Combined effects of succinylcholine and calcium on membrane-bound acetylcholinesterase activity.

Abstract:

:The effects of succinylcholine and calcium (Ca2+), alone and together, on membrane-bound acetylcholinesterase ("true-type" cholinesterase) were examined using human erythrocyte ghosts to elucidate the combined pharmacological activity of succinylcholine and calcium in in vivo system. Succinylcholine inhibited the acetylcholinesterase by a mixed style. Calcium alone exhibited an inhibitory effect on the enzyme, but a biphasic effect together with succinylcholine: marked restoration of the enzyme activity at calcium concentrations lower than 6 mM and depression at its higher concentrations. It is suggested that calcium induces a conformational change of the enzyme protein leading to the altered binding capacity of succinylcholine. In anesthetic practice, therefore, the use of calcium may not be indicated for the treatment of SCh phase II block.

journal_name

J Anesth

journal_title

Journal of anesthesia

authors

Wakamatsu M,Shimonaka H,Yamamoto M,Kawai K,Nozawa Y

doi

10.1007/s0054070010015

subject

Has Abstract

pub_date

1987-03-01 00:00:00

pages

15-21

issue

1

eissn

0913-8668

issn

1438-8359

journal_volume

1

pub_type

杂志文章
  • Presynaptic M1, M2, and A1 receptors play roles in tetanic fade induced by pancuronium or cisatracurium.

    abstract:PURPOSE:We investigated whether presynaptic facilitatory M1 and/or inhibitory M2 muscarinic receptors contributed to pancuronium- and cisatracurium-induced tetanic fade. METHODS:Phrenic nerve-diaphragm muscle preparations of rats were indirectly stimulated with tetanic frequency (75 +/- 3.3 Hz; mean +/- SD). Doses of ...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/s00540-009-0790-z

    authors: Bornia EC,Bando E,Machinski M Jr,Pereira MW,Alves-Do-Prado W

    更新日期:2009-01-01 00:00:00

  • Methadone patient-controlled analgesia for postoperative pain: a randomized, controlled, double-blind study.

    abstract:PURPOSE:Postoperative pain is an important health-care issue. Patient-controlled analgesia (PCA) is considered the gold standard for systemic postoperative pain treatment. Methadone PCA is used for patients with chronic pain and those in the palliative care setting. However, its efficacy as a first-line drug for acute ...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00540-013-1785-3

    authors: Neto JO,Machado MD,de Almeida Correa M,Scomparim HA,Posso IP,Ashmawi HA

    更新日期:2014-08-01 00:00:00

  • Condensation of humidified air in the inflation line of a polyurethane cuff precludes correct continuous pressure monitoring during mechanical ventilation.

    abstract::Within continuously controlled limits of cuff pressure, an endotracheal tube cuff made of polyurethane (PU) prevents secretion inflow better than a conventional polyvinylchloride cuff. However, the temperature difference between ventilator gas and the air inside a PU cuff produces condensation droplets that accumulate...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/s00540-014-1849-z

    authors: Spapen H,Moeyersons W,Stiers W,Desmet G,Suys E

    更新日期:2014-12-01 00:00:00

  • Hemorrhagic shock 3 days after catheterization from the axillary vein.

    abstract::A 72-year-old woman presented pulmonary embolism. Continuous intravenous administration of heparin was controlled with values of activated clotting time targeted from 150 to 180 s. On the sixth intensive care unit (ICU) day, a central vein (CV) catheter was inserted through the right axillary vein. On the ninth ICU da...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/s00540-010-0894-5

    authors: Shinzato T,Fukui M,Kooguchi K,Sakaguchi M,Joo WJ

    更新日期:2010-04-01 00:00:00

  • Does cuff pressure monitoring reduce postoperative pharyngolaryngeal adverse events after LMA-ProSeal insertion? A parallel group randomised trial.

    abstract:PURPOSE:The incidence of postoperative pharyngolaryngeal complications after laryngeal mask airway (LMA) insertion can be as high as 50%. Over-inflation of the LMA cuff may be a causal factor. We conducted a single-centre parallel group randomised trial to determine whether maintaining LMA-ProSeal intra-cuff pressures ...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00540-014-1811-0

    authors: Vasanth Karthik R,Ranganathan P,Kulkarni AP,Sharma KS

    更新日期:2014-10-01 00:00:00

  • A case report of anesthetic management of the minimally invasive Nuss operation for pectus excavatum.

    abstract::We describe the anesthetic management of a patient with pectus excavatum, receiving the minimally invasive Nuss operation, which corrects chest wall deformity by insertion of a convex steel bar (pectus bar). An 8-year-old female patient was scheduled for the Nuss operation. The manipulation of the bar in the thorax wa...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/s00540-004-0269-x

    authors: Ichizawa M,Morimura E,Tsuchiya N,Hanafusa T,Shinomura T

    更新日期:2005-01-01 00:00:00

  • Effects of osmotic pressure on intrathecal and epidural lidocaine anesthesia.

