Prolonged drug-induced myoclonus: is it related to palonosetron?

Abstract:

:We report a case of drug-induced myoclonus possibly related to palonosetron, a second-generation 5-hydroxytryptamine-3 receptor antagonist which was administered as a prophylaxis for postoperative nausea and vomiting in a 28-year-old female. The recurrent episodes of myoclonus jerk involving the head, neck and shoulder persisted for a period of 4 days. The patient also exhibited an episode of severe bradycardia leading to hypotension 7 h after surgery. To our knowledge, this is the first report presenting these adverse events potentially associated with the use of palonosetron.

journal_name

J Anesth

journal_title

Journal of anesthesia

authors

Chaw SH,Chan L,Lee PK,Bakar JA,Rasiah R,Foo LL

doi

10.1007/s00540-016-2228-8

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

1063-1066

issue

6

eissn

0913-8668

issn

1438-8359

pii

10.1007/s00540-016-2228-8

journal_volume

30

pub_type

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