Comparative inotropic effects of local anesthetics in isolated cat papillary muscles.

Abstract:

:The direct inotropic action of seven local anesthetics: procaine, mapivacaine, lidocaine, tetracaine, chloroprocaine, bupivacaine and etidocaine were compared in isolated cat papillary muscles. All of the local anesthetics produced a dose-related depression of maximal velocity of shortening (Vmax), maximal developed force (Fm) and maximal dF/dt. The more potent local anesthetics such as bupivacaine and etidocaine depressed myocardial contractility at significantly lower concentrations than the less potent local anesthetics such as lidocaine and mepivacaine. Depression of Vmax by bupivacaine or etidocaine was three times greater than that by lidocaine and ten times greater than that by procaine. At the same concentration (10(-4) M), direct myocardial depression was demonstrated in the following order of severity: etidocaine >/= bupivacaine > tetracaine > chloroprocaine >/= lidocaine > mepivacaine > procaine.

journal_name

J Anesth

journal_title

Journal of anesthesia

authors

Kemmotsu O,Nakata F,Ueda M,Mizushima M,Ishikawa T,Yamamura T

doi

10.1007/s0054000040001

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

1-8

issue

1

eissn

0913-8668

issn

1438-8359

journal_volume

4

pub_type

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