Abstract：
PURPOSE:Peripheral gangrene (PG) is a known complication requiring limb amputation among sepsis survivors; however, its incidence and associated risk factors remain controversial. We aimed to examine the incidence of limb amputation among sepsis survivors, and to investigate factors independently associated with limb amputation. METHODS:In this population-based cohort study, data obtained from the South Korean national health insurance service database between 2015 and 2016 were analyzed. A sepsis survivor was defined as someone having survived > 90 days after initiation of treatment for sepsis. RESULTS:Of 19,906 sepsis survivors, 163 (0.8%) had undergone surgical limb amputation. In a multivariable model, male sex (odds ratio [OR] 1.74, 95% confidence interval [CI] 1.26-2.40; P = 0.001), dopamine infusion (OR 1.78, 95% CI 1.22-2.60; P = 0.003), epinephrine infusion (OR 2.04, 95% CI 1.30-3.20; P = 0.002), continuous renal replacement therapy (OR 3.34, 95% CI 2.01-3.20; P < 0.001), diabetes mellitus (DM) without chronic complication (OR 1.73, 95% CI 1.19-2.51; P = 0.004), DM with chronic complication (OR 3.49, 95% CI 2.32-5.26; P < 0.001), and peripheral arterial disease (OR 6.79, 95% CO 3.70-12.46; P < 0.001) were associated with a higher incidence of limb amputation among sepsis survivors. CONCLUSIONS:In South Korea, 0.8% of sepsis survivors underwent limb amputation for the treatment of PG. Furthermore, the incidence of limb amputation was higher among the sepsis survivors having some underlying diseases (DM and peripheral arterial diseases) or receiving certain vasopressor treatments (epinephrine and dopamine).
journal_name
J Anesthjournal_title
Journal of anesthesiaauthors
Oh TK,Song IAdoi
10.1007/s00540-020-02858-9subject
Has Abstractpub_date
2021-02-01 00:00:00pages
51-58issue
1eissn
0913-8668issn
1438-8359pii
10.1007/s00540-020-02858-9journal_volume
35pub_type
杂志文章abstract：PURPOSE:We investigated whether presynaptic facilitatory M1 and/or inhibitory M2 muscarinic receptors contributed to pancuronium- and cisatracurium-induced tetanic fade. METHODS:Phrenic nerve-diaphragm muscle preparations of rats were indirectly stimulated with tetanic frequency (75 +/- 3.3 Hz; mean +/- SD). Doses of ...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-009-0790-z
更新日期：2009-01-01 00:00:00
abstract：:The electroencephalograms (EEG) of 55 children under isoflurane anesthesia were studied to elucidate any change in pattern with age. The children ranged from 1 month to 14 years of age were divided into six age groups. The standard minimum alveolar concentration (MAC) was determined in each group. Anesthesia was induc...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/BF02514699
更新日期：1994-06-01 00:00:00
abstract：BACKGROUND:Inguinal hernia repair is a common procedure, and can be performed under spinal anesthesia. Although adequate analgesia is crucial to postoperative recovery, the optimal protective analgesic regimen remains to be established. PURPOSE:To investigate the effects of preoperative etoricoxib within a protective ...
journal_title：Journal of anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00540-017-2368-5
更新日期：2017-10-01 00:00:00
abstract：:While the demand for bariatric surgery is increasing, hospital capacity remains limited. The ERABS (Enhanced Recovery After Bariatric Surgery) protocol has been implemented in a number of bariatric centers. We retrospectively compared the operating room logistics and postoperative complications between pre-ERABS and E...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-015-2089-6
更新日期：2016-02-01 00:00:00
abstract：:In recent decades anesthesia safety has not been improved in low-income countries. This prospective audit describes the incidence of hypoxia and related events detected among a cohort of patients undergoing surgery in the maternity unit at Sylvanus Olympio University Teaching Hospital, Togo, West Africa, by using puls...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-015-2048-2
更新日期：2015-12-01 00:00:00
abstract：:We have performed a systematic literature review and a meta-analysis investigating the effect of beta-adrenergic antagonist on perioperative pain in randomized clinical trials (RCTs). The search included the CENTRAL, CINAHL, EMBASE, and MEDLINE databases (from inception to 10 February 2015). From the retrieved full te...
