Abstract：
PURPOSE:Although an α-adrenoceptor has been suggested to be involved in the mechanism of asthma, the effect of α1-agonist on the airway is still unclear. In this study we evaluated the effect of phenylephrine on the airway with a direct visualization method using a superfine fiberoptic bronchoscope (SFB). METHODS:Seven mongrel dogs were anesthetized with pentobarbital (30 mg·kg-1 IV) and paralyzed by pancuronium (0.2mg·kg-1·h-1). The trachea was intubated with an endotracheal tube (ID 7 mm) that has a second lumen for insertion of a SFB (OD 2.2 mm) to monitor the bronchial cross-sectional area (BCA) continuously. The tip of a SFB was placed at the level between the second and third bronchial bifurcation. To assess hemodynamics, the direct arterial blood pressure (ABP) and pulmonary arterial pressure (PAP) were monitored via a femoral arterial catheter and Swan-Granz catheter. Bronchoconstriction was elicited by histamine (10 μg·kg-1+ 500 μg·kg-1·h-1_. At 30 min after the histamine was started, saline or phenylephrine (1, 10, and 100μg·kg-1) was given intravenously. The BCA and hemodynamic variables were assessed before (basal) and 30 min after the histamine was started and 5 min after saline and each phenylephrine dose. RESULTS:Histamine reduced BCA by 40.3±6.3%. Phenylephrine at 10 and 100 μg·kg-1 significantly increased the ABP and PAP; and it significantly decreased the BCA, by 6.5±6.9% and 14.2±7.9%, respectively. Plasma epinephrine and norepinephrine were also significantly reduced following phenylephrine 100 μg·kg-1 IV. CONCLUSION:The dose of phenylephrine that produced vasopressive actions worsened the histamine-induced bronchoconstriction slightly but significantly. Therefore, phenylephrine should be used with caution in asthmatic patients.
journal_name
J Anesthjournal_title
Journal of anesthesiaauthors
Hirota K,Sato T,Hashimoto Y,Muraoka M,Ishihara H,Matsuki Adoi
10.1007/BF02480091subject
Has Abstractpub_date
1998-09-01 00:00:00pages
133-136issue
3eissn
0913-8668issn
1438-8359pii
10.1007/BF02480091journal_volume
12pub_type
杂志文章abstract：PURPOSE:The efficacy of infraorbital nerve block in reducing isoflurane consumption and postoperative pain was evaluated in patients undergoing endoscopic endonasal maxillary sinus surgery (ESS) under general anesthesia. METHODS:Fifty patients were randomly allocated to either the block group (n =15) or the nonblock g...
journal_title：Journal of anesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s005400170014
更新日期：2001-01-01 00:00:00
abstract：PURPOSE:We previously confirmed the effectiveness of dexmedetomidine (DEX) for stabilizing hemodynamics as well as sparing anesthetics during anesthetic induction in patients undergoing cardiac surgery (Kunisawa et al. in J Clin Anesth 21:194-199, 1). In this study, we investigated whether these effects of DEX continue...
journal_title：Journal of anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00540-011-1215-3
更新日期：2011-12-01 00:00:00
abstract：PURPOSE:This observational study was designed to evaluate the clinical value of cardiac output (CO) obtained via bioreactance (NICOM™) as compared with values of CO obtained via thermodilution (using pulmonary artery catheter, Vigilance™) and the thoracic bioimpedance (BioZ.com™), in patients undergoing off-pump corona...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-014-1938-z
更新日期：2015-06-01 00:00:00
abstract：PURPOSE:Midazolam premedication administered by the intranasal route is noninvasive with good bioavailability. Atomised intranasal midazolam spray ensures accurate drug dosage and better patient acceptability, with rapid onset of action and virtually complete absorption. METHODS:Sixty pediatric patients scheduled for ...
journal_title：Journal of anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00540-012-1341-6
更新日期：2012-06-01 00:00:00
abstract：:The coronavirus disease 2019 (COVID-19) pandemic is caused by a coronavirus that is transmitted primarily via aerosol, droplets or direct contact. This may place anesthetists at higher risk of infection due to their frequent involvement in aerosol-generating airway interventions. Many anesthethetic COVID-19 guidelines...
journal_title：Journal of anesthesia
pub_type： 杂志文章,评审
doi：10.1007/s00540-020-02819-2
更新日期：2020-12-01 00:00:00
abstract：PURPOSE:In many countries, patients are generally allowed to have clear fluids until 2-3 h before surgery. In Japan, long preoperative fasting is still common practice. To shorten the preoperative fasting period in Japan, we tested the safety and efficacy of oral rehydration therapy until 2 h before surgery. METHODS:T...
