Abstract:
:The excretion of trifluoroacetic acid (TFAA) in bile, saliva and gastric juice of two groups of guinea pigs with bile fistulae was measured by ion-chromatography during inhalation of halothane (0.25% and 1.0%) for two hours and after inhalation of halothane. In another two groups without bile fistulae, excretion of TFAA was measured in saliva and gastric juice during and after inhalation of same concentrations of halothane.The excretion of TFAA increased with time and showed the highest concentrations in the saliva. The highest excretion rate and cumulative amounts of excreted TFAA were observed in bile. The cumulative amounts of TFAA excreted into the bile, saliva and gastric juice was 4.85 +/- 1.87 micro mol, 0.89 +/- 0.62 micro mol, 0.11 +/- 0.06 micro mol, respectively, after inhalation of 0.25% halothane and 5.36+/- 2.29 micro mol, 1.50 +/- 0.59 micro mol, 0.25 +/- 0.19 micro mol, respectively, after inhalation of 1.0% halothane. The excretion of TFAA in bile and saliva was saturated after inhalation of the higher concentration of halothane. The excretion of TFAA into the gastric juice was higher with 1.0% concentration of halothane and in animals without bile fistulae. We concluded that TFAA a metabolite of halothane is excreted not only in bile but also in saliva and gastric juice. Biotransformation of halothane in salivary glands seems very likely. A small amount of TFAA excreted in bile enters the enterohepatic circulation. The excretion of TFAA in digestive juice seems to be controlled by a rate-limiting mechanism.
journal_name
J Anesthjournal_title
Journal of anesthesiaauthors
Mirkov MI,Morio M,Kawahara M,Yuge O,Kinoshita H,Fujii Kdoi
10.1007/s0054080020133subject
Has Abstractpub_date
1988-09-01 00:00:00pages
133-8issue
2eissn
0913-8668issn
1438-8359journal_volume
2pub_type
杂志文章abstract::We report on five patients who underwent MRI-guided focused ultrasound ablation of prostatic cancer under epidural anesthesia with intravenous dexmedetomidine sedation. This pioneering procedure requires an immobile therapeutic field with adequate sedation and analgesia provided to the patients. Duration of the proced...
journal_title:Journal of anesthesia
pub_type: 杂志文章
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更新日期:2011-10-01 00:00:00
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journal_title:Journal of anesthesia
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更新日期:2007-01-01 00:00:00
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journal_title:Journal of anesthesia
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更新日期:2014-12-01 00:00:00
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journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s0054010050205
更新日期:1991-07-01 00:00:00
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journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/BF02482755
更新日期:1994-03-01 00:00:00
abstract:OBJECTIVES:The incidence of postoperative shivering is known to be inversely associated with core body temperature. However, previous studies have pointed out that the threshold of shivering could be affected by peripheral temperature or anesthetic agents. These reports pointed specific drugs, though, anesthesia techni...
journal_title:Journal of anesthesia
pub_type: 杂志文章
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更新日期:2020-06-01 00:00:00
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journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-010-0874-9
更新日期:2010-04-01 00:00:00
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journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/BF02479867
更新日期:1995-09-01 00:00:00
abstract::Isolated adrenocorticotropic hormone (ACTH) deficiency is an extremely rare disease in which ACTH-producing cells of the pituitary gland are selectively damaged. The resulting decline in ACTH production and secretion results in chronic secondary adrenocortical insufficiency. The patient in this case did not present wi...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-011-1118-3
更新日期:2011-06-01 00:00:00
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journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-016-2214-1
更新日期:2016-10-01 00:00:00
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journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-016-2259-1
更新日期:2016-12-01 00:00:00
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journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-011-1215-3
更新日期:2011-12-01 00:00:00
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journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-018-2525-5
更新日期:2018-08-01 00:00:00
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journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-016-2145-x
更新日期:2016-06-01 00:00:00
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journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/BF02483394
更新日期:1996-12-01 00:00:00
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journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/BF02480036
更新日期:1997-09-01 00:00:00
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journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-012-1469-4
更新日期:2013-02-01 00:00:00
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journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s005400170034
更新日期:2001-01-01 00:00:00
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journal_title:Journal of anesthesia
pub_type: 杂志文章
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更新日期:2020-10-01 00:00:00
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journal_title:Journal of anesthesia
pub_type: 杂志文章
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更新日期:2009-01-01 00:00:00
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journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/BF02480738
更新日期:1997-12-01 00:00:00
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journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-003-0209-1
更新日期:2004-01-01 00:00:00
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journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-014-1831-9
更新日期:2014-12-01 00:00:00
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journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-008-0724-1
更新日期:2009-01-01 00:00:00
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journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-008-0645-z
更新日期:2008-01-01 00:00:00
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journal_title:Journal of anesthesia
pub_type: 杂志文章,多中心研究
doi:10.1007/s00540-006-0419-4
更新日期:2006-01-01 00:00:00
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journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-006-0463-0
更新日期:2007-01-01 00:00:00
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journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-008-0694-3
更新日期:2009-01-01 00:00:00
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journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/BF02479877
更新日期:1995-09-01 00:00:00
abstract::For select total knee arthroplasty (TKA) patients, we have established an alternative pathway to bypass the acute care surgical ward and directly admit patients from the post-anesthesia care unit to on-campus rehabilitation. We retrospectively examined whether this 'fast track' pathway decreased costs and improved pat...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-017-2372-9
更新日期:2017-10-01 00:00:00