Abstract:
:Amrinone, a phosphodiesterase inhibitor, is a non-glycosidic noncatecholamine with both vasodilator and positive inotropic effects. We were interested in assessing the effect of amrinone on postischemic cardiac performance in the isolated heart-lung preparation. Twenty-four male Wistar-ST rats were used. They were randomly divided into three groups. Amrinone, 10 μg·ml-1 or 100 μg·ml-1 was administered 8 min after the start of perfusion except in the control group. Ten minutes after the start of perfusion, all hearts were made globally ischemic for 8 min. Subsequently, the preparations were reperfused for 10 min. At the end of the experimental period, the hearts were freeze-clamped, and then myocardial high-energy phosphates, lactate, pyruvate, and glycogen were measured. Hemodynamic parameters in all groups decreased significantly during ischemia. However, there were no significant differences among the groups. The myocardial ATP level in the 100 μg·ml-1 group was significantly higher than that in the control group. Adenosine diphosphate (ADP) and adenosine monophosphate (AMP) levels in the 100 μg·ml-1 group were significantly lower than those in the control group. Myocardial lactate, pyruvate, and glycogen levels were not significantly different among the groups. This result suggests that amrinone improves postischemic myocardial metabolism. Although we could not measure coronary flow, amrinone might increase coronary flow with direct coronary vasodilation which would have increased the myocardial ATP and energy charge levels.
journal_name
J Anesthjournal_title
Journal of anesthesiaauthors
Kume M,Kashimoto S,Furuya A,Kumazawa Tdoi
10.1007/BF02483394subject
Has Abstractpub_date
1996-12-01 00:00:00pages
269-275issue
4eissn
0913-8668issn
1438-8359pii
10.1007/BF02483394journal_volume
10pub_type
杂志文章abstract::Admission on the day of surgery for elective cardiac and non-cardiac surgery has been established as a prevalent, critical practice. This approach realizes medical, logistical, psychological and fiscal benefits, and its success is predicated on an effective outpatient pre-operative evaluation. The establishment of a h...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-016-2139-8
更新日期:2016-06-01 00:00:00
abstract::In a prospective controlled trial to compare conventional interscalene brachial plexus block (ISBPB) using anatomic landmarks and electro-stimulation with a combined technique of ultrasound guidance followed by nerve stimulation, 60 patients were randomized into 2 matched equal groups: Group A using nerve stimulation ...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-012-1366-x
更新日期:2012-08-01 00:00:00
abstract:PURPOSES:In the present study, we investigated whether flurbiprofen axetil (FA) alleviates hypoxemia during one-lung ventilation (OLV) by reducing the pulmonary shunt/total perfusion (Q s/Q t) ratio, and examined the relationship between the Q s/Q t ratio and the thromboxane B2 (TXB2)/6-keto-prostaglandin F1α (6-K-PGF1...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-015-2060-6
更新日期:2015-12-01 00:00:00
abstract::We report on five patients who underwent MRI-guided focused ultrasound ablation of prostatic cancer under epidural anesthesia with intravenous dexmedetomidine sedation. This pioneering procedure requires an immobile therapeutic field with adequate sedation and analgesia provided to the patients. Duration of the proced...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-011-1189-1
更新日期:2011-10-01 00:00:00
abstract:PURPOSE:Postoperative sore throat (POST) after general anesthesia with endotracheal intubation is a common and undesirable complication. In this study, we evaluated the combined effects of paracetamol and dexamethasone on the prevention of POST in patients after general anesthesia. METHODS:A total of 226 patients sche...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-017-2411-6
更新日期:2017-12-01 00:00:00
abstract::The effects of succinylcholine and calcium (Ca2+), alone and together, on membrane-bound acetylcholinesterase ("true-type" cholinesterase) were examined using human erythrocyte ghosts to elucidate the combined pharmacological activity of succinylcholine and calcium in in vivo system. Succinylcholine inhibited the acet...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s0054070010015
更新日期:1987-03-01 00:00:00
abstract::Shortly after repair of a type A aortic dissection, resternotomy was required because of tamponade. During the exploration, it was discovered that the source of bleeding was in the right pleura. Collapse of the right lung was requested. A double-lumen tube would have necessitated changing the endotracheal tube (ETT) i...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-011-1116-5
