Abstract:
PURPOSE:The purpose of this study was to determine whether intraoperative infusion of remifentanil induces acute tolerance to opioids, and compare the postoperative pain and opioid consumption by the effect site concentrations of remifentanil. METHODS:One hundred and ninety-eight patients undergoing gastrectomy were randomly assigned to maintain target effect site concentrations of remifentanil at 0 (Group 1, n = 39), 2 (Group 2, n = 40), 4 (Group 3, n = 39), 8 (Group 4, n = 40), or 12 ng/ml (Group 5, n = 40) during operation. Postoperative pain intensities and fentanyl requirement were recorded at postoperative 2, 6, 24, and 48 h. RESULTS:Fentanyl requirement for postoperative 2 h was significantly greater in Group 5 compared to Group 1 (376 ± 116 vs. 283 ± 129 µg, P = 0.03). However, there were no differences in fentanyl requirements among the groups after postoperative 2 h. Also, total fentanyl consumption for 48 h was similar in all groups (Group 1; 3106 ± 629, Group 2; 2970 ± 705, Group 3; 3017 ± 555, Group 4; 3151 ± 606, and Group 5; 2984 ± 443 µg, P = 0.717). Pain scores at rest and during deep breathing were comparable in all groups at the time of each examination. CONCLUSION:Intraoperative infusion of remifentanil with 12 ng/ml of effect site concentration in patients undergoing gastrectomy increases early postoperative fentanyl requirement. Acute opioid tolerance would be developed by higher concentration of remifentanil than dosage of common anesthetic practice.
journal_name
J Anesthjournal_title
Journal of anesthesiaauthors
Kim D,Lim HS,Kim MJ,Jeong W,Ko Sdoi
10.1007/s00540-018-2569-6subject
Has Abstractpub_date
2018-12-01 00:00:00pages
886-892issue
6eissn
0913-8668issn
1438-8359pii
10.1007/s00540-018-2569-6journal_volume
32pub_type
杂志文章,随机对照试验abstract:PURPOSE:We investigated whether presynaptic facilitatory M1 and/or inhibitory M2 muscarinic receptors contributed to pancuronium- and cisatracurium-induced tetanic fade. METHODS:Phrenic nerve-diaphragm muscle preparations of rats were indirectly stimulated with tetanic frequency (75 +/- 3.3 Hz; mean +/- SD). Doses of ...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-009-0790-z
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:We investigated the continuous infusion rates of rocuronium necessary to obtain the surgical muscle relaxation before, during, and after the Pringle maneuver on patients who underwent hepatectomy. METHODS:Fifteen patients were induced by total intravenous anesthesia with propofol. After obtaining the cali...
journal_title:Journal of anesthesia
pub_type: 临床试验,杂志文章
doi:10.1007/s00540-018-2498-4
更新日期:2018-06-01 00:00:00
abstract::Gasserian ganglion block is an established treatment for trigeminal neuralgia. A landmark approach assisted by X-ray fluoroscopy is the most common method; however, visualization of the foramen ovale is difficult in some cases. Here we report two cases in which a novel technique using modern computed tomography (CT) f...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-005-0307-3
更新日期:2005-01-01 00:00:00
abstract::Tracheal insufflation of oxygen (TRIO) is a form of constant-flow ventilation. We studied the effect of TRIO at a flow rate of 2 L/kg/min on arterial blood gases during external cardiac compressions in dogs with ventricular fibrillation. During the combined application of TRIO and external cardiac compressions, all an...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s0054090030016
更新日期:1989-03-01 00:00:00
abstract:PURPOSE:Facemask ventilation during the induction of general anesthesia in paediatric patients remains a challenge as it may result in hypoxic conditions and gastric insufflation with subsequent regurgitation and aspiration. So far, it is unclear if pressure-controlled or manual facemask ventilation is preferable in ch...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-018-2580-y
更新日期:2019-02-01 00:00:00
abstract:PURPOSE:To identify whether the presence of preoperative depression in patients with diabetes mellitus is a risk factor for postoperative cognitive dysfunction after coronary artery bypass graft (CABG) surgery. METHODS:Data from 90 patients with diabetes mellitus undergoing elective CABG were analyzed. Hemodynamic dat...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-010-1072-5
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to assess whether preanesthetic laboratory values can predict in-hospital mortality and morbidity in patients who have undergone burr hole craniostomy due to chronic subdural hematoma. METHODS:From January 2007 to February 2016, the records of 502 consecutive patients who under...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-016-2259-1
更新日期:2016-12-01 00:00:00
