Abstract:
:The incidence of an abnormal increase in the serum levels of glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) following anesthesia with halothane and 65% nitrous oxide in oxygen (halothane group) or with sevoflurane and 65% nitrous oxide in oxygen (sevoflurane group) was compared in women undergoing surgery for breast cancer. An abnormal increase in GOT and GPT, both defined as higher than 50 IU, occurred postoperatively in 2 of the 150 patients (1.7%) in the sevoflurane group, and in 37 of the 200 (18.5%) in the halothane group (P<0.001). The elevated levels of serum transaminases after sevoflurane ranged from 50 to 65 IU whereas those after halothane ranged from 50 to 1000 IU, except for a value greater than 5000 IU in 1 patient. In the halothane group, there was a significant association between postoperative increases in serum transaminases and previous exposure to inhalation anesthetics, postoperative mitomycin therapy, and radiation therapy (all P<0.001). The results of multivariate analysis, when data from all patients were taken together, showed that the type of anesthetic (halothane) was the highest factor related to postoperative increases in GOT and GPT (odds ratio 35.85; 95% confidence interval 5.92-217.37), followed next by prior exposure to inhalation anesthetics (8.65; 2.96-25.27), postoperative radiation therapy (4.37; 1.70-11.19), and postoperative mitomycin therapy (3.56; 1.23-10.35). These data suggest that sevoflurane is less likely to cause anesthesia-related liver dysfunction than halothane.
journal_name
J Anesthjournal_title
Journal of anesthesiaauthors
Tsujimoto S,Kato H,Minamoto Y,Miki H,Kitamura Rdoi
10.1007/BF02479843subject
Has Abstractpub_date
1995-06-01 00:00:00pages
129-134issue
2eissn
0913-8668issn
1438-8359pii
10.1007/BF02479843journal_volume
9pub_type
杂志文章abstract::The relationship between tumor size and the complexity of anesthetic management was studied using several values: plasma catecholamine concentrations, requirement of vasoactive agents, surgical time, blood loss, plasma glucose concentrations, and hemodynamic variables. Ten patients with clinical and laboratory diagnos...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/BF02514621
更新日期:1994-12-01 00:00:00
abstract:BACKGROUND:Inguinal hernia repair is a common procedure, and can be performed under spinal anesthesia. Although adequate analgesia is crucial to postoperative recovery, the optimal protective analgesic regimen remains to be established. PURPOSE:To investigate the effects of preoperative etoricoxib within a protective ...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-017-2368-5
更新日期:2017-10-01 00:00:00
abstract::Although rare, a change in visual acuity after surgery for nonocular procedures has devastating consequences. Increased recognition and discussion of this complication is reported in recent literature, most notably following spinal and cardiac surgery. Various pathologies may be responsible for perioperative visual lo...
journal_title:Journal of anesthesia
pub_type: 杂志文章,评审
doi:10.1007/s00540-013-1648-y
更新日期:2013-12-01 00:00:00
abstract::Tracheal insufflation of oxygen (TRIO) is a form of constant-flow ventilation. We studied the effect of TRIO at a flow rate of 2 L/kg/min on arterial blood gases during external cardiac compressions in dogs with ventricular fibrillation. During the combined application of TRIO and external cardiac compressions, all an...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s0054090030016
更新日期:1989-03-01 00:00:00
abstract:PURPOSE:In emergency situations, rescuers occasionally must secure the airway while the patient is in a position other than the ideal supine position. We hypothesized that the laryngeal mask airway Supreme(®) (Supreme) may be useful for emergent airway management in several positions and compared the utility of the Sup...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-011-1145-0
更新日期:2011-08-01 00:00:00
abstract::While the demand for bariatric surgery is increasing, hospital capacity remains limited. The ERABS (Enhanced Recovery After Bariatric Surgery) protocol has been implemented in a number of bariatric centers. We retrospectively compared the operating room logistics and postoperative complications between pre-ERABS and E...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-015-2089-6
更新日期:2016-02-01 00:00:00
abstract::Cervical spinal cord injury is a rare but serious complication after general anesthesia. The risk factors include traumatic cervical injury, cervical spine instability, and difficult airway management. It has also occurred in the absence of cervical instability. Here we report a patient who had a history of intermitte...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-013-1667-8
更新日期:2014-02-01 00:00:00
