The effect of anesthetic technique on µ-opioid receptor expression and immune cell infiltration in breast cancer.

Abstract:

BACKGROUND:Clinical histological studies demonstrate that the distribution of natural killer (NK) cells, other immune cells and μ-opioid receptors (MOR) within cancer tissue can predict cancer prognosis. No clinical study has evaluated whether anesthetic technique influences immune cell and MOR expression within human breast cancer. METHODS:Excised preoperative biopsies and intraoperative breast cancer specimens from 20 patients randomly chosen from patients previously enrolled in an ongoing, prospective, randomized trial (NCT00418457) investigating the effect of anesthetic technique on long-term breast cancer outcome were immunohistochemically stained and microscopically examined by two independent investigators, masked to randomization, to quantify MOR and immune cell infiltration: CD56, CD57 (NK cells), CD4 (T helper cells), CD8 (cytotoxic T cells) and CD68 (macrophages). Patients had been randomized to receive either a propofol-paravertebral anesthetic with continuing analgesia (PPA, n = 10) or balanced general anesthetic with opioid analgesia (GA, n = 10). RESULTS:There were no differences between the groups in staining intensity in preoperative biopsy specimens. Expression intensity values (median 25-75%) for MOR in intraoperative resected biopsy were higher in GA 8.5 (3-17) versus PPA 1 (0-10), p = 0.04. The numbers of MOR-positive cells were also higher in GA patients. Expression and absolute numbers of CD56, CD57, CD4 and CD68 were similar in resected tumor in both groups. CONCLUSION:General anesthesia with opioid analgesia increased resected tumor MOR expression compared with propofol-paravertebral anesthetic technique, but the anesthetic technique did not significantly influence the expression of immune cell markers.

journal_name

J Anesth

journal_title

Journal of anesthesia

authors

Levins KJ,Prendeville S,Conlon S,Buggy DJ

doi

10.1007/s00540-018-2554-0

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

792-796

issue

6

eissn

0913-8668

issn

1438-8359

pii

10.1007/s00540-018-2554-0

journal_volume

32

pub_type

杂志文章,多中心研究,随机对照试验
  • Anesthetic management for ascending aorta replacement in a patient who refused autologous transfusion for religious reasons.

    abstract::We report on the anesthetic management of a 69-year-old female Jehovah's Witness undergoing cardiopulmonary bypass to replace the ascending aorta; the patient refused transfusion of stored autologous or allogeneic blood products for religious reasons. The strategy involved preoperative hematopoiesis with recombinant h...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/s00540-009-0764-1

    authors: Obara S,Nakagawa M,Takahashi S,Akatu M,Isosu T,Murakawa M

    更新日期:2009-01-01 00:00:00

  • Lightwand: a useful aid in faciomaxillary trauma.

    abstract::Airway management in patients of faciomaxillary injury is of great concern to the anesthesiologist. Bag and mask ventilation and orotracheal intubation may be difficult with these patients. Recently, a middle aged, obese female presented in the emergency department after sustaining a blast injury, with laceration of t...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/s00540-010-1091-2

    authors: Jain S,Bhadani U

    更新日期:2011-04-01 00:00:00

  • Amsorb Plus and Drägersorb Free, two new-generation carbon dioxide absorbents that produce a low compound A concentration while providing sufficient CO2 absorption capacity in simulated sevoflurane anesthesia.

    abstract:PURPOSE:The properties of two new-generation CO(2) absorbents, Amsorb Plus (Armstrong Medical, Coleraine, UK) and Drägersorb Free (Drager, Lubeck, Germany), were compared with those of Amsorb (Armstrong Medical) and Sodasorb II (W.R. Grace, Lexington, MA, USA). METHODS:The concentration of compound A produced by each ...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/s00540-004-0253-5

    authors: Kobayashi S,Bito H,Morita K,Katoh T,Sato S

    更新日期:2004-01-01 00:00:00

  • Dexmedetomidine: a review of applications for cardiac surgery during perioperative period.

