Abstract:
PURPOSE:We investigated the mechanism by which inhibition of carbonic anhydrase (CA) increases organ blood flow. METHODS:Regional blood flow (rBF) in white rabbits anesthetized with ketamine/urethane was measured in the kidney, liver, stomach wall, and abdominal muscle by means of laser blood flow probes. Data obtained from rabbits receiving acetazolamide (AZ) to inhibit CA were compared with those obtained from rabbits ventilated with air containing increased concentrations of CO2. RESULTS:Systolic blood pressure, body temperature, hemoglobin, and base excess were unaffected by either treatment. Inhalation of CO2 increased blood flow in all organs tested as well as the cardiac output and PCO2 but decreased pH. Inhibition of CA by AZ administration increased the rBF only in the liver and kidney and did not increase cardiac output or decrease pH. CONCLUSION:Administration of AZ increased rBF in the tissues and organs that contained large amounts of CA without increasing the cardiac output or decreasing the pH, which suggests a direct local effect. A differential sensitivity to the retention of CO2 is suggested as a possible mechanism of the selectivity of the increase in rBF.
journal_name
J Anesthjournal_title
Journal of anesthesiaauthors
Taki K,Nagasawa I,Hirahara K,Tomita S,Baba N,Totoki Tdoi
10.1007/BF02480036subject
Has Abstractpub_date
1997-09-01 00:00:00pages
193issue
3eissn
0913-8668issn
1438-8359pii
10.1007/BF02480036journal_volume
11pub_type
杂志文章abstract:PURPOSE:Inhaled anesthetics increase the incidence of postoperative residual neuromuscular blockade, and the mechanism is still unclear. We have investigated the synergistic effect of low-concentration inhaled anesthetics and rocuronium on inhibition of the inward current of the adult-type muscle nicotinic acetylcholin...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-012-1527-y
更新日期:2013-06-01 00:00:00
abstract::Recently, gastric ultrasonography has been used as a noninvasive portable tool for evaluating gastric content and volume in adults and children. Pediatric patients are not always cooperative, especially younger ones, and it may be difficult to keep them in the appropriate scanning position without sedation. Hence, we ...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-016-2204-3
更新日期:2016-10-01 00:00:00
abstract::We report three cases with systolic anterior motion (SAM) after mitral valve plasty. Preoperative mitral valve morphology is a risk factor for SAM. The morphological characteristics of SAM have been revealed in several studies. We found a small distance between coaptation and the interventricular septum in all cases, ...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-013-1731-4
更新日期:2014-06-01 00:00:00
abstract::For select total knee arthroplasty (TKA) patients, we have established an alternative pathway to bypass the acute care surgical ward and directly admit patients from the post-anesthesia care unit to on-campus rehabilitation. We retrospectively examined whether this 'fast track' pathway decreased costs and improved pat...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-017-2372-9
更新日期:2017-10-01 00:00:00
abstract::The effect-compartment concentration (C(e)) of a drug at a specific pharmacodynamic endpoint should be independent of the rate of drug injection. We used this assumption to derive an effect-compartment equilibrium rate constant (k(eo)) for propofol during induction of anesthesia, using a target controlled infusion dev...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-005-0378-1
更新日期:2006-01-01 00:00:00
abstract::The concentrations of extracellular glutamate (Glu), aspartate (Asp) and glycine (Gly) were measured by microdialysis method in the cortex and hippocampus before, during and after 15 min of total cerebral ischemia in dogs. The correlations between the concentrations of amino acids and the changes in EEG and evoked pot...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s0054030070334
更新日期:1993-07-01 00:00:00
abstract::We tested hypertonic saline solution (HS) to determine its effectiveness in surgical procedures for prostatic hypertrophy. We randomly selected 40 patients undergoing elective transurethral resection of the prostate for either infusion of HS (3% NaCl) at 4ml·kg(-1)·min(-1) (HS group) or lactated Ringer's solution (LR)...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/BF02471385
更新日期:1996-09-01 00:00:00
abstract::Anesthetic management of anterior mediastinal masses (AMM) is challenging. We describe the successful anesthetic management of two patients with AMM in which dexmedetomidine was used at supra-sedative doses. Our first case was a 41-year-old man who presented with a 10 x 9 x 11 cm AMM, a pericardial effusion, compressi...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-010-0946-x
