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Efficacy of landiolol in attenuating hemodynamic responses to local epinephrine infiltration in patients undergoing vaginal total hysterectomy.

Abstract：

PURPOSE:Local epinephrine infiltration often causes beta1-adrenoceptor-mediated tachycardia, hypertension, and arrhythmia. Landiolol, a short acting beta1-adrenoceptor blocker, may represent the most ideal agent to attenuate these adverse effects. In this study, we examined the effects of landiolol on the hemodynamic changes resulting from local infiltration of epinephrine. METHODS:Thirty-six patients undergoing vaginal total hysterectomy under general anesthesia were randomly assigned to one of three groups: control group (n = 12), L5 group (n = 12), and L10 group (n = 12). In the control, L5, and L10 groups, the patients were given saline, landiolol 5 mg, and 10 mg, respectively, just before infiltration of epinephrine(1 : 300,000; total dose, about 100 microg) into the surgical field. Blood pressure and heart rate was assessed before and 5, 10, 15, 20, 25, 30 min after the initiation of epinephrine infiltration. If systolic blood pressure and heart rate exceeded 160 mmHg and 120 beats.min(-1), respectively, Ca blockers of either diltiazem 5 mg or nicardipine 1 mg and/or 2% sevoflurane were given. RESULTS:Epinephrine infiltration significantly increased systolic blood pressure from 122 +/- 15 to 170 +/- 29 mmHg and heart rate from 63 +/- 8 to 106 +/- 10 beats.min(-1). In both the L5 and L10 groups, the increase in heart rate (from 69 +/- 16 to 87 +/- 16 beats.min(-1), P < 0.01, and from 70 +/- 18 to 76 +/- 9 beats.min(-1), P < 0.01, respectively) was significantly smaller compared to the control group, but the increase in systolic blood pressure was significantly attenuated in the L10 group (from 116 +/- 18 to 140 +/- 27 mmHg, P < 0.01). The number of patients given either Ca blockers or sevoflurane in the control group was significantly higher than that in the landiolol groups (P < 0.01). CONCLUSION:The present study suggests that landiolol 10 mg may be a more suitable dose than landiolol 5 mg to antagonize hyperdynamic states induced by local administration of epinephrine.

journal_name

J Anesth

journal_title

Journal of anesthesia

authors

Hirota K,Baba S,Fukushi S,Muraoka M,Matsuki A

doi

10.1007/s00540-004-0281-1

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

17-20

issue

eissn

0913-8668

issn

1438-8359

journal_volume

pub_type

临床试验,杂志文章,随机对照试验

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Efficacy of landiolol in attenuating hemodynamic responses to local epinephrine infiltration in patients undergoing vaginal total hysterectomy.