Abstract:
PURPOSE:The effects of propofol on sinoatrial pacemaker activity and myocardial contractility and its interaction with the autonomic nervous system were investigated in isolated, cross-circulated right atrial canine preparations. METHODS:An isolated right atrial preparation was perfused with heparinized arterial blood from an anesthetized support dog and changes in atrial rate and atrial contractile force were recorded. RESULTS:Propofol (30-1000 microg) and thiopental (30-1000 microg), injected into the sinus node artery of the isolated atrium, induced dose-dependent decreases in atrial rate and contractile force. The negative chronotropic and inotropic effects of propofol were greater than those of thiopental. The propofol-induced negative chronotropic and inotropic responses were not inhibited by atropine. Propofol had no effects on the cardiac responses to acetylcholine, norepinephrine, and the intracardiac parasympathetic nerve stimulation which activates ganglionic nicotinic acetylcholine receptors. CONCLUSION:These results indicate that: (a) propofol directly depresses sinoatrial pacemaker activity and myocardial contractility, (b) the negative chronotropic and inotropic effects of propofol do not involve activation of muscarinic receptors, and (c) propofol has little interaction with the autonomic nervous system at the effector site.
journal_name
J Anesthjournal_title
Journal of anesthesiaauthors
Nagashima Y,Furukawa Y,Hirose M,Chiba Sdoi
10.1007/s005400050019subject
Has Abstractpub_date
1999-01-01 00:00:00pages
34-9issue
1eissn
0913-8668issn
1438-8359journal_volume
13pub_type
杂志文章abstract:PURPOSE:This study aims to identify prognostic factors related to short-term and long-term outcomes of patients with hematological malignancy (HM) admitted to the intensive care unit (ICU) in Japan during ICU stay and after discharge from ICU. METHODS:We conducted a retrospective, observational study of 169 patients w...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-017-2390-7
更新日期:2017-10-01 00:00:00
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journal_title:Journal of anesthesia
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abstract::The coronavirus disease 2019 (COVID-19) pandemic is caused by a coronavirus that is transmitted primarily via aerosol, droplets or direct contact. This may place anesthetists at higher risk of infection due to their frequent involvement in aerosol-generating airway interventions. Many anesthethetic COVID-19 guidelines...
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journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-009-0763-2
更新日期:2009-01-01 00:00:00
abstract::A large amount of pharmacological and clinical evidence supports the abuse potential of propofol. Although previous case reports have indicated that recreational use of propofol is primarily by medical professionals, its spread among the general public has recently been highlighted. This is the first case report to sh...
journal_title:Journal of anesthesia
pub_type: 杂志文章
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更新日期:2012-04-01 00:00:00
abstract:PURPOSE:The properties of two new-generation CO(2) absorbents, Amsorb Plus (Armstrong Medical, Coleraine, UK) and Drägersorb Free (Drager, Lubeck, Germany), were compared with those of Amsorb (Armstrong Medical) and Sodasorb II (W.R. Grace, Lexington, MA, USA). METHODS:The concentration of compound A produced by each ...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-004-0253-5
更新日期:2004-01-01 00:00:00
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journal_title:Journal of anesthesia
pub_type: 杂志文章
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更新日期:1990-10-01 00:00:00
abstract::Cervical spinal cord injury is a rare but serious complication after general anesthesia. The risk factors include traumatic cervical injury, cervical spine instability, and difficult airway management. It has also occurred in the absence of cervical instability. Here we report a patient who had a history of intermitte...
journal_title:Journal of anesthesia
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更新日期:2014-02-01 00:00:00
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journal_title:Journal of anesthesia
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journal_title:Journal of anesthesia
pub_type: 杂志文章
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更新日期:1997-12-01 00:00:00
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journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-007-0586-y
更新日期:2008-01-01 00:00:00
abstract::Rectal luminal regional P(CO2) (Pr(CO2)) was compared with gastric luminal Pr(CO2) measured by automated air tonometry at intervals of 10 min in 20 children aged 6-16 years scheduled for elective surgery under general anesthesia. In 5 patients, measurement of rectal Pr(CO2) failed because of catheter-related problems....
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更新日期:2006-01-01 00:00:00
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更新日期:2007-01-01 00:00:00
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doi:10.1007/s00540-013-1770-x
更新日期:2014-08-01 00:00:00
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journal_title:Journal of anesthesia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00540-004-0281-1
更新日期:2005-01-01 00:00:00
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journal_title:Journal of anesthesia
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2012-10-01 00:00:00
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journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/BF02480091
更新日期:1998-09-01 00:00:00
abstract::Holmium laser enucleation of prostate (HoLEP) is being performed with increasing frequency as a minimally invasive alternative to transurethral resection of the prostate (TURP) for the surgical management of benign prostatic hyperplasia (BPH). HoLEP offers the advantage of use of normal saline for irrigation, instead ...
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更新日期:2016-12-01 00:00:00
abstract::The objective of our study was to assess the efficacy and safety of dexmedetomidine given in a small dose for a 1-h infusion as an adjuvant to local analgesia in ophthalmic operations. The study was double-blind prospective, randomized, and placebo controlled. We studied the effects of a small dose of dexmedetomidine ...
journal_title:Journal of anesthesia
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更新日期:2006-01-01 00:00:00
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更新日期:2012-08-01 00:00:00
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journal_title:Journal of anesthesia
pub_type: 杂志文章
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更新日期:2015-02-01 00:00:00
abstract:PURPOSE:It has been suggested that the different degrees of fade induced by nondepolarizing neuromuscular blocking agents in repetitive muscular contractions may be due to the varying affinities or binding kinetics of presynaptic nicotinic receptors. We compared the degree of fade induced by mivacurium, cisatracurium, ...
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更新日期:2003-01-01 00:00:00
abstract:PURPOSE:Postoperative nausea and vomiting (PONV) after adenotonsillectomy in children is, in spite of the prophylactic administration of tropisetron, still a frequent event. The aim of this study was to evaluate the benefit of the additional systemic administration of low-dose dexamethasone (0.15 mg x kg(-1)) for the p...
journal_title:Journal of anesthesia
pub_type: 杂志文章,评审
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更新日期:2007-01-01 00:00:00