Abstract:
PURPOSE:It has been suggested that the different degrees of fade induced by nondepolarizing neuromuscular blocking agents in repetitive muscular contractions may be due to the varying affinities or binding kinetics of presynaptic nicotinic receptors. We compared the degree of fade induced by mivacurium, cisatracurium, and d-tubocurarine in the cat muscular compound action potential (mCAP). METHODS:In 21 cats, mCAPs of the gastrocnemius muscle were evoked by paired (conditioning and test stimuli) and 2 Hz train-of-four (TOF) sciatic nerve stimulation. The interval between the paired stimuli was changed stepwise from 7 to 1000 ms. The ratios of the amplitude evoked by test stimulus to that evoked by the conditioning stimulus (M2/M1 ratios) and TOF ratios were measured. After baseline variables had been obtained, the cat received either mivacurium (0.08 mg x kg(-1), n = 7), cisatracurium (0.05 mg x kg(-1), n = 7), or d-tubocurarine (0.5 mg x kg(-1), n = 7). A series of M2/M1 ratios and TOF ratios were measured at various levels of partial block during recovery. RESULTS:At 10% of baseline amplitude, all agents significantly depressed the M2/M1 ratios (i.e., fade) at relatively longer intervals of paired stimuli (mivacurium, > or = 100 ms; cisatracurium. > or = 40 ms; and d-tubocurarine, > or = 20 ms), when compared with baseline. The order of activity to produce fade was mivacurium < cisatracurium < d-tubocurarine. A similar result was obtained in TOF ratios measured at various levels of neuromuscular block. CONCLUSION:Our results suggest that mivacurium shows a lesser degree of fade during partial neuromuscular block than cisatracurium and d-tubocurarine.
journal_name
J Anesthjournal_title
Journal of anesthesiaauthors
Suzuki T,Munakata K,Watanabe N,Fukano N,Saeki S,Ogawa Sdoi
10.1007/s005400300024subject
Has Abstractpub_date
2003-01-01 00:00:00pages
98-103issue
2eissn
0913-8668issn
1438-8359journal_volume
17pub_type
杂志文章abstract:PURPOSE:Flexible fiber-optic bronchoscope-guided orotracheal intubation is a valuable technique with demonstrated benefits in the management of difficult airways. Despite its popularity with anesthesia providers, the technique is not fail-safe and airway-related complications secondary to failed intubation attempts rem...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-014-1920-9
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abstract::We report a case of diplopia during continuous epidural injection presumably caused by catheter migration. A 61-year-old woman underwent shoulder surgery under general anesthesia with cervical epidural anesthesia. The epidural catheter was placed in the C6-C7 epidural space with some difficulty before general anesthes...
journal_title:Journal of anesthesia
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journal_title:Journal of anesthesia
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journal_title:Journal of anesthesia
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doi:10.1007/BF02480091
更新日期:1998-09-01 00:00:00
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journal_title:Journal of anesthesia
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abstract:PURPOSE:We investigated whether presynaptic facilitatory M1 and/or inhibitory M2 muscarinic receptors contributed to pancuronium- and cisatracurium-induced tetanic fade. METHODS:Phrenic nerve-diaphragm muscle preparations of rats were indirectly stimulated with tetanic frequency (75 +/- 3.3 Hz; mean +/- SD). Doses of ...
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journal_title:Journal of anesthesia
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Journal of anesthesia
pub_type: 杂志文章
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journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
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更新日期:2014-10-01 00:00:00
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journal_title:Journal of anesthesia
pub_type: 杂志文章
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journal_title:Journal of anesthesia
pub_type: 临床试验,杂志文章
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journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
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更新日期:2012-12-01 00:00:00
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更新日期:2011-10-01 00:00:00
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journal_title:Journal of anesthesia
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abstract::Tracheal insufflation of oxygen (TRIO) is a form of constant-flow ventilation. We studied the effect of TRIO at a flow rate of 2 L/kg/min on arterial blood gases during external cardiac compressions in dogs with ventricular fibrillation. During the combined application of TRIO and external cardiac compressions, all an...
journal_title:Journal of anesthesia
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abstract::Fifteen infants and children (M = 7, F = 8), aged from 0 to 13 years, who underwent cardiac catheterization and cardioangiography under ketamine-diazepam anesthesia were the subjects of this study. The effect of a contrast medium, isolamate sodium (66.8%) on the plasma somolality and vasopressin concentration was stud...
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更新日期:1991-04-01 00:00:00
abstract:PURPOSE:Our purpose was to examine the effect of dexmedetomidine, when used with phenylephrine during cardiopulmonary resuscitation (CPR), on the cerebral and systemic circulations. METHODS:In pentobarbital-anesthetized, mechanically ventilated dogs, we evaluated pial vessel diameters, cerebral oxygen extraction, and ...
journal_title:Journal of anesthesia
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更新日期:2006-01-01 00:00:00
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更新日期:2019-02-01 00:00:00
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journal_title:Journal of anesthesia
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Journal of anesthesia
pub_type: 杂志文章
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更新日期:2008-01-01 00:00:00
abstract::In recent decades anesthesia safety has not been improved in low-income countries. This prospective audit describes the incidence of hypoxia and related events detected among a cohort of patients undergoing surgery in the maternity unit at Sylvanus Olympio University Teaching Hospital, Togo, West Africa, by using puls...
journal_title:Journal of anesthesia
pub_type: 杂志文章
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更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Transcutaneous electrical acupoint stimulation (TEAS), a non-invasive and non-pharmacological adjunctive intervention for perioperative analgesia, may also reduce the incidence of postoperative pulmonary complications. The effect of TEAS on video-assisted thoracic surgical (VATS) patients is still unknown, h...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
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更新日期:2017-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2013-04-01 00:00:00