Abstract:
BACKGROUND:Clinical histological studies demonstrate that the distribution of natural killer (NK) cells, other immune cells and μ-opioid receptors (MOR) within cancer tissue can predict cancer prognosis. No clinical study has evaluated whether anesthetic technique influences immune cell and MOR expression within human breast cancer. METHODS:Excised preoperative biopsies and intraoperative breast cancer specimens from 20 patients randomly chosen from patients previously enrolled in an ongoing, prospective, randomized trial (NCT00418457) investigating the effect of anesthetic technique on long-term breast cancer outcome were immunohistochemically stained and microscopically examined by two independent investigators, masked to randomization, to quantify MOR and immune cell infiltration: CD56, CD57 (NK cells), CD4 (T helper cells), CD8 (cytotoxic T cells) and CD68 (macrophages). Patients had been randomized to receive either a propofol-paravertebral anesthetic with continuing analgesia (PPA, n = 10) or balanced general anesthetic with opioid analgesia (GA, n = 10). RESULTS:There were no differences between the groups in staining intensity in preoperative biopsy specimens. Expression intensity values (median 25-75%) for MOR in intraoperative resected biopsy were higher in GA 8.5 (3-17) versus PPA 1 (0-10), p = 0.04. The numbers of MOR-positive cells were also higher in GA patients. Expression and absolute numbers of CD56, CD57, CD4 and CD68 were similar in resected tumor in both groups. CONCLUSION:General anesthesia with opioid analgesia increased resected tumor MOR expression compared with propofol-paravertebral anesthetic technique, but the anesthetic technique did not significantly influence the expression of immune cell markers.
journal_name
J Anesthjournal_title
Journal of anesthesiaauthors
Levins KJ,Prendeville S,Conlon S,Buggy DJdoi
10.1007/s00540-018-2554-0subject
Has Abstractpub_date
2018-12-01 00:00:00pages
792-796issue
6eissn
0913-8668issn
1438-8359pii
10.1007/s00540-018-2554-0journal_volume
32pub_type
杂志文章,多中心研究,随机对照试验abstract::We report on the anesthetic management of a 69-year-old female Jehovah's Witness undergoing cardiopulmonary bypass to replace the ascending aorta; the patient refused transfusion of stored autologous or allogeneic blood products for religious reasons. The strategy involved preoperative hematopoiesis with recombinant h...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-009-0764-1
更新日期:2009-01-01 00:00:00
abstract::Airway management in patients of faciomaxillary injury is of great concern to the anesthesiologist. Bag and mask ventilation and orotracheal intubation may be difficult with these patients. Recently, a middle aged, obese female presented in the emergency department after sustaining a blast injury, with laceration of t...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-010-1091-2
更新日期:2011-04-01 00:00:00
abstract:PURPOSE:The properties of two new-generation CO(2) absorbents, Amsorb Plus (Armstrong Medical, Coleraine, UK) and Drägersorb Free (Drager, Lubeck, Germany), were compared with those of Amsorb (Armstrong Medical) and Sodasorb II (W.R. Grace, Lexington, MA, USA). METHODS:The concentration of compound A produced by each ...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-004-0253-5
更新日期:2004-01-01 00:00:00
abstract::Cardiac surgery is associated with a high incidence of cardiovascular and other complications during the perioperative period that translate into increased mortality and prolonged hospital stays. Safe comprehensive perioperative management is required to eliminate these adverse events. Dexmedetomidine is a selective α...
journal_title:Journal of anesthesia
pub_type: 杂志文章,评审
doi:10.1007/s00540-014-1857-z
更新日期:2015-02-01 00:00:00
abstract::Thirty six patients were received epidural anesthesia with or without buprenorphine (BPN) during upper abdominal surgery. They were divided into three groups of 12 patients as follows; G-I received 20 ml of 1% lidocaine epidurally, G-II received 20 ml of 1% lidocaine epidurally and 0.6 mg BPN intravenously, G-III rece...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s0054000040242
更新日期:1990-07-01 00:00:00
abstract:PURPOSE:The efficacy of infraorbital nerve block in reducing isoflurane consumption and postoperative pain was evaluated in patients undergoing endoscopic endonasal maxillary sinus surgery (ESS) under general anesthesia. METHODS:Fifty patients were randomly allocated to either the block group (n =15) or the nonblock g...
