Abstract：
PURPOSES:In the present study, we investigated whether flurbiprofen axetil (FA) alleviates hypoxemia during one-lung ventilation (OLV) by reducing the pulmonary shunt/total perfusion (Q s/Q t) ratio, and examined the relationship between the Q s/Q t ratio and the thromboxane B2 (TXB2)/6-keto-prostaglandin F1α (6-K-PGF1α) ratio. METHODS:Sixty patients undergoing esophageal resection for carcinoma were randomly assigned to groups F and C (n = 30 for each group). FA and placebo were administered i.v. 15 min before skin incision in groups F and C, respectively. The partial pressure of arterial oxygen (PaO2) was measured and the Q s/Q t ratio was calculated. Serum TXB2, 6-K-PGF1α, and endothelin (ET) were measured by radioimmunoassay. The relationship between TXB2/6-K-PGF1α and Q s/Q t was investigated. RESULTS:Compared with group C, PaO2 was higher and the Q s/Q t ratio was lower during OLV in group F (P < 0.05). After treatment with FA, both serum TXB2 and 6-K-PGF1α decreased significantly (P < 0.05) but the TXB2/6-K-PGF1α ratio increased significantly (P < 0.01). Increases in the TXB2/6-K-PGF1α ratio were correlated with reductions in the Q s/Q t ratio during OLV in group F (r = -0.766, P < 0.01). There was no significant difference in serum ET between groups F and C. CONCLUSIONS:Treatment with FA reduced the Q s/Q t ratio and further increased the PaO2 level during OLV, possibly due to upregulation of the vasoactive agent TXB2/6-K-PGF1α ratio.
journal_name
J Anesthjournal_title
Journal of anesthesiaauthors
Chai XQ,Ma J,Xie YH,Wang D,Chen KZdoi
10.1007/s00540-015-2060-6subject
Has Abstractpub_date
2015-12-01 00:00:00pages
881-6issue
6eissn
0913-8668issn
1438-8359pii
10.1007/s00540-015-2060-6journal_volume
29pub_type
杂志文章,随机对照试验abstract：:The effect of famotidine on neonates was studied in 34 obstetric patients who underwent elective cesarean section. In the famotidine group, 20 mg of famotidine was intramuscularly injected at 60 min before induction of anesthesia, and 0.5 mg of atropine was injected at 30 min before induction. In the control group, on...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s0054010050276
更新日期：1991-07-01 00:00:00
abstract：:While the demand for bariatric surgery is increasing, hospital capacity remains limited. The ERABS (Enhanced Recovery After Bariatric Surgery) protocol has been implemented in a number of bariatric centers. We retrospectively compared the operating room logistics and postoperative complications between pre-ERABS and E...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-015-2089-6
更新日期：2016-02-01 00:00:00
abstract：PURPOSE:Intrathecal morphine provides superior pain control for patients undergoing cesarean delivery when compared to intravenous opioid patient-controlled analgesia. However, no study has assessed the overall cost associated with each modality as a primary outcome. The aim of this study is to determine the overall co...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-016-2263-5
更新日期：2017-02-01 00:00:00
abstract：:The effects of butorphanol injection on baroreflex control of heart rate were investigated using both pressor and depressor tests in eighteen adult patients. Baroreflex sensitivity was attenuated after butorphanol injection in the pressor test using phenylephrine, whereas it was unchanged in the depressor test using n...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s0054030070411
更新日期：1993-10-01 00:00:00
abstract：PURPOSE:A large proportion of patients experience chronic post-surgical pain (CPSP) following inguinal hernia repair surgery. The aim of this study was to investigate the predictive risk factors and protective factors for CPSP following inguinal hernia surgery. METHODS:After institutional ethics approval was obtained,...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-020-02743-5
更新日期：2020-06-01 00:00:00
abstract：:The anesthesia information management system (AIMS) will be part of the future of healthcare. An electronic medical records system or AIMS will provide clear and concise information and have the potential to integrate information across the entire hospital system, improve quality of care, reduce errors, decrease risks...
