Lack of the mechanoreceptor influences on ventilatory control during halothane anesthesia in humans.

Abstract:

:Mechanical influences independent of chemoreceptor function on ventilatory control were studied in halothane-anesthetized, artificially ventilated patients using the technique reported by Altose et al. (Respir Physiol 66: 171-180, 1986). Contribution of mechanical factor was indirectly assessed by comparing the values of arterial carbon dioxide tension at which the subjects started breathing efforts during CO(2) loading induced by the following two methods. 1) Partial rebreathing of expired gas and 2) Mechanical hypoventilation (successive decrease in inflation volume). These two maneuvers resulted in a similar rate of increase in end-expiratory carbon dioxide tension. However, contrary to the observation made by Altose et al. in awake volunteers, we found comparable values of ventilatory recruitment threshold for Pa(CO)(2). Thus, we speculate that halothane anesthesia and/or loss of consciousness impair transmission of afferent information from the lung and/or chest wall musculature. Such effects may be responsible for the depression of load compensatory mechanism during anesthesia.

journal_name

J Anesth

journal_title

Journal of anesthesia

authors

Kochi T,Ide T,Isono S,Mizuguchi T

doi

10.1007/s0054020060387

subject

Has Abstract

pub_date

1992-10-01 00:00:00

pages

387-94

issue

4

eissn

0913-8668

issn

1438-8359

journal_volume

6

pub_type

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