A prospective, randomized, double-blind, multicenter trial to evaluate the therapeutic efficacy and safety of palonosetron in the treatment of postoperative nausea and vomiting over a 72-h period.

Abstract:

PURPOSE:We performed a multicenter, randomized, double-blind trial to assess the efficacy and safety of a single, fixed, intravenous dose of palonosetron (0.075 mg) in the treatment of established postoperative nausea and vomiting (PONV). METHODS:Three hundred and eighty-four patients who had at least one risk factors of PONV and underwent surgery under general anesthesia were screened. Those who developed PONV were randomized to receive either 0.075 mg intravenous palonosetron or a placebo. The incidence of nausea and vomiting, severity of nausea, requirements for rescue anti-emetics, and adverse effects at 2, 24, and 72 h after drug administration were evaluated. Complete response (CR) and complete control (CC) rate were compared for 24 and 72 h. RESULTS:Among the 384 patients, 152 (39.6 %) developed PONV and were randomized to either the palonosetron (n = 75) or placebo (n = 77) group. The number of patients with CR at 24 and 72 h was higher in the palonosetron group than the placebo group [0-24 h: n = 49 (68.1 %) vs. n = 30 (40.5 %), p < 0.001; 0-72 h: n = 47 (65.3 %) vs. n = 28 (37.8 %), p < 0.001]. The incidence of PONV at 2, 24, and 72 h periods was lower in the palonosetron group than the placebo group (29.2, 45.8, and 50.0 % in the palonosetron group vs. 50.0, 62.2, and 66.2 % in the placebo group, p = 0.010, 0.048, 0.047, respectively). The incidence of adverse events was not different between the groups. CONCLUSION:A single 0.075 mg IV dose of palonosetron effectively increased the CR rates at 24 and 72 h in these moderate-risk patients with established PONV.

journal_name

J Anesth

journal_title

Journal of anesthesia

authors

Hahm TS,Hwang JW,Kim WH,Oh EJ,Kim DK,Choi WJ,Kim YH,Ryu JH,Yoo BH,Yon JH

doi

10.1007/s00540-014-1884-9

subject

Has Abstract

pub_date

2015-02-01 00:00:00

pages

21-8

issue

1

eissn

0913-8668

issn

1438-8359

journal_volume

29

pub_type

杂志文章,多中心研究,随机对照试验
  • A matched case-control comparison of hospital costs and outcomes for knee replacement patients admitted postoperatively to acute care versus rehabilitation.

    abstract::For select total knee arthroplasty (TKA) patients, we have established an alternative pathway to bypass the acute care surgical ward and directly admit patients from the post-anesthesia care unit to on-campus rehabilitation. We retrospectively examined whether this 'fast track' pathway decreased costs and improved pat...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/s00540-017-2372-9

    authors: Tse BK,Walters TL,Howard SK,Kim TE,Memtsoudis SG,Sun EC,Kou A,Graham L,King R,Mariano ER

    更新日期:2017-10-01 00:00:00

  • Anesthetic management for ascending aorta replacement in a patient who refused autologous transfusion for religious reasons.

    abstract::We report on the anesthetic management of a 69-year-old female Jehovah's Witness undergoing cardiopulmonary bypass to replace the ascending aorta; the patient refused transfusion of stored autologous or allogeneic blood products for religious reasons. The strategy involved preoperative hematopoiesis with recombinant h...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/s00540-009-0764-1

    authors: Obara S,Nakagawa M,Takahashi S,Akatu M,Isosu T,Murakawa M

    更新日期:2009-01-01 00:00:00

  • Comparison of cognitive, ambulatory, and psychomotor recovery profiles after day care anesthesia with propofol and sevoflurane.

    abstract:PURPOSE:We compared the recovery profile of propofol and sevoflurane when used for maintenance of anesthesia in elective day care operative procedures. METHODS:One hundred ASA physical status I and II patients, aged between 18 and 50 years, were randomly assigned to receive either propofol-nitrous oxide or sevoflurane...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00540-014-1827-5

    authors: Parida S,Badhe AS

    更新日期:2014-12-01 00:00:00

  • Comparison between propofol and dexmedetomidine in postoperative sedation after extensive cervical spine surgery.

