Abstract：
PURPOSE:Dexmedetomidine acts as a selective α2-adrenergic receptor agonist and an imidazoline receptor agonist, both of which are known to affect insulin secretion. Here, we investigated the effects of clinically relevant concentrations of dexmedetomidine on insulin secretion under in vivo conditions. Furthermore, its underlying mechanisms were examined using isolated islets in vitro. METHODS:For the in vivo oral glucose tolerance test (OGTT), male Sprague-Dawley rats were randomly allocated to one of three groups (n = 7 in each group): two groups infused with dexmedetomidine at a low (group L) or a high (group H) dose, and one control group infused with the same amount of saline (group C). For the in vitro perifusion study, insulin released from isolated islets was measured during stepwise changes in glucose. Dexmedetomidine (0.1-100 µM) was added to the chamber. RESULTS:During the OGTT test, the insulin levels in group H were significantly lower than those in group C at 30, 60, and 90 min after glucose load. On the other hand, insulin levels in group L were comparable to those of group C at all time points. In the perfusion study, dexmedetomidine inhibited glucose-stimulated insulin secretion in a concentration-dependent manner. When co-treated with yohimbine, an α2-adrenoceptor blocker, dexmedetomidine adversely increased glucose-induced insulin secretion. However, co-treatment with idazoxan, an antagonist for α2-adrenergic and imidazoline receptors, completely abolished the action of dexmedetomidine. CONCLUSIONS:Dexmedetomidine had no effect on insulin secretion at sedative dose, whereas it significantly inhibited insulin secretion at supraclinical high concentrations mainly via the α2-adrenoceptor.
journal_name
J Anesthjournal_title
Journal of anesthesiaauthors
Takahashi T,Kawano T,Eguchi S,Chi H,Iwata H,Yokoyama Mdoi
10.1007/s00540-014-1943-2subject
Has Abstractpub_date
2015-06-01 00:00:00pages
396-402issue
3eissn
0913-8668issn
1438-8359pii
10.1007/s00540-014-1943-2journal_volume
29pub_type
杂志文章abstract：:The direct effects of nitrous oxide on left ventricular contractility and myocardial oxygen consumption (MVO2) in the ischemic isolated rat heart were studied. The rat heart was isolated and perfused by a Langendorf technique. The aortic stump was cannulated and the heart was perfused with Kumpeis solution bubbled wit...
journal_title：Journal of anesthesia
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journal_title：Journal of anesthesia
pub_type： 杂志文章,多中心研究
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journal_title：Journal of anesthesia
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journal_title：Journal of anesthesia
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更新日期：2014-12-01 00:00:00
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更新日期：2015-12-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2008-01-01 00:00:00
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journal_title：Journal of anesthesia
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journal_title：Journal of anesthesia
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pub_type： 临床试验,杂志文章
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pub_type： 杂志文章,随机对照试验
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更新日期：2006-01-01 00:00:00
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journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/BF02514709
更新日期：1994-06-01 00:00:00
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更新日期：2005-01-01 00:00:00
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journal_title：Journal of anesthesia
pub_type： 杂志文章,随机对照试验
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更新日期：2006-01-01 00:00:00
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更新日期：2010-04-01 00:00:00
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journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s0054080020028
更新日期：1988-03-01 00:00:00
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更新日期：2015-10-01 00:00:00
