Abstract:
PURPOSE:The sedative effects of pregabalin during perioperative period have not been sufficiently characterized. The aim of this study was to verify the sedative effects of premedication with pregabalin on intravenous sedation (IVS) using propofol and also to assess the influences of this agent on circulation, respiration, and postanesthetic complications. METHODS:Ten healthy young volunteers underwent 1 h of IVS using propofol, three times per subject, on separate days (first time, no pregabalin; second time, pregabalin 100 mg; third time, pregabalin 200 mg). The target blood concentration (C T) of propofol was increased in a stepwise fashion based on the bispectral index (BIS) value. Ramsay's sedation score (RSS) was determined at each propofol C T. Propofol C T was analyzed at each sedation level. Circulation and respiration during IVS and complications were also verified. RESULTS:Propofol C T was reduced at BIS values of 60 and 70 in both premedicated groups (100 mg: p = 0.043 and 0.041; 200 mg: p = 0.004 and 0.016, respectively) and at a BIS value of 80 in the pregabalin 200 mg group (p < 0.001). Propofol C T was decreased at RSS 4-6 in the pregabalin 100 mg group (RSS 4: p = 0.047; RSS 5: p = 0.007; RSS 6: p = 0.014), and at RSS 3-6 in the pregabalin 200 mg group (RSS 3-5: p < 0.001; RSS 6: p = 0.002). CONCLUSION:We conclude that oral premedication with pregabalin reduces the amount of propofol required to obtain an acceptable and adequate sedation level.
journal_name
J Anesthjournal_title
Journal of anesthesiaauthors
Karube N,Ito S,Sako S,Hirokawa J,Yokoyama Tdoi
10.1007/s00540-017-2366-7subject
Has Abstractpub_date
2017-08-01 00:00:00pages
586-592issue
4eissn
0913-8668issn
1438-8359pii
10.1007/s00540-017-2366-7journal_volume
31pub_type
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更新日期:1989-03-01 00:00:00
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journal_title:Journal of anesthesia
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