Abstract:
:The acute neuroinflammatory response to surgery may play a key pathogenic role in postoperative delirium (POD). Here, we investigated the contribution of acute postoperative pain to neuroinflammation and related delirium-like behaviors after surgery in adult and aged rats. Animals were assigned into four groups: control, abdominal surgery, surgery with analgesia using local ropivacaine, and surgery with analgesia using systemic morphine. Pain was assessed by the Rat Grimace Scale (RGS). Trace and context memory retention was evaluated following trace fear conditioning during the first 2 days after surgery. Pro-inflammatory cytokines in medial prefrontal cortex and hippocampus were measured by enzyme-linked immunosorbent assay. In both age groups, the RGS increased significantly from baseline until 6 h after surgery. The postoperative analgesia with either local or systemic regimens comparably alleviated the RGS increase in adult and aged animals. The two analgesic regimens attenuated the surgery-induced trace and context memory deficits, as well as cytokines overproduction in both medial prefrontal cortex and hippocampus. No age-related differences were found in the neuro-cognitive effectiveness of postoperative analgesia. Our experimental findings provide proof-of-concept for adequate postoperative pain management as one of the main preventive strategies of POD.
journal_name
J Anesthjournal_title
Journal of anesthesiaauthors
Koyama T,Kawano T,Iwata H,Aoyama B,Eguchi S,Nishigaki A,Yamanaka D,Tateiwa H,Shigematsu-Locatelli M,Locatelli FM,Yokoyama Mdoi
10.1007/s00540-019-02635-3subject
Has Abstractpub_date
2019-06-01 00:00:00pages
482-486issue
3eissn
0913-8668issn
1438-8359pii
10.1007/s00540-019-02635-3journal_volume
33pub_type
杂志文章abstract::To evaluate the effects of cardiopulmonary bypass (CPB) on the release of polymorphonuclear leukocyte elastase (PMN-E) and postoperative pulmonary function, the perioperative plasma levels of PMN-E in α1-antitrypsin complex (EAC) and hydrogen peroxide concentration in the expired breath were measured in eight patients...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/BF02479945
更新日期:1995-12-01 00:00:00
abstract:PURPOSE:Numerous reports suggest that intravenously administered (IV) anesthetics affect postsynaptic events in the central nervous system. However, there is little evidence about how general anesthetics influence the presynaptic processes. The level of presynaptic calcium (Ca(2+)) concentration ([Ca(2+)](pre)) regulat...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-011-1186-4
更新日期:2011-10-01 00:00:00
abstract::Neuraxial anesthesia is a common practice in obstetrics. Evidence suggests that preprocedural ultrasound versus the conventional landmark location method accurately identifies a given intervertebral space and predicts the needle insertion depth required to reach the spinal canal. However, whether the preprocedural ult...
journal_title:Journal of anesthesia
pub_type: 杂志文章,meta分析
doi:10.1007/s00540-020-02750-6
更新日期:2020-06-01 00:00:00
abstract:PURPOSE:Because blood concentrations of local anesthetics sometimes reach toxic levels after transversus abdominis plane (TAP) block, reduction of the dose has been necessary to reduce the risk of systemic toxicity. We therefore investigated the effects of TAP block with 0.25 % levobupivacaine (100 mg) on postoperative...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-015-1993-0
更新日期:2015-08-01 00:00:00
abstract::Levobupivacaine has been developed as a safer alternative to bupivacaine because of its reduced systemic toxicity. However, the effect of directly delivering levobupivacaine into tracheal smooth muscle has not been adequately explored. We performed this study to determine the in vitro effects of levobupivacaine on iso...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-015-2026-8
更新日期:2015-10-01 00:00:00
abstract:PURPOSE:Propofol and ketamine have become progressively popular in electroconvulsive therapy (ECT) anesthesia, although propofol shortened seizure duration and ketamine might cause cardiotoxicity, psychotic episodes, and delayed recovery. Ketofol is a combination of ketamine and propofol, and the current study was desi...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-012-1378-6
更新日期:2012-08-01 00:00:00
abstract::Dexmedetomidine (DEX) for sedation in diagnostic and interventional cardiac catheterization (DICC) has been reported to require other drugs or rescue drugs because of its insufficient sedative effect when used alone. We administered DEX and adjusted its dose according to the bispectral index (BIS) monitor™ for DICC in...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-011-1312-3
更新日期:2012-04-01 00:00:00
abstract::We encountered three cases of lung disorders caused by drowning in the recent large tsunami that struck following the Great East Japan Earthquake. All three were females, and two of them were old elderly. All segments of both lungs were involved in all the three patients, necessitating ICU admission and endotracheal i...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-011-1273-6
更新日期:2012-04-01 00:00:00
abstract::We report on five patients who underwent MRI-guided focused ultrasound ablation of prostatic cancer under epidural anesthesia with intravenous dexmedetomidine sedation. This pioneering procedure requires an immobile therapeutic field with adequate sedation and analgesia provided to the patients. Duration of the proced...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-011-1189-1
