Abstract:
:The purpose of this multi-center study was to evaluate the efficacy and safety of prostaglandin E1 (PGE1) administration in achieving deliberate hypotension and in treating intraoperative hypertension for patients with a history of hypertension and ischemic heart disease. PGE1 (0.08 microg.kg(-1).min(-1)) decreased systolic blood pressure from 125 +/- 29 to 106 +/- 22 mmHg (mean +/- SD) in the deliberate hypotension group (n = 158) and from 155 +/- 34 to 125 +/- 32 mmHg in the antihypertension group (n = 55). The heart rate significantly increased from 80 +/- 15 to 85 +/- 18 beats.min(-1) in the deliberate hypotension group, but was not significantly altered in the antihypertension group. The time required to obtain the desired level of blood pressure was approximately 20 min in the deliberate hypotension group. When the infusion was stopped, blood pressure returned approximately to the preinfusion level within about 20 min. No rebound hypertension was observed. PGE1 significantly increased the urine flow in patients who had a low urine flow before PGE1 infusion. Thirteen out of 213 patients (5.6%) had side effects such as excessive hypotension (1%), phlebitis (3%), and unexpected tachycardia (1%), which were alleviated gradually after discontinuation of PGE1 infusion. No dysarrhythmia and further ST segment changes in the electrocardiograms were observed. These findings suggest that PGE1 can be safely used to control arterial blood pressure during surgery in patients having preoperative hypertension and ischemic heart disease.
journal_name
J Anesthjournal_title
Journal of anesthesiaauthors
Hoka S,Yoshitake J,Dan K,Goto Y,Honda N,Morioka T,Muteki T,Okuda Y,Shigematsu A,Takasaki M,Totoki T,Yoshimura N,Intraoperative PGE1 Study Group.doi
10.1007/s0054030070173subject
Has Abstractpub_date
1993-04-01 00:00:00pages
173-83issue
2eissn
0913-8668issn
1438-8359journal_volume
7pub_type
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journal_title:Journal of anesthesia
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Journal of anesthesia
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journal_title:Journal of anesthesia
pub_type: 杂志文章
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更新日期:1996-06-01 00:00:00
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journal_title:Journal of anesthesia
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journal_title:Journal of anesthesia
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pub_type: 杂志文章
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journal_title:Journal of anesthesia
pub_type: 杂志文章
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journal_title:Journal of anesthesia
pub_type: 杂志文章
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journal_title:Journal of anesthesia
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更新日期:2017-02-01 00:00:00
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