abstract:PURPOSE:We investigated the effect of low-dose droperidol on heart rate-corrected QT (QTc) interval and interaction with propofol. METHODS:Seventy-two patients undergoing upper limb surgery were included in this study. Patients were randomly allocated to one of three groups: group S (n = 24), which received 1 ml salin...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-013-1625-5
更新日期:2013-12-01 00:00:00
abstract::Adenosine triphosphate as well as sodium nitroprusside has been used for hypotensive anesthesia. The purpose of this study was to examine the possibility that two hypotensive drugs may exert different effects on venous capacitance during controlled hypotension. In rats anesthetized with ketamine, mean arterial pressur...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s0054070010143
更新日期:1987-09-01 00:00:00
abstract:PURPOSE:The incidence of postoperative pharyngolaryngeal complications after laryngeal mask airway (LMA) insertion can be as high as 50%. Over-inflation of the LMA cuff may be a causal factor. We conducted a single-centre parallel group randomised trial to determine whether maintaining LMA-ProSeal intra-cuff pressures ...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-014-1811-0
更新日期:2014-10-01 00:00:00
abstract::We report on five patients who underwent MRI-guided focused ultrasound ablation of prostatic cancer under epidural anesthesia with intravenous dexmedetomidine sedation. This pioneering procedure requires an immobile therapeutic field with adequate sedation and analgesia provided to the patients. Duration of the proced...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-011-1189-1
更新日期:2011-10-01 00:00:00
abstract:PURPOSE:The ProSeal™ laryngeal mask airway (PLMA) can be more difficult to insert than the classic laryngeal mask, especially in patients who have a thin palate with a steep oropharyngeal curve. Here, an oral gastric (OG) tube-guided technique is considered as a method that makes it easier to successfully insert a PLMA...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-012-1361-2
更新日期:2012-08-01 00:00:00
abstract::The acute neuroinflammatory response to surgery may play a key pathogenic role in postoperative delirium (POD). Here, we investigated the contribution of acute postoperative pain to neuroinflammation and related delirium-like behaviors after surgery in adult and aged rats. Animals were assigned into four groups: contr...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-019-02635-3
更新日期:2019-06-01 00:00:00
abstract:PURPOSE:The present study, conducted in rats, investigated whether propofol attenuates lipopolysaccharide (LPS)-triggered liver dysfunction via regulation of tumor necrosis factor (TNF)-α production in activated Kupffer cells. METHODS:Rats received LPS (500 μg/kg) under Urethane™ sedation (1 g/kg) in combination with ...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-016-2145-x
更新日期:2016-06-01 00:00:00
abstract:PURPOSE:Numerous reports suggest that intravenously administered (IV) anesthetics affect postsynaptic events in the central nervous system. However, there is little evidence about how general anesthetics influence the presynaptic processes. The level of presynaptic calcium (Ca(2+)) concentration ([Ca(2+)](pre)) regulat...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-011-1186-4
更新日期:2011-10-01 00:00:00
abstract::To evaluate the effects of cardiopulmonary bypass (CPB) on the release of polymorphonuclear leukocyte elastase (PMN-E) and postoperative pulmonary function, the perioperative plasma levels of PMN-E in α1-antitrypsin complex (EAC) and hydrogen peroxide concentration in the expired breath were measured in eight patients...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/BF02479945
更新日期:1995-12-01 00:00:00
abstract:PURPOSE:Painful neuropathic conditions of cancer pain often show little response to nonopioid and opioid analgesics but may be eased by antidepressants and anticonvulsants. Although gabapentin is effective in the treatment of neuropathic pain in patients with cancer, some patients experience intolerable side effects su...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-010-0913-6
更新日期:2010-06-01 00:00:00
abstract:PURPOSE:The aim of this pilot study was to evaluate the diagnostic value of pleth variability index (PVI) to predict fluid responsiveness in newborn infants during surgery. METHODS:PVI was continuously recorded in 29 mechanically ventilated newborn infants during surgery, and episodes of clinically indicated volume ex...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-012-1511-6
更新日期:2013-04-01 00:00:00
abstract:PURPOSE:Hereditary hemorrhagic telangiectasia is a rare autosomal dominant disease characterized by capillary malformation leading to multisite cutaneomucosal telangiectasias and multiorgan arteriovenous malformations, which can present challenges to anesthetic care. The primary aim of this report is to present a large...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-013-1601-0
