Abstract:
PURPOSE:Volatile anesthetics affect the cardiovascular and immune systems. Toward a better understanding of the molecular mechanisms behind the modulation exerted by these agents, we focused on the effects of halothane and isoflurane on the activation of p38 mitogen-activated protein kinase (MAPK), which plays a critical role in the cellular responses to extracellular stimuli such as lipopolysaccharide (LPS) and proinflammatory cytokines, including tumor necrosis factor (TNF) and interleukin 1 (IL-1). METHODS:Human umbilical vein endothelial cells and HeLa cells, an established cell line, were examined by molecular biological methods. Cells were treated with proinflammatory compounds with or without the volatile anesthetics. p38 MAPK activation was investigated by Western blotting analysis with phosphospecific anti-p38 MAPK antibodies. RESULTS:Isoflurane activated p38 MAPK by itself, but halothane did not. Halothane or isoflurane augmented the LPS- and TNF-induced activation of p38 MAPK. In contrast, neither halothane nor isoflurane enhanced the p38 MAPK activation induced by IL-1. Neither of the anesthetics affected H(2)O(2) or MAPK kinase 3 (MKK3)-induced p38 MAPK activation. CONCLUSION:Our in vitro results indicate that the volatile anesthetics used in the clinical field and in animal experiments modify the p38 MAPK signaling cascade and suggest that the target molecules of the anesthetics are not unique and the anesthetics regulate them differentially at clinically relevant doses.
journal_name
J Anesthjournal_title
Journal of anesthesiaauthors
Itoh T,Hirota K,Hisano T,Namba T,Fukuda Kdoi
10.1007/s00540-004-0237-5subject
Has Abstractpub_date
2004-01-01 00:00:00pages
203-9issue
3eissn
0913-8668issn
1438-8359journal_volume
18pub_type
杂志文章abstract:PURPOSE:Transthoracic esophagectomy is an invasive surgery, and the excessive surgical stress produces inflammatory cytokines, which provoke acute respiratory distress syndrome (ARDS). Sivelestat sodium hydrate-a selective neutrophil elastase inhibitor-is used to treat or prevent ARDS in patients undergoing esophagecto...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-018-2602-9
更新日期:2019-04-01 00:00:00
abstract:PURPOSE:"Juci", one of the traditional acupuncture techniques, means contralateral acupuncture; i.e., implanting a needle into an acupoint to treat a given disease or disorder, but on the side of the body opposite to the diseased side. The aim of this study was: (1) to assess acupuncture effects on formalin-induced noc...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-006-0443-4
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Clinical histological studies demonstrate that the distribution of natural killer (NK) cells, other immune cells and μ-opioid receptors (MOR) within cancer tissue can predict cancer prognosis. No clinical study has evaluated whether anesthetic technique influences immune cell and MOR expression within human ...
journal_title:Journal of anesthesia
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00540-018-2554-0
更新日期:2018-12-01 00:00:00
abstract::To evaluate the effects of cardiopulmonary bypass (CPB) on the release of polymorphonuclear leukocyte elastase (PMN-E) and postoperative pulmonary function, the perioperative plasma levels of PMN-E in α1-antitrypsin complex (EAC) and hydrogen peroxide concentration in the expired breath were measured in eight patients...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/BF02479945
更新日期:1995-12-01 00:00:00
abstract:PURPOSE:Hypoxia promotes the progression of lung cancer cells. Unfortunately, anesthetic technique might aggravate hypoxia of lung cancer cells. Sevoflurane is a commonly used anesthetic. Its effect on hypoxia-induced aggressiveness of lung cancer cells remains unknown. The aim of the study is to investigate the effect...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-015-2035-7
更新日期:2015-12-01 00:00:00
abstract::While the demand for bariatric surgery is increasing, hospital capacity remains limited. The ERABS (Enhanced Recovery After Bariatric Surgery) protocol has been implemented in a number of bariatric centers. We retrospectively compared the operating room logistics and postoperative complications between pre-ERABS and E...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-015-2089-6
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Inguinal hernia repair is a common procedure, and can be performed under spinal anesthesia. Although adequate analgesia is crucial to postoperative recovery, the optimal protective analgesic regimen remains to be established. PURPOSE:To investigate the effects of preoperative etoricoxib within a protective ...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-017-2368-5
更新日期:2017-10-01 00:00:00
