Abstract：
:Muscle relaxation induced by neuromuscular blocking agents (NMBAs) is necessary for tracheal intubation and immobilization during surgery. Although acetylcholinesterase inhibitors have been successfully used as antagonists for NMBAs, they have their limitations; their effects are transient and ineffective against profound neuromuscular blockade. In the past, alternative antagonists were developed, such as germine and 4-aminopyridine, which are effective for the treatment of diseases causing muscle weakness and could potentially be used as antagonists for NMBAs. Unfortunately, these drugs did not come into practical use due to unwanted side-effects. Sugammadex is an almost ideal antagonist because it rapidly forms a rigid complex with rocuronium and produces less adverse effects. The development of novel NMBAs and antagonists, especially sugammadex, has revolutionized anesthesia practice. Recently, novel short-acting NMBAs, such as gantacurium and CW002 have been developed. Their effects can be reversed by the amino-acid L-cysteine. More recently, calabadions have been developed, which can form complexes with both steroidal and bisbenzyl-isoquinolinium NMBAs, in a similar fashion as sugammadex. Understanding the history of the NMBA antagonist's development is interesting and useful for modern anesthesiologists since it enhances their knowledge about the mechanisms involved in neuromuscular transmission and might lead to the development of ideal NMBA antagonists.
journal_name
J Anesthjournal_title
Journal of anesthesiaauthors
Suzuki K,Takazawa T,Saito Sdoi
10.1007/s00540-020-02836-1subject
Has Abstractpub_date
2020-10-01 00:00:00pages
723-728issue
5eissn
0913-8668issn
1438-8359pii
10.1007/s00540-020-02836-1journal_volume
34pub_type
杂志文章abstract：PURPOSE:Intrathecal morphine provides superior pain control for patients undergoing cesarean delivery when compared to intravenous opioid patient-controlled analgesia. However, no study has assessed the overall cost associated with each modality as a primary outcome. The aim of this study is to determine the overall co...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-016-2263-5
更新日期：2017-02-01 00:00:00
abstract：:Congenital insensitivity to pain with anhidrosis (CIPA) is a rare autosomal recessive disease, characterized by episodes of unexplained fever, anhidrosis, pain insensitivity despite intact tactile perception, self-mutilating behavior, mental retardation, and autonomic nervous system (ANS) abnormalities. We present a c...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-010-0985-3
更新日期：2010-10-01 00:00:00
abstract：PURPOSE:We compared the insertion performance of the pediatric size 1.5-3 i-gel airway device with that of the ProSeal laryngeal mask airway (PLMA) in anesthetized children in a prospective, randomized, controlled manner. METHODS:We included 134 children, aged 3 months to 15 years, scheduled for elective surgery under...
journal_title：Journal of anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00540-012-1477-4
更新日期：2013-02-01 00:00:00
abstract：:Amrinone, a phosphodiesterase inhibitor, is a non-glycosidic noncatecholamine with both vasodilator and positive inotropic effects. We were interested in assessing the effect of amrinone on postischemic cardiac performance in the isolated heart-lung preparation. Twenty-four male Wistar-ST rats were used. They were ran...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/BF02483394
更新日期：1996-12-01 00:00:00
abstract：PURPOSE:The CO(2) reactivity of cortical cerebral vessels and local cortical blood flow (l-CoBF) were evaluated during anesthesia in patients with moyamoya disease who were undergoing revascularization surgery. METHODS:Using laser-Doppler flowmetry, the CO(2) reactivity of cortical cerebral vessels and l-CoBF were mea...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s005400050043
更新日期：1999-01-01 00:00:00
abstract：BACKGROUND:Inguinal hernia repair is a common procedure, and can be performed under spinal anesthesia. Although adequate analgesia is crucial to postoperative recovery, the optimal protective analgesic regimen remains to be established. PURPOSE:To investigate the effects of preoperative etoricoxib within a protective ...