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:The effect of the Mega Acer kit(@), a new heated and humidified breathing circuit (HHBC) containing a fluid-warming device, was investigated on intraoperative core temperature (T c). METHODS:A total of 102 patients undergoing elective craniotomies were randomly divided into three groups based on the breathi...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-015-1994-z
更新日期:2015-08-01 00:00:00
abstract::Fifteen infants and children (M = 7, F = 8), aged from 0 to 13 years, who underwent cardiac catheterization and cardioangiography under ketamine-diazepam anesthesia were the subjects of this study. The effect of a contrast medium, isolamate sodium (66.8%) on the plasma somolality and vasopressin concentration was stud...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s0054010050203
更新日期:1991-04-01 00:00:00
abstract::We report a case of drug-induced myoclonus possibly related to palonosetron, a second-generation 5-hydroxytryptamine-3 receptor antagonist which was administered as a prophylaxis for postoperative nausea and vomiting in a 28-year-old female. The recurrent episodes of myoclonus jerk involving the head, neck and shoulde...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-016-2228-8
更新日期:2016-12-01 00:00:00
abstract::Dexmedetomidine (DEX) for sedation in diagnostic and interventional cardiac catheterization (DICC) has been reported to require other drugs or rescue drugs because of its insufficient sedative effect when used alone. We administered DEX and adjusted its dose according to the bispectral index (BIS) monitor™ for DICC in...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-011-1312-3
更新日期:2012-04-01 00:00:00
abstract::Mechanical influences independent of chemoreceptor function on ventilatory control were studied in halothane-anesthetized, artificially ventilated patients using the technique reported by Altose et al. (Respir Physiol 66: 171-180, 1986). Contribution of mechanical factor was indirectly assessed by comparing the values...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s0054020060387
更新日期:1992-10-01 00:00:00
abstract:PURPOSE:Propofol and ketamine have become progressively popular in electroconvulsive therapy (ECT) anesthesia, although propofol shortened seizure duration and ketamine might cause cardiotoxicity, psychotic episodes, and delayed recovery. Ketofol is a combination of ketamine and propofol, and the current study was desi...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-012-1378-6
更新日期:2012-08-01 00:00:00
abstract::To compare tracheal intubation with the Pentax Airway Scope (AWS) and the Macintosh laryngoscope (McL) during chest compression, 25 anesthesiologists (including 12 specialists having >5 years of experience and 13 trainees having <2 years of experience) performed tracheal intubation using either the McL or the AWS, wit...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-010-0874-9
更新日期:2010-04-01 00:00:00
abstract:PURPOSE:Direct hemoperfusion (DHP) with polymixin B-immobilized fiber (PMX) has been reported to be effective for patients with septic shock. The aim of this study was to clarify the mechanism of PMX-DHP effect on septic shock. METHODS:The following parameters were measured in septic shock patients who were treated wi...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-005-0366-5
更新日期:2006-01-01 00:00:00
abstract:PURPOSE:The present case-control study was conducted to evaluate whether acute normovolemic hemodilution (ANH) can reduce the need for perioperative allogeneic blood transfusion (ABT) and affect the incidence of perioperative complications in free-flap reconstruction of the head and neck. METHODS:This single-center, r...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-019-02714-5
更新日期:2020-04-01 00:00:00
abstract::Recent publications provided controversial results indicating that perioperative heparin bridging anticoagulation (HBA) increased the bleeding risk without decreasing the thromboembolic risk in patients undergoing minor surgery. To investigate if this is also the case in high-risk patients undergoing major abdominal m...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-016-2187-0
更新日期:2016-08-01 00:00:00
abstract:PURPOSE:The present study aimed to investigate the effects of different dosages of propofol, that induced different depths of anesthesia, on the local activity and connectivity of nuclei within the cortico-reticulo-thalamic loops, as well as the release of amino acids in those nuclei. METHODS:The nonlinear dynamics an...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-019-02667-9