abstract:PURPOSE:Remifentanil has been available in Japan for 3 years. The use of this new opioid is considered a useful adjuvant to general anesthesia. Knowing the exact cost-effectiveness of remifentanil should lead to improved anesthetic outcomes with a reasonable cost. METHODS:This single-blinded, prospective, randomized s...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-010-1006-2
更新日期:2010-12-01 00:00:00
abstract::The direct effects of nitrous oxide on left ventricular contractility and myocardial oxygen consumption (MVO2) in the ischemic isolated rat heart were studied. The rat heart was isolated and perfused by a Langendorf technique. The aortic stump was cannulated and the heart was perfused with Kumpeis solution bubbled wit...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/BF02514658
更新日期:1994-09-01 00:00:00
abstract::Alveolar capillary dysplasia (ACD), which is a rare and lethal congenital pulmonary anomaly found in newborns, begins its onset or causes deterioration of the infant's condition some time after birth. Various congenital anomalies in combination with ACD have been reported, except for subglottic stenosis. Therefore, we...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-010-1080-5
更新日期:2011-04-01 00:00:00
abstract:PURPOSE:We compared the insertion performance of the pediatric size 1.5-3 i-gel airway device with that of the ProSeal laryngeal mask airway (PLMA) in anesthetized children in a prospective, randomized, controlled manner. METHODS:We included 134 children, aged 3 months to 15 years, scheduled for elective surgery under...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-012-1477-4
更新日期:2013-02-01 00:00:00
abstract:PURPOSE:In order to elucidate the prominent factors involved in intraoperative bradycardia in adult patients, we retrospectively investigated the association between the potential risk factors and intraoperative bradycardia, using multiple logistic regression. METHODS:The perioperative records for 499 adult patients w...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-006-0469-7
更新日期:2007-01-01 00:00:00
abstract::May-Hegglin anomaly (MHA) is an inherited autosomal dominant disorder characterized by giant platelets and inclusion bodies in granulocytes, and thrombocytopenia. There is no consensus on the perioperative management of this disorder. We report a case involving a patient with MHA who was perioperatively managed withou...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-018-2522-8
更新日期:2018-08-01 00:00:00
abstract::Congenital insensitivity to pain with anhidrosis (CIPA) is a rare autosomal recessive disease, characterized by episodes of unexplained fever, anhidrosis, pain insensitivity despite intact tactile perception, self-mutilating behavior, mental retardation, and autonomic nervous system (ANS) abnormalities. We present a c...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-010-0985-3
更新日期:2010-10-01 00:00:00
abstract:PURPOSE:The present case-control study was conducted to evaluate whether acute normovolemic hemodilution (ANH) can reduce the need for perioperative allogeneic blood transfusion (ABT) and affect the incidence of perioperative complications in free-flap reconstruction of the head and neck. METHODS:This single-center, r...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-019-02714-5
更新日期:2020-04-01 00:00:00
abstract:PURPOSE:Skin incision before percutaneous central venous catheterization may cause serious hemorrhage and/or skin cicatrization. To minimize these adverse effects, we improved the shape of a dilator and coated it with lubricant to reduce insertion load. METHODS:We selected three types of dilators from different manufa...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-004-0292-y
更新日期:2005-01-01 00:00:00
abstract:PURPOSE:It seems controversial whether or not neutrophil elastase inhibitors are effective in attenuating myocardial ischemia/reperfusion injury. We thus investigated possible protective effects of sivelestat, a neutrophil elastase inhibitor, against myocardial stunning i.e., prolonged myocardial dysfunction following ...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-010-0948-8
更新日期:2010-08-01 00:00:00
abstract:PURPOSE:Although an α-adrenoceptor has been suggested to be involved in the mechanism of asthma, the effect of α1-agonist on the airway is still unclear. In this study we evaluated the effect of phenylephrine on the airway with a direct visualization method using a superfine fiberoptic bronchoscope (SFB). METHODS:Seve...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/BF02480091
更新日期:1998-09-01 00:00:00
abstract:OBJECTIVES:When physicians become patients, they may expect special privileges, extra attention from caregivers, and non-routine treatments. Consequently, physician patients may not be treated per routine-which possibly worsens care rather than improving it. We thus tested the primary hypothesis that in-hospital mortal...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-016-2273-3
