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Atomised intranasal midazolam spray as premedication in pediatric patients: comparison between two doses of 0.2 and 0.3 mg/kg.

Abstract：

PURPOSE:Midazolam premedication administered by the intranasal route is noninvasive with good bioavailability. Atomised intranasal midazolam spray ensures accurate drug dosage and better patient acceptability, with rapid onset of action and virtually complete absorption. METHODS:Sixty pediatric patients scheduled for elective surgeries were administered atomised intranasal midazolam. Two doses of midazolam, of 0.2 and 0.3 mg/kg, were compared. Children were observed for achieving satisfactory sedation and separation scores, and face mask acceptance. RESULTS:At 10 and 20 min of nasal administration, 70 and 76% of the children, respectively, in the 0.3 mg/kg dose group, while 40 and 63% of the children, respectively, in the 0.2 mg/kg group were adequately sedated. Similarly, at 10 and 20 min after administration, 66.6 and 73.3% of children, respectively, in the 0.3 mg/kg group, and 30 and 60% in the 0.2 mg/kg group were easily separated from their parents. With regard to face mask acceptance, 33.3% of patients in the 0.3 mg/kg group and 16.6% in the 0.2 mg/kg group accepted the mask easily. CONCLUSION:Atomised midazolam at 0.3 mg/kg is safe, and achieves faster sedation and better separation scores as compared to 0.2 mg/kg.

journal_name

J Anesth

journal_title

Journal of anesthesia

authors

Baldwa NM,Padvi AV,Dave NM,Garasia MB

doi

10.1007/s00540-012-1341-6

subject

Has Abstract

pub_date

2012-06-01 00:00:00

pages

346-50

issue

3

eissn

0913-8668

issn

1438-8359

journal_volume

26

pub_type

杂志文章,随机对照试验

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