journal_title：Journal of anesthesia
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s00540-011-1261-x
更新日期：2012-02-01 00:00:00
abstract：PURPOSE:To evaluate the role of the phosphatidylinositol 3 kinase (PI3K)/protein kinase B (Akt)/hypoxia-inducible factor 1α (HIF-1α) signaling pathway in the protection by dexmedetomidine against lung ischemia-reperfusion injury (IRI) in rats. METHODS:Forty-eight male Sprague-Dawley rats weighing 250-350 g were random...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-016-2214-1
更新日期：2016-10-01 00:00:00
abstract：PURPOSE:Intrathecal morphine provides superior pain control for patients undergoing cesarean delivery when compared to intravenous opioid patient-controlled analgesia. However, no study has assessed the overall cost associated with each modality as a primary outcome. The aim of this study is to determine the overall co...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-016-2263-5
更新日期：2017-02-01 00:00:00
abstract：PURPOSE:The general public's perceptions of anesthesia and the risks associated with it may be skewed. The outpatient preoperative appointment with an anesthesiologist allows for patient education regarding different anesthetic options and counseling regarding anxiety related to anesthesia and surgery. This study inves...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-018-02608-y
更新日期：2019-04-01 00:00:00
abstract：PURPOSE:The present study aimed to investigate the effects of different dosages of propofol, that induced different depths of anesthesia, on the local activity and connectivity of nuclei within the cortico-reticulo-thalamic loops, as well as the release of amino acids in those nuclei. METHODS:The nonlinear dynamics an...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-019-02667-9
更新日期：2019-10-01 00:00:00
abstract：:The purpose of this study was to determine the mortality rate in 527 critically ill patients with multiple organ failure (MOF), treated in our ICU between August, 1986 and January, 1992, and to compare it with the results obtained in a group of patients studied who had been treated between October, 1978 and July, 1986...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/BF02514648
更新日期：1994-09-01 00:00:00
abstract：BACKGROUND:Inguinal hernia repair is a common procedure, and can be performed under spinal anesthesia. Although adequate analgesia is crucial to postoperative recovery, the optimal protective analgesic regimen remains to be established. PURPOSE:To investigate the effects of preoperative etoricoxib within a protective ...
journal_title：Journal of anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00540-017-2368-5
更新日期：2017-10-01 00:00:00
abstract：:Neuropathic pain has a substantial effect on quality of life (QOL). The Japanese Society of Pain Clinicians (JSPC) has developed clinical guidelines of pharmacotherapy for neuropathic pain. These guidelines offer clarity on recommendations based on both the most recent scientific evidence and expert opinions. Understa...
journal_title：Journal of anesthesia
pub_type： 杂志文章,实务指引
doi：10.1007/s00540-018-2501-0
更新日期：2018-06-01 00:00:00
abstract：PURPOSE:This prospective, randomized trial was designed to assess whether the i-gel supraglottic airway device is suitable for volume-controlled ventilation while applying positive end-expiratory pressure (PEEP) of 5 cmH(2)O under general anesthesia. It was believed that this device might improve arterial oxygenation. ...
journal_title：Journal of anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00540-013-1628-2
更新日期：2013-12-01 00:00:00
abstract：PURPOSE:To investigate the differences in recovery of postural stability, after obtaining similar intravenous sedation levels with midazolam, in elderly and younger patients undergoing dental surgery. METHODS:We studied 15 elderly patients (>65 years) and 15 younger patients (<55 years) after intravenous sedation. Mid...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s005400200024
更新日期：2002-01-01 00:00:00
abstract：:We experienced simultaneous coronary artery bypass grafting and cardiac pheochromocytoma resection under cardiopulmonary bypass in a 79-year-old woman with atherosclerotic angina. During manipulation of the tumor under cardiopulmonary bypass, the serum norepinephrine concentration increased to over seventy times the n...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-007-0549-3
更新日期：2007-01-01 00:00:00
abstract：BACKGROUND:The effect of the Mega Acer kit(@), a new heated and humidified breathing circuit (HHBC) containing a fluid-warming device, was investigated on intraoperative core temperature (T c). METHODS:A total of 102 patients undergoing elective craniotomies were randomly divided into three groups based on the breathi...