更新日期:2017-02-01 00:00:00
abstract:PURPOSE:We aimed to introduce a simple, lightweight continuous positive airway pressure (CPAP)-delivery device for the nondependent lung during one-lung ventilation, to investigate how the type of three-way stopcocks, and the compliance and resistance of a test lung affect the relationship between the oxygen flow rate ...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-008-0681-8
更新日期:2009-01-01 00:00:00
abstract:PURPOSE:This prospective, randomized trial was designed to assess whether the i-gel supraglottic airway device is suitable for volume-controlled ventilation while applying positive end-expiratory pressure (PEEP) of 5 cmH(2)O under general anesthesia. It was believed that this device might improve arterial oxygenation. ...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-013-1628-2
更新日期:2013-12-01 00:00:00
abstract::The effects of butorphanol injection on baroreflex control of heart rate were investigated using both pressor and depressor tests in eighteen adult patients. Baroreflex sensitivity was attenuated after butorphanol injection in the pressor test using phenylephrine, whereas it was unchanged in the depressor test using n...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s0054030070411
更新日期:1993-10-01 00:00:00
abstract:PURPOSE:Numerous reports suggest that intravenously administered (IV) anesthetics affect postsynaptic events in the central nervous system. However, there is little evidence about how general anesthetics influence the presynaptic processes. The level of presynaptic calcium (Ca(2+)) concentration ([Ca(2+)](pre)) regulat...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-011-1186-4
更新日期:2011-10-01 00:00:00
abstract::Brachial plexus block is commonly used for upper limb surgery. Although the procedure is safe, it may be associated with some life-threatening complications. We performed right-sided supraclavicular brachial plexus block for below-elbow amputation in a 45-year-old female. At completion of the block the patient develop...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-010-1076-1
更新日期:2011-04-01 00:00:00
abstract::We measured plasma epinephrine and norepinephrine concentrations in a rabbit model simulating subarachnoid hemorrhage (SAH), following the injection of prostaglandin F(2alpha) (PGF(2alpha)) into the basal cistern. In this model, plasma epinephrine values increased significantly (to 4.2-fold those before injection), su...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s0054020060161
更新日期:1992-04-01 00:00:00
abstract::To study the effects of repeated ketamine administration (0: saline, 12.5, 25, and 50 mg·kg-1 every 3 days for a total of five times, subcutaneously) on the central muscarinic acetylcholine receptors (mAchRs), receptor binding assays of mAchR were carried out in the forebrain of mice, using [3H]quinuclidinyl benzilate...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/BF02479877
更新日期:1995-09-01 00:00:00
abstract::Preeclampsia can cause myriad organ dysfunction, including cranial nerve palsies that pose diagnostic and management dilemmas. We present an unusual case of third nerve palsy, (presenting as diplopia, ptosis) with hypertension, hyperreflexia, proteinuria, easy bruising in a parturient at 34 + 6/52 weeks of twins gesta...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-013-1586-8
更新日期:2013-10-01 00:00:00
abstract:PURPOSE:Patients in whom neutropenia recovery is complicated by pneumonia have an increased risk of acute lung injury (ALI) and detrimental outcomes. The aim of the present study was to investigate whether inhibition of neutrophil elastase (NE) is effective in lipopolysaccharide (LPS)-induced ALI during neutropenia rec...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-017-2311-9
更新日期:2017-06-01 00:00:00
abstract::It is recommended that the period of fasting before elective surgery should be shortened to facilitate a rapid recovery by preventing catabolism. We examined the effects of a short period of fasting on metabolism by performing indirect calorimetry (IC) under general anesthesia. A prospective observational study involv...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-014-1950-3
更新日期:2015-06-01 00:00:00
abstract:PURPOSES:In the present study, we investigated whether flurbiprofen axetil (FA) alleviates hypoxemia during one-lung ventilation (OLV) by reducing the pulmonary shunt/total perfusion (Q s/Q t) ratio, and examined the relationship between the Q s/Q t ratio and the thromboxane B2 (TXB2)/6-keto-prostaglandin F1α (6-K-PGF1...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-015-2060-6
更新日期:2015-12-01 00:00:00