journal_title：Journal of anesthesia
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00540-015-2041-9
更新日期：2015-12-01 00:00:00
abstract：:Bronchial thermoplasty (BT) is a recently introduced bronchoscopic treatment for patients with asthma refractory to pharmacotherapy. Intraprocedural sedation management is important for successful performance of BT. However, the results of general anesthesia in patients undergoing BT have not been well described. The ...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-018-2485-9
更新日期：2018-06-01 00:00:00
abstract：PURPOSE:The aim of this pilot study was to evaluate the diagnostic value of pleth variability index (PVI) to predict fluid responsiveness in newborn infants during surgery. METHODS:PVI was continuously recorded in 29 mechanically ventilated newborn infants during surgery, and episodes of clinically indicated volume ex...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-012-1511-6
更新日期：2013-04-01 00:00:00
abstract：PURPOSE:Hypoxia promotes the progression of lung cancer cells. Unfortunately, anesthetic technique might aggravate hypoxia of lung cancer cells. Sevoflurane is a commonly used anesthetic. Its effect on hypoxia-induced aggressiveness of lung cancer cells remains unknown. The aim of the study is to investigate the effect...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-015-2035-7
更新日期：2015-12-01 00:00:00
abstract：:The intradiscal high-pressure injection of saline and lidocaine (IDHP) is a minimally invasive percutaneous procedure for a lumbar intervertebral disc extrusion. The purpose of this study was to investigate the clinical outcomes of IDHP in terms of pain relief, reduction of disability, and risk of complications. Thirt...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-012-1419-1
更新日期：2012-10-01 00:00:00
abstract：PURPOSE:Postoperative pain is an important health-care issue. Patient-controlled analgesia (PCA) is considered the gold standard for systemic postoperative pain treatment. Methadone PCA is used for patients with chronic pain and those in the palliative care setting. However, its efficacy as a first-line drug for acute ...
journal_title：Journal of anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00540-013-1785-3
更新日期：2014-08-01 00:00:00
abstract：PURPOSES:In the present study, we investigated whether flurbiprofen axetil (FA) alleviates hypoxemia during one-lung ventilation (OLV) by reducing the pulmonary shunt/total perfusion (Q s/Q t) ratio, and examined the relationship between the Q s/Q t ratio and the thromboxane B2 (TXB2)/6-keto-prostaglandin F1α (6-K-PGF1...
journal_title：Journal of anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00540-015-2060-6
更新日期：2015-12-01 00:00:00
abstract：PURPOSE:The aim of this study was to determine the hemodynamic and blood gas effects of inhalational anesthetics on the maternal-fetal sheep unit. The principal hypothesis, tested in chronically instrumented near-term pregnant ewes, was that sevoflurane anesthesia may be safe and useful for the mother and fetus during ...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-009-0763-2
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:The relationship between preoperative hyperglycemia and postoperative acute kidney injury (AKI) occurrence in non-cardiac surgery including laparoscopic surgery remains unclear. This study aimed to assess the relationship between preoperative chronic hyperglycemia and postoperative AKI occurrence after a maj...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-018-2551-3
更新日期：2018-10-01 00:00:00
abstract：:Optimal visualization of the glottis can be crucial to successful laryngoscopy. Limited information has been published on the light intensity delivered from laryngoscopes powered by rechargeable batteries. In this study the laryngoscope light intensity delivered from 10 nickel metal hydride (NiMH), 7 nickel cadmium (N...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-013-1618-4
更新日期：2013-10-01 00:00:00
abstract：:A 72-year-old woman presented pulmonary embolism. Continuous intravenous administration of heparin was controlled with values of activated clotting time targeted from 150 to 180 s. On the sixth intensive care unit (ICU) day, a central vein (CV) catheter was inserted through the right axillary vein. On the ninth ICU da...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-010-0894-5
更新日期：2010-04-01 00:00:00
abstract：:The anesthesia information management system (AIMS) will be part of the future of healthcare. An electronic medical records system or AIMS will provide clear and concise information and have the potential to integrate information across the entire hospital system, improve quality of care, reduce errors, decrease risks...