journal_title：Journal of anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00540-015-1994-z
更新日期：2015-08-01 00:00:00
abstract：PURPOSE:"Juci", one of the traditional acupuncture techniques, means contralateral acupuncture; i.e., implanting a needle into an acupoint to treat a given disease or disorder, but on the side of the body opposite to the diseased side. The aim of this study was: (1) to assess acupuncture effects on formalin-induced noc...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-006-0443-4
更新日期：2007-01-01 00:00:00
abstract：:Anesthesiologists daily witness the consequences of tobacco use, the most common preventable cause of death. Smoking-related diseases such as atherosclerosis and chronic obstructive pulmonary disease increase anesthetic risk, and even smokers without overt disease are at increased risk for morbidity such as pulmonary ...
journal_title：Journal of anesthesia
pub_type： 杂志文章,评审
doi：10.1007/s00540-006-0483-9
更新日期：2007-01-01 00:00:00
abstract：:We encountered three cases of lung disorders caused by drowning in the recent large tsunami that struck following the Great East Japan Earthquake. All three were females, and two of them were old elderly. All segments of both lungs were involved in all the three patients, necessitating ICU admission and endotracheal i...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-011-1273-6
更新日期：2012-04-01 00:00:00
abstract：:Intractable perineal pain often appears in the anal region following abdominoperineal resection for the treatment of rectal cancer. In such cases, a subarachnoid block or transsacral block is generally used to control pain. However, these procedures sometimes cause complications such as dysuria or sensory paralysis of...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/BF02482755
更新日期：1994-03-01 00:00:00
abstract：:We aimed to perform an epidural patch using platelet rich plasma (PRP), which has the potential to regenerate and heal tissues via degranulation of platelets, in a 34-year-old parturient suffering from persistent post-dural puncture headache (PDPH) after failed epidural blood patch (EBP). After her admission to our un...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-017-2400-9
更新日期：2017-12-01 00:00:00
abstract：:To evaluate the effects of subanesthetic enflurane and sevoflurane on the sympathetic nervous system (SNS) and the parasympathetic nervous system (PNS), the blood level of norepinephrine (NE) and fluctuations in the R-R intervals were measured on electrocardiogram in humans given either 0.5 MAC enflurane or sevofluran...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/BF02482745
更新日期：1994-03-01 00:00:00
abstract：:Adenosine triphosphate as well as sodium nitroprusside has been used for hypotensive anesthesia. The purpose of this study was to examine the possibility that two hypotensive drugs may exert different effects on venous capacitance during controlled hypotension. In rats anesthetized with ketamine, mean arterial pressur...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s0054070010143
更新日期：1987-09-01 00:00:00
abstract：BACKGROUND:Clinical histological studies demonstrate that the distribution of natural killer (NK) cells, other immune cells and μ-opioid receptors (MOR) within cancer tissue can predict cancer prognosis. No clinical study has evaluated whether anesthetic technique influences immune cell and MOR expression within human ...
journal_title：Journal of anesthesia
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s00540-018-2554-0
更新日期：2018-12-01 00:00:00
abstract：:A 72-year-old woman presented pulmonary embolism. Continuous intravenous administration of heparin was controlled with values of activated clotting time targeted from 150 to 180 s. On the sixth intensive care unit (ICU) day, a central vein (CV) catheter was inserted through the right axillary vein. On the ninth ICU da...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-010-0894-5
更新日期：2010-04-01 00:00:00
abstract：PURPOSE:Peripheral gangrene (PG) is a known complication requiring limb amputation among sepsis survivors; however, its incidence and associated risk factors remain controversial. We aimed to examine the incidence of limb amputation among sepsis survivors, and to investigate factors independently associated with limb a...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-020-02858-9
更新日期：2021-02-01 00:00:00
abstract：PURPOSE:Painful neuropathic conditions of cancer pain often show little response to nonopioid and opioid analgesics but may be eased by antidepressants and anticonvulsants. Although gabapentin is effective in the treatment of neuropathic pain in patients with cancer, some patients experience intolerable side effects su...
journal_title：Journal of anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00540-010-0913-6
更新日期：2010-06-01 00:00:00
abstract：PURPOSE:To study the delivery efficiency of procaterol aerosols administered through the tracheal tube (ETT) with a metered-dose inhaler (MDI) during apnea. METHODS:First, in a normal room air environment (at ambient temperatures of 24 degrees to 26 degrees C), we measured the amount of aerosol delivered through the E...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s005400200044
更新日期：2002-01-01 00:00:00
abstract：:Muscle relaxation induced by neuromuscular blocking agents (NMBAs) is necessary for tracheal intubation and immobilization during surgery. Although acetylcholinesterase inhibitors have been successfully used as antagonists for NMBAs, they have their limitations; their effects are transient and ineffective against prof...
journal_title：Journal of anesthesia
pub_type： 杂志文章
doi：10.1007/s00540-020-02836-1
更新日期：2020-10-01 00:00:00
