Abstract：
BACKGROUND:Epidemiologic studies suggest the possibility of a modestly elevated risk of adverse neurodevelopmental outcomes in children exposed to anesthesia during early childhood. Sevoflurane is widely used in pediatric anesthetic practice because of its rapid induction and lower pungency. However, it is reported that sevoflurane leads to the long-term cognitive impairment. Some evidence revealed that the selective α2-adrenoreceptor agonist dexmedetomidine (DEX) exerts neuroprotective effects in various brain injury models of animals. But the role of DEX on sevoflurane-induced neuro-damage remains elusive. MATERIALS AND METHODS:In our study, we isolated the hippocampal neuron cells from newborn neonatal rats and verified the purity of neurons by immunocytochemistry. We employed the flow cytometry and western blot to examine the effect of sevoflurane, DEX and α2-adrenergic receptor antagonist yohimbine on cell cycle distribution. RESULTS:Immunocytochemistry results showed the purity of neurons > 94%, which provided a good model for neural pharmacology experiments. The exposure of sevoflurane-induced cell cycle arrest at S phase and suppressed the expression of brain-derived neurotrophic factor (BDNF) and tyrosine kinase B (TrkB). The addition of DEX suppressed sevoflurane-induced cell cycle arrest and the inhibitory of BDNF and TrkB expression. But the function of DEX was partly blocked by a α2 adrenergic receptor blocker yohimbine. CONCLUSION:Sevoflurane suppressed neuron cell proliferation via inhibiting the expression of BDNF and TrkB, and DEX relieved the neurotoxicity induced by sevoflurane via α2 adrenergic receptor. These findings provided new evidence that DEX exerted as a neuroprotective strategy in sevoflurane-induced neuro-damage, and provided new basis for the clinical application of DEX.
journal_name
J Anesthjournal_title
Journal of anesthesiaauthors
Bo LJ,Yu PX,Zhang FZ,Dong ZMdoi
10.1007/s00540-018-2545-1subject
Has Abstractpub_date
2018-10-01 00:00:00pages
717-724issue
5eissn
0913-8668issn
1438-8359pii
10.1007/s00540-018-2545-1journal_volume
32pub_type
杂志文章abstract：BACKGROUND:The purpose of this study was to assess whether preanesthetic laboratory values can predict in-hospital mortality and morbidity in patients who have undergone burr hole craniostomy due to chronic subdural hematoma. METHODS:From January 2007 to February 2016, the records of 502 consecutive patients who under...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-016-2259-1
更新日期：2016-12-01 00:00:00
abstract：:We report a case of hyperglycemic shock associated with hepatic portal venous gas. A 79-year-old woman with post-stroke depression developed severe tachycardiac atrial fibrillation and hypotension due to hypovolemia caused by severe hyperglycemia, as well as showing disseminated intravascular coagulation (DIC). Contin...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-007-0586-y
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND:The relationship between preoperative hyperglycemia and postoperative acute kidney injury (AKI) occurrence in non-cardiac surgery including laparoscopic surgery remains unclear. This study aimed to assess the relationship between preoperative chronic hyperglycemia and postoperative AKI occurrence after a maj...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-018-2551-3
更新日期：2018-10-01 00:00:00
abstract：PURPOSE:Numerous reports suggest that intravenously administered (IV) anesthetics affect postsynaptic events in the central nervous system. However, there is little evidence about how general anesthetics influence the presynaptic processes. The level of presynaptic calcium (Ca(2+)) concentration ([Ca(2+)](pre)) regulat...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-011-1186-4
更新日期：2011-10-01 00:00:00
abstract：:Within the airway management field, simulation has been used as a tool of training for over 40 years. Simulation training offers a chance of active involvement for the trainees. It can effectively enhance and upgrade the knowledge and skills of the trainees in airway management, and subsequently decrease medical error...
journal_title：Journal of anesthesia
pub_type： 杂志文章,评审
doi：10.1007/s00540-015-2116-7
更新日期：2016-04-01 00:00:00
abstract：PURPOSE:The use of low-flow anesthesia causes a discrepancy between the delivered fraction (FD) and the inspired fraction (FI) of inhaled gases. We compared the FI/FD ratios of a new circle (fresh gas inlet located between the inspiratory valve and the patient) to those of the conventional circle (fresh gas inlet locat...