journal_title:Journal of anesthesia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s005400170014
更新日期:2001-01-01 00:00:00
abstract::Tarsal tunnel syndrome (TTS) is a compression neuropathy that results from entrapment of the posterior tibial nerve or its branches. TTS may be treated either by conservative measures, including physical therapy, medications, and steroid injections, or by surgical decompression. Despite a variety of treatments, a few ...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-014-1831-9
更新日期:2014-12-01 00:00:00
abstract::We experienced simultaneous coronary artery bypass grafting and cardiac pheochromocytoma resection under cardiopulmonary bypass in a 79-year-old woman with atherosclerotic angina. During manipulation of the tumor under cardiopulmonary bypass, the serum norepinephrine concentration increased to over seventy times the n...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-007-0549-3
更新日期:2007-01-01 00:00:00
abstract:PURPOSE:In a previous study using the tail-flick test, we found that intracerebroventricular administration of D-serine, an endogenous co-agonist at the glycine sites of N-methyl-D-aspartate (NMDA) receptors, elicited an antinociceptive effect on thermal nociception. The purpose of the present study was to evaluate the...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-013-1708-3
更新日期:2014-04-01 00:00:00
abstract:PURPOSE:We compared the insertion performance of the pediatric size 1.5-3 i-gel airway device with that of the ProSeal laryngeal mask airway (PLMA) in anesthetized children in a prospective, randomized, controlled manner. METHODS:We included 134 children, aged 3 months to 15 years, scheduled for elective surgery under...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-012-1477-4
更新日期:2013-02-01 00:00:00
abstract::The intradiscal high-pressure injection of saline and lidocaine (IDHP) is a minimally invasive percutaneous procedure for a lumbar intervertebral disc extrusion. The purpose of this study was to investigate the clinical outcomes of IDHP in terms of pain relief, reduction of disability, and risk of complications. Thirt...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-012-1419-1
更新日期:2012-10-01 00:00:00
abstract::Although maintaining anesthesia for myasthenia gravis (MG) with minimal muscle relaxants (MR) is common, the success rate of anesthetic management for MG without MR is not clear. We therefore retrospectively examined the success rate of anesthetic management for MG without MR among 66 consecutive cases of thymectomy f...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-015-1999-7
更新日期:2015-10-01 00:00:00
abstract::Iatrogenic injury is a difficult situation for a surgeon. Being successful in saving a patient at risk is the major concern in this situation. Once an iatrogenic injury to the superior vena cava (SVC) is found, increasing the intrathoracic pressure is theoretically able to overcome the venous pressure and to alleviate...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-009-0857-x
更新日期:2010-04-01 00:00:00
abstract:PURPOSE:Patients in whom neutropenia recovery is complicated by pneumonia have an increased risk of acute lung injury (ALI) and detrimental outcomes. The aim of the present study was to investigate whether inhibition of neutrophil elastase (NE) is effective in lipopolysaccharide (LPS)-induced ALI during neutropenia rec...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-017-2311-9
更新日期:2017-06-01 00:00:00
abstract::In recent decades anesthesia safety has not been improved in low-income countries. This prospective audit describes the incidence of hypoxia and related events detected among a cohort of patients undergoing surgery in the maternity unit at Sylvanus Olympio University Teaching Hospital, Togo, West Africa, by using puls...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-015-2048-2
更新日期:2015-12-01 00:00:00
abstract::Familial dysautonomia is an inherited disorder characterized by autonomic and sensory nervous system neuropathy resulting in extremely labile blood pressure (severe hypertension followed by hypotension). As more patients with familial dysautonomia reach adulthood due to improved medical treatment, perioperative encoun...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-009-0795-7
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:The relationship between preoperative hyperglycemia and postoperative acute kidney injury (AKI) occurrence in non-cardiac surgery including laparoscopic surgery remains unclear. This study aimed to assess the relationship between preoperative chronic hyperglycemia and postoperative AKI occurrence after a maj...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-018-2551-3
更新日期:2018-10-01 00:00:00
abstract:PURPOSE:The CO(2) reactivity of cortical cerebral vessels and local cortical blood flow (l-CoBF) were evaluated during anesthesia in patients with moyamoya disease who were undergoing revascularization surgery. METHODS:Using laser-Doppler flowmetry, the CO(2) reactivity of cortical cerebral vessels and l-CoBF were mea...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s005400050043
