Abstract：
PURPOSE:Morphine is a powerful analgesic but its effect is often diminished owing to the development of tolerance. It has been suggested that morphine activates microglia through its action on the toll-like receptor 4 (TLR4) in the spinal cord, leading to suppression of the morphine effect. However, it has not been examined whether the development of morphine tolerance is affected by the deletion and mutation of the TLR4 gene. METHODS:Mice were treated with morphine (60 mg/kg) or vehicle once daily for five consecutive days to induce morphine tolerance, which was assessed by the tail-flick test before and after the treatment period. The effect of the microglial inhibitor minocycline, and the effect of TLR4 mutation (C3H/HeJ mouse) and deletion (TLR4-knockout mouse) on the development of morphine tolerance were tested. The expression of the microglial activation marker, CD11b, in the spinal cords of TLR4-knockout and wild-type mice after morphine treatment for 5 days was assessed by reverse-transcription polymerase chain reaction. RESULTS:Minocycline attenuated the development of morphine tolerance in mice. Mutation or deletion of the TLR4 gene did not significantly affect the development of morphine tolerance. CD11b mRNA expression was increased after morphine treatment both in TLR4-knockout and wild-type mice. CONCLUSION:Microglial activation caused by a mechanism independent of TLR4 is involved in the development of morphine tolerance. Further studies are necessary to clarify the cellular mechanisms of morphine-induced microglial activation.
journal_name
J Anesthjournal_title
Journal of anesthesiaauthors
Fukagawa H,Koyama T,Kakuyama M,Fukuda Kdoi
10.1007/s00540-012-1469-4subject
Has Abstractpub_date
2013-02-01 00:00:00pages
93-7issue
1eissn
0913-8668issn
1438-8359journal_volume
27pub_type
杂志文章abstract：:Opioid-related postoperative nausea and vomiting should not occur following remifentanil administration because of its relatively short time to elimination. However, studies have indicated that the incidence of postoperative nausea and vomiting associated with remifentanil is similar to that with other opioids. Hence,...
journal_title：Journal of anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00540-018-2550-4
更新日期：2018-10-01 00:00:00
abstract：:Beta-adrenergic blockers (β-blockers) are clearly indicated for the long-term treatment of patients with systolic heart failure and post-acute myocardial infarction. Early small-scale studies reported their potential benefits for perioperative use; subsequent randomized controlled trials, however, failed to reproduce ...
journal_title：Journal of anesthesia
pub_type： 杂志文章,评审
doi：10.1007/s00540-019-02691-9
更新日期：2020-02-01 00:00:00
abstract：PURPOSE:Stroke volume variation (SVV) is affected by many factors. Although elevated intra-abdominal pressure and a pneumoperitoneum have been shown to increase SVV in animals, a recent human study showed that SVV did not change as a pneumoperitoneum was established. However, we considered the results of this study que...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-014-1963-y
更新日期：2015-08-01 00:00:00
abstract：:The intradiscal high-pressure injection of saline and lidocaine (IDHP) is a minimally invasive percutaneous procedure for a lumbar intervertebral disc extrusion. The purpose of this study was to investigate the clinical outcomes of IDHP in terms of pain relief, reduction of disability, and risk of complications. Thirt...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-012-1419-1
更新日期：2012-10-01 00:00:00
abstract：:Optimal visualization of the glottis can be crucial to successful laryngoscopy. Limited information has been published on the light intensity delivered from laryngoscopes powered by rechargeable batteries. In this study the laryngoscope light intensity delivered from 10 nickel metal hydride (NiMH), 7 nickel cadmium (N...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-013-1618-4
更新日期：2013-10-01 00:00:00
abstract：PURPOSE:Bone metastasis is one of the major causes of cancer-related pain, and not all bone cancer pain can be effectively treated. Recently, a mouse model of bone cancer pain was introduced. To test the analgesic effects of nonsteroidal antiinflammatory drugs on bone cancer pain, the authors examined the effects of or...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-005-0323-3
更新日期：2005-01-01 00:00:00
abstract：PURPOSE:We compared the recovery profile of propofol and sevoflurane when used for maintenance of anesthesia in elective day care operative procedures. METHODS:One hundred ASA physical status I and II patients, aged between 18 and 50 years, were randomly assigned to receive either propofol-nitrous oxide or sevoflurane...