journal_title：Journal of anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00540-006-0417-6
更新日期：2006-01-01 00:00:00
abstract：PURPOSE:This observational study was designed to evaluate the clinical value of cardiac output (CO) obtained via bioreactance (NICOM™) as compared with values of CO obtained via thermodilution (using pulmonary artery catheter, Vigilance™) and the thoracic bioimpedance (BioZ.com™), in patients undergoing off-pump corona...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-014-1938-z
更新日期：2015-06-01 00:00:00
abstract：PURPOSE:This study demonstrated the effects of perfluorobutane (Sonazoid®) with contrast-enhanced ultrasonography (CEUS) to identify the spread of local anesthetics in ultrasound-guided nerve block. METHODS:This study consists of simulation, cadaveric, and animal studies. In a simulation study, 1% lidocaine with 10- t...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-017-2347-x
更新日期：2017-06-01 00:00:00
abstract：:This study investigated right ventricular (RV) performance during hypotensive anesthesia and compared the effect of the vasodilators prostaglandin E1 (PGE1), nicardipine HCl (Nic), glycerin trinitrate (GTN), and isosorbide dinitrate (ISDN) on RV function. Fifty patients were allocated into four groups [PGE1 (n=20), Ni...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/BF02480070
更新日期：1997-06-01 00:00:00
abstract：:The optimal time of intravenous lidocaine for attenuation of pressor responses to laryngoscopy and endotracheal intubation was evaluated in fifty adult patients and the correlation between plasma lidocaine level and its clinical effects were also studied. The plasma lidocaine levels were highest 0.5 min after administ...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s0054000040150
更新日期：1990-04-01 00:00:00
abstract：PURPOSE:The aim of this study was to evaluate the effect of adhesiolysis followed by the injection of steroid and local anesthetic during epiduroscopy on sensory nerve function, pain, and functional disability in patients with chronic sciatica. METHODS:Epidural adhesiolysis, using epiduroscopy, followed by the injecti...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-008-0616-4
更新日期：2008-01-01 00:00:00
abstract：:Cardiac effects of sevoflurane (SE) with or without nitrous oxide were examined in the canine blood-perfused papillary muscle and sinoatrial node preparations. Although SE depressed developed tension (DT), mean arterial pressure (MAP) and heart rate of the donor dog (DHR) dose dependently, sinoatrial rate (SAR) was no...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s0054090030145
更新日期：1989-09-01 00:00:00
abstract：PURPOSE:In many countries, patients are generally allowed to have clear fluids until 2-3 h before surgery. In Japan, long preoperative fasting is still common practice. To shorten the preoperative fasting period in Japan, we tested the safety and efficacy of oral rehydration therapy until 2 h before surgery. METHODS:T...
journal_title：Journal of anesthesia
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s00540-011-1261-x
更新日期：2012-02-01 00:00:00
abstract：:We report three cases with systolic anterior motion (SAM) after mitral valve plasty. Preoperative mitral valve morphology is a risk factor for SAM. The morphological characteristics of SAM have been revealed in several studies. We found a small distance between coaptation and the interventricular septum in all cases, ...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-013-1731-4
更新日期：2014-06-01 00:00:00
abstract：BACKGROUND:Emergency surgery itself induces high risk for postoperative mortality and morbidities; however, it remains unknown which concomitant pathological conditions of emergency surgeries are causative factors of deteriorating outcomes. This study examined the causal factors of postoperative mortality and morbidity...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-013-1639-z
更新日期：2013-12-01 00:00:00
abstract：:There is little evidence of gastric excretion after ingestion of solids. We examined gastric emptying times after ingesting normal breakfast in healthy adult volunteer using ultrasonography. Eight adult volunteers fasted for 8 h, and we examined the gastric antral area in the right lateral decubitus position using ult...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-019-02694-6
更新日期：2019-12-01 00:00:00
abstract：:To evaluate the effects of subanesthetic enflurane and sevoflurane on the sympathetic nervous system (SNS) and the parasympathetic nervous system (PNS), the blood level of norepinephrine (NE) and fluctuations in the R-R intervals were measured on electrocardiogram in humans given either 0.5 MAC enflurane or sevofluran...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/BF02482745
更新日期：1994-03-01 00:00:00
abstract：PURPOSE:Spinal anesthesia (SA) is being increasingly used in infants to avoid the potential negative neurocognitive effects of general anesthesia (GA). However, SA has been reported to provide a relatively short duration of surgical anesthesia. METHODS:We retrospectively reviewed SA cases for surgical procedures lasti...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-018-2517-5
更新日期：2018-08-01 00:00:00
abstract：:In a case with malignant hyperthermia (MH), membrane fluidity of erythrocytes was studied by electron spin resonance (ESR)-spin labeling technique. The measurement was made with samples obtained during and after pyrexic crisis until full recovery. The results indicated that membrane fluidity increased during pyrexic c...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s0054070010088
更新日期：1987-03-01 00:00:00
abstract：PURPOSE:The sedative effects of pregabalin during perioperative period have not been sufficiently characterized. The aim of this study was to verify the sedative effects of premedication with pregabalin on intravenous sedation (IVS) using propofol and also to assess the influences of this agent on circulation, respirat...