更新日期:1999-01-01 00:00:00
abstract::To determine whether there is any systemic relationship between the distance from the skin to the epidural space and physical constitution, the distance from the skin to the epidural space was measured in 1007 epidural punctures. The distance from the skin to the epidural space in male was greater than that in female ...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s0054080020198
更新日期:1988-09-01 00:00:00
abstract:PURPOSE:Intravenous cannulation is a painful and stressful procedure. The objective of this study was to compare the analgesic efficacy of the eutectic mixture of local anesthetics (EMLA(®)) with that of the Valsalva maneuver in adult patients during i.v. cannulation. METHODS:One hundred ninety-five patients were rand...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-012-1540-1
更新日期:2013-06-01 00:00:00
abstract::May-Hegglin anomaly (MHA) is an inherited autosomal dominant disorder characterized by giant platelets and inclusion bodies in granulocytes, and thrombocytopenia. There is no consensus on the perioperative management of this disorder. We report a case involving a patient with MHA who was perioperatively managed withou...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-018-2522-8
更新日期:2018-08-01 00:00:00
abstract::The aim of this study was to determine what effects low reactive-level laser irradiation (LLLI) of the stellate ganglion might have on the sympathetic fibers of the stellate ganglion in dogs. Following general anesthesia, the right stellate ganglion was exposed by thoracotomy. After stabilization, the following baseli...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/BF02479853
更新日期:1995-06-01 00:00:00
abstract:BACKGROUND:Emergency surgery itself induces high risk for postoperative mortality and morbidities; however, it remains unknown which concomitant pathological conditions of emergency surgeries are causative factors of deteriorating outcomes. This study examined the causal factors of postoperative mortality and morbidity...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-013-1639-z
更新日期:2013-12-01 00:00:00
abstract:PURPOSE:The newly introduced erector spinae plane block (ESPB) has given anesthesiologists an alternative regional anesthetic technique for thoracic analgesia. Although ESPB and retrolaminar block (RLB) have similar puncture sites, no clinical study comparing ESPB and RLB has been reported. The aim of this study was to...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-020-02855-y
更新日期:2021-02-01 00:00:00
abstract::Anesthesiologists daily witness the consequences of tobacco use, the most common preventable cause of death. Smoking-related diseases such as atherosclerosis and chronic obstructive pulmonary disease increase anesthetic risk, and even smokers without overt disease are at increased risk for morbidity such as pulmonary ...
journal_title:Journal of anesthesia
pub_type: 杂志文章,评审
doi:10.1007/s00540-006-0483-9
更新日期:2007-01-01 00:00:00
abstract::Enzyme inhibition on anaerobic dehalogenation of halothane by various analgesic or hypnotic agents was investigated in vitro using rat liver microsomal fraction. The production rate of chloro-difluoro-ethylene (CDE) and chloro-trifluoro-ethane (CTE), anaerobic metabolites of halothane, was measured when various concen...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s0054010050331
更新日期:1991-10-01 00:00:00
abstract:PURPOSE:In order to elucidate the prominent factors involved in intraoperative bradycardia in adult patients, we retrospectively investigated the association between the potential risk factors and intraoperative bradycardia, using multiple logistic regression. METHODS:The perioperative records for 499 adult patients w...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-006-0469-7
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:The effect of the Mega Acer kit(@), a new heated and humidified breathing circuit (HHBC) containing a fluid-warming device, was investigated on intraoperative core temperature (T c). METHODS:A total of 102 patients undergoing elective craniotomies were randomly divided into three groups based on the breathi...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-015-1994-z
更新日期:2015-08-01 00:00:00
abstract:PURPOSE:We aimed to evaluate postoperative analgesia of morphine, or clonidine, or morphine plus clonidine, added to caudal bupivacaine in children undergoing infra-umbilical urological and genital procedures. METHODS:Eighty patients aged 1-10 years were prospectively enrolled. After the induction of general anesthesi...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-011-1297-y
更新日期:2012-04-01 00:00:00
abstract::To evaluate the effects of cardiopulmonary bypass (CPB) on the release of polymorphonuclear leukocyte elastase (PMN-E) and postoperative pulmonary function, the perioperative plasma levels of PMN-E in α1-antitrypsin complex (EAC) and hydrogen peroxide concentration in the expired breath were measured in eight patients...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/BF02479945
更新日期:1995-12-01 00:00:00