更新日期:2011-10-01 00:00:00
abstract::Mechanical influences independent of chemoreceptor function on ventilatory control were studied in halothane-anesthetized, artificially ventilated patients using the technique reported by Altose et al. (Respir Physiol 66: 171-180, 1986). Contribution of mechanical factor was indirectly assessed by comparing the values...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s0054020060387
更新日期:1992-10-01 00:00:00
abstract:PURPOSE:The properties of two new-generation CO(2) absorbents, Amsorb Plus (Armstrong Medical, Coleraine, UK) and Drägersorb Free (Drager, Lubeck, Germany), were compared with those of Amsorb (Armstrong Medical) and Sodasorb II (W.R. Grace, Lexington, MA, USA). METHODS:The concentration of compound A produced by each ...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-004-0253-5
更新日期:2004-01-01 00:00:00
abstract:PURPOSE:Spinal anesthesia (SA) is being increasingly used in infants to avoid the potential negative neurocognitive effects of general anesthesia (GA). However, SA has been reported to provide a relatively short duration of surgical anesthesia. METHODS:We retrospectively reviewed SA cases for surgical procedures lasti...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-018-2517-5
更新日期:2018-08-01 00:00:00
abstract:PURPOSE:The purpose of this study was to determine whether intraoperative infusion of remifentanil induces acute tolerance to opioids, and compare the postoperative pain and opioid consumption by the effect site concentrations of remifentanil. METHODS:One hundred and ninety-eight patients undergoing gastrectomy were r...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-018-2569-6
更新日期:2018-12-01 00:00:00
abstract::Tracheomalacia after thyroidectomy is a life-threatening situation. However, it is difficult to predict postoperative tracheal obstruction with certainty. A case of a 74-year-old woman with a long-standing adenomatous goiter (98 g) is reported. She had undergone partial right lobe thyroidectomy 54 years earlier. After...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-011-1181-9
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:During perioperative care, the continuous measurement of blood pressure (BP) provides superior physiological monitoring compared to intermittent techniques, especially for patients with comorbid conditions such as severe obesity. The current study prospectively assesses the accuracy of a continuous, noninvas...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-014-1835-5
更新日期:2014-12-01 00:00:00
abstract:PURPOSE:Factors affecting perioperative development of coronary spasm have not been elucidated. A number of case reports describing perioperative coronary spasm have appeared in Japanese anesthesia journals, mostly published in Japanese. The purpose of this study was to investigate the contributing factors affecting pe...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s005400170034
更新日期:2001-01-01 00:00:00
abstract:PURPOSE:To evaluate the role of the phosphatidylinositol 3 kinase (PI3K)/protein kinase B (Akt)/hypoxia-inducible factor 1α (HIF-1α) signaling pathway in the protection by dexmedetomidine against lung ischemia-reperfusion injury (IRI) in rats. METHODS:Forty-eight male Sprague-Dawley rats weighing 250-350 g were random...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-016-2214-1
更新日期:2016-10-01 00:00:00
abstract::Small children are physiologically subject to arterial oxygen desaturation. However, few reports have referred to the risk factors related to postanesthetic hypoxemia and the duration of hypoxemia. The purpose of this study was to clarify these two aspects. Eighty-five ASA physical status I infants and children were i...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s0054030070016
更新日期:1993-01-01 00:00:00
abstract::Fifteen surgical patients received an epidural injection of 12 ml of 1.5% lidocaine through a catheter placed at C7-T1, followed by further injection as required. An intravenous bolus of 0.5 mg of atropine sulfate was administered simultaneously with the initial epidural injection. The high-(HFC: 0.15-0.4 Hz) and low-...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/BF02482031
更新日期:1995-03-01 00:00:00
abstract::In recent decades anesthesia safety has not been improved in low-income countries. This prospective audit describes the incidence of hypoxia and related events detected among a cohort of patients undergoing surgery in the maternity unit at Sylvanus Olympio University Teaching Hospital, Togo, West Africa, by using puls...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-015-2048-2
更新日期:2015-12-01 00:00:00
abstract::Within continuously controlled limits of cuff pressure, an endotracheal tube cuff made of polyurethane (PU) prevents secretion inflow better than a conventional polyvinylchloride cuff. However, the temperature difference between ventilator gas and the air inside a PU cuff produces condensation droplets that accumulate...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-014-1849-z
更新日期:2014-12-01 00:00:00
abstract:PURPOSE:The sedative effects of pregabalin during perioperative period have not been sufficiently characterized. The aim of this study was to verify the sedative effects of premedication with pregabalin on intravenous sedation (IVS) using propofol and also to assess the influences of this agent on circulation, respirat...