更新日期:2011-06-01 00:00:00
abstract::Since perioperative anaphylaxis occurs suddenly, and it can be life-threatening, anesthesiologists need to have sufficient knowledge of the epidemiology of perioperative anaphylaxis and appropriate coping strategies to deal with it. Recent studies conducted in Western countries reported the characteristics of perioper...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-020-02886-5
更新日期:2021-02-01 00:00:00
abstract::Adenosine triphosphate as well as sodium nitroprusside has been used for hypotensive anesthesia. The purpose of this study was to examine the possibility that two hypotensive drugs may exert different effects on venous capacitance during controlled hypotension. In rats anesthetized with ketamine, mean arterial pressur...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s0054070010143
更新日期:1987-09-01 00:00:00
abstract::We report a case of diplopia during continuous epidural injection presumably caused by catheter migration. A 61-year-old woman underwent shoulder surgery under general anesthesia with cervical epidural anesthesia. The epidural catheter was placed in the C6-C7 epidural space with some difficulty before general anesthes...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-013-1721-6
更新日期:2014-06-01 00:00:00
abstract::The excretion of trifluoroacetic acid (TFAA) in bile, saliva and gastric juice of two groups of guinea pigs with bile fistulae was measured by ion-chromatography during inhalation of halothane (0.25% and 1.0%) for two hours and after inhalation of halothane. In another two groups without bile fistulae, excretion of TF...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s0054080020133
更新日期:1988-09-01 00:00:00
abstract::A 24-year-old man underwent surgery for a fractured left clavicle and received an interscalene brachial plexus block for intraoperative and postoperative analgesia. After injection of 40 ml 0.5% ropivacaine and confirmation of analgesia, general anesthesia was induced and maintained with propofol. Although the operati...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-011-1125-4
更新日期:2011-06-01 00:00:00
abstract::We present a case of a 33-year-old woman with Kabuki syndrome (KS) presenting with Henoch-Schönlein purpura (HSP). She was admitted to our hospital with a brain abscess in the lateral ventricle and meningitis. She had been diagnosed with KS. Skin eruptions had appeared on her lower extremities, with arthralgia, cough,...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-008-0656-9
更新日期:2008-01-01 00:00:00
abstract:PURPOSE:It seems controversial whether or not neutrophil elastase inhibitors are effective in attenuating myocardial ischemia/reperfusion injury. We thus investigated possible protective effects of sivelestat, a neutrophil elastase inhibitor, against myocardial stunning i.e., prolonged myocardial dysfunction following ...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-010-0948-8
更新日期:2010-08-01 00:00:00
abstract::Cardiac effects of sevoflurane (SE) with or without nitrous oxide were examined in the canine blood-perfused papillary muscle and sinoatrial node preparations. Although SE depressed developed tension (DT), mean arterial pressure (MAP) and heart rate of the donor dog (DHR) dose dependently, sinoatrial rate (SAR) was no...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s0054090030145
更新日期:1989-09-01 00:00:00
abstract::A substantial proportion of patients with coronavirus disease 19 (COVID-19) develop severe respiratory failure. Although the exact pathophysiology of severe COVID-19 pneumonia remains unknown and the characteristics of these patients are heterogeneous, the acute respiratory failure often fulfills criteria for acute re...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-020-02845-0
更新日期:2020-08-31 00:00:00
abstract::The concentrations of placental transfer of halothane (H), enflurane (E), sevoflurane (S), and isoflurane (I) were measured in 46 patients during cesarean section. The mean inhalation times of H (0.5%), E (1%), S (0.8%), and I (0.6%) were 13 min 27 s, 13 min 49s, 13 min 20s, and 8 min 8s, respectively. The mean concen...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/BF02479867
更新日期:1995-09-01 00:00:00
abstract:PURPOSE:We performed a multicenter, randomized, double-blind trial to assess the efficacy and safety of a single, fixed, intravenous dose of palonosetron (0.075 mg) in the treatment of established postoperative nausea and vomiting (PONV). METHODS:Three hundred and eighty-four patients who had at least one risk factors...