    abstract::Cardiac surgery is associated with a high incidence of cardiovascular and other complications during the perioperative period that translate into increased mortality and prolonged hospital stays. Safe comprehensive perioperative management is required to eliminate these adverse events. Dexmedetomidine is a selective α...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章,评审

    doi:10.1007/s00540-014-1857-z

    authors: Zhang X,Zhao X,Wang Y

    更新日期:2015-02-01 00:00:00

  • Comparison of anesthetic effects of epidural and intravenous administration of buprenorphine during operation.

    abstract::Thirty six patients were received epidural anesthesia with or without buprenorphine (BPN) during upper abdominal surgery. They were divided into three groups of 12 patients as follows; G-I received 20 ml of 1% lidocaine epidurally, G-II received 20 ml of 1% lidocaine epidurally and 0.6 mg BPN intravenously, G-III rece...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/s0054000040242

    authors: Yonemura E,Fukushima K

    更新日期:1990-07-01 00:00:00

  • Effect of infraorbital nerve block under general anesthesia on consumption of isoflurane and postoperative pain in endoscopic endonasal maxillary sinus surgery.

    abstract:PURPOSE:The efficacy of infraorbital nerve block in reducing isoflurane consumption and postoperative pain was evaluated in patients undergoing endoscopic endonasal maxillary sinus surgery (ESS) under general anesthesia. METHODS:Fifty patients were randomly allocated to either the block group (n =15) or the nonblock g...

    journal_title:Journal of anesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/s005400170014

    authors: Higashizawa T,Koga Y

    更新日期:2001-01-01 00:00:00

  • Pulsed radiofrequency under ultrasound guidance for the tarsal tunnel syndrome: two case reports.

    abstract::Tarsal tunnel syndrome (TTS) is a compression neuropathy that results from entrapment of the posterior tibial nerve or its branches. TTS may be treated either by conservative measures, including physical therapy, medications, and steroid injections, or by surgical decompression. Despite a variety of treatments, a few ...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/s00540-014-1831-9

    authors: Chon JY,Hahn YJ,Sung CH,Jung SH,Moon HS

    更新日期:2014-12-01 00:00:00

  • Anesthetic management of simultaneous coronary artery bypass grafting and cardiac pheochromocytoma resection under cardiopulmonary bypass.

    abstract::We experienced simultaneous coronary artery bypass grafting and cardiac pheochromocytoma resection under cardiopulmonary bypass in a 79-year-old woman with atherosclerotic angina. During manipulation of the tumor under cardiopulmonary bypass, the serum norepinephrine concentration increased to over seventy times the n...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/s00540-007-0549-3

    authors: Kojima Y,Kitahara H,Kimura H,Nakamura T,Ina H,Yokota S

    更新日期:2007-01-01 00:00:00

  • Antinociceptive effect of intracerebroventricular administration of D-serine on formalin-induced pain.

    abstract:PURPOSE:In a previous study using the tail-flick test, we found that intracerebroventricular administration of D-serine, an endogenous co-agonist at the glycine sites of N-methyl-D-aspartate (NMDA) receptors, elicited an antinociceptive effect on thermal nociception. The purpose of the present study was to evaluate the...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/s00540-013-1708-3

    authors: Ito M,Yoshikawa M,Ito K,Matsuda M,Jin XL,Takahashi S,Kobayashi H,Suzuki T

    更新日期:2014-04-01 00:00:00

  • A randomized comparison of the i-gel and the ProSeal laryngeal mask airway in pediatric patients: performance and fiberoptic findings.

    abstract:PURPOSE:We compared the insertion performance of the pediatric size 1.5-3 i-gel airway device with that of the ProSeal laryngeal mask airway (PLMA) in anesthetized children in a prospective, randomized, controlled manner. METHODS:We included 134 children, aged 3 months to 15 years, scheduled for elective surgery under...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00540-012-1477-4

    authors: Fukuhara A,Okutani R,Oda Y

    更新日期:2013-02-01 00:00:00

  • Percutaneous intradiscal high-pressure injection of saline and lidocaine in patients with lumbar intervertebral disc extrusion.