    abstract::Lidocaine (1%), either in plain distilled water or in 10% dextrose, was intrathecally or epidurally administered to urethane-chloralose anesthetized cats. Electrical stimulation was applied to the gracile tract at a cervical level, and the resultant antidromic compound action potentials were recorded from the sural ne...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/BF02482066

    authors: Minami T,Koyama N,Amakata Y

    更新日期:1996-03-01 00:00:00

  • Aberrant halt of syringe pump motion: an improved system to prevent false setting of the syringe.

    abstract::A syringe pump is used to inject precise doses of drugs having a strong action; for example, vasoactive drugs. Unexpected and undetected halt of a syringe pump can lead to potentially life-threatening complications. We experienced a sudden halt in the movement of a syringe pump (Terufusion syringe pump; Terumo, Tokyo,...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/s00540-005-0382-5

    authors: Tokumine J,Sugahara K,Nitta K,Fuchigami T,Abe M,Gushiken K,Oda M,Okayama H

    更新日期:2006-01-01 00:00:00

  • Analysis of the cost-effectiveness of remifentanil-based general anesthesia: a survey of clinical economics under the Japanese health care system.

    abstract:PURPOSE:Remifentanil has been available in Japan for 3 years. The use of this new opioid is considered a useful adjuvant to general anesthesia. Knowing the exact cost-effectiveness of remifentanil should lead to improved anesthetic outcomes with a reasonable cost. METHODS:This single-blinded, prospective, randomized s...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00540-010-1006-2

    authors: Nakada T,Ikeda D,Yokota M,Kawahara K

    更新日期:2010-12-01 00:00:00

  • Cost comparison of intrathecal morphine to intravenous patient-controlled analgesia for the first 24 h post cesarean delivery: a retrospective cohort study.

    abstract:PURPOSE:Intrathecal morphine provides superior pain control for patients undergoing cesarean delivery when compared to intravenous opioid patient-controlled analgesia. However, no study has assessed the overall cost associated with each modality as a primary outcome. The aim of this study is to determine the overall co...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/s00540-016-2263-5

    authors: Patel N,Bryant A,Duncan K,Kukreja P,Powell MF

    更新日期:2017-02-01 00:00:00

  • Peak airway pressure is lower during pressure-controlled than during manual facemask ventilation for induction of anesthesia in pediatric patients-a randomized, clinical crossover trial.

    abstract:PURPOSE:Facemask ventilation during the induction of general anesthesia in paediatric patients remains a challenge as it may result in hypoxic conditions and gastric insufflation with subsequent regurgitation and aspiration. So far, it is unclear if pressure-controlled or manual facemask ventilation is preferable in ch...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00540-018-2580-y

    authors: Goebel U,Schumann S,Wirth S

    更新日期:2019-02-01 00:00:00

  • Pulsed radiofrequency under ultrasound guidance for the tarsal tunnel syndrome: two case reports.

    abstract::Tarsal tunnel syndrome (TTS) is a compression neuropathy that results from entrapment of the posterior tibial nerve or its branches. TTS may be treated either by conservative measures, including physical therapy, medications, and steroid injections, or by surgical decompression. Despite a variety of treatments, a few ...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/s00540-014-1831-9

    authors: Chon JY,Hahn YJ,Sung CH,Jung SH,Moon HS

    更新日期:2014-12-01 00:00:00

  • Effects of epidural anesthesia on postoperative nausea and vomiting in laparoscopic gynecological surgery: a randomized controlled trial.

    abstract:PURPOSE:Patients undergoing laparoscopic gynecological surgery are susceptible to postoperative nausea and vomiting (PONV). We hypothesized that a combination of epidural and general anesthesia to minimize intraoperative opioid administration would reduce the incidence of PONV following laparoscopic gynecological surge...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00540-018-2525-5

    authors: Seki H,Furumoto K,Sato M,Kagoya A,Hashimoto H,Sekiguchi Y,Nakatsuka I

    更新日期:2018-08-01 00:00:00

  • Lipid peroxide and leukotriene B3 production in patients undergoing cardiopulmonary bypass.

    abstract::Cardiac surgery with cardiopulmonary bypass (CPB) is frequently associated with a complex array of post-operative clinical abnormalities, including low-output syndrome and pulmonary dysfunction. It has been reported that oxygen free radicals are one of the important factors causing reperfusion injury. To determine whe...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/BF02483345

    authors: Kawamura T,Sakurada H,Okada K,Wakusawa R,Ito H

    更新日期:1996-06-01 00:00:00

  • Spinal anesthesia for surgery longer than 60 min in infants: experience from the first 2 years of a spinal anesthesia program.

