysrhythmias. When verapamil was ineffective, lidocaine (1 approximately 2 mg/kg) was given following the administration of verapamil. In 7 dogs of group II, lidocaine alone was given. Verapamil was effective in 16 animals of group I, and in 10 animals of group II. Lidocaine was ineffective in the remaining 4 of group I, whereas effective in the remaining 17, including those given lidocaine alone of group II. From these findings, it was inferred that Ca(2+) dependent abnormal automaticity and/or re-entry may be more closely related to the genesis of halothane-epinephrine-induced ventricular dysrhythmias refractory to lidocaine, whereas triggered activity may be more closely related to that of digitalis-induced ventricular dysrhythmias. In conclusion, verapamil was more effective against halothane-epinephrine-induced ventricular dysrhythmias than against digitalis-induced ventricular dysrhythmias.

journal_name

J Anesth

journal_title

Journal of anesthesia

authors

Yoshizawa Y,Shimizu R,Kasuda H,Akazawa S,Nemoto K,Inoue S

doi

10.1007/s0054080020028

subject

Has Abstract

pub_date

1988-03-01 00:00:00

pages

28-35

issue

1

eissn

0913-8668

issn

1438-8359

journal_volume

2

pub_type

杂志文章

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