journal_title：Journal of anesthesia
pub_type： 杂志文章,评审
doi：10.1007/s00540-008-0643-1
更新日期：2008-01-01 00:00:00
abstract：PURPOSE:Transthoracic esophagectomy is an invasive surgery, and the excessive surgical stress produces inflammatory cytokines, which provoke acute respiratory distress syndrome (ARDS). Sivelestat sodium hydrate-a selective neutrophil elastase inhibitor-is used to treat or prevent ARDS in patients undergoing esophagecto...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-018-2602-9
更新日期：2019-04-01 00:00:00
abstract：:Amrinone, a phosphodiesterase inhibitor, is a non-glycosidic noncatecholamine with both vasodilator and positive inotropic effects. We were interested in assessing the effect of amrinone on postischemic cardiac performance in the isolated heart-lung preparation. Twenty-four male Wistar-ST rats were used. They were ran...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/BF02483394
更新日期：1996-12-01 00:00:00
abstract：BACKGROUND:The relationship between preoperative hyperglycemia and postoperative acute kidney injury (AKI) occurrence in non-cardiac surgery including laparoscopic surgery remains unclear. This study aimed to assess the relationship between preoperative chronic hyperglycemia and postoperative AKI occurrence after a maj...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-018-2551-3
更新日期：2018-10-01 00:00:00
abstract：:In a prospective controlled trial to compare conventional interscalene brachial plexus block (ISBPB) using anatomic landmarks and electro-stimulation with a combined technique of ultrasound guidance followed by nerve stimulation, 60 patients were randomized into 2 matched equal groups: Group A using nerve stimulation ...
journal_title：Journal of anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00540-012-1366-x
更新日期：2012-08-01 00:00:00
abstract：:The hemodynamic and metabolic changes in hypotensive state induced with prostaglandin E1 (PGE1) or trimetaphan (TMT) infusion were investigated in dogs. Mean arterial pressure was decreased by about 50% with 1.58 microg/kg/min of PGE1 or 45 microg/kg/min of TMT. Heart rate, pulmonary capillary wedge pressure and centr...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s0054090030210
更新日期：1989-09-01 00:00:00
abstract：:A male patient with Marfan syndrome underwent aortic root replacement and developed left ventricular (LV) failure. Four years later, he underwent aortic arch and aortic valve replacement. Thereafter, his LV failure progressed, and cardiogenic pulmonary edema (CPE) appeared, which we treated with extracorporeal LV assi...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-016-2163-8
更新日期：2016-08-01 00:00:00
abstract：:Cerebral injury following cardiac surgery continues to be a significant source of morbidity and mortality after cardiac surgery. A spectrum of injuries ranging from subtle neurocognitive dysfunction to fatal strokes are caused by a complex series of multifactorial mechanisms. Protecting the brain from these injuries h...
journal_title：Journal of anesthesia
pub_type： 杂志文章,评审
doi：10.1007/s00540-007-0514-1
更新日期：2007-01-01 00:00:00
abstract：:Treacher Collins syndrome (TCS) is a congenital malformation of craniofacial development; in these patients conventional direct laryngoscopy is very difficult and often unsuccessful because of the upper airway malformation. A 20-year-old man with TCS was scheduled for elective tympanoplasty. The patient showed the cha...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-007-0598-7
更新日期：2008-01-01 00:00:00
abstract：:The electroencephalograms (EEG) of 55 children under isoflurane anesthesia were studied to elucidate any change in pattern with age. The children ranged from 1 month to 14 years of age were divided into six age groups. The standard minimum alveolar concentration (MAC) was determined in each group. Anesthesia was induc...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/BF02514699
更新日期：1994-06-01 00:00:00
abstract：PURPOSE:We compared the insertion performance of the pediatric size 1.5-3 i-gel airway device with that of the ProSeal laryngeal mask airway (PLMA) in anesthetized children in a prospective, randomized, controlled manner. METHODS:We included 134 children, aged 3 months to 15 years, scheduled for elective surgery under...
journal_title：Journal of anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00540-012-1477-4
更新日期：2013-02-01 00:00:00
abstract：PURPOSE:Facemask ventilation during the induction of general anesthesia in paediatric patients remains a challenge as it may result in hypoxic conditions and gastric insufflation with subsequent regurgitation and aspiration. So far, it is unclear if pressure-controlled or manual facemask ventilation is preferable in ch...
