The impact of hyperlactatemia on postoperative outcome after adult cardiac surgery.

Abstract:

PURPOSE:To evaluate the value of blood lactate value in predicting postoperative mortality (primary outcome), duration of ventilation, and length of stay in an intensive care unit (ICU) and hospital (secondary outcomes). METHODS:We performed a prospective observation study on 1,820 consecutive patients undergoing open heart surgery in a tertiary university medical center. Blood lactate levels were obtained from patients on admission to the cardiac surgical ICU and measured serially. RESULTS:All patients were divided into three groups according to their maximum blood lactate levels: group I (normolactatemia, lactate ≤2.2 mmol/l), 332 patients; group II (mild hyperlactatemia, lactate 2.2-4.1 mmol/l), 1,054 patients; and group III (severe hyperlactatemia, lactate ≥4.4 mmol/l), 434 patients. Maximum blood lactate levels ≥4.4 mmol/l during the first 10 h post admission were associated with prolonged ventilation time, longer ICU stay, and increased mortality (P < 0.001). CONCLUSIONS:Hyperlactatemia is common after cardiac surgery. Maximal lactate threshold ≥4.4 mmol/l in the first 10 h after operation accurately predicts postoperative mortality.

journal_name

J Anesth

journal_title

Journal of anesthesia

authors

Kogan A,Preisman S,Bar A,Sternik L,Lavee J,Malachy A,Spiegelstein D,Berkenstadt H,Raanani E

doi

10.1007/s00540-011-1287-0

subject

Has Abstract

pub_date

2012-04-01 00:00:00

pages

174-8

issue

2

eissn

0913-8668

issn

1438-8359

journal_volume

26

pub_type

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