    abstract::The intradiscal high-pressure injection of saline and lidocaine (IDHP) is a minimally invasive percutaneous procedure for a lumbar intervertebral disc extrusion. The purpose of this study was to investigate the clinical outcomes of IDHP in terms of pain relief, reduction of disability, and risk of complications. Thirt...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/s00540-012-1419-1

    authors: Fukui S,Nitta K,Iwashita N,Tomie H,Nosaka S

    更新日期:2012-10-01 00:00:00

  • Estimation of the success rate of anesthetic management for thymectomy in patients with myasthenia gravis treated without muscle relaxants: a retrospective observational cohort study.

    abstract::Although maintaining anesthesia for myasthenia gravis (MG) with minimal muscle relaxants (MR) is common, the success rate of anesthetic management for MG without MR is not clear. We therefore retrospectively examined the success rate of anesthetic management for MG without MR among 66 consecutive cases of thymectomy f...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/s00540-015-1999-7

    authors: Fujita Y,Moriyama S,Aoki S,Yoshizawa S,Tomita M,Kojima T,Mori Y,Takeuchi N,So MH,Yano M,Sobue K

    更新日期:2015-10-01 00:00:00

  • Application of positive end-expiratory pressure in a case with large laceration on the superior vena cava.

    abstract::Iatrogenic injury is a difficult situation for a surgeon. Being successful in saving a patient at risk is the major concern in this situation. Once an iatrogenic injury to the superior vena cava (SVC) is found, increasing the intrathoracic pressure is theoretically able to overcome the venous pressure and to alleviate...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/s00540-009-0857-x

    authors: Chao CS,Chao CT,Chin HK,Chang YP

    更新日期:2010-04-01 00:00:00

  • Inhibition of neutrophil elastase contributes to attenuation of lipopolysaccharide-induced acute lung injury during neutropenia recovery in mice.

    abstract:PURPOSE:Patients in whom neutropenia recovery is complicated by pneumonia have an increased risk of acute lung injury (ALI) and detrimental outcomes. The aim of the present study was to investigate whether inhibition of neutrophil elastase (NE) is effective in lipopolysaccharide (LPS)-induced ALI during neutropenia rec...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/s00540-017-2311-9

    authors: Lee JM,Yeo CD,Lee HY,Rhee CK,Kim IK,Lee DG,Lee SH,Kim JW

    更新日期:2017-06-01 00:00:00

  • Incidence of hypoxia and related events detected by pulse oximeters provided by the Lifebox Foundation in the maternity unit at Sylvanus Olympio University Teaching Hospital, Togo.

    abstract::In recent decades anesthesia safety has not been improved in low-income countries. This prospective audit describes the incidence of hypoxia and related events detected among a cohort of patients undergoing surgery in the maternity unit at Sylvanus Olympio University Teaching Hospital, Togo, West Africa, by using puls...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/s00540-015-2048-2

    authors: Sama HD,Maman AF,Walker IA

    更新日期:2015-12-01 00:00:00

  • Anesthetic management of renal transplantation in a patient with familial dysautonomia.

    abstract::Familial dysautonomia is an inherited disorder characterized by autonomic and sensory nervous system neuropathy resulting in extremely labile blood pressure (severe hypertension followed by hypotension). As more patients with familial dysautonomia reach adulthood due to improved medical treatment, perioperative encoun...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/s00540-009-0795-7

    authors: Koshibe G,Lee HT

    更新日期:2009-01-01 00:00:00

  • Chronic hyperglycemia with elevated glycated hemoglobin level and its association with postoperative acute kidney injury after a major laparoscopic abdominal surgery in diabetes patients.