journal_title：Journal of anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00540-018-2580-y
更新日期：2019-02-01 00:00:00
abstract：:Although maintaining anesthesia for myasthenia gravis (MG) with minimal muscle relaxants (MR) is common, the success rate of anesthetic management for MG without MR is not clear. We therefore retrospectively examined the success rate of anesthetic management for MG without MR among 66 consecutive cases of thymectomy f...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-015-1999-7
更新日期：2015-10-01 00:00:00
abstract：:The incidence of an abnormal increase in the serum levels of glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) following anesthesia with halothane and 65% nitrous oxide in oxygen (halothane group) or with sevoflurane and 65% nitrous oxide in oxygen (sevoflurane group) was compared in wome...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/BF02479843
更新日期：1995-06-01 00:00:00
abstract：:Cardiac effects of sevoflurane (SE) with or without nitrous oxide were examined in the canine blood-perfused papillary muscle and sinoatrial node preparations. Although SE depressed developed tension (DT), mean arterial pressure (MAP) and heart rate of the donor dog (DHR) dose dependently, sinoatrial rate (SAR) was no...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s0054090030145
更新日期：1989-09-01 00:00:00
abstract：PURPOSE:Although non-steroidal anti-inflammatory drugs and acetaminophen have no proven efficacy against neuropathic pain, they are frequently prescribed for neuropathic pain patients. We examined whether the combination of opioids (tramadol and morphine) with indomethacin or acetaminophen produce favorable effects on ...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-014-1953-0
更新日期：2015-06-01 00:00:00
abstract：:A 24-year-old man underwent surgery for a fractured left clavicle and received an interscalene brachial plexus block for intraoperative and postoperative analgesia. After injection of 40 ml 0.5% ropivacaine and confirmation of analgesia, general anesthesia was induced and maintained with propofol. Although the operati...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-011-1125-4
更新日期：2011-06-01 00:00:00
abstract：PURPOSE:We conducted a survey to clarify the actual circumstances in which the lungs could not be ventilated and the trachea could not be intubated (CVCI). METHODS:A questionnaire was mailed to all the university hospitals in Japan, asking about CVCI they had experienced during induction of anesthesia in 1998, and bef...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-003-0187-3
更新日期：2003-01-01 00:00:00
abstract：:Mechanical influences independent of chemoreceptor function on ventilatory control were studied in halothane-anesthetized, artificially ventilated patients using the technique reported by Altose et al. (Respir Physiol 66: 171-180, 1986). Contribution of mechanical factor was indirectly assessed by comparing the values...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s0054020060387
更新日期：1992-10-01 00:00:00
abstract：:We report on five patients who underwent MRI-guided focused ultrasound ablation of prostatic cancer under epidural anesthesia with intravenous dexmedetomidine sedation. This pioneering procedure requires an immobile therapeutic field with adequate sedation and analgesia provided to the patients. Duration of the proced...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-011-1189-1
更新日期：2011-10-01 00:00:00
abstract：PURPOSE:In a previous study using the tail-flick test, we found that intracerebroventricular administration of D-serine, an endogenous co-agonist at the glycine sites of N-methyl-D-aspartate (NMDA) receptors, elicited an antinociceptive effect on thermal nociception. The purpose of the present study was to evaluate the...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-013-1708-3
更新日期：2014-04-01 00:00:00
abstract：PURPOSE:To evaluate the value of blood lactate value in predicting postoperative mortality (primary outcome), duration of ventilation, and length of stay in an intensive care unit (ICU) and hospital (secondary outcomes). METHODS:We performed a prospective observation study on 1,820 consecutive patients undergoing open...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-011-1287-0
更新日期：2012-04-01 00:00:00
abstract：:The direct inotropic action of seven local anesthetics: procaine, mapivacaine, lidocaine, tetracaine, chloroprocaine, bupivacaine and etidocaine were compared in isolated cat papillary muscles. All of the local anesthetics produced a dose-related depression of maximal velocity of shortening (Vmax), maximal developed f...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s0054000040001
更新日期：1990-01-01 00:00:00
abstract：PURPOSE:The diaphragm is one of the organs directly affected by abdominal sepsis. Evidence suggests that sepsis induces diaphragmatic fatigability and that activated neutrophils play a crucial role in the development of diaphragmatic fatigability. In the present study, we investigated whether olprinone, a phosphodieste...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-007-0572-4
更新日期：2008-01-01 00:00:00
abstract：PURPOSE:The use of low-flow anesthesia causes a discrepancy between the delivered fraction (FD) and the inspired fraction (FI) of inhaled gases. We compared the FI/FD ratios of a new circle (fresh gas inlet located between the inspiratory valve and the patient) to those of the conventional circle (fresh gas inlet locat...
journal_title：Journal of anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00540-006-0417-6
更新日期：2006-01-01 00:00:00