journal_title：Journal of anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00540-014-1827-5
更新日期：2014-12-01 00:00:00
abstract：PURPOSE:The CO(2) reactivity of cortical cerebral vessels and local cortical blood flow (l-CoBF) were evaluated during anesthesia in patients with moyamoya disease who were undergoing revascularization surgery. METHODS:Using laser-Doppler flowmetry, the CO(2) reactivity of cortical cerebral vessels and l-CoBF were mea...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s005400050043
更新日期：1999-01-01 00:00:00
abstract：PURPOSE:Patients in whom neutropenia recovery is complicated by pneumonia have an increased risk of acute lung injury (ALI) and detrimental outcomes. The aim of the present study was to investigate whether inhibition of neutrophil elastase (NE) is effective in lipopolysaccharide (LPS)-induced ALI during neutropenia rec...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-017-2311-9
更新日期：2017-06-01 00:00:00
abstract：PURPOSE:The sedative effects of pregabalin during perioperative period have not been sufficiently characterized. The aim of this study was to verify the sedative effects of premedication with pregabalin on intravenous sedation (IVS) using propofol and also to assess the influences of this agent on circulation, respirat...
journal_title：Journal of anesthesia
pub_type： 临床试验,杂志文章
doi：10.1007/s00540-017-2366-7
更新日期：2017-08-01 00:00:00
abstract：PURPOSE:There are no sufficient evidences for the sedative effect of gabapentin during anesthesia, especially intravenous sedation (IVS). The purpose of this study was to evaluate the sedative effect of gabapentin as preanesthetic medication during the IVS with propofol. METHODS:10 volunteer subjects joined this study...
journal_title：Journal of anesthesia
pub_type： 临床试验,杂志文章
doi：10.1007/s00540-018-2559-8
更新日期：2018-12-01 00:00:00
abstract：PURPOSE:Because blood concentrations of local anesthetics sometimes reach toxic levels after transversus abdominis plane (TAP) block, reduction of the dose has been necessary to reduce the risk of systemic toxicity. We therefore investigated the effects of TAP block with 0.25 % levobupivacaine (100 mg) on postoperative...
journal_title：Journal of anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00540-015-1993-0
更新日期：2015-08-01 00:00:00
abstract：PURPOSE:We hypothesized that, after axillary block, positioning the patient in a lateral position with the injected side down and simultaneously in a 20° Trendelenburg position will increase the success rate and quality of the block. METHODS:Fifty patients with chronic renal failure (ASA 2-3) scheduled for arterioveno...
journal_title：Journal of anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00540-013-1766-6
更新日期：2014-08-01 00:00:00
abstract：:The concentrations of extracellular glutamate (Glu), aspartate (Asp) and glycine (Gly) were measured by microdialysis method in the cortex and hippocampus before, during and after 15 min of total cerebral ischemia in dogs. The correlations between the concentrations of amino acids and the changes in EEG and evoked pot...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s0054030070334
更新日期：1993-07-01 00:00:00
abstract：:We have performed a systematic literature review and a meta-analysis investigating the effect of beta-adrenergic antagonist on perioperative pain in randomized clinical trials (RCTs). The search included the CENTRAL, CINAHL, EMBASE, and MEDLINE databases (from inception to 10 February 2015). From the retrieved full te...
