Abstract：
PURPOSE:We investigated the effect of low-dose droperidol on heart rate-corrected QT (QTc) interval and interaction with propofol. METHODS:Seventy-two patients undergoing upper limb surgery were included in this study. Patients were randomly allocated to one of three groups: group S (n = 24), which received 1 ml saline; group D1 (n = 24), which received 1.25 mg droperidol; or group D2 (n = 24), which received 2.5 mg droperidol. One minute later, fentanyl (3 μg/kg) was administered. Two minutes after fentanyl administration, anesthesia was induced using propofol (1.5 mg/kg) and vecronium. Tracheal intubation was performed 3 min after the administration of propofol. Heart rate, mean arterial pressure, bispectral index, and QTc interval were recorded at the following time points: immediately before the droperidol injection (baseline); 3 min after the saline or droperidol injection; 3 min after the propofol injection; and 2 min after tracheal intubation. RESULTS:Compared to baseline, the QTc interval in group S and group D1 was significantly shorter after propofol injection, but recovered after tracheal intubation. In group D2, the QTc interval was significantly prolonged after droperidol injection, but recovered after propofol injection, and was significantly prolonged after tracheal intubation. CONCLUSIONS:We found that saline or 1.25 mg droperidol did not prolong QTc interval, whereas 2.5 mg droperidol prolonged the QTc interval significantly, and that propofol injection counteracted the prolongation of the QTc interval induced by 2.5 mg droperidol.
journal_name
J Anesthjournal_title
Journal of anesthesiaauthors
Toyoda T,Terao Y,Oji M,Okada M,Fukusaki M,Sumikawa Kdoi
10.1007/s00540-013-1625-5subject
Has Abstractpub_date
2013-12-01 00:00:00pages
885-9issue
6eissn
0913-8668issn
1438-8359journal_volume
27pub_type
杂志文章,随机对照试验abstract：PURPOSE:The present study aimed to investigate the effects of different dosages of propofol, that induced different depths of anesthesia, on the local activity and connectivity of nuclei within the cortico-reticulo-thalamic loops, as well as the release of amino acids in those nuclei. METHODS:The nonlinear dynamics an...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-019-02667-9
更新日期：2019-10-01 00:00:00
abstract：:Rectal luminal regional P(CO2) (Pr(CO2)) was compared with gastric luminal Pr(CO2) measured by automated air tonometry at intervals of 10 min in 20 children aged 6-16 years scheduled for elective surgery under general anesthesia. In 5 patients, measurement of rectal Pr(CO2) failed because of catheter-related problems....
journal_title：Journal of anesthesia
pub_type： 临床试验,杂志文章
doi：10.1007/s00540-006-0410-0
更新日期：2006-01-01 00:00:00
abstract：PURPOSE:Unilateral spinal anesthesia is beneficial in patients undergoing unilateral leg surgery. The direction and the shape of the spinal needle are thought to influence the unilateral distribution of the local anesthetic in the intrathecal space. Therefore, to study the effects of different spinal needles we compare...
journal_title：Journal of anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00540-012-1496-1
更新日期：2013-04-01 00:00:00
abstract：:Bronchial thermoplasty (BT) is a recently introduced bronchoscopic treatment for patients with asthma refractory to pharmacotherapy. Intraprocedural sedation management is important for successful performance of BT. However, the results of general anesthesia in patients undergoing BT have not been well described. The ...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-018-2485-9
更新日期：2018-06-01 00:00:00
abstract：PURPOSE:Inhaled anesthetics increase the incidence of postoperative residual neuromuscular blockade, and the mechanism is still unclear. We have investigated the synergistic effect of low-concentration inhaled anesthetics and rocuronium on inhibition of the inward current of the adult-type muscle nicotinic acetylcholin...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-012-1527-y
更新日期：2013-06-01 00:00:00
abstract：PURPOSE:Direct hemoperfusion (DHP) with polymixin B-immobilized fiber (PMX) has been reported to be effective for patients with septic shock. The aim of this study was to clarify the mechanism of PMX-DHP effect on septic shock. METHODS:The following parameters were measured in septic shock patients who were treated wi...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-005-0366-5
更新日期：2006-01-01 00:00:00
abstract：PURPOSE:Volatile anesthetics affect the cardiovascular and immune systems. Toward a better understanding of the molecular mechanisms behind the modulation exerted by these agents, we focused on the effects of halothane and isoflurane on the activation of p38 mitogen-activated protein kinase (MAPK), which plays a critic...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-004-0237-5
更新日期：2004-01-01 00:00:00
abstract：PURPOSE:The newly introduced erector spinae plane block (ESPB) has given anesthesiologists an alternative regional anesthetic technique for thoracic analgesia. Although ESPB and retrolaminar block (RLB) have similar puncture sites, no clinical study comparing ESPB and RLB has been reported. The aim of this study was to...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-020-02855-y
更新日期：2021-02-01 00:00:00
abstract：PURPOSE:Compared with open thoracotomy, minimally invasive esophagectomy (MIE) methods, such as transhiatal or thoracoscopic esophagectomy, likely have lower morbidity. However, the relationship between intraoperative fluid management and postoperative complications after MIE remains unclear. Thus, we investigated the ...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-020-02766-y
更新日期：2020-06-01 00:00:00
abstract：PURPOSE:To compare clinical advantages and hemodynamic and respiratory changes during one lung-collapsed ventilation (OLCV) using a double-lumen tube (DLT) or a single-lumen tube (SLT) with intrathoracic CO(2) insufflation, in patients undergoing thoracic sympathectomy (TS) under general anesthesia. METHODS:One hundre...
