Abstract:
PURPOSE:Sevoflurane increases reactive oxygen species (ROS), which mediate cardioprotection against myocardial ischemia-reperfusion injury. Emerging evidence suggests that autophagy is involved in cardioprotection. We examined whether reactive oxygen species mediate sevoflurane preconditioning through autophagy. METHODS:Isolated guinea pigs hearts were subjected to 30 min ischemia followed by 120 min reperfusion (control). Anesthetic preconditioning was elicited with 2 % sevoflurane for 10 min before ischemia (SEVO). The ROS-scavenger, N-(2-mercaptopropionyl) glycine (MPG, 1 mmol/l), was administered starting 30 min before ischemia to sevoflurane-treated (SEVO + MPG) or non-sevoflurane-treated (MPG) hearts. Infarct size was determined by triphenyltetrazolium chloride stain. Tissue samples were obtained after reperfusion to determine autophagy-related protein (microtubule-associated protein light chain I and II: LC3-I, -II) and 5' AMP-activated protein kinase (AMPK) expression using Western blot analysis. Electron microscopy was used to detect autophagosomes. RESULTS:Infarct size was significantly reduced and there were more abundant autophagosomes in SEVO compared with control. Western blot analysis revealed that the ratio of LC3-II/I and phosphorylation of AMPK were significantly increased in SEVO. These effects were abolished by MPG. CONCLUSIONS:Sevoflurane induces cardioprotection through ROS-mediated upregulation of autophagy.
journal_name
J Anesthjournal_title
Journal of anesthesiaauthors
Shiomi M,Miyamae M,Takemura G,Kaneda K,Inamura Y,Onishi A,Koshinuma S,Momota Y,Minami T,Figueredo VMdoi
10.1007/s00540-013-1755-9subject
Has Abstractpub_date
2014-08-01 00:00:00pages
593-600issue
4eissn
0913-8668issn
1438-8359journal_volume
28pub_type
杂志文章abstract:PURPOSE:In a previous study using the tail-flick test, we found that intracerebroventricular administration of D-serine, an endogenous co-agonist at the glycine sites of N-methyl-D-aspartate (NMDA) receptors, elicited an antinociceptive effect on thermal nociception. The purpose of the present study was to evaluate the...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-013-1708-3
更新日期:2014-04-01 00:00:00
abstract:PURPOSE:Peripheral gangrene (PG) is a known complication requiring limb amputation among sepsis survivors; however, its incidence and associated risk factors remain controversial. We aimed to examine the incidence of limb amputation among sepsis survivors, and to investigate factors independently associated with limb a...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-020-02858-9
更新日期:2021-02-01 00:00:00
abstract:PURPOSE:Skin incision before percutaneous central venous catheterization may cause serious hemorrhage and/or skin cicatrization. To minimize these adverse effects, we improved the shape of a dilator and coated it with lubricant to reduce insertion load. METHODS:We selected three types of dilators from different manufa...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-004-0292-y
更新日期:2005-01-01 00:00:00
abstract:PURPOSE:Transthoracic esophagectomy is an invasive surgery, and the excessive surgical stress produces inflammatory cytokines, which provoke acute respiratory distress syndrome (ARDS). Sivelestat sodium hydrate-a selective neutrophil elastase inhibitor-is used to treat or prevent ARDS in patients undergoing esophagecto...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-018-2602-9
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:During the induction of anesthesia, patients are at risk of aspiration while awaiting full muscle relaxation. Magnesium has been shown to have synergistic effects with neuromuscular blocking drugs. We tested if magnesium, as an adjunct, increases the speed of onset of muscle relaxation, thereby decreasing th...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-012-1439-x
更新日期:2012-12-01 00:00:00
abstract:PURPOSE:The use of continuous epidural anesthesia in patients with chronic renal failure is rare and controversial. In this study, we compared the effects of epidural versus general anesthesia on early postoperative renal function in patients who underwent renal transplantation surgery. METHODS:Sixty-eight adult patie...
journal_title:Journal of anesthesia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s005400200004
更新日期:2002-01-01 00:00:00
abstract:PURPOSE:This study aimed to evaluate whether the three ryanodine receptor type 1 (RYR1) variants (p.Ser2345Thr, p.Ser2345Arg, and p.Lys3367Arg) which we identified in Japanese malignant hyperthermia (MH) patients with a clinical grading scale rank of 6 were causative for MH. METHODS:We prepared human embryonic kidney ...
