Abstract：
PURPOSE:Painful neuropathic conditions of cancer pain often show little response to nonopioid and opioid analgesics but may be eased by antidepressants and anticonvulsants. Although gabapentin is effective in the treatment of neuropathic pain in patients with cancer, some patients experience intolerable side effects sufficient to warrant discontinuation. The aim of this study was to see whether low-dose gabapentin is effective in treating cancer-related neuropathic pain when combined with low-dose imipramine. METHODS:Fifty-two cancer patients diagnosed as having neuropathic pain were allocated into four groups: G400-I group took gabapentin 200 mg and imipramine 10 mg every 12 h orally; G400 group took gabapentin 200 mg every 12 h orally; G800 group took gabapentin 400 mg every 12 h orally; I group took imipramine 10 mg every 12 h orally. RESULTS:Low-dose gabapentin-imipramine significantly decreased the total pain score and daily paroxysmal pain episodes. Several patients developed mild adverse symptoms in the four groups, and three patients discontinued treatment due to severe adverse events in the G800 group. CONCLUSION:Low-dose gabapentin-antidepressant combination with opioids was effective in managing neuropathic cancer pain without severe adverse effects.
journal_name
J Anesthjournal_title
Journal of anesthesiaauthors
Arai YC,Matsubara T,Shimo K,Suetomi K,Nishihara M,Ushida T,Kobayashi K,Suzuki C,Kinoshita A,Kondo M,Matsubara S,Hayashi R,Tohyama Y,Nishida K,Arakawa Mdoi
10.1007/s00540-010-0913-6subject
Has Abstractpub_date
2010-06-01 00:00:00pages
407-10issue
3eissn
0913-8668issn
1438-8359journal_volume
24pub_type
杂志文章,随机对照试验abstract：:Cerebral injury following cardiac surgery continues to be a significant source of morbidity and mortality after cardiac surgery. A spectrum of injuries ranging from subtle neurocognitive dysfunction to fatal strokes are caused by a complex series of multifactorial mechanisms. Protecting the brain from these injuries h...
journal_title：Journal of anesthesia
pub_type： 杂志文章,评审
doi：10.1007/s00540-007-0514-1
更新日期：2007-01-01 00:00:00
abstract：:The intradiscal high-pressure injection of saline and lidocaine (IDHP) is a minimally invasive percutaneous procedure for a lumbar intervertebral disc extrusion. The purpose of this study was to investigate the clinical outcomes of IDHP in terms of pain relief, reduction of disability, and risk of complications. Thirt...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-012-1419-1
更新日期：2012-10-01 00:00:00
abstract：PURPOSE:It seems controversial whether or not neutrophil elastase inhibitors are effective in attenuating myocardial ischemia/reperfusion injury. We thus investigated possible protective effects of sivelestat, a neutrophil elastase inhibitor, against myocardial stunning i.e., prolonged myocardial dysfunction following ...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-010-0948-8
更新日期：2010-08-01 00:00:00
abstract：:A modified thermodilution catheter (KATS catheter) capable of monitoring continuous cardiac output by thermodeprivation and preserving its conventional function was devised. The KATS catheter has a thermistor incorporated closer to the tip of the catheter in addition to the usual thermistor used for conventional therm...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s0054010050205
更新日期：1991-07-01 00:00:00
abstract：:Congenital insensitivity to pain with anhidrosis (CIPA) is a rare autosomal recessive disease, characterized by episodes of unexplained fever, anhidrosis, pain insensitivity despite intact tactile perception, self-mutilating behavior, mental retardation, and autonomic nervous system (ANS) abnormalities. We present a c...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-010-0985-3
更新日期：2010-10-01 00:00:00
abstract：:Within continuously controlled limits of cuff pressure, an endotracheal tube cuff made of polyurethane (PU) prevents secretion inflow better than a conventional polyvinylchloride cuff. However, the temperature difference between ventilator gas and the air inside a PU cuff produces condensation droplets that accumulate...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-014-1849-z
更新日期：2014-12-01 00:00:00
abstract：PURPOSE:The aim of this pilot study was to evaluate the diagnostic value of pleth variability index (PVI) to predict fluid responsiveness in newborn infants during surgery. METHODS:PVI was continuously recorded in 29 mechanically ventilated newborn infants during surgery, and episodes of clinically indicated volume ex...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-012-1511-6
更新日期：2013-04-01 00:00:00
abstract：:Anesthetic management of anterior mediastinal masses (AMM) is challenging. We describe the successful anesthetic management of two patients with AMM in which dexmedetomidine was used at supra-sedative doses. Our first case was a 41-year-old man who presented with a 10 x 9 x 11 cm AMM, a pericardial effusion, compressi...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-010-0946-x
更新日期：2010-08-01 00:00:00
abstract：PURPOSE:The use of volatile anesthetics is reportedly related to altered cerebrovascular carbon dioxide (CO2) reactivity. We examined the comparative effects of sevoflurane versus isoflurane on cerebrovascular CO2 reactivity in patients with previous stroke. METHODS:Twenty-four patients with previous stroke and 20 pat...