journal_title：Journal of anesthesia
pub_type： 杂志文章,评审
doi：10.1007/s00540-008-0643-1
更新日期：2008-01-01 00:00:00
abstract：PURPOSE:It seems controversial whether or not neutrophil elastase inhibitors are effective in attenuating myocardial ischemia/reperfusion injury. We thus investigated possible protective effects of sivelestat, a neutrophil elastase inhibitor, against myocardial stunning i.e., prolonged myocardial dysfunction following ...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-010-0948-8
更新日期：2010-08-01 00:00:00
abstract：PURPOSE:Volatile anesthetics affect the cardiovascular and immune systems. Toward a better understanding of the molecular mechanisms behind the modulation exerted by these agents, we focused on the effects of halothane and isoflurane on the activation of p38 mitogen-activated protein kinase (MAPK), which plays a critic...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-004-0237-5
更新日期：2004-01-01 00:00:00
abstract：:The purpose of this study was to determine the mortality rate in 527 critically ill patients with multiple organ failure (MOF), treated in our ICU between August, 1986 and January, 1992, and to compare it with the results obtained in a group of patients studied who had been treated between October, 1978 and July, 1986...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/BF02514648
更新日期：1994-09-01 00:00:00
abstract：:Laparoscopic adjustable gastric banding (LAGB) is a common type of bariatric surgery worldwide, though not so in Japan. Here we report the anesthetic management of LAGB in ten Japanese patients with morbid obesity. General anesthesia was induced with propofol, fentanyl, and vecuronium bromide and maintained with sevof...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-007-0529-7
更新日期：2007-01-01 00:00:00
abstract：:Somato-sympathetic reflex discharges (SSRDs) which were induced from the lumbar sympathetic truck elicited by train pulse stimulation of femoral nerves in anesthetized cats were examined during and after intravenous infusion of 1 mg.kg(-1).min(-1) of procaine. The infusion demonstrated that amplitudes were suppressed ...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s0054020060461
更新日期：1992-10-01 00:00:00
abstract：PURPOSE:To evaluate the role of the phosphatidylinositol 3 kinase (PI3K)/protein kinase B (Akt)/hypoxia-inducible factor 1α (HIF-1α) signaling pathway in the protection by dexmedetomidine against lung ischemia-reperfusion injury (IRI) in rats. METHODS:Forty-eight male Sprague-Dawley rats weighing 250-350 g were random...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-016-2214-1
更新日期：2016-10-01 00:00:00
abstract：:Alveolar capillary dysplasia (ACD), which is a rare and lethal congenital pulmonary anomaly found in newborns, begins its onset or causes deterioration of the infant's condition some time after birth. Various congenital anomalies in combination with ACD have been reported, except for subglottic stenosis. Therefore, we...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-010-1080-5
更新日期：2011-04-01 00:00:00
abstract：:We measured free and total catecholamine in ten patients undergoing coronary artery-bypass grafting under high-dose fentanyl (93.9 +/- 2.2 microg.kg(-1), mean +/- SE) anesthesia. Arterial blood samples were obtained: 1) before induction of anesthesia (control), 2) 1 min after intubation, 3) 1 min after skin incision, ...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s0054030070086
更新日期：1993-01-01 00:00:00
abstract：:Lead aprons are worn by medical workers to reduce the effects of the radiation doses to which they are exposed during radiography and surgery performed with radioscopic apparatus. Regarding the management of such aprons, the Radiation Protection Section of the Japanese Society of Radiological Technology issued the "Gu...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-016-2140-2
更新日期：2016-06-01 00:00:00
abstract：BACKGROUND:Clinical histological studies demonstrate that the distribution of natural killer (NK) cells, other immune cells and μ-opioid receptors (MOR) within cancer tissue can predict cancer prognosis. No clinical study has evaluated whether anesthetic technique influences immune cell and MOR expression within human ...
journal_title：Journal of anesthesia
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s00540-018-2554-0
更新日期：2018-12-01 00:00:00
abstract：:In many anesthesia textbooks written in English, lidocaine, tetracaine, bupivacaine, ropivacaine, and chloroprocaine are listed as useful local anesthetics for spinal anesthesia. In contrast, T-cain is not included in these lists, even though it has been reported to be suitable for spinal anesthesia in Japan. T-cain w...
journal_title：Journal of anesthesia
pub_type： 杂志文章,评审
doi：10.1007/s00540-015-2066-0
更新日期：2015-10-01 00:00:00
abstract：PURPOSE:Numerous reports suggest that intravenously administered (IV) anesthetics affect postsynaptic events in the central nervous system. However, there is little evidence about how general anesthetics influence the presynaptic processes. The level of presynaptic calcium (Ca(2+)) concentration ([Ca(2+)](pre)) regulat...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-011-1186-4
更新日期：2011-10-01 00:00:00
abstract：:The aim of this study was to determine what effects low reactive-level laser irradiation (LLLI) of the stellate ganglion might have on the sympathetic fibers of the stellate ganglion in dogs. Following general anesthesia, the right stellate ganglion was exposed by thoracotomy. After stabilization, the following baseli...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/BF02479853
更新日期：1995-06-01 00:00:00