    abstract:BACKGROUND:The relationship between preoperative hyperglycemia and postoperative acute kidney injury (AKI) occurrence in non-cardiac surgery including laparoscopic surgery remains unclear. This study aimed to assess the relationship between preoperative chronic hyperglycemia and postoperative AKI occurrence after a maj...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/s00540-018-2551-3

    authors: Oh TK,Han S,Oh AY,Kim S,Ryu JH

    更新日期:2018-10-01 00:00:00

  • Local cortical cerebral blood flow and response to carbon dioxide during anesthesia in patients with moyamoya disease.

    abstract:PURPOSE:The CO(2) reactivity of cortical cerebral vessels and local cortical blood flow (l-CoBF) were evaluated during anesthesia in patients with moyamoya disease who were undergoing revascularization surgery. METHODS:Using laser-Doppler flowmetry, the CO(2) reactivity of cortical cerebral vessels and l-CoBF were mea...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/s005400050043

    authors: Yusa T,Yamashiro K

    更新日期:1999-01-01 00:00:00

  • The distance from the skin to the epidural space.

    abstract::To determine whether there is any systemic relationship between the distance from the skin to the epidural space and physical constitution, the distance from the skin to the epidural space was measured in 1007 epidural punctures. The distance from the skin to the epidural space in male was greater than that in female ...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/s0054080020198

    authors: Hirabayashi Y,Matsuda I,Inoue S,Shimizu R

    更新日期:1988-09-01 00:00:00

  • Comparison of the use of the Valsalva maneuver and the eutectic mixture of local anesthetics (EMLA®) to relieve venipuncture pain: a randomized controlled trial.

    abstract:PURPOSE:Intravenous cannulation is a painful and stressful procedure. The objective of this study was to compare the analgesic efficacy of the eutectic mixture of local anesthetics (EMLA(®)) with that of the Valsalva maneuver in adult patients during i.v. cannulation. METHODS:One hundred ninety-five patients were rand...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00540-012-1540-1

    authors: Suren M,Kaya Z,Ozkan F,Erkorkmaz U,Arıcı S,Karaman S

    更新日期:2013-06-01 00:00:00

  • Anesthetic management without perioperative platelet transfusion for cervical laminectomy and laminoplasty in a case of May-Hegglin anomaly.

    abstract::May-Hegglin anomaly (MHA) is an inherited autosomal dominant disorder characterized by giant platelets and inclusion bodies in granulocytes, and thrombocytopenia. There is no consensus on the perioperative management of this disorder. We report a case involving a patient with MHA who was perioperatively managed withou...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/s00540-018-2522-8

    authors: Kumemura M,Omae T,Kou K,Sakuraba S,Niimi N,Kunishima S

    更新日期:2018-08-01 00:00:00

  • Low reactive-level laser irradiation on the stellate ganglion in dogs.

    abstract::The aim of this study was to determine what effects low reactive-level laser irradiation (LLLI) of the stellate ganglion might have on the sympathetic fibers of the stellate ganglion in dogs. Following general anesthesia, the right stellate ganglion was exposed by thoracotomy. After stabilization, the following baseli...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/BF02479853

    authors: Okuda Y,Kitajima T

    更新日期:1995-06-01 00:00:00

  • Risk factors for postoperative mortality and morbidities in emergency surgeries.

    abstract:BACKGROUND:Emergency surgery itself induces high risk for postoperative mortality and morbidities; however, it remains unknown which concomitant pathological conditions of emergency surgeries are causative factors of deteriorating outcomes. This study examined the causal factors of postoperative mortality and morbidity...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/s00540-013-1639-z

    authors: Matsuyama T,Iranami H,Fujii K,Inoue M,Nakagawa R,Kawashima K

    更新日期:2013-12-01 00:00:00

  • Erector spinae plane block versus retrolaminar block for postoperative analgesia after breast surgery: a randomized controlled trial.