journal_title：Journal of anesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s540-002-8088-z
更新日期：2002-01-01 00:00:00
abstract：:The purpose of this study was to determine the mortality rate in 527 critically ill patients with multiple organ failure (MOF), treated in our ICU between August, 1986 and January, 1992, and to compare it with the results obtained in a group of patients studied who had been treated between October, 1978 and July, 1986...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/BF02514648
更新日期：1994-09-01 00:00:00
abstract：:Tracheomalacia after thyroidectomy is a life-threatening situation. However, it is difficult to predict postoperative tracheal obstruction with certainty. A case of a 74-year-old woman with a long-standing adenomatous goiter (98 g) is reported. She had undergone partial right lobe thyroidectomy 54 years earlier. After...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-011-1181-9
更新日期：2011-10-01 00:00:00
abstract：PURPOSE:Nowadays the size of the streamlined liner of the pharynx airway (SLIPA™) is selected by matching the width of the thyroid cartilage of the patient to the widest dimension of the SLIPA™. The objective of this work was to improve the method of selection by matching the distance between the otobasion inferius and...
journal_title：Journal of anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00540-013-1571-2
更新日期：2013-08-01 00:00:00
abstract：:In this case series study, we prospectively examined whether it might be possible to check the effect of spinal anesthesia (SA), based on the disappearance of lower extremity reflexes and spasticity, in patients with spinal cord injury (SCI), in whom the effect cannot be confirmed by the pinprick test or by using the ...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-012-1429-z
更新日期：2012-12-01 00:00:00
abstract：PURPOSE:We hypothesized that, after axillary block, positioning the patient in a lateral position with the injected side down and simultaneously in a 20° Trendelenburg position will increase the success rate and quality of the block. METHODS:Fifty patients with chronic renal failure (ASA 2-3) scheduled for arterioveno...
journal_title：Journal of anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00540-013-1766-6
更新日期：2014-08-01 00:00:00
abstract：PURPOSE:Spinal anesthesia (SA) is being increasingly used in infants to avoid the potential negative neurocognitive effects of general anesthesia (GA). However, SA has been reported to provide a relatively short duration of surgical anesthesia. METHODS:We retrospectively reviewed SA cases for surgical procedures lasti...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-018-2517-5
更新日期：2018-08-01 00:00:00
abstract：:Arthrogryposis multiplex congenita (AMC) consists of complex congenital anomalies characterized by multiple contractures. Anesthetic management of these patients requires special care: as this disease often progresses until dysfunction of multiple organ systems occur, it may have an impact on the anesthetic management...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-011-1309-y
更新日期：2012-04-01 00:00:00
abstract：PURPOSE:Patients undergoing extensive cervical spine surgery (ECSS) occasionally require emergency reintubation due to postoperative airway complications. To avoid it, an endotracheal tube is retained in patients maintained under sedation overnight. This study was conducted to determine whether dexmedetomidine would be...
