Abstract:
PURPOSE:Because blood concentrations of local anesthetics sometimes reach toxic levels after transversus abdominis plane (TAP) block, reduction of the dose has been necessary to reduce the risk of systemic toxicity. We therefore investigated the effects of TAP block with 0.25 % levobupivacaine (100 mg) on postoperative pain and measured its plasma concentration after gynecological surgery. METHODS:Forty women undergoing elective open gynecological surgery were randomized to receive bilateral TAP block with 20 ml 0.25 % levobupivacaine on each side (TAP group) or not (non-TAP group) before surgery. Postoperative pain was treated with intravenous patient-controlled analgesia by use of morphine. Patients were evaluated 3 and 24 h after the end of surgery. Visual analog scale (VAS) for pain at rest and with movement, and morphine consumption were recorded. Plasma concentrations of levobupivacaine after TAP block were measured. RESULTS:Three hours after surgery, total morphine consumption was significantly lower in the TAP group (2.8 ± 1.6 mg) than in the non-TAP group (6.4 ± 4.8 mg, P = 0.03). There were no significant differences between VAS in the two groups. Mean plasma concentration of levobupivacaine peaked 10 min after TAP block (0.99 ± 0.43 μg/ml), and the highest concentration was 1.99 μg/ml. CONCLUSION:TAP block with 100 mg levobupivacaine is a safe and efficacious multimodal analgesic regimen for postoperative pain after open gynecological surgery.
journal_name
J Anesthjournal_title
Journal of anesthesiaauthors
Ishida T,Sakamoto A,Tanaka H,Ide S,Ishida K,Tanaka S,Mori T,Kawamata Mdoi
10.1007/s00540-015-1993-0subject
Has Abstractpub_date
2015-08-01 00:00:00pages
557-61issue
4eissn
0913-8668issn
1438-8359journal_volume
29pub_type
杂志文章,随机对照试验abstract::Controlled hypotension was employed during resection of lumbar herniated disc on 10 patients. Prostaglandin E(1) (PG) was used as a hypotensive agent. The systolic blood pressure was lowered less than 100 mmHg in the hypotensive group. The average blood loss during surgery was 95 +/- 41 ml for the hypotensive group co...
journal_title:Journal of anesthesia
pub_type: 杂志文章
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abstract:PURPOSE:The aim of this pilot study was to evaluate the diagnostic value of pleth variability index (PVI) to predict fluid responsiveness in newborn infants during surgery. METHODS:PVI was continuously recorded in 29 mechanically ventilated newborn infants during surgery, and episodes of clinically indicated volume ex...
journal_title:Journal of anesthesia
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journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/BF02482745
更新日期:1994-03-01 00:00:00
abstract::We report a case of diplopia during continuous epidural injection presumably caused by catheter migration. A 61-year-old woman underwent shoulder surgery under general anesthesia with cervical epidural anesthesia. The epidural catheter was placed in the C6-C7 epidural space with some difficulty before general anesthes...
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abstract::Arthrogryposis multiplex congenita (AMC) consists of complex congenital anomalies characterized by multiple contractures. Anesthetic management of these patients requires special care: as this disease often progresses until dysfunction of multiple organ systems occur, it may have an impact on the anesthetic management...
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abstract::In many anesthesia textbooks written in English, lidocaine, tetracaine, bupivacaine, ropivacaine, and chloroprocaine are listed as useful local anesthetics for spinal anesthesia. In contrast, T-cain is not included in these lists, even though it has been reported to be suitable for spinal anesthesia in Japan. T-cain w...
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更新日期:2014-06-01 00:00:00
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journal_title:Journal of anesthesia
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journal_title:Journal of anesthesia
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更新日期:2004-01-01 00:00:00
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journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s0054020060461
更新日期:1992-10-01 00:00:00
abstract:PURPOSE:Transthoracic esophagectomy is an invasive surgery, and the excessive surgical stress produces inflammatory cytokines, which provoke acute respiratory distress syndrome (ARDS). Sivelestat sodium hydrate-a selective neutrophil elastase inhibitor-is used to treat or prevent ARDS in patients undergoing esophagecto...
journal_title:Journal of anesthesia
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更新日期:2019-04-01 00:00:00
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journal_title:Journal of anesthesia
pub_type: 杂志文章,评审
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更新日期:2013-12-01 00:00:00
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journal_title:Journal of anesthesia
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更新日期:2020-08-31 00:00:00
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更新日期:2020-12-01 00:00:00
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journal_title:Journal of anesthesia
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更新日期:2003-01-01 00:00:00
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journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-012-1447-x
更新日期:2012-12-01 00:00:00
abstract::It is recommended that the period of fasting before elective surgery should be shortened to facilitate a rapid recovery by preventing catabolism. We examined the effects of a short period of fasting on metabolism by performing indirect calorimetry (IC) under general anesthesia. A prospective observational study involv...
journal_title:Journal of anesthesia
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更新日期:2015-06-01 00:00:00
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journal_title:Journal of anesthesia
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更新日期:2014-06-01 00:00:00
abstract::Cerebral injury following cardiac surgery continues to be a significant source of morbidity and mortality after cardiac surgery. A spectrum of injuries ranging from subtle neurocognitive dysfunction to fatal strokes are caused by a complex series of multifactorial mechanisms. Protecting the brain from these injuries h...
journal_title:Journal of anesthesia
pub_type: 杂志文章,评审
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更新日期:2007-01-01 00:00:00
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更新日期:2012-08-01 00:00:00
abstract:PURPOSE:The present study, conducted in rats, investigated whether propofol attenuates lipopolysaccharide (LPS)-triggered liver dysfunction via regulation of tumor necrosis factor (TNF)-α production in activated Kupffer cells. METHODS:Rats received LPS (500 μg/kg) under Urethane™ sedation (1 g/kg) in combination with ...
journal_title:Journal of anesthesia
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doi:10.1007/s00540-016-2145-x
更新日期:2016-06-01 00:00:00
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journal_title:Journal of anesthesia
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doi:10.1007/s005400050019
更新日期:1999-01-01 00:00:00
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journal_title:Journal of anesthesia
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更新日期:2011-06-01 00:00:00
abstract::Fifteen infants and children (M = 7, F = 8), aged from 0 to 13 years, who underwent cardiac catheterization and cardioangiography under ketamine-diazepam anesthesia were the subjects of this study. The effect of a contrast medium, isolamate sodium (66.8%) on the plasma somolality and vasopressin concentration was stud...
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abstract::The concentrations of placental transfer of halothane (H), enflurane (E), sevoflurane (S), and isoflurane (I) were measured in 46 patients during cesarean section. The mean inhalation times of H (0.5%), E (1%), S (0.8%), and I (0.6%) were 13 min 27 s, 13 min 49s, 13 min 20s, and 8 min 8s, respectively. The mean concen...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/BF02479867
更新日期:1995-09-01 00:00:00
abstract:PURPOSE:Our purpose was to examine the effect of dexmedetomidine, when used with phenylephrine during cardiopulmonary resuscitation (CPR), on the cerebral and systemic circulations. METHODS:In pentobarbital-anesthetized, mechanically ventilated dogs, we evaluated pial vessel diameters, cerebral oxygen extraction, and ...
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doi:10.1007/s00540-006-0402-0
更新日期:2006-01-01 00:00:00