    abstract:PURPOSE:Patients undergoing extensive cervical spine surgery (ECSS) occasionally require emergency reintubation due to postoperative airway complications. To avoid it, an endotracheal tube is retained in patients maintained under sedation overnight. This study was conducted to determine whether dexmedetomidine would be...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00540-011-1300-7

    authors: Terao Y,Ichinomiya T,Higashijima U,Tanise T,Miura K,Fukusaki M,Sumikawa K

    更新日期:2012-04-01 00:00:00

  • Mean operating room times differ by 50% among hospitals in different countries for laparoscopic cholecystectomy and lung lobectomy.

    abstract::We explored whether there were large differences in operating room (OR) times for two common procedures performed by multiple surgeons at each of several hospitals thousands of miles apart. Mean OR time, "wheels in" to "wheels out," for ten consecutive cases of each of laparoscopic cholecystectomy and lung lobectomy w...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00540-006-0419-4

    authors: Dexter F,Davis M,Egger Halbeis CB,Marjamaa R,Marty J,McIntosh C,Nakata Y,Thenuwara KN,Sawa T,Vigoda M

    更新日期:2006-01-01 00:00:00

  • Neuroprotection during cardiac surgery.

    abstract::Cerebral injury following cardiac surgery continues to be a significant source of morbidity and mortality after cardiac surgery. A spectrum of injuries ranging from subtle neurocognitive dysfunction to fatal strokes are caused by a complex series of multifactorial mechanisms. Protecting the brain from these injuries h...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章,评审

    doi:10.1007/s00540-007-0514-1

    authors: Grocott HP,Yoshitani K

    更新日期:2007-01-01 00:00:00

  • Low-dose gabapentin as useful adjuvant to opioids for neuropathic cancer pain when combined with low-dose imipramine.

    abstract:PURPOSE:Painful neuropathic conditions of cancer pain often show little response to nonopioid and opioid analgesics but may be eased by antidepressants and anticonvulsants. Although gabapentin is effective in the treatment of neuropathic pain in patients with cancer, some patients experience intolerable side effects su...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00540-010-0913-6

    authors: Arai YC,Matsubara T,Shimo K,Suetomi K,Nishihara M,Ushida T,Kobayashi K,Suzuki C,Kinoshita A,Kondo M,Matsubara S,Hayashi R,Tohyama Y,Nishida K,Arakawa M

    更新日期:2010-06-01 00:00:00

  • Combined effects of succinylcholine and calcium on membrane-bound acetylcholinesterase activity.

    abstract::The effects of succinylcholine and calcium (Ca2+), alone and together, on membrane-bound acetylcholinesterase ("true-type" cholinesterase) were examined using human erythrocyte ghosts to elucidate the combined pharmacological activity of succinylcholine and calcium in in vivo system. Succinylcholine inhibited the acet...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/s0054070010015

    authors: Wakamatsu M,Shimonaka H,Yamamoto M,Kawai K,Nozawa Y

    更新日期:1987-03-01 00:00:00

  • Third nerve palsy associated with preeclampsia and HELLP syndrome.

    abstract::Preeclampsia can cause myriad organ dysfunction, including cranial nerve palsies that pose diagnostic and management dilemmas. We present an unusual case of third nerve palsy, (presenting as diplopia, ptosis) with hypertension, hyperreflexia, proteinuria, easy bruising in a parturient at 34 + 6/52 weeks of twins gesta...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/s00540-013-1586-8

    authors: Chutatape A,Teoh WH

    更新日期:2013-10-01 00:00:00

  • The use of a needle guide kit improves the stability of ultrasound-guided techniques.