journal_title：Journal of anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00540-017-2368-5
更新日期：2017-10-01 00:00:00
abstract：:While the demand for bariatric surgery is increasing, hospital capacity remains limited. The ERABS (Enhanced Recovery After Bariatric Surgery) protocol has been implemented in a number of bariatric centers. We retrospectively compared the operating room logistics and postoperative complications between pre-ERABS and E...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-015-2089-6
更新日期：2016-02-01 00:00:00
abstract：:The relationship between tumor size and the complexity of anesthetic management was studied using several values: plasma catecholamine concentrations, requirement of vasoactive agents, surgical time, blood loss, plasma glucose concentrations, and hemodynamic variables. Ten patients with clinical and laboratory diagnos...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/BF02514621
更新日期：1994-12-01 00:00:00
abstract：:Cardiopulmonary resuscitation (CPR) in the lateral position during noncardiac surgery has been described in only a few reports in the past. Here, we report a case of cardiac arrest in a 61-year-old man undergoing microvascular decompression surgery for trigeminal neuralgia in the left lateral decubitus position. Durin...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-010-0911-8
更新日期：2010-06-01 00:00:00
abstract：:Lidocaine (1%), either in plain distilled water or in 10% dextrose, was intrathecally or epidurally administered to urethane-chloralose anesthetized cats. Electrical stimulation was applied to the gracile tract at a cervical level, and the resultant antidromic compound action potentials were recorded from the sural ne...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/BF02482066
更新日期：1996-03-01 00:00:00
abstract：:Opioid-related postoperative nausea and vomiting should not occur following remifentanil administration because of its relatively short time to elimination. However, studies have indicated that the incidence of postoperative nausea and vomiting associated with remifentanil is similar to that with other opioids. Hence,...
journal_title：Journal of anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00540-018-2550-4
更新日期：2018-10-01 00:00:00
abstract：:The pharmacokinetics and pharmacodynamics of vecuronium bromide were studied in patients under general anesthesia of enflurane and nitrous oxide in oxygen. Eighteen patients were randomly divided into two groups which received either 0.05 mg.kg(-1) (low dose group) or 0.20 mg.kg(-1) (high dose group) of vecuronium int...
journal_title：Journal of anesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s0054020060028
更新日期：1992-01-01 00:00:00
abstract：:We report a case of drug-induced myoclonus possibly related to palonosetron, a second-generation 5-hydroxytryptamine-3 receptor antagonist which was administered as a prophylaxis for postoperative nausea and vomiting in a 28-year-old female. The recurrent episodes of myoclonus jerk involving the head, neck and shoulde...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-016-2228-8
更新日期：2016-12-01 00:00:00
abstract：:In this study induction of anesthesia using the single-breath technique with either enflurane or sevoflurane in oxygen was compared. Each group consisted of 16 unpremedicated volunteers who breathed approximately 1.7 minimum alveolar concentration (MAC) equivalents of either vapor. There were no significant difference...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/BF02514709
更新日期：1994-06-01 00:00:00
abstract：:The antiarrhythmic effect of flecainide acetate (FCN), a newly developed class I antiarrhythmic drug, was evaluated on epinephrine (E)-halothane induced arrhythmias in dogs. The arrhythmogenic dose of E (ADE) under 1% of halothane was significantly increased from 0.71 +/- 0.08 to 1.08 +/- 0.11 and 1.84 +/- 0.23 micro ...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s0054000040303
更新日期：1990-10-01 00:00:00
abstract：BACKGROUND:We hypothesized that body shape metrics influence the anatomy of spinal canal and intraabdominal pressure in three dimensions. We explored the effects of abdominal circumference, trunk length, and their combination on the level of spinal anesthesia in the term parturient in this study. METHODS:Thirty term p...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-013-1715-4
更新日期：2014-04-01 00:00:00
abstract：:A large amount of pharmacological and clinical evidence supports the abuse potential of propofol. Although previous case reports have indicated that recreational use of propofol is primarily by medical professionals, its spread among the general public has recently been highlighted. This is the first case report to sh...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-011-1275-4
更新日期：2012-04-01 00:00:00
abstract：PURPOSE:Increased glucose variability may be associated with worse outcomes in critically ill patients. Hyperinsulinemic normoglycemia provides intensive glucose control during surgery and may reduce glucose variability. Our objective was to compare glycemic variability between two methods of glucose control in cardiac...