    abstract:PURPOSE:The newly introduced erector spinae plane block (ESPB) has given anesthesiologists an alternative regional anesthetic technique for thoracic analgesia. Although ESPB and retrolaminar block (RLB) have similar puncture sites, no clinical study comparing ESPB and RLB has been reported. The aim of this study was to...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/s00540-020-02855-y

    authors: Sotome S,Sawada A,Wada A,Shima H,Kutomi G,Yamakage M

    更新日期:2021-02-01 00:00:00

  • Tobacco control for anesthesiologists.

    abstract::Anesthesiologists daily witness the consequences of tobacco use, the most common preventable cause of death. Smoking-related diseases such as atherosclerosis and chronic obstructive pulmonary disease increase anesthetic risk, and even smokers without overt disease are at increased risk for morbidity such as pulmonary ...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章,评审

    doi:10.1007/s00540-006-0483-9

    authors: Warner DO

    更新日期:2007-01-01 00:00:00

  • Enzyme inhibition by analgesic and hypnotic agents on anaerobic dehalogenation of halothane.

    abstract::Enzyme inhibition on anaerobic dehalogenation of halothane by various analgesic or hypnotic agents was investigated in vitro using rat liver microsomal fraction. The production rate of chloro-difluoro-ethylene (CDE) and chloro-trifluoro-ethane (CTE), anaerobic metabolites of halothane, was measured when various concen...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/s0054010050331

    authors: Yamanoue T,Kikuchi H,Fujii K,Yuge O,Kawahara M,Morio M

    更新日期:1991-10-01 00:00:00

  • Factors influencing intraoperative bradycardia in adult patients.

    abstract:PURPOSE:In order to elucidate the prominent factors involved in intraoperative bradycardia in adult patients, we retrospectively investigated the association between the potential risk factors and intraoperative bradycardia, using multiple logistic regression. METHODS:The perioperative records for 499 adult patients w...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/s00540-006-0469-7

    authors: Yorozu T,Iijima T,Matsumoto M,Yeo X,Takagi T

    更新日期:2007-01-01 00:00:00

  • Effect of a new heated and humidified breathing circuit with a fluid-warming device on intraoperative core temperature: a prospective randomized study.

    abstract:BACKGROUND:The effect of the Mega Acer kit(@), a new heated and humidified breathing circuit (HHBC) containing a fluid-warming device, was investigated on intraoperative core temperature (T c). METHODS:A total of 102 patients undergoing elective craniotomies were randomly divided into three groups based on the breathi...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00540-015-1994-z

    authors: Kim E,Lee SY,Lim YJ,Choi JY,Jeon YT,Hwang JW,Park HP

    更新日期:2015-08-01 00:00:00

  • Caudal bupivacaine supplemented with morphine or clonidine, or supplemented with morphine plus clonidine in children undergoing infra-umbilical urological and genital procedures: a prospective, randomized and double-blind study.

    abstract:PURPOSE:We aimed to evaluate postoperative analgesia of morphine, or clonidine, or morphine plus clonidine, added to caudal bupivacaine in children undergoing infra-umbilical urological and genital procedures. METHODS:Eighty patients aged 1-10 years were prospectively enrolled. After the induction of general anesthesi...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00540-011-1297-y

    authors: Fernandes ML,Pires KC,Tibúrcio MA,Gomez RS

    更新日期:2012-04-01 00:00:00

  • Relationship between plasma neutrophil elastase and respiratory index of patients who had undergone cardiac surgery with cardiopulmonary bypass.

    abstract::To evaluate the effects of cardiopulmonary bypass (CPB) on the release of polymorphonuclear leukocyte elastase (PMN-E) and postoperative pulmonary function, the perioperative plasma levels of PMN-E in α1-antitrypsin complex (EAC) and hydrogen peroxide concentration in the expired breath were measured in eight patients...

    journal_title:Journal of anesthesia

    pub_type: 杂志文章

    doi:10.1007/BF02479945

    authors: Yusa T,Nohara A,Sunagawa M

    更新日期:1995-12-01 00:00:00