    abstract::A needle guide kit will be able to improve visibility on ultrasonic images. We examined the degree of stability using a SIVA guide. The SIVA guide is a needle guide kit in which the angle is not restricted, allowing the puncture to be made at any angle. We punctured the Blue Phantom™ with a high-frequency linear probe...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/s00540-015-2021-0

    authors: Ueshima H,Kitamura A

    更新日期:2015-10-01 00:00:00

  • The hemodynamic and metabolic changes in prostaglandin E1-induced hypotension in dogs--a comparative study with trimetaphan-induced hypotension.

    abstract::The hemodynamic and metabolic changes in hypotensive state induced with prostaglandin E1 (PGE1) or trimetaphan (TMT) infusion were investigated in dogs. Mean arterial pressure was decreased by about 50% with 1.58 microg/kg/min of PGE1 or 45 microg/kg/min of TMT. Heart rate, pulmonary capillary wedge pressure and centr...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/s0054090030210

    authors: Nam YT,Takahashi S,Tominaga M,Yoshitake J

    更新日期:1989-09-01 00:00:00

  • Changes in left ventricular end-diastolic area, end-systolic wall stress, and fractional area change during anesthetic induction with propofol or thiamylal.

    abstract:PURPOSE:To elucidate the mechanisms of the more profound hypotensive effects of propofol relative to thiamylal, we monitored changes in left ventricular (LV) preload, afterload, and contractility during the course of anesthetic induction with propofol and thiamylal. METHODS:Thirty-two patients (ASA I) were randomly as...

    journal_title:Journal of anesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/s005400070021

    authors: Yamaura K,Hoka S,Okamoto H,Kandabashi T,Akiyoshi K,Takahashi S

    更新日期:2000-01-01 00:00:00

  • Site of fresh gas inlet and ratios of the delivered fraction and inspired fraction of inhaled isoflurane and sevoflurane in low-flow anesthesia.

    abstract:PURPOSE:The use of low-flow anesthesia causes a discrepancy between the delivered fraction (FD) and the inspired fraction (FI) of inhaled gases. We compared the FI/FD ratios of a new circle (fresh gas inlet located between the inspiratory valve and the patient) to those of the conventional circle (fresh gas inlet locat...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00540-006-0417-6

    authors: Fukuda T,Fukunaga A,Toyooka H

    更新日期:2006-01-01 00:00:00

  • Lateral Trendelenburg with the injected side down after the block improves the efficacy of the axillary approach to brachial plexus block.

    abstract:PURPOSE:We hypothesized that, after axillary block, positioning the patient in a lateral position with the injected side down and simultaneously in a 20° Trendelenburg position will increase the success rate and quality of the block. METHODS:Fifty patients with chronic renal failure (ASA 2-3) scheduled for arterioveno...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00540-013-1766-6

    authors: Salih Sevdi M,Gunday I,Arar C,Colak A,Turan N

    更新日期:2014-08-01 00:00:00

  • Intraoperative fluid therapy and postoperative complications during minimally invasive esophagectomy for esophageal cancer: a single-center retrospective study.

    abstract:PURPOSE:Compared with open thoracotomy, minimally invasive esophagectomy (MIE) methods, such as transhiatal or thoracoscopic esophagectomy, likely have lower morbidity. However, the relationship between intraoperative fluid management and postoperative complications after MIE remains unclear. Thus, we investigated the ...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/s00540-020-02766-y

    authors: Hikasa Y,Suzuki S,Mihara Y,Tanabe S,Shirakawa Y,Fujiwara T,Morimatsu H

    更新日期:2020-06-01 00:00:00

  • Pituitary apoplexy during general anesthesia in beach chair position for shoulder joint arthroplasty.

    abstract::Pituitary apoplexy is a rare but potentially life-threatening clinical syndrome caused by the sudden enlargement of pituitary adenoma secondary to infarction and/or hemorrhage. It may be the first presentation of previously undiagnosed pituitary adenoma. Although various precipitating factors of pituitary apoplexy are...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/s00540-010-0929-y

    authors: Koga T,Miyao M,Sato M,Hirota K,Kakuyama M,Tanabe H,Fukuda K

    更新日期:2010-06-01 00:00:00

  • Aligning difficult airway guidelines with the anesthetic COVID-19 guidelines to develop a COVID-19 difficult airway strategy: a narrative review.