abstract::We measured free and total catecholamine in ten patients undergoing coronary artery-bypass grafting under high-dose fentanyl (93.9 +/- 2.2 microg.kg(-1), mean +/- SE) anesthesia. Arterial blood samples were obtained: 1) before induction of anesthesia (control), 2) 1 min after intubation, 3) 1 min after skin incision, ...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s0054030070086
更新日期:1993-01-01 00:00:00
abstract::Laryngeal mask airway (LMA) insertion was tried in 120 pediatric cases, from 2 months to 12 years of age. Initial indications for LMA were the same as for a face mask, except for two additional conditions; anticipation of difficulty with intubation and difficulty in management by a face mask. Size 2 LMA was used in th...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s0054010050160
更新日期:1991-04-01 00:00:00
abstract:PURPOSE:Bone metastasis is one of the major causes of cancer-related pain, and not all bone cancer pain can be effectively treated. Recently, a mouse model of bone cancer pain was introduced. To test the analgesic effects of nonsteroidal antiinflammatory drugs on bone cancer pain, the authors examined the effects of or...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-005-0323-3
更新日期:2005-01-01 00:00:00
abstract::The pharmacokinetics and pharmacodynamics of vecuronium bromide were studied in patients under general anesthesia of enflurane and nitrous oxide in oxygen. Eighteen patients were randomly divided into two groups which received either 0.05 mg.kg(-1) (low dose group) or 0.20 mg.kg(-1) (high dose group) of vecuronium int...
journal_title:Journal of anesthesia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s0054020060028
更新日期:1992-01-01 00:00:00
abstract:PURPOSE:Flexible fiber-optic bronchoscope-guided orotracheal intubation is a valuable technique with demonstrated benefits in the management of difficult airways. Despite its popularity with anesthesia providers, the technique is not fail-safe and airway-related complications secondary to failed intubation attempts rem...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-014-1920-9
更新日期:2015-04-01 00:00:00
abstract::We aimed to perform an epidural patch using platelet rich plasma (PRP), which has the potential to regenerate and heal tissues via degranulation of platelets, in a 34-year-old parturient suffering from persistent post-dural puncture headache (PDPH) after failed epidural blood patch (EBP). After her admission to our un...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-017-2400-9
更新日期:2017-12-01 00:00:00
abstract:INTRODUCTION:We investigated the continuous infusion rates of rocuronium necessary to obtain the surgical muscle relaxation before, during, and after the Pringle maneuver on patients who underwent hepatectomy. METHODS:Fifteen patients were induced by total intravenous anesthesia with propofol. After obtaining the cali...
journal_title:Journal of anesthesia
pub_type: 临床试验,杂志文章
doi:10.1007/s00540-018-2498-4
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to assess whether preanesthetic laboratory values can predict in-hospital mortality and morbidity in patients who have undergone burr hole craniostomy due to chronic subdural hematoma. METHODS:From January 2007 to February 2016, the records of 502 consecutive patients who under...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-016-2259-1
更新日期:2016-12-01 00:00:00
abstract::Arthrogryposis multiplex congenita (AMC) consists of complex congenital anomalies characterized by multiple contractures. Anesthetic management of these patients requires special care: as this disease often progresses until dysfunction of multiple organ systems occur, it may have an impact on the anesthetic management...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-011-1309-y
更新日期:2012-04-01 00:00:00
abstract:PURPOSE:To study the delivery efficiency of procaterol aerosols administered through the tracheal tube (ETT) with a metered-dose inhaler (MDI) during apnea. METHODS:First, in a normal room air environment (at ambient temperatures of 24 degrees to 26 degrees C), we measured the amount of aerosol delivered through the E...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s005400200044
更新日期:2002-01-01 00:00:00
abstract::A needle guide kit will be able to improve visibility on ultrasonic images. We examined the degree of stability using a SIVA guide. The SIVA guide is a needle guide kit in which the angle is not restricted, allowing the puncture to be made at any angle. We punctured the Blue Phantom™ with a high-frequency linear probe...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-015-2021-0
更新日期:2015-10-01 00:00:00
abstract::Beta-adrenergic blockers (β-blockers) are clearly indicated for the long-term treatment of patients with systolic heart failure and post-acute myocardial infarction. Early small-scale studies reported their potential benefits for perioperative use; subsequent randomized controlled trials, however, failed to reproduce ...