journal_title:Journal of anesthesia
pub_type: 杂志文章,收录出版
doi:10.1007/s00540-020-02803-w
更新日期:2020-10-01 00:00:00
abstract::Lead aprons are worn by medical workers to reduce the effects of the radiation doses to which they are exposed during radiography and surgery performed with radioscopic apparatus. Regarding the management of such aprons, the Radiation Protection Section of the Japanese Society of Radiological Technology issued the "Gu...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-016-2140-2
更新日期:2016-06-01 00:00:00
abstract:PURPOSE:Painful neuropathic conditions of cancer pain often show little response to nonopioid and opioid analgesics but may be eased by antidepressants and anticonvulsants. Although gabapentin is effective in the treatment of neuropathic pain in patients with cancer, some patients experience intolerable side effects su...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-010-0913-6
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:Clinical histological studies demonstrate that the distribution of natural killer (NK) cells, other immune cells and μ-opioid receptors (MOR) within cancer tissue can predict cancer prognosis. No clinical study has evaluated whether anesthetic technique influences immune cell and MOR expression within human ...
journal_title:Journal of anesthesia
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00540-018-2554-0
更新日期:2018-12-01 00:00:00
abstract:PURPOSE:Intravenous infusion of lidocaine attenuates the stress response to surgery. We aimed to evaluate the effects of perioperative lidocaine on the hemodynamic and hormonal responses for cesarean delivery. METHODS:After the gaining of ethical approval, 90 patients scheduled for elective cesarean delivery were rand...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-009-0738-3
更新日期:2009-01-01 00:00:00
abstract:PURPOSE:Hereditary hemorrhagic telangiectasia is a rare autosomal dominant disease characterized by capillary malformation leading to multisite cutaneomucosal telangiectasias and multiorgan arteriovenous malformations, which can present challenges to anesthetic care. The primary aim of this report is to present a large...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-013-1601-0
更新日期:2013-10-01 00:00:00
abstract:PURPOSE:Morphine is a powerful analgesic but its effect is often diminished owing to the development of tolerance. It has been suggested that morphine activates microglia through its action on the toll-like receptor 4 (TLR4) in the spinal cord, leading to suppression of the morphine effect. However, it has not been exa...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-012-1469-4
更新日期:2013-02-01 00:00:00
abstract:PURPOSE:This prospective, randomized trial was designed to assess whether the i-gel supraglottic airway device is suitable for volume-controlled ventilation while applying positive end-expiratory pressure (PEEP) of 5 cmH(2)O under general anesthesia. It was believed that this device might improve arterial oxygenation. ...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-013-1628-2
更新日期:2013-12-01 00:00:00
abstract::Within the airway management field, simulation has been used as a tool of training for over 40 years. Simulation training offers a chance of active involvement for the trainees. It can effectively enhance and upgrade the knowledge and skills of the trainees in airway management, and subsequently decrease medical error...
journal_title:Journal of anesthesia
pub_type: 杂志文章,评审
doi:10.1007/s00540-015-2116-7
更新日期:2016-04-01 00:00:00
abstract::Levobupivacaine has been developed as a safer alternative to bupivacaine because of its reduced systemic toxicity. However, the effect of directly delivering levobupivacaine into tracheal smooth muscle has not been adequately explored. We performed this study to determine the in vitro effects of levobupivacaine on iso...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-015-2026-8
更新日期:2015-10-01 00:00:00
abstract:PURPOSE:Local epinephrine infiltration often causes beta1-adrenoceptor-mediated tachycardia, hypertension, and arrhythmia. Landiolol, a short acting beta1-adrenoceptor blocker, may represent the most ideal agent to attenuate these adverse effects. In this study, we examined the effects of landiolol on the hemodynamic c...