    abstract::The coronavirus disease 2019 (COVID-19) pandemic is caused by a coronavirus that is transmitted primarily via aerosol, droplets or direct contact. This may place anesthetists at higher risk of infection due to their frequent involvement in aerosol-generating airway interventions. Many anesthethetic COVID-19 guidelines...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章,评审

    doi:10.1007/s00540-020-02819-2

    authors: Wong P,Lim WY

    更新日期:2020-12-01 00:00:00

  • The effect of midazolam-thiopental coinduction on recovery in minor surgery.

    abstract:PURPOSE:The effects of midazolam-thiopental coinduction on recovery were investigated and compared with thiopental induction. METHODS:Fifty patients, ASA 1 or 2, undergoing minor orthopedic surgery, were randomly divided into coinduction and thiopental groups. During preoxygenation, the patients received midazolam 0.1...

    journal_title:Journal of anesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/s005400170044

    authors: Baykara N,Sahin T,Toker K

    更新日期:2001-01-01 00:00:00

  • Calcium channel blockers are inadequate for malignant hyperthermia crisis.

    abstract:PURPOSE:Malignant hyperthermia (MH) results from disordered calcium (Ca(2+)) homeostasis in skeletal muscle during general anesthesia. Although Ca(2+) channel blockers may be given to treat the tachycardia and circulatory instability, coadministration of Ca(2+) channel blockers and dantrolene is contraindicated during ...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/s00540-012-1347-0

    authors: Migita T,Mukaida K,Yasuda T,Hamada H,Kawamoto M

    更新日期:2012-08-01 00:00:00

  • Caudal bupivacaine supplemented with morphine or clonidine, or supplemented with morphine plus clonidine in children undergoing infra-umbilical urological and genital procedures: a prospective, randomized and double-blind study.

    abstract:PURPOSE:We aimed to evaluate postoperative analgesia of morphine, or clonidine, or morphine plus clonidine, added to caudal bupivacaine in children undergoing infra-umbilical urological and genital procedures. METHODS:Eighty patients aged 1-10 years were prospectively enrolled. After the induction of general anesthesi...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00540-011-1297-y

    authors: Fernandes ML,Pires KC,Tibúrcio MA,Gomez RS

    更新日期:2012-04-01 00:00:00

  • Comparison of tracheal intubation by the Macintosh laryngoscope and Pentax-AWS (Airway Scope) during chest compression: a manikin study.

    abstract::To compare tracheal intubation with the Pentax Airway Scope (AWS) and the Macintosh laryngoscope (McL) during chest compression, 25 anesthesiologists (including 12 specialists having >5 years of experience and 13 trainees having <2 years of experience) performed tracheal intubation using either the McL or the AWS, wit...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/s00540-010-0874-9

    authors: Komasawa N,Ueki R,Nomura H,Itani M,Kaminoh Y

    更新日期:2010-04-01 00:00:00

  • Factors influencing intraoperative bradycardia in adult patients.

    abstract:PURPOSE:In order to elucidate the prominent factors involved in intraoperative bradycardia in adult patients, we retrospectively investigated the association between the potential risk factors and intraoperative bradycardia, using multiple logistic regression. METHODS:The perioperative records for 499 adult patients w...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/s00540-006-0469-7

    authors: Yorozu T,Iijima T,Matsumoto M,Yeo X,Takagi T

    更新日期:2007-01-01 00:00:00

  • Severe hyperglycemic shock associated with hepatic portal venous gas.

    abstract::We report a case of hyperglycemic shock associated with hepatic portal venous gas. A 79-year-old woman with post-stroke depression developed severe tachycardiac atrial fibrillation and hypotension due to hypovolemia caused by severe hyperglycemia, as well as showing disseminated intravascular coagulation (DIC). Contin...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/s00540-007-0586-y

    authors: Nishikawa K,Higuchi M,Kimura S,Shimodate Y,Namiki A

    更新日期:2008-01-01 00:00:00

  • Prolonged drug-induced myoclonus: is it related to palonosetron?