更新日期:2013-10-01 00:00:00
abstract::Laparoscopic adjustable gastric banding (LAGB) is a common type of bariatric surgery worldwide, though not so in Japan. Here we report the anesthetic management of LAGB in ten Japanese patients with morbid obesity. General anesthesia was induced with propofol, fentanyl, and vecuronium bromide and maintained with sevof...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-007-0529-7
更新日期:2007-01-01 00:00:00
abstract::The direct inotropic action of seven local anesthetics: procaine, mapivacaine, lidocaine, tetracaine, chloroprocaine, bupivacaine and etidocaine were compared in isolated cat papillary muscles. All of the local anesthetics produced a dose-related depression of maximal velocity of shortening (Vmax), maximal developed f...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s0054000040001
更新日期:1990-01-01 00:00:00
abstract::A substantial proportion of patients with coronavirus disease 19 (COVID-19) develop severe respiratory failure. Although the exact pathophysiology of severe COVID-19 pneumonia remains unknown and the characteristics of these patients are heterogeneous, the acute respiratory failure often fulfills criteria for acute re...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-020-02845-0
更新日期:2020-08-31 00:00:00
abstract::Cardiac surgery-associated acute kidney injury (AKI) is a major health problem that is extremely common and has a significant effect on cardiac surgical outcomes. AKI occurs in nearly 30 % of patients undergoing cardiac surgery, with about 1-2 % of these ultimately requiring dialysis. The development of AKI predicts a...
journal_title:Journal of anesthesia
pub_type: 杂志文章,评审
doi:10.1007/s00540-012-1523-2
更新日期:2013-06-01 00:00:00
abstract:PURPOSE:This prospective, randomized trial was designed to assess whether the i-gel supraglottic airway device is suitable for volume-controlled ventilation while applying positive end-expiratory pressure (PEEP) of 5 cmH(2)O under general anesthesia. It was believed that this device might improve arterial oxygenation. ...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-013-1628-2
更新日期:2013-12-01 00:00:00
abstract::The impact of postoperative atrial fibrillation (PAF) on patient outcomes has prompted intense investigation into the optimal methods for prevention and treatment of this complication. In the prevention of PAF, β-blockers and amiodarone are particularly effective and are recommended by guidelines. However, their use r...
journal_title:Journal of anesthesia
pub_type: 杂志文章,评审
doi:10.1007/s00540-012-1330-9
更新日期:2012-06-01 00:00:00
abstract:PURPOSE:We performed a multicenter, randomized, double-blind trial to assess the efficacy and safety of a single, fixed, intravenous dose of palonosetron (0.075 mg) in the treatment of established postoperative nausea and vomiting (PONV). METHODS:Three hundred and eighty-four patients who had at least one risk factors...
journal_title:Journal of anesthesia
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00540-014-1884-9
更新日期:2015-02-01 00:00:00
abstract:AIM:Assessment of breathing on clinical examination requires visualization of "chest" wall movement. However, in mechanically ventilated paralyzed patients, chest expansion is smaller than that of the abdomen. The aim of this study was to determine chest and upper abdominal movements in mechanically ventilated patients...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-013-1703-8
更新日期:2014-04-01 00:00:00
abstract::The concentrations of placental transfer of halothane (H), enflurane (E), sevoflurane (S), and isoflurane (I) were measured in 46 patients during cesarean section. The mean inhalation times of H (0.5%), E (1%), S (0.8%), and I (0.6%) were 13 min 27 s, 13 min 49s, 13 min 20s, and 8 min 8s, respectively. The mean concen...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/BF02479867
更新日期:1995-09-01 00:00:00
abstract:PURPOSE:Morphine is a powerful analgesic but its effect is often diminished owing to the development of tolerance. It has been suggested that morphine activates microglia through its action on the toll-like receptor 4 (TLR4) in the spinal cord, leading to suppression of the morphine effect. However, it has not been exa...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-012-1469-4
更新日期:2013-02-01 00:00:00
abstract::The objective of our study was to assess the efficacy and safety of dexmedetomidine given in a small dose for a 1-h infusion as an adjuvant to local analgesia in ophthalmic operations. The study was double-blind prospective, randomized, and placebo controlled. We studied the effects of a small dose of dexmedetomidine ...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-005-0351-z
更新日期:2006-01-01 00:00:00