Antinociceptive effect of intracerebroventricular administration of D-serine on formalin-induced pain.

Abstract:

PURPOSE:In a previous study using the tail-flick test, we found that intracerebroventricular administration of D-serine, an endogenous co-agonist at the glycine sites of N-methyl-D-aspartate (NMDA) receptors, elicited an antinociceptive effect on thermal nociception. The purpose of the present study was to evaluate the effect of intracerebroventricular administration of D-serine on nociception induced by tissue damage or inflammation using the formalin test. METHODS:Infusion of drugs into the third ventricle in rat was performed via indwelling cannulae. Drugs were infused at a volume of 10 μl over 2 min, and the infusion cannula was left in place for 2 min before removal. The formalin test was performed 10 min after drug administration. RESULTS:Intracerebroventricular administration of D-serine significantly and dose-dependently decreased the number of flinches in both the early and late phases in the formalin test. This antinociceptive effect was antagonized by intracerebroventricular administration of L-701,324, a selective antagonist at the glycine sites of NMDA receptors. CONCLUSION:The present data suggest that activation of NMDA receptors via glycine sites at the supraspinal level induces an antinociceptive effect on both acute and tonic pain.

journal_name

J Anesth

journal_title

Journal of anesthesia

authors

Ito M,Yoshikawa M,Ito K,Matsuda M,Jin XL,Takahashi S,Kobayashi H,Suzuki T

doi

10.1007/s00540-013-1708-3

subject

Has Abstract

pub_date

2014-04-01 00:00:00

pages

228-34

issue

2

eissn

0913-8668

issn

1438-8359

journal_volume

28

pub_type

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