journal_title：Journal of anesthesia
pub_type： 临床试验,杂志文章
doi：10.1007/s00540-017-2366-7
更新日期：2017-08-01 00:00:00
abstract：PURPOSE:This study aimed to investigate the efficacy of the ClearSight™ system (Edwards Lifesciences, Irvine, CA) for reducing the incidence of hypotension compared with the traditional oscillometric blood pressure monitoring in cesarean delivery under spinal anesthesia. METHODS:Forty patients undergoing cesarean deli...
journal_title：Journal of anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00540-018-2560-2
更新日期：2018-12-01 00:00:00
abstract：:To compare tracheal intubation with the Pentax Airway Scope (AWS) and the Macintosh laryngoscope (McL) during chest compression, 25 anesthesiologists (including 12 specialists having >5 years of experience and 13 trainees having <2 years of experience) performed tracheal intubation using either the McL or the AWS, wit...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-010-0874-9
更新日期：2010-04-01 00:00:00
abstract：:The effects of butorphanol injection on baroreflex control of heart rate were investigated using both pressor and depressor tests in eighteen adult patients. Baroreflex sensitivity was attenuated after butorphanol injection in the pressor test using phenylephrine, whereas it was unchanged in the depressor test using n...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s0054030070411
更新日期：1993-10-01 00:00:00
abstract：OBJECTIVES:When physicians become patients, they may expect special privileges, extra attention from caregivers, and non-routine treatments. Consequently, physician patients may not be treated per routine-which possibly worsens care rather than improving it. We thus tested the primary hypothesis that in-hospital mortal...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-016-2273-3
更新日期：2017-02-01 00:00:00
abstract：PURPOSE:The present study, conducted in rats, investigated whether propofol attenuates lipopolysaccharide (LPS)-triggered liver dysfunction via regulation of tumor necrosis factor (TNF)-α production in activated Kupffer cells. METHODS:Rats received LPS (500 μg/kg) under Urethane™ sedation (1 g/kg) in combination with ...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-016-2145-x
更新日期：2016-06-01 00:00:00
abstract：:Cardiopulmonary resuscitation (CPR) in the lateral position during noncardiac surgery has been described in only a few reports in the past. Here, we report a case of cardiac arrest in a 61-year-old man undergoing microvascular decompression surgery for trigeminal neuralgia in the left lateral decubitus position. Durin...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-010-0911-8
更新日期：2010-06-01 00:00:00
abstract：:In this case series study, we prospectively examined whether it might be possible to check the effect of spinal anesthesia (SA), based on the disappearance of lower extremity reflexes and spasticity, in patients with spinal cord injury (SCI), in whom the effect cannot be confirmed by the pinprick test or by using the ...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-012-1429-z
更新日期：2012-12-01 00:00:00
abstract：BACKGROUND:Transcutaneous electrical acupoint stimulation (TEAS), a non-invasive and non-pharmacological adjunctive intervention for perioperative analgesia, may also reduce the incidence of postoperative pulmonary complications. The effect of TEAS on video-assisted thoracic surgical (VATS) patients is still unknown, h...
journal_title：Journal of anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00540-015-2057-1
更新日期：2017-02-01 00:00:00
abstract：:Tarsal tunnel syndrome (TTS) is a compression neuropathy that results from entrapment of the posterior tibial nerve or its branches. TTS may be treated either by conservative measures, including physical therapy, medications, and steroid injections, or by surgical decompression. Despite a variety of treatments, a few ...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-014-1831-9
更新日期：2014-12-01 00:00:00
abstract：:A syringe pump is used to inject precise doses of drugs having a strong action; for example, vasoactive drugs. Unexpected and undetected halt of a syringe pump can lead to potentially life-threatening complications. We experienced a sudden halt in the movement of a syringe pump (Terufusion syringe pump; Terumo, Tokyo,...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-005-0382-5
更新日期：2006-01-01 00:00:00