journal_title：Journal of anesthesia
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00540-015-2041-9
更新日期：2015-12-01 00:00:00
abstract：PURPOSE:The diaphragm is one of the organs directly affected by abdominal sepsis. Evidence suggests that sepsis induces diaphragmatic fatigability and that activated neutrophils play a crucial role in the development of diaphragmatic fatigability. In the present study, we investigated whether olprinone, a phosphodieste...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-007-0572-4
更新日期：2008-01-01 00:00:00
abstract：:The purpose of this study was to determine the mortality rate in 527 critically ill patients with multiple organ failure (MOF), treated in our ICU between August, 1986 and January, 1992, and to compare it with the results obtained in a group of patients studied who had been treated between October, 1978 and July, 1986...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/BF02514648
更新日期：1994-09-01 00:00:00
abstract：PURPOSE:The present study, conducted in rats, investigated whether propofol attenuates lipopolysaccharide (LPS)-triggered liver dysfunction via regulation of tumor necrosis factor (TNF)-α production in activated Kupffer cells. METHODS:Rats received LPS (500 μg/kg) under Urethane™ sedation (1 g/kg) in combination with ...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-016-2145-x
更新日期：2016-06-01 00:00:00
abstract：:We present a case of a 33-year-old woman with Kabuki syndrome (KS) presenting with Henoch-Schönlein purpura (HSP). She was admitted to our hospital with a brain abscess in the lateral ventricle and meningitis. She had been diagnosed with KS. Skin eruptions had appeared on her lower extremities, with arthralgia, cough,...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-008-0656-9
更新日期：2008-01-01 00:00:00
abstract：PURPOSE:In a previous study using the tail-flick test, we found that intracerebroventricular administration of D-serine, an endogenous co-agonist at the glycine sites of N-methyl-D-aspartate (NMDA) receptors, elicited an antinociceptive effect on thermal nociception. The purpose of the present study was to evaluate the...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-013-1708-3
更新日期：2014-04-01 00:00:00
abstract：:A syringe pump is used to inject precise doses of drugs having a strong action; for example, vasoactive drugs. Unexpected and undetected halt of a syringe pump can lead to potentially life-threatening complications. We experienced a sudden halt in the movement of a syringe pump (Terufusion syringe pump; Terumo, Tokyo,...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-005-0382-5
更新日期：2006-01-01 00:00:00
abstract：:In recent decades anesthesia safety has not been improved in low-income countries. This prospective audit describes the incidence of hypoxia and related events detected among a cohort of patients undergoing surgery in the maternity unit at Sylvanus Olympio University Teaching Hospital, Togo, West Africa, by using puls...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-015-2048-2
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND:The purpose of this study was to assess whether preanesthetic laboratory values can predict in-hospital mortality and morbidity in patients who have undergone burr hole craniostomy due to chronic subdural hematoma. METHODS:From January 2007 to February 2016, the records of 502 consecutive patients who under...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-016-2259-1
更新日期：2016-12-01 00:00:00
abstract：PURPOSE:The general public's perceptions of anesthesia and the risks associated with it may be skewed. The outpatient preoperative appointment with an anesthesiologist allows for patient education regarding different anesthetic options and counseling regarding anxiety related to anesthesia and surgery. This study inves...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-018-02608-y
更新日期：2019-04-01 00:00:00
abstract：PURPOSE:Postoperative sore throat (POST) after general anesthesia with endotracheal intubation is a common and undesirable complication. In this study, we evaluated the combined effects of paracetamol and dexamethasone on the prevention of POST in patients after general anesthesia. METHODS:A total of 226 patients sche...
journal_title：Journal of anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00540-017-2411-6
更新日期：2017-12-01 00:00:00
abstract：:Mechanical influences independent of chemoreceptor function on ventilatory control were studied in halothane-anesthetized, artificially ventilated patients using the technique reported by Altose et al. (Respir Physiol 66: 171-180, 1986). Contribution of mechanical factor was indirectly assessed by comparing the values...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s0054020060387
更新日期：1992-10-01 00:00:00
abstract：PURPOSE:Unilateral spinal anesthesia is beneficial in patients undergoing unilateral leg surgery. The direction and the shape of the spinal needle are thought to influence the unilateral distribution of the local anesthetic in the intrathecal space. Therefore, to study the effects of different spinal needles we compare...
journal_title：Journal of anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00540-012-1496-1
更新日期：2013-04-01 00:00:00
abstract：:The effects of succinylcholine and calcium (Ca2+), alone and together, on membrane-bound acetylcholinesterase ("true-type" cholinesterase) were examined using human erythrocyte ghosts to elucidate the combined pharmacological activity of succinylcholine and calcium in in vivo system. Succinylcholine inhibited the acet...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s0054070010015
更新日期：1987-03-01 00:00:00
abstract：:Gasserian ganglion block is an established treatment for trigeminal neuralgia. A landmark approach assisted by X-ray fluoroscopy is the most common method; however, visualization of the foramen ovale is difficult in some cases. Here we report two cases in which a novel technique using modern computed tomography (CT) f...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-005-0307-3
更新日期：2005-01-01 00:00:00
abstract：PURPOSE:We assessed the accuracy of a point-of-care blood gas analyzer in providing data from saline samples obtained by gastrointestinal tonometry (Tonometrics Catheter; Tonometrics Division, Instrumentarium, Helsinki, Finland) for the calculation of intramucosal pH (pHi) and the P(CO)(2) gap (intramucosal P(CO)(2) - ...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-003-0209-1
更新日期：2004-01-01 00:00:00