    abstract::We report a case of drug-induced myoclonus possibly related to palonosetron, a second-generation 5-hydroxytryptamine-3 receptor antagonist which was administered as a prophylaxis for postoperative nausea and vomiting in a 28-year-old female. The recurrent episodes of myoclonus jerk involving the head, neck and shoulde...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/s00540-016-2228-8

    authors: Chaw SH,Chan L,Lee PK,Bakar JA,Rasiah R,Foo LL

    更新日期:2016-12-01 00:00:00

  • Changes in plasma catecholamine levels following injection of prostaglandin F2alpha into the basal cistern in rabbits.

    abstract::We measured plasma epinephrine and norepinephrine concentrations in a rabbit model simulating subarachnoid hemorrhage (SAH), following the injection of prostaglandin F(2alpha) (PGF(2alpha)) into the basal cistern. In this model, plasma epinephrine values increased significantly (to 4.2-fold those before injection), su...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/s0054020060161

    authors: Yokoyama Y,Uchida M,Matsumoto S,Saito K,Fukuda M

    更新日期:1992-04-01 00:00:00

  • The interaction of antiemetic dose of droperidol with propofol on QT interval during anesthetic induction.

    abstract:PURPOSE:We investigated the effect of low-dose droperidol on heart rate-corrected QT (QTc) interval and interaction with propofol. METHODS:Seventy-two patients undergoing upper limb surgery were included in this study. Patients were randomly allocated to one of three groups: group S (n = 24), which received 1 ml salin...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00540-013-1625-5

    authors: Toyoda T,Terao Y,Oji M,Okada M,Fukusaki M,Sumikawa K

    更新日期:2013-12-01 00:00:00

  • Flurbiprofen axetil increases arterial oxygen partial pressure by decreasing intrapulmonary shunt in patients undergoing one-lung ventilation.

    abstract:PURPOSES:In the present study, we investigated whether flurbiprofen axetil (FA) alleviates hypoxemia during one-lung ventilation (OLV) by reducing the pulmonary shunt/total perfusion (Q s/Q t) ratio, and examined the relationship between the Q s/Q t ratio and the thromboxane B2 (TXB2)/6-keto-prostaglandin F1α (6-K-PGF1...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00540-015-2060-6

    authors: Chai XQ,Ma J,Xie YH,Wang D,Chen KZ

    更新日期:2015-12-01 00:00:00

  • Dexmedetomidine: a review of applications for cardiac surgery during perioperative period.

    abstract::Cardiac surgery is associated with a high incidence of cardiovascular and other complications during the perioperative period that translate into increased mortality and prolonged hospital stays. Safe comprehensive perioperative management is required to eliminate these adverse events. Dexmedetomidine is a selective α...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章,评审

    doi:10.1007/s00540-014-1857-z

    authors: Zhang X,Zhao X,Wang Y

    更新日期:2015-02-01 00:00:00

  • Changes in free and total catecholamine concentrations in plasma in patients undergoing coronary artery bypass grafting under high-dose fentanyl anesthesia.

    abstract::We measured free and total catecholamine in ten patients undergoing coronary artery-bypass grafting under high-dose fentanyl (93.9 +/- 2.2 microg.kg(-1), mean +/- SE) anesthesia. Arterial blood samples were obtained: 1) before induction of anesthesia (control), 2) 1 min after intubation, 3) 1 min after skin incision, ...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/s0054030070086

    authors: Takino Y,Shimada M,Miyagawa F

    更新日期:1993-01-01 00:00:00

  • Pharmacokinetics and pharmacodynamics of vecuronium bromide.

    abstract::The pharmacokinetics and pharmacodynamics of vecuronium bromide were studied in patients under general anesthesia of enflurane and nitrous oxide in oxygen. Eighteen patients were randomly divided into two groups which received either 0.05 mg.kg(-1) (low dose group) or 0.20 mg.kg(-1) (high dose group) of vecuronium int...

    journal_title:Journal of anesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/s0054020060028

    authors: Nomura T

    更新日期:1992-01-01 00:00:00