Abstract：
PURPOSE:Numerous reports suggest that intravenously administered (IV) anesthetics affect postsynaptic events in the central nervous system. However, there is little evidence about how general anesthetics influence the presynaptic processes. The level of presynaptic calcium (Ca(2+)) concentration ([Ca(2+)](pre)) regulates neurotransmitter release. In this study, we investigated the effects of anesthetic propofol IV and the barbiturate pentobarbital on neurotransmitter release by measuring [Ca(2+)](pre) in the presynaptic nerve terminals (boutons) on a dissociated single hippocampal rat neuron. METHODS:Sprague-Dawley rats 10-14 days old were decapitated under pentobarbital anesthesia, and brain slices were prepared. The hippocampal CA1 area was touched with a fire-polished glass pipette, which vibrated horizontally, and neurons were dissociated, along with the attached presynaptic boutons. The presynaptic boutons were visualized under a confocal laser-scanning microscope after staining with FM1-43 dye, and [Ca(2+)](pre) was measured with acetoxymethyl ester of fluo-3 (fluo-3 AM). RESULTS:High potassium (K(+)) (15-90 mM) increased the [Ca(2+)](pre) in the Ca(2+)-containing solution in a concentration-dependent manner. Whereas propofol (10 μM) and pentobarbital (300 μM) suppressed the high K(+) (60 mM)-induced increase in [Ca(2+)](pre) in the boutons attached to the dendrite, they did not affect [Ca(2+)](pre) in the boutons attached to the soma or dendrite base. As a large majority of excitatory synapses are located on dendritic spines, these agents may affect Ca(2+) mobilization in the excitatory presynaptic boutons. CONCLUSIONS:Propofol and pentobarbital may affect neurotransmitter release from the excitatory presynaptic nerve terminals due to inhibition of increase in [Ca(2+)](pre).
journal_name
J Anesthjournal_title
Journal of anesthesiaauthors
Ito S,Sugiyama H,Kitahara S,Ikemoto Y,Yokoyama Tdoi
10.1007/s00540-011-1186-4subject
Has Abstractpub_date
2011-10-01 00:00:00pages
727-33issue
5eissn
0913-8668issn
1438-8359journal_volume
25pub_type
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journal_title：Journal of anesthesia
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doi：10.1007/s00540-012-1341-6
更新日期：2012-06-01 00:00:00
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journal_title：Journal of anesthesia
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更新日期：2011-04-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s00540-016-2204-3
更新日期：2016-10-01 00:00:00
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journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-007-0529-7
更新日期：2007-01-01 00:00:00
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pub_type： 杂志文章,随机对照试验
doi：10.1007/s00540-010-1006-2
更新日期：2010-12-01 00:00:00
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journal_title：Journal of anesthesia
pub_type： 杂志文章
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更新日期：1993-04-01 00:00:00
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更新日期：2017-04-01 00:00:00
abstract：:To compare tracheal intubation with the Pentax Airway Scope (AWS) and the Macintosh laryngoscope (McL) during chest compression, 25 anesthesiologists (including 12 specialists having >5 years of experience and 13 trainees having <2 years of experience) performed tracheal intubation using either the McL or the AWS, wit...
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更新日期：2010-04-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s00540-005-0382-5
更新日期：2006-01-01 00:00:00
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更新日期：2012-12-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2014-06-01 00:00:00
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journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/BF02514699
更新日期：1994-06-01 00:00:00
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journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/BF02479853
更新日期：1995-06-01 00:00:00
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journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-008-0696-1
更新日期：2009-01-01 00:00:00
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journal_title：Journal of anesthesia
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doi：10.1007/BF02483394
更新日期：1996-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：2012-04-01 00:00:00
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journal_title：Journal of anesthesia
pub_type： 杂志文章
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更新日期：2017-06-01 00:00:00
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journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/BF02482031
更新日期：1995-03-01 00:00:00
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journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s005400050043
更新日期：1999-01-01 00:00:00
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journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-006-0443-4
更新日期：2007-01-01 00:00:00
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pub_type： 临床试验,杂志文章
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更新日期：2006-01-01 00:00:00
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journal_title：Journal of anesthesia
pub_type： 杂志文章
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更新日期：1992-07-01 00:00:00
abstract：:A 75-year-old female patient underwent right vitrectomy under total intravenous anesthesia with propofol, ketamine and fentanyl. During the surgery sudden severe bradycardia (heart rate, 33 beats per min), without hypotension, occurred, which was relatively atropine-insensitive. This event was accompanied by a marked ...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-008-0632-4
更新日期：2008-01-01 00:00:00
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journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s0054010050205
更新日期：1991-07-01 00:00:00