    abstract:PURPOSE:Spinal anesthesia (SA) is being increasingly used in infants to avoid the potential negative neurocognitive effects of general anesthesia (GA). However, SA has been reported to provide a relatively short duration of surgical anesthesia. METHODS:We retrospectively reviewed SA cases for surgical procedures lasti...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/s00540-018-2517-5

    authors: Trifa M,Tumin D,Whitaker EE,Bhalla T,Jayanthi VR,Tobias JD

    更新日期:2018-08-01 00:00:00

  • Lingual traction to facilitate fiber-optic intubation of difficult airways: a single-anesthesiologist randomized trial.

    abstract:PURPOSE:Flexible fiber-optic bronchoscope-guided orotracheal intubation is a valuable technique with demonstrated benefits in the management of difficult airways. Despite its popularity with anesthesia providers, the technique is not fail-safe and airway-related complications secondary to failed intubation attempts rem...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00540-014-1920-9

    authors: Ching YH,Karlnoski RA,Chen H,Camporesi EM,Shah VV,Padhya TA,Mangar D

    更新日期:2015-04-01 00:00:00

  • Effects of battery type and age on performance of rechargeable laryngoscopes.

    abstract::Optimal visualization of the glottis can be crucial to successful laryngoscopy. Limited information has been published on the light intensity delivered from laryngoscopes powered by rechargeable batteries. In this study the laryngoscope light intensity delivered from 10 nickel metal hydride (NiMH), 7 nickel cadmium (N...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/s00540-013-1618-4

    authors: Milne AD,Brousseau CA

    更新日期:2013-10-01 00:00:00

  • Effects of propofol and pentobarbital on calcium concentration in presynaptic boutons on a rat hippocampal neuron.

    abstract:PURPOSE:Numerous reports suggest that intravenously administered (IV) anesthetics affect postsynaptic events in the central nervous system. However, there is little evidence about how general anesthetics influence the presynaptic processes. The level of presynaptic calcium (Ca(2+)) concentration ([Ca(2+)](pre)) regulat...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/s00540-011-1186-4

    authors: Ito S,Sugiyama H,Kitahara S,Ikemoto Y,Yokoyama T

    更新日期:2011-10-01 00:00:00

  • Accuracy of the CNAP™ monitor, a noninvasive continuous blood pressure device, in providing beat-to-beat blood pressure measurements during bariatric surgery in severely obese adolescents and young adults.

    abstract:BACKGROUND:During perioperative care, the continuous measurement of blood pressure (BP) provides superior physiological monitoring compared to intermittent techniques, especially for patients with comorbid conditions such as severe obesity. The current study prospectively assesses the accuracy of a continuous, noninvas...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/s00540-014-1835-5

    authors: Tobias JD,McKee C,Herz D,Teich S,Sohner P,Rice J,Barry N,Michalsky M

    更新日期:2014-12-01 00:00:00

  • Effectiveness of preanesthetic administration of gabapentin on sedative action during intravenous sedation with propofol.

    abstract:PURPOSE:There are no sufficient evidences for the sedative effect of gabapentin during anesthesia, especially intravenous sedation (IVS). The purpose of this study was to evaluate the sedative effect of gabapentin as preanesthetic medication during the IVS with propofol. METHODS:10 volunteer subjects joined this study...

    journal_title:Journal of anesthesia

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00540-018-2559-8

    authors: Hosokawa R,Ito S,Hirokawa J,Oshima Y,Yokoyama T

    更新日期:2018-12-01 00:00:00

  • Oral gastric tube-guided insertion of the ProSeal™ laryngeal mask is an easy and noninvasive method for less experienced users.

    abstract:PURPOSE:The ProSeal™ laryngeal mask airway (PLMA) can be more difficult to insert than the classic laryngeal mask, especially in patients who have a thin palate with a steep oropharyngeal curve. Here, an oral gastric (OG) tube-guided technique is considered as a method that makes it easier to successfully insert a PLMA...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00540-012-1361-2

    authors: Nagata T,Kishi Y,Tanigami H,Hiuge Y,Sonoda S,Ohashi Y,Kagawa K,Ushioda A

    更新日期:2012-08-01 00:00:00

  • Respiratory characteristics and related intraoperative ventilatory management for patients with COVID-19 pneumonia.

    abstract::A substantial proportion of patients with coronavirus disease 19 (COVID-19) develop severe respiratory failure. Although the exact pathophysiology of severe COVID-19 pneumonia remains unknown and the characteristics of these patients are heterogeneous, the acute respiratory failure often fulfills criteria for acute re...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/s00540-020-02845-0

    authors: Aoyama H,Uchida K

    更新日期:2020-08-31 00:00:00

  • Attenuation of the vagolytic effect of atropine during high thoracic epidural anesthesia by heart rate fluctuation analysis.