journal_title:Journal of anesthesia
pub_type: 临床试验,杂志文章
doi:10.1007/s00540-017-2366-7
更新日期:2017-08-01 00:00:00
abstract::To evaluate the effects of subanesthetic enflurane and sevoflurane on the sympathetic nervous system (SNS) and the parasympathetic nervous system (PNS), the blood level of norepinephrine (NE) and fluctuations in the R-R intervals were measured on electrocardiogram in humans given either 0.5 MAC enflurane or sevofluran...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/BF02482745
更新日期:1994-03-01 00:00:00
abstract:PURPOSE:We assessed the accuracy of a point-of-care blood gas analyzer in providing data from saline samples obtained by gastrointestinal tonometry (Tonometrics Catheter; Tonometrics Division, Instrumentarium, Helsinki, Finland) for the calculation of intramucosal pH (pHi) and the P(CO)(2) gap (intramucosal P(CO)(2) - ...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-003-0209-1
更新日期:2004-01-01 00:00:00
abstract::Brachial plexus block is commonly used for upper limb surgery. Although the procedure is safe, it may be associated with some life-threatening complications. We performed right-sided supraclavicular brachial plexus block for below-elbow amputation in a 45-year-old female. At completion of the block the patient develop...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-010-1076-1
更新日期:2011-04-01 00:00:00
abstract::We present a life-threatening case of hemothorax resulting from right brachiocephalic vein perforation during right internal jugular vein catheterization. We considered that the guidewire had punctured the right brachiocephalic vein extraluminally and the catheter inserted over the guidewire had enlarged the size of t...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-008-0696-1
更新日期:2009-01-01 00:00:00
abstract::The relationship between tumor size and the complexity of anesthetic management was studied using several values: plasma catecholamine concentrations, requirement of vasoactive agents, surgical time, blood loss, plasma glucose concentrations, and hemodynamic variables. Ten patients with clinical and laboratory diagnos...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/BF02514621
更新日期:1994-12-01 00:00:00
abstract:PURPOSE:The present study aimed to investigate the effects of different dosages of propofol, that induced different depths of anesthesia, on the local activity and connectivity of nuclei within the cortico-reticulo-thalamic loops, as well as the release of amino acids in those nuclei. METHODS:The nonlinear dynamics an...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-019-02667-9
更新日期:2019-10-01 00:00:00
abstract::In this study induction of anesthesia using the single-breath technique with either enflurane or sevoflurane in oxygen was compared. Each group consisted of 16 unpremedicated volunteers who breathed approximately 1.7 minimum alveolar concentration (MAC) equivalents of either vapor. There were no significant difference...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/BF02514709
更新日期:1994-06-01 00:00:00
abstract:PURPOSE:The study was planned to compare the sensitivity of a twitch neuromuscular monitoring test, the train-of-four (TOF), with a tetanic test, double-burst stimulation (DBS), during a subclinical dose of vecuronium. METHODS:Twenty consenting. ASA I patients (16 to 65 years of age) of both sexes were studied. The ul...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/BF02480738
更新日期:1997-12-01 00:00:00