更新日期:2019-10-01 00:00:00
abstract::It is recommended that the period of fasting before elective surgery should be shortened to facilitate a rapid recovery by preventing catabolism. We examined the effects of a short period of fasting on metabolism by performing indirect calorimetry (IC) under general anesthesia. A prospective observational study involv...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-014-1950-3
更新日期:2015-06-01 00:00:00
abstract::Laryngeal mask airway (LMA) insertion was tried in 120 pediatric cases, from 2 months to 12 years of age. Initial indications for LMA were the same as for a face mask, except for two additional conditions; anticipation of difficulty with intubation and difficulty in management by a face mask. Size 2 LMA was used in th...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s0054010050160
更新日期:1991-04-01 00:00:00
abstract:PURPOSE:Newborns are often sedated during MRI but sedation itself creates adverse events and management is more challenging in this environment. Oral glucose/sucrose administration has been studied in newborns during painful procedures; however, its effectiveness in keeping newborns sleepy and motionlessness during pai...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-016-2296-9
更新日期:2017-04-01 00:00:00
abstract::Cardiac surgery with cardiopulmonary bypass (CPB) is frequently associated with a complex array of post-operative clinical abnormalities, including low-output syndrome and pulmonary dysfunction. It has been reported that oxygen free radicals are one of the important factors causing reperfusion injury. To determine whe...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/BF02483345
更新日期:1996-06-01 00:00:00
abstract:PURPOSE:Increased glucose variability may be associated with worse outcomes in critically ill patients. Hyperinsulinemic normoglycemia provides intensive glucose control during surgery and may reduce glucose variability. Our objective was to compare glycemic variability between two methods of glucose control in cardiac...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-016-2295-x
更新日期:2017-04-01 00:00:00
abstract::Lidocaine (1%), either in plain distilled water or in 10% dextrose, was intrathecally or epidurally administered to urethane-chloralose anesthetized cats. Electrical stimulation was applied to the gracile tract at a cervical level, and the resultant antidromic compound action potentials were recorded from the sural ne...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/BF02482066
更新日期:1996-03-01 00:00:00
abstract::Anesthesia requires informed consent because it is an invasive procedure with certain risks. However, the state of informed consent for anesthesia in Japan remains unclear. The purpose of this survey was to examine the state of informed consent for anesthesia in Japan. A questionnaire was sent to all hospitals certifi...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-005-0332-2
更新日期:2005-01-01 00:00:00
abstract::The direct effects of nitrous oxide on left ventricular contractility and myocardial oxygen consumption (MVO2) in the ischemic isolated rat heart were studied. The rat heart was isolated and perfused by a Langendorf technique. The aortic stump was cannulated and the heart was perfused with Kumpeis solution bubbled wit...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/BF02514658
更新日期:1994-09-01 00:00:00
abstract:PURPOSE:Morphine is a powerful analgesic but its effect is often diminished owing to the development of tolerance. It has been suggested that morphine activates microglia through its action on the toll-like receptor 4 (TLR4) in the spinal cord, leading to suppression of the morphine effect. However, it has not been exa...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-012-1469-4
更新日期:2013-02-01 00:00:00
abstract::Perioperative positive airway pressure (PAP) is recommended by the American Society of Anesthesiologists for patients with obstructive sleep apnea, but a readily available and personalized intraoperative delivery system does not exist. We present the successful use of a patient's own nasal PAP machine in the operating...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-016-2188-z
更新日期:2016-08-01 00:00:00
abstract:PURPOSE:We investigated whether presynaptic facilitatory M1 and/or inhibitory M2 muscarinic receptors contributed to pancuronium- and cisatracurium-induced tetanic fade. METHODS:Phrenic nerve-diaphragm muscle preparations of rats were indirectly stimulated with tetanic frequency (75 +/- 3.3 Hz; mean +/- SD). Doses of ...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-009-0790-z
更新日期:2009-01-01 00:00:00