journal_title:Journal of anesthesia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00540-004-0281-1
更新日期:2005-01-01 00:00:00
abstract::Controlled hypotension was employed during resection of lumbar herniated disc on 10 patients. Prostaglandin E(1) (PG) was used as a hypotensive agent. The systolic blood pressure was lowered less than 100 mmHg in the hypotensive group. The average blood loss during surgery was 95 +/- 41 ml for the hypotensive group co...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s0054020060294
更新日期:1992-07-01 00:00:00
abstract::The excretion of trifluoroacetic acid (TFAA) in bile, saliva and gastric juice of two groups of guinea pigs with bile fistulae was measured by ion-chromatography during inhalation of halothane (0.25% and 1.0%) for two hours and after inhalation of halothane. In another two groups without bile fistulae, excretion of TF...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s0054080020133
更新日期:1988-09-01 00:00:00
abstract:PURPOSE:The purpose of this study was to determine whether intraoperative infusion of remifentanil induces acute tolerance to opioids, and compare the postoperative pain and opioid consumption by the effect site concentrations of remifentanil. METHODS:One hundred and ninety-eight patients undergoing gastrectomy were r...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-018-2569-6
更新日期:2018-12-01 00:00:00
abstract::We encountered three cases of lung disorders caused by drowning in the recent large tsunami that struck following the Great East Japan Earthquake. All three were females, and two of them were old elderly. All segments of both lungs were involved in all the three patients, necessitating ICU admission and endotracheal i...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-011-1273-6
更新日期:2012-04-01 00:00:00
abstract:AIM:Assessment of breathing on clinical examination requires visualization of "chest" wall movement. However, in mechanically ventilated paralyzed patients, chest expansion is smaller than that of the abdomen. The aim of this study was to determine chest and upper abdominal movements in mechanically ventilated patients...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-013-1703-8
更新日期:2014-04-01 00:00:00
abstract:PURPOSE:The diaphragm is one of the organs directly affected by abdominal sepsis. Evidence suggests that sepsis induces diaphragmatic fatigability and that activated neutrophils play a crucial role in the development of diaphragmatic fatigability. In the present study, we investigated whether olprinone, a phosphodieste...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-007-0572-4
更新日期:2008-01-01 00:00:00
abstract::Neuraxial anesthesia is a common practice in obstetrics. Evidence suggests that preprocedural ultrasound versus the conventional landmark location method accurately identifies a given intervertebral space and predicts the needle insertion depth required to reach the spinal canal. However, whether the preprocedural ult...
journal_title:Journal of anesthesia
pub_type: 杂志文章,meta分析
doi:10.1007/s00540-020-02750-6
更新日期:2020-06-01 00:00:00
abstract::We present a life-threatening case of hemothorax resulting from right brachiocephalic vein perforation during right internal jugular vein catheterization. We considered that the guidewire had punctured the right brachiocephalic vein extraluminally and the catheter inserted over the guidewire had enlarged the size of t...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-008-0696-1
更新日期:2009-01-01 00:00:00
abstract:PURPOSE:"Juci", one of the traditional acupuncture techniques, means contralateral acupuncture; i.e., implanting a needle into an acupoint to treat a given disease or disorder, but on the side of the body opposite to the diseased side. The aim of this study was: (1) to assess acupuncture effects on formalin-induced noc...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-006-0443-4
更新日期:2007-01-01 00:00:00
abstract::Lidocaine (1%), either in plain distilled water or in 10% dextrose, was intrathecally or epidurally administered to urethane-chloralose anesthetized cats. Electrical stimulation was applied to the gracile tract at a cervical level, and the resultant antidromic compound action potentials were recorded from the sural ne...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/BF02482066
更新日期:1996-03-01 00:00:00
abstract:PURPOSE:It seems controversial whether or not neutrophil elastase inhibitors are effective in attenuating myocardial ischemia/reperfusion injury. We thus investigated possible protective effects of sivelestat, a neutrophil elastase inhibitor, against myocardial stunning i.e., prolonged myocardial dysfunction following ...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-010-0948-8
更新日期:2010-08-01 00:00:00
abstract:PURPOSE:Atrial arrhythmias are common after non-cardiac thoracic surgery. We tested the hypothesis that TEA reduces the risk of new-onset atrial arrhythmias after pulmonary resection. METHODS:We evaluated patients who had pulmonary resection. New-onset atrial arrhythmias detected before hospital discharge was our prim...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-014-1865-z
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:We hypothesized that body shape metrics influence the anatomy of spinal canal and intraabdominal pressure in three dimensions. We explored the effects of abdominal circumference, trunk length, and their combination on the level of spinal anesthesia in the term parturient in this study. METHODS:Thirty term p...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-013-1715-4
更新日期:2014-04-01 00:00:00