journal_title：Journal of anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00540-008-0608-4
更新日期：2008-01-01 00:00:00
abstract：:This study investigated right ventricular (RV) performance during hypotensive anesthesia and compared the effect of the vasodilators prostaglandin E1 (PGE1), nicardipine HCl (Nic), glycerin trinitrate (GTN), and isosorbide dinitrate (ISDN) on RV function. Fifty patients were allocated into four groups [PGE1 (n=20), Ni...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/BF02480070
更新日期：1997-06-01 00:00:00
abstract：:May-Hegglin anomaly (MHA) is an inherited autosomal dominant disorder characterized by giant platelets and inclusion bodies in granulocytes, and thrombocytopenia. There is no consensus on the perioperative management of this disorder. We report a case involving a patient with MHA who was perioperatively managed withou...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-018-2522-8
更新日期：2018-08-01 00:00:00
abstract：PURPOSE:Remifentanil has been available in Japan for 3 years. The use of this new opioid is considered a useful adjuvant to general anesthesia. Knowing the exact cost-effectiveness of remifentanil should lead to improved anesthetic outcomes with a reasonable cost. METHODS:This single-blinded, prospective, randomized s...
journal_title：Journal of anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00540-010-1006-2
更新日期：2010-12-01 00:00:00
abstract：BACKGROUND:During the induction of anesthesia, patients are at risk of aspiration while awaiting full muscle relaxation. Magnesium has been shown to have synergistic effects with neuromuscular blocking drugs. We tested if magnesium, as an adjunct, increases the speed of onset of muscle relaxation, thereby decreasing th...
journal_title：Journal of anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00540-012-1439-x
更新日期：2012-12-01 00:00:00
abstract：PURPOSE:A large proportion of patients experience chronic post-surgical pain (CPSP) following inguinal hernia repair surgery. The aim of this study was to investigate the predictive risk factors and protective factors for CPSP following inguinal hernia surgery. METHODS:After institutional ethics approval was obtained,...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-020-02743-5
更新日期：2020-06-01 00:00:00
abstract：:The coronavirus disease 2019 (COVID-19) pandemic is caused by a coronavirus that is transmitted primarily via aerosol, droplets or direct contact. This may place anesthetists at higher risk of infection due to their frequent involvement in aerosol-generating airway interventions. Many anesthethetic COVID-19 guidelines...
