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Local cortical cerebral blood flow and response to carbon dioxide during anesthesia in patients with moyamoya disease.

Abstract：

PURPOSE:The CO(2) reactivity of cortical cerebral vessels and local cortical blood flow (l-CoBF) were evaluated during anesthesia in patients with moyamoya disease who were undergoing revascularization surgery. METHODS:Using laser-Doppler flowmetry, the CO(2) reactivity of cortical cerebral vessels and l-CoBF were measured continuously in five patients at the local surgical field of the middle cerebral artery (MCA) territory. RESULTS:Local-CoBF values obtained during the normocapnic condition varied from site to site of gyrus in the MCA region (0-73 ml. 100 g(-1).min(-1)). Local-CoBF was maximal at 39-43 mmHg of the PaCO(2) range, and decreased above and below this range. The response of l-CoBF to CO(2) was larger at the sites where the maximal level was obtained during normocapnia. In two patients, l-CoBF decreased by about 50%, and remained law even 40 min after administration of acetazolamide. CONCLUSION:In patients with moyamoya disease, l-CoBF values obtained during the normocapnic condition varied from site to site of gyrus, and not only hypocapnia but also hypercapnia decreased l-CoBF within the MCA region.

journal_name

J Anesth

journal_title

Journal of anesthesia

authors

Yusa T,Yamashiro K

doi

10.1007/s005400050043

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

131-5

issue

3

eissn

0913-8668

issn

1438-8359

journal_volume

13

pub_type

杂志文章

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