journal_title:Journal of anesthesia
pub_type: 杂志文章,评审
doi:10.1007/s00540-019-02691-9
更新日期:2020-02-01 00:00:00
abstract::Although anaphylactoid reactions to local anesthetics are well known, a radioallergosorbent test (RAST) to detect specific drug reagin (IgE) anti-body has not been developed. We established RAST for local anesthetics by using carboxylic acid derivatives of lidocaine, procaine and methylparaben. Serum samples were take...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s0054090030074
更新日期:1989-03-01 00:00:00
abstract::In a case with malignant hyperthermia (MH), membrane fluidity of erythrocytes was studied by electron spin resonance (ESR)-spin labeling technique. The measurement was made with samples obtained during and after pyrexic crisis until full recovery. The results indicated that membrane fluidity increased during pyrexic c...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s0054070010088
更新日期:1987-03-01 00:00:00
abstract:PURPOSE:The diaphragm is one of the organs directly affected by abdominal sepsis. Evidence suggests that sepsis induces diaphragmatic fatigability and that activated neutrophils play a crucial role in the development of diaphragmatic fatigability. In the present study, we investigated whether olprinone, a phosphodieste...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-007-0572-4
更新日期:2008-01-01 00:00:00
abstract::Anesthesia requires informed consent because it is an invasive procedure with certain risks. However, the state of informed consent for anesthesia in Japan remains unclear. The purpose of this survey was to examine the state of informed consent for anesthesia in Japan. A questionnaire was sent to all hospitals certifi...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-005-0332-2
更新日期:2005-01-01 00:00:00
abstract:PURPOSE:The sedative effects of pregabalin during perioperative period have not been sufficiently characterized. The aim of this study was to verify the sedative effects of premedication with pregabalin on intravenous sedation (IVS) using propofol and also to assess the influences of this agent on circulation, respirat...
journal_title:Journal of anesthesia
pub_type: 临床试验,杂志文章
doi:10.1007/s00540-017-2366-7
更新日期:2017-08-01 00:00:00
abstract:PURPOSE:Intravenous infusion of lidocaine attenuates the stress response to surgery. We aimed to evaluate the effects of perioperative lidocaine on the hemodynamic and hormonal responses for cesarean delivery. METHODS:After the gaining of ethical approval, 90 patients scheduled for elective cesarean delivery were rand...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-009-0738-3
更新日期:2009-01-01 00:00:00
abstract::Neuraxial anesthesia is a common practice in obstetrics. Evidence suggests that preprocedural ultrasound versus the conventional landmark location method accurately identifies a given intervertebral space and predicts the needle insertion depth required to reach the spinal canal. However, whether the preprocedural ult...
journal_title:Journal of anesthesia
pub_type: 杂志文章,meta分析
doi:10.1007/s00540-020-02750-6
更新日期:2020-06-01 00:00:00
abstract::We present a life-threatening case of hemothorax resulting from right brachiocephalic vein perforation during right internal jugular vein catheterization. We considered that the guidewire had punctured the right brachiocephalic vein extraluminally and the catheter inserted over the guidewire had enlarged the size of t...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-008-0696-1
更新日期:2009-01-01 00:00:00
abstract:PURPOSE:We performed a multicenter, randomized, double-blind trial to assess the efficacy and safety of a single, fixed, intravenous dose of palonosetron (0.075 mg) in the treatment of established postoperative nausea and vomiting (PONV). METHODS:Three hundred and eighty-four patients who had at least one risk factors...
journal_title:Journal of anesthesia
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00540-014-1884-9
更新日期:2015-02-01 00:00:00
abstract:PURPOSE:The present study aimed to investigate the effects of different dosages of propofol, that induced different depths of anesthesia, on the local activity and connectivity of nuclei within the cortico-reticulo-thalamic loops, as well as the release of amino acids in those nuclei. METHODS:The nonlinear dynamics an...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-019-02667-9
更新日期:2019-10-01 00:00:00
abstract::We report a case involving a 55-year-old man who had a recent resection of tracheal carcinoma and tracheal reanastomosis. He subsequently developed tracheomalacia and anastomotic dehiscence requiring airway stenting via an armored endotracheal tube (ETT). Placement of the armored ETT was technically difficult. It requ...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-006-0463-0
更新日期:2007-01-01 00:00:00