journal_title：Journal of anesthesia
pub_type： 杂志文章,评审
doi：10.1007/s00540-020-02819-2
更新日期：2020-12-01 00:00:00
abstract：PURPOSE:We aimed to introduce a simple, lightweight continuous positive airway pressure (CPAP)-delivery device for the nondependent lung during one-lung ventilation, to investigate how the type of three-way stopcocks, and the compliance and resistance of a test lung affect the relationship between the oxygen flow rate ...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-008-0681-8
更新日期：2009-01-01 00:00:00
abstract：PURPOSE:The diaphragm is one of the organs directly affected by abdominal sepsis. Evidence suggests that sepsis induces diaphragmatic fatigability and that activated neutrophils play a crucial role in the development of diaphragmatic fatigability. In the present study, we investigated whether olprinone, a phosphodieste...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-007-0572-4
更新日期：2008-01-01 00:00:00
abstract：:Recently, gastric ultrasonography has been used as a noninvasive portable tool for evaluating gastric content and volume in adults and children. Pediatric patients are not always cooperative, especially younger ones, and it may be difficult to keep them in the appropriate scanning position without sedation. Hence, we ...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-016-2204-3
更新日期：2016-10-01 00:00:00
abstract：:The incidence of noncardiac surgery in patients with the Fontan circulation has increased over the years due to the elongated life expectancy of these patients. In patients with the Fontan circulation, pulmonary blood flow is passive, so it is important to keep pulmonary vascular resistance low. One-lung ventilation (...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-012-1333-6
更新日期：2012-06-01 00:00:00
abstract：:We report a case involving a 55-year-old man who had a recent resection of tracheal carcinoma and tracheal reanastomosis. He subsequently developed tracheomalacia and anastomotic dehiscence requiring airway stenting via an armored endotracheal tube (ETT). Placement of the armored ETT was technically difficult. It requ...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-006-0463-0
更新日期：2007-01-01 00:00:00
abstract：PURPOSE:Hereditary hemorrhagic telangiectasia is a rare autosomal dominant disease characterized by capillary malformation leading to multisite cutaneomucosal telangiectasias and multiorgan arteriovenous malformations, which can present challenges to anesthetic care. The primary aim of this report is to present a large...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-013-1601-0
更新日期：2013-10-01 00:00:00
abstract：:Perioperative positive airway pressure (PAP) is recommended by the American Society of Anesthesiologists for patients with obstructive sleep apnea, but a readily available and personalized intraoperative delivery system does not exist. We present the successful use of a patient's own nasal PAP machine in the operating...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-016-2188-z
更新日期：2016-08-01 00:00:00
abstract：PURPOSE:Unilateral spinal anesthesia is beneficial in patients undergoing unilateral leg surgery. The direction and the shape of the spinal needle are thought to influence the unilateral distribution of the local anesthetic in the intrathecal space. Therefore, to study the effects of different spinal needles we compare...
journal_title：Journal of anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00540-012-1496-1
更新日期：2013-04-01 00:00:00
abstract：BACKGROUND:Clinical histological studies demonstrate that the distribution of natural killer (NK) cells, other immune cells and μ-opioid receptors (MOR) within cancer tissue can predict cancer prognosis. No clinical study has evaluated whether anesthetic technique influences immune cell and MOR expression within human ...
journal_title：Journal of anesthesia
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s00540-018-2554-0
更新日期：2018-12-01 00:00:00
abstract：PURPOSE:The effects of propofol on sinoatrial pacemaker activity and myocardial contractility and its interaction with the autonomic nervous system were investigated in isolated, cross-circulated right atrial canine preparations. METHODS:An isolated right atrial preparation was perfused with heparinized arterial blood...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s005400050019
更新日期：1999-01-01 00:00:00
abstract：PURPOSE:In order to elucidate the prominent factors involved in intraoperative bradycardia in adult patients, we retrospectively investigated the association between the potential risk factors and intraoperative bradycardia, using multiple logistic regression. METHODS:The perioperative records for 499 adult patients w...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-006-0469-7
更新日期：2007-01-01 00:00:00
abstract：PURPOSE:Postoperative sore throat (POST) after general anesthesia with endotracheal intubation is a common and undesirable complication. In this study, we evaluated the combined effects of paracetamol and dexamethasone on the prevention of POST in patients after general anesthesia. METHODS:A total of 226 patients sche...
journal_title：Journal of anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00540-017-2411-6
更新日期：2017-12-01 00:00:00
abstract：:We describe the anesthetic management of a patient with pectus excavatum, receiving the minimally invasive Nuss operation, which corrects chest wall deformity by insertion of a convex steel bar (pectus bar). An 8-year-old female patient was scheduled for the Nuss operation. The manipulation of the bar in the thorax wa...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-004-0269-x
更新日期：2005-01-01 00:00:00
abstract：PURPOSE:Postoperative pain is an important health-care issue. Patient-controlled analgesia (PCA) is considered the gold standard for systemic postoperative pain treatment. Methadone PCA is used for patients with chronic pain and those in the palliative care setting. However, its efficacy as a first-line drug for acute ...
journal_title：Journal of anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00540-013-1785-3
更新日期：2014-08-01 00:00:00
abstract：PURPOSE:Intravenous cannulation is a painful and stressful procedure. The objective of this study was to compare the analgesic efficacy of the eutectic mixture of local anesthetics (EMLA(®)) with that of the Valsalva maneuver in adult patients during i.v. cannulation. METHODS:One hundred ninety-five patients were rand...
journal_title：Journal of anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00540-012-1540-1
更新日期：2013-06-01 00:00:00
