The antiarrhythmic effect of flecainide on halothane-epinephrine induced arrhythmias in dogs.

Abstract:

:The antiarrhythmic effect of flecainide acetate (FCN), a newly developed class I antiarrhythmic drug, was evaluated on epinephrine (E)-halothane induced arrhythmias in dogs. The arrhythmogenic dose of E (ADE) under 1% of halothane was significantly increased from 0.71 +/- 0.08 to 1.08 +/- 0.11 and 1.84 +/- 0.23 micro g.kg(-1).min(-1) by the administration of 2 and 4 mg.kg(-1) of FCN, respectively. The arrhythmias induced by ADE in the absence of FCN were stopped by 1.78 +/- 0.29 mg.kg(-1) of FCN in bolus injections. These results suggest that FCN can be used for the treatment of arrhythmias that E contributes to under halothane anesthesia.

journal_name

J Anesth

journal_title

Journal of anesthesia

authors

Iwatsuki N,Takahashi M,Satoh S,Tajima T

doi

10.1007/s0054000040303

subject

Has Abstract

pub_date

1990-10-01 00:00:00

pages

303-8

issue

4

eissn

0913-8668

issn

1438-8359

journal_volume

4

pub_type

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