Placental transfer and effects of famotidine on neonates.

Abstract:

:The effect of famotidine on neonates was studied in 34 obstetric patients who underwent elective cesarean section. In the famotidine group, 20 mg of famotidine was intramuscularly injected at 60 min before induction of anesthesia, and 0.5 mg of atropine was injected at 30 min before induction. In the control group, only atropine was given. Ratio of famotidine concentration in the umbilical venous blood to that in the maternal venous blood was determined as 0.64 +/- 0.13 (mean +/- SD). No significant differences were noted in the Apgar scores, neonatal gastric acidity, and results of liver function tests between the two groups. No side effect, such as the development of gastrointestinal infections, was observed.

journal_name

J Anesth

journal_title

Journal of anesthesia

authors

Doi H,Maruta H,Kudoh I,Takahashi Y,Takano O,Ogawa K,Satoh K,Okutsu Y

doi

10.1007/s0054010050276

subject

Has Abstract

pub_date

1991-07-01 00:00:00

pages

276-80

issue

3

eissn

0913-8668

issn

1438-8359

journal_volume

5

pub_type

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