journal_title：Journal of anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00540-016-2295-x
更新日期：2017-04-01 00:00:00
abstract：:A 72-year-old woman presented pulmonary embolism. Continuous intravenous administration of heparin was controlled with values of activated clotting time targeted from 150 to 180 s. On the sixth intensive care unit (ICU) day, a central vein (CV) catheter was inserted through the right axillary vein. On the ninth ICU da...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-010-0894-5
更新日期：2010-04-01 00:00:00
abstract：:In recent decades anesthesia safety has not been improved in low-income countries. This prospective audit describes the incidence of hypoxia and related events detected among a cohort of patients undergoing surgery in the maternity unit at Sylvanus Olympio University Teaching Hospital, Togo, West Africa, by using puls...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-015-2048-2
更新日期：2015-12-01 00:00:00
abstract：PURPOSE:We hypothesized anterograde amnesia could be predicted by the bispectral index (BIS) during epidural puncture in patients premedicated with intramuscular midazolam. METHODS:We investigated 64 consecutive patients undergoing gynecological laparotomy under general anesthesia combined with epidural anesthesia. Mi...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-009-0748-1
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:During perioperative care, the continuous measurement of blood pressure (BP) provides superior physiological monitoring compared to intermittent techniques, especially for patients with comorbid conditions such as severe obesity. The current study prospectively assesses the accuracy of a continuous, noninvas...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-014-1835-5
更新日期：2014-12-01 00:00:00
abstract：:In the original publication of the article, the acknowledgment section was not included and provided in this correction. ...
journal_title：Journal of anesthesia
pub_type： 已发布勘误
doi：10.1007/s00540-020-02774-y
更新日期：2020-08-01 00:00:00
abstract：:This study investigated right ventricular (RV) performance during hypotensive anesthesia and compared the effect of the vasodilators prostaglandin E1 (PGE1), nicardipine HCl (Nic), glycerin trinitrate (GTN), and isosorbide dinitrate (ISDN) on RV function. Fifty patients were allocated into four groups [PGE1 (n=20), Ni...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/BF02480070
更新日期：1997-06-01 00:00:00
abstract：:We report an 83-year-old man with myasthenia gravis (MG) who developed respiratory depression after spinal anesthesia for transurethral laser enucleation of the prostate. He became less responsive after complained of dyspnea, with a decrease of SpO2 to 83% approximately 13 min after intrathecal administration of 0.5% ...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-020-02874-9
更新日期：2021-02-01 00:00:00
abstract：PURPOSE:This study aimed to evaluate whether the three ryanodine receptor type 1 (RYR1) variants (p.Ser2345Thr, p.Ser2345Arg, and p.Lys3367Arg) which we identified in Japanese malignant hyperthermia (MH) patients with a clinical grading scale rank of 6 were causative for MH. METHODS:We prepared human embryonic kidney ...
journal_title：Journal of anesthesia
pub_type： 杂志文章,收录出版
doi：10.1007/s00540-020-02803-w
更新日期：2020-10-01 00:00:00
abstract：PURPOSE:Propofol and ketamine have become progressively popular in electroconvulsive therapy (ECT) anesthesia, although propofol shortened seizure duration and ketamine might cause cardiotoxicity, psychotic episodes, and delayed recovery. Ketofol is a combination of ketamine and propofol, and the current study was desi...
journal_title：Journal of anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00540-012-1378-6
更新日期：2012-08-01 00:00:00
abstract：PURPOSE:Intravenous cannulation is a painful and stressful procedure. The objective of this study was to compare the analgesic efficacy of the eutectic mixture of local anesthetics (EMLA(®)) with that of the Valsalva maneuver in adult patients during i.v. cannulation. METHODS:One hundred ninety-five patients were rand...
journal_title：Journal of anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00540-012-1540-1
更新日期：2013-06-01 00:00:00
abstract：:Holmium laser enucleation of prostate (HoLEP) is being performed with increasing frequency as a minimally invasive alternative to transurethral resection of the prostate (TURP) for the surgical management of benign prostatic hyperplasia (BPH). HoLEP offers the advantage of use of normal saline for irrigation, instead ...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-016-2256-4
更新日期：2016-12-01 00:00:00
abstract：PURPOSE:To examine the relationships between effect-site concentrations and electroencephalographic parameters after the induction of general anesthesia with midazolam. METHODS:Twenty-four patients with American Society of Anesthesiologists status I or II were randomly allocated to receive either an intravenous (i.v.)...
journal_title：Journal of anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00540-010-0907-4
更新日期：2010-06-01 00:00:00