journal_title:Journal of anesthesia
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00540-014-1884-9
更新日期:2015-02-01 00:00:00
abstract:PURPOSE:The present study, conducted in rats, investigated whether propofol attenuates lipopolysaccharide (LPS)-triggered liver dysfunction via regulation of tumor necrosis factor (TNF)-α production in activated Kupffer cells. METHODS:Rats received LPS (500 μg/kg) under Urethane™ sedation (1 g/kg) in combination with ...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-016-2145-x
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Postanesthetic shivering can be triggered by surgical stress and several aspects of anesthetic management and is frequently preceded by a decrease in peripheral blood flow due to thermoregulatory vasoconstriction. As perfusion index correlates with peripheral blood flow, we examined whether perioperative per...
journal_title:Journal of anesthesia
pub_type: 临床试验,杂志文章
doi:10.1007/s00540-013-1658-9
更新日期:2014-02-01 00:00:00
abstract::To evaluate the effects of subanesthetic enflurane and sevoflurane on the sympathetic nervous system (SNS) and the parasympathetic nervous system (PNS), the blood level of norepinephrine (NE) and fluctuations in the R-R intervals were measured on electrocardiogram in humans given either 0.5 MAC enflurane or sevofluran...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/BF02482745
更新日期:1994-03-01 00:00:00
abstract:PURPOSE:Although uniportal video-assisted thoracoscopic surgery (VATS) has been widely used, the associated postoperative pain is still severe. Currently, a variety of regional anesthesia methods have been used to relieve postoperative pain. In our study, we wanted to evaluate the effectiveness of ultrasound-guided ere...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-020-02848-x
更新日期:2021-02-01 00:00:00
abstract::Rectal luminal regional P(CO2) (Pr(CO2)) was compared with gastric luminal Pr(CO2) measured by automated air tonometry at intervals of 10 min in 20 children aged 6-16 years scheduled for elective surgery under general anesthesia. In 5 patients, measurement of rectal Pr(CO2) failed because of catheter-related problems....
journal_title:Journal of anesthesia
pub_type: 临床试验,杂志文章
doi:10.1007/s00540-006-0410-0
更新日期:2006-01-01 00:00:00
abstract::Although maintaining anesthesia for myasthenia gravis (MG) with minimal muscle relaxants (MR) is common, the success rate of anesthetic management for MG without MR is not clear. We therefore retrospectively examined the success rate of anesthetic management for MG without MR among 66 consecutive cases of thymectomy f...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-015-1999-7
更新日期:2015-10-01 00:00:00
abstract:PURPOSE:This prospective, randomized trial was designed to assess whether the i-gel supraglottic airway device is suitable for volume-controlled ventilation while applying positive end-expiratory pressure (PEEP) of 5 cmH(2)O under general anesthesia. It was believed that this device might improve arterial oxygenation. ...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-013-1628-2
更新日期:2013-12-01 00:00:00
abstract:PURPOSE:To study the delivery efficiency of procaterol aerosols administered through the tracheal tube (ETT) with a metered-dose inhaler (MDI) during apnea. METHODS:First, in a normal room air environment (at ambient temperatures of 24 degrees to 26 degrees C), we measured the amount of aerosol delivered through the E...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s005400200044
更新日期:2002-01-01 00:00:00
abstract:PURPOSE:Skin incision before percutaneous central venous catheterization may cause serious hemorrhage and/or skin cicatrization. To minimize these adverse effects, we improved the shape of a dilator and coated it with lubricant to reduce insertion load. METHODS:We selected three types of dilators from different manufa...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-004-0292-y
更新日期:2005-01-01 00:00:00
abstract::We aimed to perform an epidural patch using platelet rich plasma (PRP), which has the potential to regenerate and heal tissues via degranulation of platelets, in a 34-year-old parturient suffering from persistent post-dural puncture headache (PDPH) after failed epidural blood patch (EBP). After her admission to our un...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-017-2400-9
更新日期:2017-12-01 00:00:00
abstract::There has been no study comparing the advantage and disadvantage of various antihypertensive agents during surgery for pheochromocytomas because the study is difficult in clinical setting. In the present experiments using dogs, after increasing the arterial blood pressure with norepinephrine, we decreased it to the ba...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s0054010050396
更新日期:1991-10-01 00:00:00
abstract:PURPOSE:This study aimed to examine the incidence, case fatality rate, and characteristics of perioperative symptomatic pulmonary thromboembolism (PS-PTE) throughout Japan. METHODS:From 2002 to 2011, confidential questionnaires were mailed annually to all Japanese Society of Anesthesiologists-certified training hospit...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-014-1939-y
更新日期:2015-06-01 00:00:00