Abstract:
BACKGROUND:Rocuronium (Rb) is ideal for continuous infusion but has a widely variable duration of action. We investigated the distribution of Rb infusion in a steady state of optimal muscle relaxation and the relationship between the measured and predicted blood Rb concentrations in laparoscopic surgery. METHODS:Seventeen patients were anesthetized with propofol. Continuous Rb infusion was commenced at 7.5 µg/kg/min from 15 min after an initial Rb injection (0.6 mg/kg) and adjusted every 15 min to keep T1 within 3-10 %. Blood concentration was measured at the first onset of steady state, predicted concentration was calculated pharmacokinetically, and 25 % recovery time was measured. The distribution of the predicted concentration and infusion rate was plotted by histogram, the median value and 95th percentile were calculated, and the relationship between measured and predicted concentrations was analyzed by regression analysis. RESULTS:The rate during the stable state was 7.3 ± 2.1 µg/kg/min on average, 4 at minimum, 12 at maximum, and 12 at the 95th percentile. The predicted concentration was 1.7 ± 0.5 µg/ml on average, 0.8 at minimum, and 2.9 at maximum. The mean measured concentration was 1.4 ± 0.4 µg/ml. The predicted concentration was proportional to the measured concentration (y = 0.91x, r = 0.475; p < 0.001). A significant linear relationship was observed between the measured concentration and infusion rate (y = 0.64 + 0.11x, r = 0.618; p < 0.05). CONCLUSION:The measured blood concentration of Rb was comparable to the predicted value. Anesthesiologists can avoid overdose and attain a reliable muscle relaxant effect by maintaining a continuous dose by titration according to individual differences under muscle relaxant monitoring.
journal_name
J Anesthjournal_title
Journal of anesthesiaauthors
Kajiura A,Nagata O,Takizawa Y,Nakatomi T,Kodera S,Murayama Tdoi
10.1007/s00540-014-1879-6subject
Has Abstractpub_date
2015-02-01 00:00:00pages
9-14issue
1eissn
0913-8668issn
1438-8359journal_volume
29pub_type
杂志文章abstract::We report an 83-year-old man with myasthenia gravis (MG) who developed respiratory depression after spinal anesthesia for transurethral laser enucleation of the prostate. He became less responsive after complained of dyspnea, with a decrease of SpO2 to 83% approximately 13 min after intrathecal administration of 0.5% ...
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journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-012-1540-1
更新日期:2013-06-01 00:00:00
abstract::In this case series study, we prospectively examined whether it might be possible to check the effect of spinal anesthesia (SA), based on the disappearance of lower extremity reflexes and spasticity, in patients with spinal cord injury (SCI), in whom the effect cannot be confirmed by the pinprick test or by using the ...
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doi:10.1007/s00540-012-1429-z
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journal_title:Journal of anesthesia
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更新日期:1997-06-01 00:00:00
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abstract::We compared the characteristics of postoperative pharyngeal morbidity in intubation between the AirWay Scope (AWS) and Macintosh laryngoscope in 68 ASA I-II female patients aged 35-77 years in a randomized, double-blinded, controlled fashion. After induction of general anesthesia, the patient's trachea was intubated u...
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journal_title:Journal of anesthesia
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doi:10.1007/s0054010050160
更新日期:1991-04-01 00:00:00
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更新日期:2013-02-01 00:00:00
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更新日期:2007-01-01 00:00:00
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更新日期:2009-01-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2018-08-01 00:00:00
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journal_title:Journal of anesthesia
pub_type: 杂志文章
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更新日期:2003-01-01 00:00:00
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更新日期:2011-06-01 00:00:00
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更新日期:2014-06-01 00:00:00
abstract:PURPOSE:To investigate the differences in recovery of postural stability, after obtaining similar intravenous sedation levels with midazolam, in elderly and younger patients undergoing dental surgery. METHODS:We studied 15 elderly patients (>65 years) and 15 younger patients (<55 years) after intravenous sedation. Mid...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s005400200024
更新日期:2002-01-01 00:00:00
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更新日期:2014-02-01 00:00:00
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更新日期:2010-08-01 00:00:00
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journal_title:Journal of anesthesia
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2002-01-01 00:00:00
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更新日期:2010-06-01 00:00:00