    abstract::Fifteen surgical patients received an epidural injection of 12 ml of 1.5% lidocaine through a catheter placed at C7-T1, followed by further injection as required. An intravenous bolus of 0.5 mg of atropine sulfate was administered simultaneously with the initial epidural injection. The high-(HFC: 0.15-0.4 Hz) and low-...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/BF02482031

    authors: Shimoda O,Kano T,Ikuta Y,Tashiro M,Nakayama R,Oda T,Morioka T

    更新日期:1995-03-01 00:00:00

  • Severe stridor and marked respiratory difficulty after right-sided supraclavicular brachial plexus block.

    abstract::Brachial plexus block is commonly used for upper limb surgery. Although the procedure is safe, it may be associated with some life-threatening complications. We performed right-sided supraclavicular brachial plexus block for below-elbow amputation in a 45-year-old female. At completion of the block the patient develop...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/s00540-010-1076-1

    authors: Solanki SL,Jain A,Makkar JK,Nikhar SA

    更新日期:2011-04-01 00:00:00

  • Anesthetic management of simultaneous coronary artery bypass grafting and cardiac pheochromocytoma resection under cardiopulmonary bypass.

    abstract::We experienced simultaneous coronary artery bypass grafting and cardiac pheochromocytoma resection under cardiopulmonary bypass in a 79-year-old woman with atherosclerotic angina. During manipulation of the tumor under cardiopulmonary bypass, the serum norepinephrine concentration increased to over seventy times the n...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/s00540-007-0549-3

    authors: Kojima Y,Kitahara H,Kimura H,Nakamura T,Ina H,Yokota S

    更新日期:2007-01-01 00:00:00

  • Pituitary apoplexy during general anesthesia in beach chair position for shoulder joint arthroplasty.

    abstract::Pituitary apoplexy is a rare but potentially life-threatening clinical syndrome caused by the sudden enlargement of pituitary adenoma secondary to infarction and/or hemorrhage. It may be the first presentation of previously undiagnosed pituitary adenoma. Although various precipitating factors of pituitary apoplexy are...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/s00540-010-0929-y

    authors: Koga T,Miyao M,Sato M,Hirota K,Kakuyama M,Tanabe H,Fukuda K

    更新日期:2010-06-01 00:00:00

  • Postoperative cognitive dysfunction after noncardiac surgery: effects of metabolic syndrome.

    abstract:PURPOSE:Vascular risk factors, including metabolic syndrome, are known to contribute to the development of cognitive dysfunction. We tested the hypothesis that patients with metabolic syndrome are more likely to develop cognitive dysfunction after noncardiac surgery. METHODS:Age- and education-balanced patients (n = 6...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/s00540-011-1137-0

    authors: Hudetz JA,Patterson KM,Amole O,Riley AV,Pagel PS

    更新日期:2011-06-01 00:00:00

  • Prolonged drug-induced myoclonus: is it related to palonosetron?

    abstract::We report a case of drug-induced myoclonus possibly related to palonosetron, a second-generation 5-hydroxytryptamine-3 receptor antagonist which was administered as a prophylaxis for postoperative nausea and vomiting in a 28-year-old female. The recurrent episodes of myoclonus jerk involving the head, neck and shoulde...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/s00540-016-2228-8

    authors: Chaw SH,Chan L,Lee PK,Bakar JA,Rasiah R,Foo LL

    更新日期:2016-12-01 00:00:00

  • Lateral Trendelenburg with the injected side down after the block improves the efficacy of the axillary approach to brachial plexus block.

    abstract:PURPOSE:We hypothesized that, after axillary block, positioning the patient in a lateral position with the injected side down and simultaneously in a 20° Trendelenburg position will increase the success rate and quality of the block. METHODS:Fifty patients with chronic renal failure (ASA 2-3) scheduled for arterioveno...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00540-013-1766-6

    authors: Salih Sevdi M,Gunday I,Arar C,Colak A,Turan N

    更新日期:2014-08-01 00:00:00

  • Dexmedetomidine: a review of applications for cardiac surgery during perioperative period.

    abstract::Cardiac surgery is associated with a high incidence of cardiovascular and other complications during the perioperative period that translate into increased mortality and prolonged hospital stays. Safe comprehensive perioperative management is required to eliminate these adverse events. Dexmedetomidine is a selective α...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章,评审

    doi:10.1007/s00540-014-1857-z

    authors: Zhang X,Zhao X,Wang Y

    更新日期:2015-02-01 00:00:00