journal_title：Journal of anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00540-011-1300-7
更新日期：2012-04-01 00:00:00
abstract：PURPOSE:Because the safety of intravenous fentanyl patient-controlled analgesia (iv-PCA) administered during labor remains unclear, we retrospectively examined the labor records from January 2005 to December 2007 in our institution, with a focus on both maternal and neonatal outcomes, as compared to no analgesia. METH...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-011-1292-3
更新日期：2012-04-01 00:00:00
abstract：PURPOSE:It seems controversial whether or not neutrophil elastase inhibitors are effective in attenuating myocardial ischemia/reperfusion injury. We thus investigated possible protective effects of sivelestat, a neutrophil elastase inhibitor, against myocardial stunning i.e., prolonged myocardial dysfunction following ...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-010-0948-8
更新日期：2010-08-01 00:00:00
abstract：:Enzyme inhibition on anaerobic dehalogenation of halothane by various analgesic or hypnotic agents was investigated in vitro using rat liver microsomal fraction. The production rate of chloro-difluoro-ethylene (CDE) and chloro-trifluoro-ethane (CTE), anaerobic metabolites of halothane, was measured when various concen...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s0054010050331
更新日期：1991-10-01 00:00:00
abstract：:Laryngeal mask airway (LMA) insertion was tried in 120 pediatric cases, from 2 months to 12 years of age. Initial indications for LMA were the same as for a face mask, except for two additional conditions; anticipation of difficulty with intubation and difficulty in management by a face mask. Size 2 LMA was used in th...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s0054010050160
更新日期：1991-04-01 00:00:00
abstract：:Fifteen surgical patients received an epidural injection of 12 ml of 1.5% lidocaine through a catheter placed at C7-T1, followed by further injection as required. An intravenous bolus of 0.5 mg of atropine sulfate was administered simultaneously with the initial epidural injection. The high-(HFC: 0.15-0.4 Hz) and low-...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/BF02482031
更新日期：1995-03-01 00:00:00
abstract：:Although maintaining anesthesia for myasthenia gravis (MG) with minimal muscle relaxants (MR) is common, the success rate of anesthetic management for MG without MR is not clear. We therefore retrospectively examined the success rate of anesthetic management for MG without MR among 66 consecutive cases of thymectomy f...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-015-1999-7
更新日期：2015-10-01 00:00:00
abstract：PURPOSE:The aim of this study was to determine the hemodynamic and blood gas effects of inhalational anesthetics on the maternal-fetal sheep unit. The principal hypothesis, tested in chronically instrumented near-term pregnant ewes, was that sevoflurane anesthesia may be safe and useful for the mother and fetus during ...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-009-0763-2
更新日期：2009-01-01 00:00:00
abstract：:The concentrations of extracellular glutamate (Glu), aspartate (Asp) and glycine (Gly) were measured by microdialysis method in the cortex and hippocampus before, during and after 15 min of total cerebral ischemia in dogs. The correlations between the concentrations of amino acids and the changes in EEG and evoked pot...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s0054030070334
更新日期：1993-07-01 00:00:00
abstract：PURPOSE:Atrial arrhythmias are common after non-cardiac thoracic surgery. We tested the hypothesis that TEA reduces the risk of new-onset atrial arrhythmias after pulmonary resection. METHODS:We evaluated patients who had pulmonary resection. New-onset atrial arrhythmias detected before hospital discharge was our prim...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-014-1865-z
更新日期：2015-02-01 00:00:00
abstract：PURPOSE:We hypothesized anterograde amnesia could be predicted by the bispectral index (BIS) during epidural puncture in patients premedicated with intramuscular midazolam. METHODS:We investigated 64 consecutive patients undergoing gynecological laparotomy under general anesthesia combined with epidural anesthesia. Mi...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-009-0748-1
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:Epidemiologic studies suggest the possibility of a modestly elevated risk of adverse neurodevelopmental outcomes in children exposed to anesthesia during early childhood. Sevoflurane is widely used in pediatric anesthetic practice because of its rapid induction and lower pungency. However, it is reported tha...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-018-2545-1
更新日期：2018-10-01 00:00:00
abstract：:We measured free and total catecholamine in ten patients undergoing coronary artery-bypass grafting under high-dose fentanyl (93.9 +/- 2.2 microg.kg(-1), mean +/- SE) anesthesia. Arterial blood samples were obtained: 1) before induction of anesthesia (control), 2) 1 min after intubation, 3) 1 min after skin incision, ...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s0054030070086
更新日期：1993-01-01 00:00:00
